Estimating the parameters of mixture models with modal estimators

This paper extends some of the work presented in Redner and Walker [I9841 on the maximum likelihood estimate of parameters in a mixture model to a Bayesian modal estimate. The problem of determining the mode of the joint posterior distribution is discussed. Necessary conditions are given for a choice of parameters to be the mode and a numerical scheme based on the EM algorithm is presented. Some theoretical remarks on the resulting iterative scheme and simulation results are also given.     

Checking identifiability of covariance parameters in linear mixed effects models

To build a linear mixed effects model, one needs to specify the random effects and often the associated parametrized covariance matrix structure. Inappropriate specification of the structures can result in the covariance parameters of the model not identifiable. Non-identifiability can result in extraordinary wide confidence intervals, and unreliable parameter inference. Sometimes software produces implication of model non-identifiability, but not always. In the simulation of fitting non-identifiable models we tried, about half of the times the software output did not look abnormal. We derive necessary and sufficient conditions of covariance parameters identifiability which does not require any prior model fitting. The results are easy to implement and are applicable to commonly used covariance matrix structures.     

Estimating multiple-membership logit models with mixed effects: indirect inference versus data cloning

Multiple-membership logit models with random effects are models for clustered binary data, where each statistical unit can belong to more than one group. The likelihood function of these models is analytically intractable. We propose two different approaches for parameter estimation: indirect inference and data cloning (DC). The former is a non-likelihood-based method which uses an auxiliary model to select reasonable estimates. We propose an auxiliary model with the same dimension of parameter space as the target model, which is particularly convenient to reach good estimates very fast. The latter method computes maximum likelihood estimates through the posterior distribution of an adequate Bayesian model, fitted to cloned data. We implement a DC algorithm specifically for multiple-membership models. A Monte Carlo experiment compares the two methods on simulated data. For further comparison, we also report Bayesian posterior mean and Integrated Nested Laplace Approximation hybrid DC estimates. Simulations show a negligible loss of efficiency for the indirect inference estimator, compensated by a relevant computational gain. The approaches are then illustrated with two real examples on matched paired data.     

A comparison of mixed and minimax estimators of linear models

In this paper the stochastic properties of two estimators of linear models, mixed and minimax, based on different types of prior information, are compared using quadratic risk as the criterion for superiority. A necessary and sufficient condition for the minimax estimator to be superior to the comparable mixed estimator is derived as well as a simpler necessary but not sufficient condition.     

Random effects models for count data

Random effects models are considered for count data obtained in a cross or nested classification. The main feature of the proposed models is the use of the additive effects on the original scale in contrast to the commonly used log scale. The rationale behind this approach is given. The estimation of variance components is based on the usual mean square approach. Directly analogous results to those from the analysis of variance models for continuous data are obtained. The usual Poisson dispersion test procedure can be used not only to test for no overall random effects but also to assess the adequacy of the model. Individual variance component can be tested by using the usual F-test. To get a reliable estimate, a large number of factor levels seem to be required.     

Variance components estimation for the balanced random effects model under mixed prior distributions

For the balanced random effects models, when the variance components are correlated either naturally or through common prior structures, by assuming a mixed prior distribution for the variance components, we propose some new Bayesian estimators. To contrast and compare the new estimators with the minimum variance unbiased (MVUE) and restricted maximum likelihood estimators (RMLE), some simulation studies are also carried out. It turns out that the proposed estimators have smaller mean squared errors than the MVUE and RMLE.     

Confidence intervals and tests on the variance ratio in random models with two variance components

The LM test is modified to test any value of the ratio of two variance components in a mixed effects linear model with two variance components. The test is exact, so it can be used to construct exact confidence intervals on this ratio.Exact Neyman-Pearson (NP) tests on the variance ratio are described.Their powers provide attainable upper bounds on powers of tests on the variance ratio.Efficiencies of LM tests, which include ANOVA tests, and NP tests are compared for unbalanced, random, one-way ANOVA models.Confidence intervals corresponding to LM tests and NP tests are described.     

Criteria for the equality between ordinary least squares and best linear unbiased estimators under certain linear models

A new necessary and sufficient condition is derived for the equality between the ordinary least-squares estimator and the best linear unbiased estimator of the expectation vector in linear models with certain specific design matrices. This condition is then applied to special cases involving one-way and two-way classification models.     

Applying skovgaard's modified directed likelihood statistic to mixed linear models

The introduction of software to calculate maximum likelihood estimates for mixed linear models has made likelihood estimation a practical alternative to methods based on sums of squares. Likelihood based tests and confidence intervals, however, may be misleading in problems with small sample sizes. This paper discusses an adjusted version of the directed log-likelihood statistic for mixed models that is highly accurate for testing one parameter hypotheses. Indroduced by Skovgaard (1996, Journal of the Bernoulli Society,2,145-165), we show in mixed models that the statistic has a simple conpact from that may be obtained from standard software. Simulation studies indicate that this statistic is more accurate than many of the specialized procedure that have been advocated.     

Estimating common parameters in heterogeneous random effects models

A question of fundamental importance for meta-analysis of heterogeneous multidimensional data studies is how to form a best consensus estimator of common parameters, and what uncertainty to attach to the estimate. This issue is addressed for a class of unbalanced linear designs which include classical growth curve models. The solution obtained is similar to the popular DerSimonian and Laird (1986) method for a simple meta-analysis model. By using almost unbiased variance estimators, an estimator of the covariance matrix of this procedure is derived. Combination of these methods is illustrated by two examples and are compared via simulation.     

Counterexamples to a result of broemeling on simultaneous inferences for variance ratios of some mixed linear models

In a recent paper5 Broemeling (1978) extended his earlier work on one-sided confidence regions for the variance ratios of balanced random-effects models to the two-sided case. The extension depends on a probability Inequality which was claimed to be tru We show here that it is false, hence the proof of the main result given in Ms parer is in error W also show Lhat the ntatement of his result remains true in certain special cases.     

Bayesian inference for the variance components in general mixed linear models

The general mixed linear model, containing both the fixed and random effects, is considered. Using gamma priors for the variance components, the conditional posterior distributions of the fixed effects and the variance components, conditional on the random effects, are obtained. Using the normal approximation for the multiple t distribution, approximations are obtained for the posterior distributions of the variance components in infinite series form. The same approximation Is used to obtain closed expressions for the moments of the variance components. An example is considered to illustrate the procedure and a numerical study examines the closeness of the approximations.     

A bayesian analysis of the mixed linear model

The mixed model is defined. The exact posterior distribution for the fixed effect vector is obtained. The exact posterior distribution for the error variance is obtained. The exact posterior mean and variance of a Bayesian estimator for the variances of random effects is also derived. All computations are non-iterative and avoid numerical integrations.     

Generalized confidence intervals for proportions of total variance in mixed linear models

Exact confidence intervals for a proportion of total variance, based on pivotal quantities, only exist for mixed linear models having two variance components. Generalized confidence intervals (GCIs) introduced by Weerahandi [1993. Generalized confidence intervals (Corr: 94V89 p726). J. Am. Statist. Assoc. 88, 899–905] are based on generalized pivotal quantities (GPQs) and can be constructed for a much wider range of models. In this paper, the author investigates the coverage probabilities, as well as the utility of GCIs, for a proportion of total variance in mixed linear models having more than two variance components. Particular attention is given to the formation of GPQs and GCIs in mixed linear models having three variance components in situations where the data exhibit complete balance, partial balance, and partial imbalance. The GCI procedure is quite general and provides a useful method to construct confidence intervals in a variety of applications.     

On biased linear estimators in models with arbitrary rank

In this paper we define a class of biased linear estimators for the unknown parameters in linear models with arbitrary rank. The feature of our approach is to reduce the estimation problem in arbitrary rank models to the one in full-rank models. Some important properties are discussed. As special cases of our class, we extend to deficient-rank models six known biased linear estimators.     

A new REML (parameter expanded) EM algorithm for linear mixed models

Linear mixed models are regularly applied to animal and plant breeding data to evaluate genetic potential. Residual maximum likelihood (REML) is the preferred method for estimating variance parameters associated with this type of model. Typically an iterative algorithm is required for the estimation of variance parameters. Two algorithms which can be used for this purpose are the expectation‐maximisation (EM) algorithm and the parameter expanded EM (PX‐EM) algorithm. Both, particularly the EM algorithm, can be slow to converge when compared to a Newton‐Raphson type scheme such as the average information (AI) algorithm. The EM and PX‐EM algorithms require specification of the complete data, including the incomplete and missing data. We consider a new incomplete data specification based on a conditional derivation of REML. We illustrate the use of the resulting new algorithm through two examples: a sire model for lamb weight data and a balanced incomplete block soybean variety trial. In the cases where the AI algorithm failed, a REML PX‐EM based on the new incomplete data specification converged in 28% to 30% fewer iterations than the alternative REML PX‐EM specification. For the soybean example a REML EM algorithm using the new specification converged in fewer iterations than the current standard specification of a REML PX‐EM algorithm. The new specification integrates linear mixed models, Henderson's mixed model equations, REML and the REML EM algorithm into a cohesive framework.     

Best minimum bias linear estimators in gauss-markoff model

In this note we present a criterion for linear estimation which is similar to MV-MB-LE of Rao (1978) in Gauss-Markoff model (Y, XB, α²G). We call this criterion MMS-MB-LE (Minimum Mean Square Error-Minimum Bias-Linear Estimation)> Representations of solutions to such estimators similar to those of Rao (1978) are provided.     

Unbiasedness of two-stage estimation and prediction procedures for mixed linear models

The traditional method for estimating or predicting linear combinations of the fixed effects and realized values of the random effects in mixed linear models is first to estimate the variance components and then to proceed as if the estimated values of the variance components were the true values. This two-stage procedure gives unbiased estimators or predictors of the linear combinations provided the data vector is symmetrically distributed about its expected value and provided the variance component estimators are translation-invariant and are even functions of the data vector. The standard procedures for estimating the variance components yield even, translation-invariant estimators.     

The relative efficiency of the restricted estimators in linear regression models

This paper deals with the problem of multicollinearity in a multiple linear regression model with linear equality restrictions. The restricted two parameter estimator which was proposed in case of multicollinearity satisfies the restrictions. The performance of the restricted two parameter estimator over the restricted least squares (RLS) estimator and the ordinary least squares (OLS) estimator is examined under the mean square error (MSE) matrix criterion when the restrictions are correct and not correct. The necessary and sufficient conditions for the restricted ridge regression, restricted Liu and restricted shrunken estimators, which are the special cases of the restricted two parameter estimator, to have a smaller MSE matrix than the RLS and the OLS estimators are derived when the restrictions hold true and do not hold true. Theoretical results are illustrated with numerical examples based on Webster, Gunst and Mason data and Gorman and Toman data. We conduct a final demonstration of the performance of the estimators by running a Monte Carlo simulation which shows that when the variance of the error term and the correlation between the explanatory variables are large, the restricted two parameter estimator performs better than the RLS estimator and the OLS estimator under the configurations examined.