A a comparison of the markov chain and the integral equation approaches for evaluating the run length distribution of quality control charts

Two methods that are often used to evaluate the run length distribution of quality control charts are the Markov chain and integral equation approaches. Both methods have been used to evaluate the cumulative sum (CUSUM) charts and the exponentially weighted moving average (EWMA) control charts. The Markov chain approach involves "discretiz-ing" the possible values which can be plotted. Using properties of finite Markov chains, expressions for the distribution of the run length, and for the average run length (ARL), can be obtained. For the CUSUM and EWMA charts there exist integral equations whose solution gives the ARL. Approximate methods can then be used to solve the integral equation. In this article we show that if the product midpoint rule is used to approximate the integral in the integral equation, then both approaches yield the same approximations for the ARL. In addition we show that the recursive expressions for the probability functions are the same for the two approaches. These results establish the integral equation approach as preferable whenever an integral equation can be found     

Joint coverage probability in a simulation study on continuous-time Markov chain parameter estimation

Parameter dependency within data sets in simulation studies is common, especially in models such as continuous-time Markov chains (CTMCs). Additionally, the literature lacks a comprehensive examination of estimation performance for the likelihood-based general multi-state CTMC. Among studies attempting to assess the estimation, none have accounted for dependency among parameter estimates. The purpose of this research is twofold: (1) to develop a multivariate approach for assessing accuracy and precision for simulation studies (2) to add to the literature a comprehensive examination of the estimation of a general 3-state CTMC model. Simulation studies are conducted to analyze longitudinal data with a trinomial outcome using a CTMC with and without covariates. Measures of performance including bias, component-wise coverage probabilities, and joint coverage probabilities are calculated. An application is presented using Alzheimer's disease caregiver stress levels. Comparisons of joint and component-wise parameter estimates yield conflicting inferential results in simulations from models with and without covariates. In conclusion, caution should be taken when conducting simulation studies aiming to assess performance and choice of inference should properly reflect the purpose of the simulation.