Simultaneous Confidence Intervals for Monotone Contrasts of Normal Means

The one-way ANOVA model is considered. The variances are assumed to be either equal but unknown or unequal and unknown. Two-stage procedures for generating simultaneous confidence intervals (SCI) for the class of monotone contrasts of the means are presented. The intervals are of fixed length and independent of the unknown variances.     

Asymptotically valid single-stage multiple-comparison procedures

We establish general conditions for the asymptotic validity of single-stage multiple-comparison procedures (MCPs) under the following general framework. There is a finite number of independent alternatives to compare, where each alternative can represent, e.g., a population, treatment, system or stochastic process. Associated with each alternative is an unknown parameter to be estimated, and the goal is to compare the alternatives in terms of the parameters. We establish the MCPs’ asymptotic validity, which occurs as the sample size of each alternative grows large, under two assumptions. First, for each alternative, the estimator of its parameter satisfies a central limit theorem (CLT). Second, we have a consistent estimator of the variance parameter appearing in the CLT. Our framework encompasses comparing means (or other moments) of independent (not necessarily normal) populations, functions of means, quantiles, steady-state means of stochastic processes, and optimal solutions of stochastic approximation by the Kiefer–Wolfowitz algorithm. The MCPs we consider are multiple comparisons with the best, all pairwise comparisons, all contrasts, and all linear combinations, and they allow for unknown and unequal variance parameters and unequal sample sizes across alternatives.     

Comparing several experimental groups with a control in the multivariate case

This paper presents a multivariate extension of Dunnett's test for comparing simultaneously k treatment group means with a single control group mean. A test based on Hotelling T²statistics is presented and approximate critical values are evaluated for the case of equal numbers of observations in each group, for the .05 and .01 levels of significance, for 1 to 5 variates, for 1 to 10 treatment groups, and for varying degrees of freedom. The accuracy of the procedure for generating approximate critical values is assessed via simulation studies conducted for selected cases and an example is presented using real data.     

On the Skew-Normal-Cauchy Distribution

A fixed effects one-way layout model of analysis of variance is considered where the variances are taken to be possibly unequal. Conservative single-stage procedures based on Banerjee’s method for the solution of the Behrens-Fisher problem are proposed for the following multiple comparisons problems: 1) all pairwise comparisons with a control population mean, and 2) all pairwise comparisons and all linear contrasts among the means. Since these procedures are likely to be very conservative in practice, approximate procedures based on Welch’s method for the solution of the Behrens-Fisher problem are suggested as alternatives. Monte Carlo studies indicate that the latter are much less conservative and hence may be better in practice. Both these sets of procedures need only the tables of the Student’s t-distribution for their application and are very simple to use. Exact two-stage procedures are proposed for the following multiple comparisons problems: 1) all pairwise comparisons and all linear contrasts among the means, and 2) all linear combinations of the means.     

Precedence tests for equality of two distributions based on early failures of ranked set samples

In this article, two different types of precedence tests, each with two different test statistics, based on ranked set samples for testing the equality of two distributions are discussed. The exact null distributions of proposed test statistics are derived, critical values are tabulated for both set size and number of cycles up to 8, and the exact power functions of these two types of precedence tests under the Lehmann alternative are derived. Then, the power values of these two test procedures and their competitors based on simple random samples and based on ranked set samples are compared under the Lehmann alternative exactly and also under a location-shift alternative by means of Monte Carlo simulations. Finally, the impact of imperfect ranking is discussed and some concluding remarks are presented.     

Between-group comparison of principal components — some sampling results

Sampling distributions arc Investigated for the critical angles proposed by Krzanowski (1979) as a means of comparing principal component analyses done on two sets of individuals, each of which has had the same p responses measured on it. A summary of the distributions is presented, by giving mean angles and 95% points. The emphasis is on the null case, when the two sets of individuals are assumed to be independent samples from the same population, but a limited study is also made of the case where the two samples come from different populations.     

Hypothesis testing for two-group incomplete-data growth curve problems

Using simulation techniques, the null distribution properties of seven hypothesis testing procedures and a comparison of their powers are investigated for incomplete-data small-sample growth curve situations. The testing procedures are a combination of two growth curve models (the Potthoff and Roy model for complete data and Kleinbaum's extention to incomplete data) and three estimation techniques (two involving means of existing observations and the other using the EM algorithm) plus an analysis of a subset of complete data. All of the seven tests use the Kleinbaum Wald statistic, but different tests use different information. The hypotheses of identical and parallel growth curves are tested under the assumptions of multivariate normality and a linear polynomial mean growth curve for each of two groups. Good approximate null distributions are found for all procedures and one procedure is identified as empirically most powerful for the situations investigated.     

Some comments on a class of simultaneous inference procedures in ancova

Methods for constructing simultaneous confidence intervals for contrasts of treatment effects in analysis of covariance (ANCOVA) models are discussed and compared. A simple procedure is given by which, under a normality assumption made on the covariates, any method appropriate in an analysis of variance (ANOVA) may be applied to a corresponding ANCOVA by means of a simple adjustment of the required critical values. Some properties of this procedure are noted.     

Analysis of incomplete data under non-random mechanisms: bayesian inference

Inferences are made concerning population proportions when data are not missing at random.Both one sample and two sample situations are considered with examples in clinical trials.The one samplesituation involves the existence of response related incomplete data in a study conducted to make inferences involving the proportion. The two sample problem involves comparing two treatments in clinical trials when there exists dropouts due to both the treatment and the response to the treatment.Bayes procedures are used in estimating parameters of interest and testing hypotheses of interest in these two situations. An ad-hoc approach to the classical inference is presented for each ofthe two situations and compared with the Bayesian approach discussed. To illustrate the theory developed, data from clinical trials of severe head trauma patients at the Medical College of Virginia Head Injury Center from 1984 to 1987 is considered     

Testing Equality of Means Under Order Restrictions Using Multiple Contrasts

The likelihood ratio test for equality of ordered means is known to have power characteristics that are generally superior to those of competing procedures. Difficulties in implementing this test have led to the development of alternative approaches, most of which are based on contrasts. While orthogonal contrasts can be chosen to simplify the distribution theory, we propose a class of tests that is easy to implement even if the contrasts used are not orthogonal. An overall measure of significance may be obtained by using Fisher's combination statistic to combine the dependent p-values arising from these contrasts. This method can be easily implemented for testing problems involving unequal sample sizes and any partial order, and has power properties that compare well with those of the likelihood ratio test and other contrast-based tests.     

Inferences on the difference between future observations for comparing two treatments

The comparison of two treatments with normally distributed data is considered. Inferences are considered based upon the difference between single potential future observations from each of the two treatments, which provides a useful and easily interpretable assessment of the difference between the two treatments. These methodologies combine information from a standard confidence interval analysis of the difference between the two treatment means, with information available from standard prediction intervals of future observations. Win-probabilities, which are the probabilities that a future observation from one treatment will be superior to a future observation from the other treatment, are a special case of these methodologies. The theoretical derivation of these methodologies is based upon inferences about the non-centrality parameter of a non-central t-distribution. Equal and unequal variance situations are addressed, and extensions to groups of future observations from the two treatments are also considered. Some examples and discussions of the methodologies are presented.     

Multiple comparisons of several populations with more than one control with respectto scale parameter

In this paper, one-sided and two-sided test procedures for comparing several treatments with more than one control with respect to scale parameter are proposed. The proposed test procedures are inverted to obtain the associated simultaneous confidence intervals. The multiple comparisons of test treatments with the best control are also developed. The computation of the critical points, required to implement the proposed procedures, is discussed by taking the normal probability model. Applications of the proposed test procedures to two-parameter exponential probability model are also demonstrated.     

Indicator function based on complex contrasts and its application in general factorial designs

A factorial design can be uniquely determined by an indicator function which is constructed by means of orthogonal contrasts. Since the orthogonal contrasts are not unique, invariant measures are preferred. However, some particular orthogonal contrasts may express more information about designs than the others and be worth our attention. In this paper, a kind of indicator function based on orthogonal complex contrasts is introduced to represent general factorial designs and its significance on projection designs is presented. Based on this function, a generalized resolution and a new aberration criterion are developed to rank combinatorially non-isomorphic designs with prime levels. Some results and comparison are provided by means of examples.     

comparing several accelerated life models

This paper presents two approaches for comparing several exponential accelerated life models under the usual stress levels. The approaches are based on on the likelihood ratio statistics and on the posterior Bayes factor ( Aitkin, 1991). These procedures can be useful in many practical situations. An exact distribution and a table of critical values of the likelihood ratio statistics are presented. A simulation study is also performed.     

Rank-based test procedures for interaction in the two-way layout with one observation per cell

New aligned-rank test procedures for the composite null hypothesis of no interaction effects (without placing restrictions on the two main effects) against appropriate composite general alternatives are developed for the standard two-way layout with a single observation per cell. Relative power performances of the two new aligned-rank procedures and existing tests due to Tukey (1949) and to de Kroon & van der Laan (1981) are examined via Monte Carlo simulation. Extensive power studies conducted on the 5 × 6 and 5 × 9 two-way layouts with one observation per cell show superior performance of the new procedures for a variety of interaction effects. Simulated critical values for the new procedures are provided in settings where the number of levels for each of the factors is between 3 and 9, inclusive.     

A revision of the tukey multiple comparisons procedure to control the probability of committing at most one type i error

Halperin et al. (1988) suggested an approach which allows for k Type I errors while using Scheffe's method of multiple comparisons for linear combinations of p means. In this paper we apply the same type of error control to Tukey's method of multiple pairwise comparisons. In fact, the variant of the Tukey (1953) approach discussed here defines the error control objective as assuring with a specified probability that at most one out of the p(p-l)/2 comparisons between all pairs of the treatment means is significant in two-sided tests when an overall null hypothesis (all p means are equal) is true or, from a confidence interval point of view, that at most one of a set of simultaneous confidence intervals for all of the pairwise differences of the treatment means is incorrect. The formulae which yield the critical values needed to carry out this new procedure are derived and the critical values are tabulated. A Monte Carlo study was conducted and several tables are presented to demonstrate the experimentwise Type I error rates and the gains in power furnished by the proposed procedure     

Estimation of critical points in the mixture inverse Gaussian model

The maximum likelihood estimation for the critical points of the failure rate and the mean residual life function are presented in the case of mixture inverse Gaussian model. Several important data sets are analyzed from this point of view. For each of the data sets, Bootstrapping is used to construct confidence intervals of the critical points.     

Multiple comparison procedures for finding non-maximum normal means

Abstract

In this study, we discuss multiple comparison procedures for finding normal means which are not maximum among several normal means. Specifically, we propose the single step procedure, the sequentially rejective step down procedure and the step up procedure. For the single step procedure we determine the critical value for a specified significance level. For the sequentially rejective step down procedure and the step up procedure we determine the critical value at each step of the test for a specified significance level. For three procedures we formulate the power of the test under a specified alternative hypothesis. We give some numerical examples regarding critical values and power of the test intended to compare three procedures.     

Regression Parameter Estimation from Panel Counts

This paper considers a study where each subject may experience multiple occurrences of an event and the rate of the event occurrences is of primary interest. Specifically, we are concerned with the situations where, for each subject, there are only records of the accumulated counts for the event occurrences at a finite number of time points over the study period. Sets of observation times may vary from subject to subject and differ between groups. We model the mean of the event occurrence number over time semiparametrically, and estimate the regression parameter. The proposed estimation procedures are illustrated with data from a bladder cancer study ( Byar, 1980 ). Both asymptotics and simulation studies on the estimators are presented.     

A Simulation Comparison of Approximate Tests for Fixed Effects in Random Coefficients Growth Curve Models

Often, the response variables on sampling units are observed repeatedly over time. The sampling units may come from different populations, such as treatment groups. This setting is routinely modeled by a random coefficients growth curve model, and the techniques of general linear mixed models are applied to address the primary research aim. An alternative approach is to reduce each subject’s data to summary measures, such as within-subject averages or regression coefficients. One may then test for equality of means of the summary measures (or functions of them) among treatment groups. Here, we compare by simulation the performance characteristics of three approximate tests based on summary measures and one based on the full data, focusing mainly on accuracy of p-values. We find that performances of these procedures can be quite different for small samples in several different configurations of parameter values. The summary-measures approach performed at least as well as the full-data mixed models approach.