On a conjecture concerning the least favorable configuration of a two-stage selection procedure

A two-stage procedure 𝓅with screening in the first stage to find the population with the largest mean out of k ≧ 2 normal populations with unknown means and a common variance is under concern. It was proposed and previousiy studied by Cohen (1959), Alam (1970) and Tamhane and Bechhofer (1977, 1979) using the indifference-zone approach. The conjecture that the least favourable parameter configuration for the probability of a correct selection is of the slippage type remained unproved for k ≧ 3. Miescke and Sehr (1980) proved the conjecture for k=3. The problem was further discussed by Gupta and Miescke (1982). A general proof for rhe conjecture will be given in this paper.     

Runs tests for group control charts

When a process consists of several identical streams that are not highly correlated, an alternative to using separate control charts for each stream is to use a group control chart. Rather than plotting sample means from each stream at any time point, one could plot only the largest and/or smallest sample mean from among all the streams. Using the theory of stochastic processes and majorization together with numerical methods, the properties of a test that signals if r consecutive extreme values come from the same stream are examined. Both one and two-sided cases are considered. Average run lengths (ARL's), the least favorable configuration of the stream (population) means, and sample sizes necessary to have specified in-control and out-of-control ARL's are obtained. A test that signals if r-1 out of r consecutive extreme values come from the same stream is also considered     

Two stage multiple comparison procedures based on the studentized range

Stein’s (1945) two sample approach and Tukey’s T-Method of multiple comparisons (see e.g. Miller, 1966, Ch. 2) are combined to obtain fixed width simultaneous confidence intervals and simultaneous test procedures of predetermined Type I and Type II error levels, for all contrasts, in a one way layout. The necessary constants for implementing the two stage procedure are obtained under a least favorable configuration of the parameters. This provides the required protection of the null and alternative hypotheses under any configuration of parameters. A table is provided for some selected designs and error levels and an example is given to illustrate certain features of the new procedure.     

Closed inverse sampling procedure for selecting the largest multinomial cell probability

A class of closed inverse sampling procedures R(n,m) for selecting the multinomial cell with the largest probability is considered; here n is the maximum sample size that an experimenter can take and m is the maximum frequency that a multinomial cell can have. The proposed procedures R(n,m) achieve the same probability of a correct selection as do the corresponding fixed sample size procedures and the curtailed sequential procedures when m is at least n/2. A monotonicity property on the probability of a correct selection is proved and it is used to find the least favorable configurations and to tabulate the necessary probabilities of a correct selection and corresponding expected sample sizes     

On testing the bioequivalence of several treatments using the measure of distance

A studentized range test is proposed to test the hypothesis of bioequivalence of normal means in terms of a standardized distance among means. A least favourable configuration (LFC) of means to guarantee the maximum level at a null hypothesis and an LFC of means to guarantee the minimum power at an alternative hypothesis are obtained. This level and power of the test are fully independent of the unknown means and variances. For a given level, the critical value of the test under a null hypothesis can be determined. Furthermore, if the power under an alternative is also required at a given level, then both the critical value and the required sample size for an experiment can be simultaneously determined. In situations where the common population variance is unknown and the bioequivalence is the actual distance between means without standardization, a two-stage sampling procedure can be employed to find these solutions.     

Multiple comparisons with ‘best’ for multivariate normal populations

Comparisons of multivariate normal populations are made using a mul-tivariate approach (instead of reducing the problem to a univariate one). A rather negative finding is that, for comparisons with the ‘best’ of each variate, repeated univariate comparisons appear to be almost as efficient as multivariate comparisons, at least for the bivariate case and, under certain circumstances, for higher dimensional cases. Investigations are done on comparisons with the ‘MAX-best’ population (that one having the largest maximum of the marginal means), the ‘MIN-best’ (having the largest minimum) and the ‘O-best’ (being closest to largest in all marginal means). Detailed results are given for the bivariate normal with extensions indicated for the multivariate.     

Selecting the t-best cells in a multinomial distribution

The problem of selecting the t-best cells in a multinomial distribution with t + k cells, k > 1, 2 <= t is considered under the fixed sample-size indifference zone approach. The least favourable configuration is derived for the usual procedure of selection, for large values of N (the sample size). The result settles Conjecture I (for large N) and Conjecture IV of Chen and Hwang (Commun. Statist. - Theory Meth. 13 (10), 1289-1298, 1984) in the affirmative.     

Determination of sample size for selecting the smallest of k poisson population means

A procedure for selecting a Poisson population with smallest mean is considered using an indifference zone approach. The objective is to determine the smallest sample size n required from k ≥ 2 populations in order to attain the desired probability of correct selection. Since the means procedure is not consistent with respect to the difference or ratio alone, two distance measures are used simultaneously to overcome the difficulty in obtaining the smallest probability of correct selection that is greater than some specified limit. The constants required to determine n are computed and tabulated. The asymptotic results are derived using a normal approximation. A comparison with the exact results indicates that the proposed approximation works well. Only in the extreme cases small increases in n are observed. An example of industrial accident data is used to illustrate this procedure.     

Sample size determination of steel's nonparametric many-one test

We derive sample size formulas for the many-one test of Steel (1959) when the all-pairs power is preassigned. In this large sample approach we replace, similar to Noether (1987), the unknown variances and also the unknown correlation coefficients in the power expressions by their known values under the null hypotheses. We then obtain least favorable configurations for one-and two-sided comparisons. The reliability of our formulas is examined in computer simulations for different alternatives with various distributions.     

On Testing the Mean Equivalence of Treatments from Correlated Normal Populations

Let there be k equally correlated treatment populations under consideration, a Studentized range test is proposed to test the hypothesis of average mean equivalence against the alternative hypothesis of inequivalence. The maximum level and minimum power at some least favorable configurations of means are used to calculate the critical value and the required sample size simultaneously when testing a null against an alternative hypothesis. The range test is applied to a real world problem to find out if the stress levels among children at four time periods due to a newly built nearby airport are equivalent.     

Subset selection of the t best populations

Selection of the “best” t out of k populations has been considered in the indifferece zone formulation by Bachhofer (1954) and in the subset selection formulation by Carroll, Gupta and Huang (1975). The latter approach is used here to obtain conservative solutions for the goals of selecting (i) all the “good” or (ii) only “good” populations, where “good” means having a location parameter among the largest t. For the case of normal distributions, with common unknown variance, tables are produced for implementing these procedures. Also, for this case, simulation results suggest that the procedure may not be too conservative.     

Sample size calculation for testing non-inferiority and equivalence under Poisson distribution

When counting the number of chemical parts in air pollution studies or when comparing the occurrence of congenital malformations between a uranium mining town and a control population, we often assume Poisson distribution for the number of these rare events. Some discussions on sample size calculation under Poisson model appear elsewhere, but all these focus on the case of testing equality rather than testing equivalence. We discuss sample size and power calculation on the basis of exact distribution under Poisson models for testing non-inferiority and equivalence with respect to the mean incidence rate ratio. On the basis of large sample theory, we further develop an approximate sample size calculation formula using the normal approximation of a proposed test statistic for testing non-inferiority and an approximate power calculation formula for testing equivalence. We find that using these approximation formulae tends to produce an underestimate of the minimum required sample size calculated from using the exact test procedure. On the other hand, we find that the power corresponding to the approximate sample sizes can be actually accurate (with respect to Type I error and power) when we apply the asymptotic test procedure based on the normal distribution. We tabulate in a variety of situations the minimum mean incidence needed in the standard (or the control) population, that can easily be employed to calculate the minimum required sample size from each comparison group for testing non-inferiority and equivalence between two Poisson populations.     

A Two-stage minimax procedure with screening for selecting the largest normal mean

The problem of selecting the normal population with the largest population mean when the populations have a common known variance is considered. A two-stage procedure is proposed which guarantees the same probability requirement using the indifference-zone approach as does the single-stage procedure of Bechhofer (1954). The two-stage procedure has the highly desirable property that the expected total number of observations required by the procedure is always less than the total number of observations required by the corresponding single-stage procedure, regardless of the configuration of the population means. The saving in expected total number of observations can be substantial, particularly when the configuration of the population means is favorable to the experimenter. The saving is accomplished by screening out “non-contending” populations in the first stage, and concentrating sampling only on “contending” populations in the second stage.

The two-stage procedure can be regarded as a composite one which uses a screening subset-type approach (Gupta (1956), (1965)) in the first stage, and an indifference-zone approach (Bechhofer (1954)) applied to all populations retained in the selected sub-set in the second stage. Constants to implement the procedure for various k and P? are provided, as are calculations giving the saving in expected total sample size if the two-stage procedure is used in place of the corresponding single-stage procedure.     

Screening for Multiple Target Detection

We apply statistical selection theory to multiple target detection problems by analyzing the Mahalanobis distances between multivariate normal populations and a desired standard (a known characteristic of a target). We want to achieve the goal of selecting a subset that contains no non target (negative) sites, which entails screening out all non targets. Correct selection (CS) is defined according to this goal. We consider two cases: (1) that all covariance matrices are known; and (2) that all covariance matrices are unknown, including both heteroscedastic and homoscedastic cases. Optimal selection procedures are proposed in order to reach the selection goal. The least favorable configurations (LFC) are found. Tables and figures are presented to illustrate the properties of our proposed procedures. Simulation examples are given to show that our procedures work well. The log-concavity results of the operating characteristic functions are also given.     

Power and sample size determination for a stepwise test procedure for finding the maximum safe dose

This paper addresses the problem of power and sample size calculation for a stepwise multiple test procedure (SD2PC) proposed in Tamhane et al. [2001. Multiple test procedures for identifying the maximum safe dose. J. Amer. Statist. Assoc. 96, 835–843] to identify the maximum safe dose of a compound. A general expression for the power of this procedure is derived. It is used to find the minimum overall power and minimum power under the constraint that the dose response function is bounded from below by a linear response function. It is shown that the two minima are attained under step and linear response functions, respectively. The sample sizes necessary on the zero dose control and each of the positive doses to guarantee a specified power requirement are calculated under these two least favorable configurations. A technique involving a continuous approximation to the sample sizes is used to reduce the number of quantities that need to be tabled, and to derive the asymptotically optimal allocation of the total sample size between the zero dose and the positive doses. An example is given to illustrate use of the tables. Extensions of the basic formulation are noted.     

On rules based on sample medians for selection of the largest location parameter

The problem of selection of a subset containing the largest of several location parameters is considered, and a Gupta-type selection rule based on sample medians is investigated for normal and double exponential populations. Numerical comparisons between rules based on medians and means of small samples are made for normal and contaminated normal populations, assuming the popula-tion means to be equally spaced. It appears that the rule based on sample means loses its superiority over the rule based on sample medians in case the samples are heavily contaminated. The asymptotic relative efficiency (ARE) of the medians procedure relative to the means procedure is also computed, assuming the normal means to be in a slippage configuration. The means proce-dure is found to be superior to the median procedure in the sense of ARE. As in the small sample case, the situation is reversed if the normal populations are highly contaminate.     

Comparing multiple treatments to both positive and negative controls

In the past, most comparison to control problems have dealt with comparing k test treatments to either positive or negative controls. Dasgupta et al. [2006. Using numerical methods to find the least favorable configuration when comparing k test treatments to both positive and negative controls. Journal of Statistical Computation and Simulation 76, 251–265] enumerate situations where it is imperative to compare several test treatments to both a negative as well as a positive control simultaneously. Specifically, the aim is to see if the test treatments are worse than the negative control, or if they are better than the positive control when the two controls are sufficiently apart. To find critical regions for this problem, one needs to find the least favorable configuration (LFC) under the composite null. In their paper, Dasgupta et al. [2006. Using numerical methods to find the least favorable configuration when comparing k test treatments to both positive and negative controls. Journal of Statistical Computation and Simulation 76, 251–265] came up with a numerical technique to find the LFC. In this paper we verify their result analytically. Via Monte Carlo simulation we compare the proposed method to the logical single step alternatives: Dunnett's [1955. A multiple comparison procedure for comparing several treatments with a control. Journal of the American Statistical Association 50, 1096–1121] or the Bonferroni correction. The proposed method is superior in terms of both the Type I error and the marginal power.     

Least significant spacing for ‘one versus the rest’ normal populations

Consider sample means from k(≥2) normal populations where the variances and sample sizes are equal. The problem is to find the ‘least significant difference’ or ‘spacing’ (LSS) between the two largest means, so that if an observed spacing is larger we have confidence 1 - α that the population with largest sample mean also has the largest population mean.

When the variance is known it is shown that the maximum LSS occurs when k = 2, provided a < .2723. In other words, for any value of k we may use the usual (one-tailed) least significant difference to demonstrate that one population has a population mean greater than (or equal to) the rest.

When the variance is estimated bounds are obtained for the confidence which indicate that this last result is approximately correct.     

Selecting logistic populations using the sample medians

This paper is concerned primarily with subset selection procedures based on the sample mediansof logistic populations. A procedure is given which chooses a nonempty subset from among kindependent logistic populations, having a common known variance, so that the populations with thelargest location parameter is contained in the subset with a pre‐specified probability. Theconstants required to apply the median procedure with small sample sizes (≤= 19) are tabulated and can also be used to construct simultaneous confidence intervals. Asymptotic formulae are provided for application with larger sample sizes. It is shown that, under certain situations, rules based on the median are substantially more efficient than analogous procedures based either on sample means or on the sum of joint ranks.     

Approximating sample size requirements for s2 charts

Sample size determination is one of the most important considerations in the design of a control chart. The optimal sample size will provide control over both type I and type II errors. The optimal sample size for an S2 chart can be determined exactly using an iterative procedure. Duncan presented a procedure to approximate the required sample size. The accuracy of Duncan's approximation is examined and an improved approximation is proposed.