Clustered Survival Data with Left‐truncation

Left‐truncation occurs frequently in survival studies, and it is well known how to deal with this for univariate survival times. However, there are few results on how to estimate dependence parameters and regression effects in semiparametric models for clustered survival data with delayed entry. Surprisingly, existing methods only deal with special cases. In this paper, we clarify different kinds of left‐truncation and suggest estimators for semiparametric survival models under specific truncation schemes. The large‐sample properties of the estimators are established. Small‐sample properties are investigated via simulation studies, and the suggested estimators are used in a study of prostate cancer based on the Finnish twin cohort where a twin pair is included only if both twins were alive in 1974.     

Estimating the parameters of a doubly truncated normal distribution

This paper deals with the maximum likelihood estimation of parameters for a doubly truncated normal distribution when the truncation points are known. We prove, in this case, that the MLEs are nonexistent (become infinite) with positive probability. For estimators that exist with probability one, the class of Bayes modal estimators or modified maximum likelihood estimators is explored. Another useful estimating procedure, called mixed estimation, is proposed. Simulations compare the behavior of the MLEs, the modified MLEs, and the mixed estimators which reveal that the MLE, in addition to being nonexistent with positive probability, behaves poorly near the upper boundary of the interval of its existence. The modified MLEs and the mixed estimators are seen to be remarkably better than the MLE     

Nonparametric bounds for the survivor function under general dependent truncation

Truncation occurs in cohort studies with complex sampling schemes. When truncation is ignored or incorrectly assumed to be independent of the event time in the observable region, bias can result. We derive completely nonparametric bounds for the survivor function under truncation and censoring; these extend prior nonparametric bounds derived in the absence of truncation. We also define a hazard ratio function that links the unobservable region in which event time is less than truncation time, to the observable region in which event time is greater than truncation time, under dependent truncation. When this function can be bounded, and the probability of truncation is known approximately, it yields narrower bounds than the purely nonparametric bounds. Importantly, our approach targets the true marginal survivor function over its entire support, and is not restricted to the observable region, unlike alternative estimators. We evaluate the methods in simulations and in clinical applications.     

Minimum variance unbiased estmation in some nonregulr families

Explicit expressions for the umvues of the means survival functions quantiles of order p and density are obtaicned for some one and two truncation parameter probability density functions the umvue of the hazard fuction whenever it exsts is also derived variances of some of these estimators are also computed .     

Estimation in a truncated bivariate poisson distribution

Moment estimators for parameters in a truncated bivariate Poisson distribution are derived in Hamdan (1972) for the special case of λ₁ = λ₂, Where λ₁, λ₂ are the marginal means. Here we derive the maximum likelihood estimators for this special case. The information matrix is also obtained which provides asymptotic covariance matrix of the maximum likelihood estimators. The asymptotic covariance matrix of moment estimators is also derived. The asymptotic efficiency of moment estimators is computed and found to be very low.     

Minimum variance unbiased estimation for modified power series distribution

In this paper we study the problem of finding the minimum variance unbiased (MVU) estimators of the functions of the para-meters of the modified power series distributions (MPSD). A theorem giving the necessary and sufficient conditions for the existence of the MVU estimators has been proved. Also, the estimators for a number of estimable functions of a parameter are obtained. Two other theorems dealing with the MVU estimation of the left truncated MPSD with unknown truncation point are also given. The particular case of the Lagrangian Poisson, the Lagrangian binomial and the Borel-Tanner distributions are considered and tables are also provided for the MVU estimators for some functions of the parameters. The variances of the estimators are also given for some cases.     

Penalized likelihood estimators for truncated data

We investigate the performance of linearly penalized likelihood estimators for estimating distributional parameters in the presence of data truncation. Truncation distorts the likelihood surface to create instabilities and high variance in the estimation of these parameters, and the penalty terms help in many cases to decrease estimation error and increase robustness. Approximate methods are provided for choosing a priori good penalty estimators, which are shown to perform well in a series of simulation experiments. The robustness of the methods is explored heuristically using both simulated and real data drawn from an operational risk context.     

Estimation of association parameters in copula models for bivariate left-truncated and right-censored data

We investigate the problem of estimating the association between two related survival variables when they follow a copula model and bivariate left-truncated and right-censored data are available. By expressing truncation probability as the functional of marginal survival functions, we propose a two-stage estimation procedure for estimating the parameters of Archimedean copulas. The asymptotic properties of the proposed estimators are established. Simulation studies are conducted to investigate the finite sample properties of the proposed estimators. The proposed method is applied to a bivariate RNA data.     

Asymptotic Distribution of the Maximum Likelihood Estimators of the Parameters of the Right-Truncated Dagum Distribution

In this work we have determined the asymptotic distribution of the maximum likelihood estimators of the parameters β, λ, and δ for the right-truncated Dagum model. Some numerical comparisons show that, for each combination of the parameters and for each sample size, the variance of maximum likelihood estimators increases as the truncation point decreases, i.e., with the increase in the cut of the right tail of distribution.     

Analysis of transformation models with right-truncated data

In many applications, statistical data are frequently observed subject to a retrospective sampling criterion resulting in right-truncated data. In this article, a general class of semiparametric transformation models that include proportional hazards model and proportional odds model as special cases is studied for the analysis of right-truncated data. We proposed two estimators for regression coefficients. The first estimator is based on martingale estimating equations. The second estimator is based on the conditional likelihood function given the truncation times. The asymptotic properties of both estimators are derived. The finite sample performance is examined through a simulation study.     

Minimum variance unbiased estimation in doubly type II censored samples from families of distributions involving two truncation parameters

In this paper we construct uniformly minimum variance unbiased estimators for U-estimable functions when the underlying family of distributions involves two unknown truncation parameters and the sample is doubly Type II censored. Previous relevant results for the complete sample case are obtained as special cases of our results.     

Estimation of parameters of inverse Weibull distribution and application to multi-component stress-strength model

The problem of estimation of the parameters of two-parameter inverse Weibull distributions has been considered. We establish existence and uniqueness of the maximum likelihood estimators of the scale and shape parameters. We derive Bayes estimators of the parameters under the entropy loss function. Hierarchical Bayes estimator, equivariant estimator and a class of minimax estimators are derived when shape parameter is known. Ordered Bayes estimators using information about second population are also derived. We investigate the reliability of multi-component stress-strength model using classical and Bayesian approaches. Risk comparison of the classical and Bayes estimators is done using Monte Carlo simulations. Applications of the proposed estimators are shown using real data sets.     

Semiparametric estimation of the cumulative incidence function under competing risks and left-truncated sampling

In this article, we propose semiparametric methods to estimate the cumulative incidence function of two dependent competing risks for left-truncated and right-censored data. The proposed method is based on work by Huang and Wang (1995). We extend previous model by allowing for a general parametric truncation distribution and a third competing risk before recruitment. Based on work by Vardi (1989), several iterative algorithms are proposed to obtain the semiparametric estimates of cumulative incidence functions. The asymptotic properties of the semiparametric estimators are derived. Simulation results show that a semiparametric approach assuming the parametric truncation distribution is correctly specified produces estimates with smaller mean squared error than those obtained in a fully nonparametric model.     

Nonparametric estimation with left-truncated and right-censored data when the sample size before truncation is known

In this article, we consider nonparametric estimation of the survival function when the data are subject to left-truncation and right-censoring and the sample size before truncation is known. We propose two estimators. The first estimator is derived based on a self-consistent estimating equation. The second estimator is obtained by using the constrained expectation-maximization algorithm. Simulation results indicate that both estimators are more efficient than the product-limit estimator. When there is no censoring, the performance of the proposed estimators is compared with that of the estimator proposed by Li and Qin [Semiparametric likelihood-based inference for biased and truncated data when total sample size is known, J. R. Stat. Soc. B 60 (1998), pp. 243–254] via simulation study.     

Feasible minimax estimators in the simultaneous equations model under partial restrictions

Approximate minimax estimators based on partial constraints on the structural parameters are derived in a single equation of a simultaneous equations model. The feasible versions of these estimators are shown to be biased but consistent.     

Estimation of the parameters of the gamma distribution by means of a maximal invariant

The use of a scale invariance criterion allows estimation of the shape parameter of the two parameter gamma distribution without estimating the scale parameter. Simulation experiments are used to show that the resulting estimators of both parameters are better than the usual maximum likelihood estimators in terms of both bias and mean square error. Approximately unbiased versions of the maximal invariant based estimators are derived and are shown to be as good as approximately unbiased versions of the usual maximum likelihood estimators     

Large sample theory for a multivariate structural relationship with replication

For a multivariate structural relationship, where the replicated observations are available and the covariance matrix of the observational error is not restricted to diagonal, we consider the generalized least-squares estimators of the unknown structural parameters. The estimators are proved to be asymptotically normally distributed using the Liapunov central limit theorem under mild conditions on the incidental parameters. Their asymptotic covariance matrix is also derived.     

Non-minimaxity of linear combinations of restricted location estimators and related problems

The estimation of a linear combination of several restricted location parameters is addressed from a decision-theoretic point of view. Although the corresponding linear combination of the unbiased estimators is minimax under the restricted problem, it has a drawback of taking values outside the restricted parameter space. Thus, it is reasonable to use the linear combination of the restricted estimators such as maximum likelihood or truncated estimators. In this paper, a necessary and sufficient condition for such restricted estimators to be minimax is derived, and it is shown that the restricted estimators are not minimax when the number of the location parameters is large. The condition for minimaxity is examined for some specific distributions. Finally, similar problems of estimating the product and sum of the restricted scale parameters are studied, and it is shown that analogous non-dominance properties appear when the number of the scale parameters is large.     

Fitting polynomial trend to time series by the method of Buys-Ballot estimators

The statistical properties of two closed-form estimators of the parameters of the quadratic time trend model are derived. The estimators are based on the derived variables from Buys-Ballot table. The estimators are derived by assuming that error term is identically and independently distributed. However, the validity of this assumption is sometimes difficult to verify. We also study, through simulations, the impact of misspecifying the error distribution on the estimation and prediction accuracy in the quadratic time trend model. It is shown that the estimators are inconsistent in the presence of misspecification. T methods are illustrated with real-life examples.     

Nonparametric estimation of the bivariate survival function with left-truncated and right-censored data

In this note, we consider estimating the bivariate survival function when both components are subject to left truncation and right censoring. We propose two types of estimators as generalizations of the Dabrowska and Campbell and Földes estimators. The consistency of the proposed estimators is established. A simple bootstrap method is used for obtaining precision estimation of the proposed estimators. A simulation study is conducted to investigate the performance of the proposed estimators.