Pooling multivariate data

In case it is doubtful whether two sets of data have the same mean vector, four estimation strategies have been developed for the target mean vector. In this situation, the estimates based on a preliminary test as well as on Stein-rule are advantageous. Two measures of relative efficiency are considered; one based on thequadratic loss function, and the other on the determinant of the mean square error matrix. A max-min rule for the size of the preliminary test of significance is presented. It is demonstrated that the shrinkage estimator dominates the classical estimator, whereas none of the shrinkage estimator and the preliminary test estimator dominate each other. The range in the parameter space where preliminary test estimator dominates shrinkage is investigated analytically and computationally. It is found that the shrinkage estimator outperform the preliminary test estimator except in a region around the null hypothesis. Moreover, for large values of a, the level of statistical significance, shrinkage estimator dominates the preliminary test estimator uniformly. The relative dominance of the estimators is presented.     

Fitting asymmetric bimodal data with selected distributions

ABSTRACT

This article discusses two asymmetrization methods, Azzalini's representation and beta generation, to generate asymmetric bimodal models including two novel beta-generated models. The practical utility of these models is assessed with nine data sets from different fields of applied sciences. Besides this tutorial assessment, some methodological contributions are made: a random number generator for the asymmetric Rathie–Swamee model is developed (generators for the other models are already known and briefly described) and a new likelihood ratio test of unimodality is compared via simulations with other available tests. Several tools have been used to quantify and test for bimodality and assess goodness of fit including Bayesian information criterion, measures of agreement with the empirical distribution and the Kolmogorov–Smirnoff test. In the nine case studies, the results favoured models derived from Azzalini's asymmetrization, but no single model provided a best fit across the applications considered. In only two cases the normal mixture was selected as best model. Parameter estimation has been done by likelihood maximization. Numerical optimization must be performed with care since local optima are often present. We concluded that the models considered are flexible enough to fit different bimodal shapes and that the tools studied should be used with care and attention to detail.     

Conjugate analysis of multivariate normal data with incomplete observations

The authors discuss prior distributions that are conjugate to the multivariate normal likelihood when some of the observations are incomplete. They present a general class of priors for incorporating information about unidentified parameters in the covariance matrix. They analyze the special case of monotone patterns of missing data, providing an explicit recursive form for the posterior distribution resulting from a conjugate prior distribution. They develop an importance sampling and a Gibbs sampling approach to sample from a general posterior distribution and compare the two methods.     

Modelling spatially correlated data via mixtures: a Bayesian approach

Summary. The paper develops mixture models for spatially indexed data. We confine attention to the case of finite, typically irregular, patterns of points or regions with prescribed spatial relationships, and to problems where it is only the weights in the mixture that vary from one location to another. Our specific focus is on Poisson-distributed data, and applications in disease mapping. We work in a Bayesian framework, with the Poisson parameters drawn from gamma priors, and an unknown number of components. We propose two alternative models for spatially dependent weights, based on transformations of autoregressive Gaussian processes: in one (the logistic normal model), the mixture component labels are exchangeable; in the other (the grouped continuous model), they are ordered. Reversible jump Markov chain Monte Carlo algorithms for posterior inference are developed. Finally, the performances of both of these formulations are examined on synthetic data and real data on mortality from a rare disease.     

Comparing the methods of measuring multi-rater agreement on an ordinal rating scale: a simulation study with an application to real data

Agreement among raters is an important issue in medicine, as well as in education and psychology. The agreement among two raters on a nominal or ordinal rating scale has been investigated in many articles. The multi-rater case with normally distributed ratings has also been explored at length. However, there is a lack of research on multiple raters using an ordinal rating scale. In this simulation study, several methods were compared with analyze rater agreement. The special case that was focused on was the multi-rater case using a bounded ordinal rating scale. The proposed methods for agreement were compared within different settings. Three main ordinal data simulation settings were used (normal, skewed and shifted data). In addition, the proposed methods were applied to a real data set from dermatology. The simulation results showed that the Kendall's W and mean gamma highly overestimated the agreement in data sets with shifts in data. ICC₄ for bounded data should be avoided in agreement studies with rating scales<5, where this method highly overestimated the simulated agreement. The difference in bias for all methods under study, except the mean gamma and Kendall's W, decreased as the rating scale increased. The bias of ICC₃ was consistent and small for nearly all simulation settings except the low agreement setting in the shifted data set. Researchers should be careful in selecting agreement methods, especially if shifts in ratings between raters exist and may apply more than one method before any conclusions are made.     

A monte carlo investigation of a statistic for a bivariate missing data problem

Testing the equal means hypothesis of a bivariate normal distribution with homoscedastic varlates when the data are incomplete is considered. If the correlational parameter, ρ, is known, the well-known theory of the general linear model is easily employed to construct the likelihood ratio test for the two sided alternative. A statistic, T, for the case of ρ unknown is proposed by direct analogy to the likelihood ratio statistic when ρ is known. The null and nonnull distribution of T is investigated by Monte Carlo techniques. It is concluded that T may be compared to the conventional t distribution for testing the null hypothesis and that this procedure results in a substantial increase in power-efficiency over the procedure based on the paired t test which ignores the incomplete data. A Monte Carlo comparison to two statistics proposed by Lin and Stivers (1974) suggests that the test based on T is more conservative than either of their statistics.     

Robust likelihood inferences for multivariate correlated data

Multivariate normal, due to its well-established theories, is commonly utilized to analyze correlated data of various types. However, the validity of the resultant inference is, more often than not, erroneous if the model assumption fails. We present a modification for making the multivariate normal likelihood acclimatize itself to general correlated data. The modified likelihood is asymptotically legitimate for any true underlying joint distributions so long as they have finite second moments. One can, hence, acquire full likelihood inference without knowing the true random mechanisms underlying the data. Simulations and real data analysis are provided to demonstrate the merit of our proposed parametric robust method.     

Multivariate data with missing observations

In this paper, multivariate data with missing observations, where missing values could be by chance or by design, are considered for various models including the growth curve model. The likelihood equations are derived and the consistency of the estimates established. The likelihood ratio tests are explicity derived.     

A joint model for hierarchical continuous and zero-inflated overdispersed count data

Many applications in public health, medical and biomedical or other studies demand modelling of two or more longitudinal outcomes jointly to get better insight into their joint evolution. In this regard, a joint model for a longitudinal continuous and a count sequence, the latter possibly overdispersed and zero-inflated (ZI), will be specified that assembles aspects coming from each one of them into one single model. Further, a subject-specific random effect is included to account for the correlation in the continuous outcome. For the count outcome, clustering and overdispersion are accommodated through two distinct sets of random effects in a generalized linear model as proposed by Molenberghs et al. [A family of generalized linear models for repeated measures with normal and conjugate random effects. Stat Sci. 2010;25:325–347]; one is normally distributed, the other conjugate to the outcome distribution. The association among the two sequences is captured by correlating the normal random effects describing the continuous and count outcome sequences, respectively. An excessive number of zero counts is often accounted for by using a so-called ZI or hurdle model. ZI models combine either a Poisson or negative-binomial model with an atom at zero as a mixture, while the hurdle model separately handles the zero observations and the positive counts. This paper proposes a general joint modelling framework in which all these features can appear together. We illustrate the proposed method with a case study and examine it further with simulations.     

Comparing the Fisher information in record data and random observations

We compare the Fisher information (FI) contained in the firstn record values and record times with the FI inn i. i. d. observations. General results are established for exponential family and Weibull type setups, and a summary table is provided listing several common distributions. We show that the FI in record data improves notably once the record times are included, often changing from being less to being equal or greater than the FI in a random sample of the same size. The behavior in the Weibull case is surprising. There it depends onn, whether the record or the i.i. d. observations have more FI. We propose new estimators based on record data. The results may be of interest in some life testing situations. Supported in part by Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) grant # 1010222 of Chile.     

Multiple imputation for ordinal longitudinal data with monotone missing data patterns

Missing data often complicate the analysis of scientific data. Multiple imputation is a general purpose technique for analysis of datasets with missing values. The approach is applicable to a variety of missing data patterns but often complicated by some restrictions like the type of variables to be imputed and the mechanism underlying the missing data. In this paper, the authors compare the performance of two multiple imputation methods, namely fully conditional specification and multivariate normal imputation in the presence of ordinal outcomes with monotone missing data patterns. Through a simulation study and an empirical example, the authors show that the two methods are indeed comparable meaning any of the two may be used when faced with scenarios, at least, as the ones presented here.     

Optimal asymmetric classification procedures for interval-screened normal data

Statistical methods for an asymmetric normal classification do not adapt well to the situations where the population distributions are perturbed by an interval-screening scheme. This paper explores methods for providing an optimal classification of future samples in this situation. The properties of the screened population distributions are considered and two optimal regions for classifying the future samples are obtained. These developments yield yet other rules for the interval-screened asymmetric normal classification. The rules are studied from several aspects such as the probability of misclassification, robustness, and estimation of the rules. The investigation of the performance of the rules as well as the illustration of the screened classification idea, using two numerical examples, is also considered.     

Bayesian analysis of semiparametric Bernstein polynomial regression models for data with sample selection

In regression analysis, a sample selection scheme often applies to the response variable, which results in missing not at random observations on the variable. In this case, a regression analysis using only the selected cases would lead to biased results. This paper proposes a Bayesian methodology to correct this bias based on a semiparametric Bernstein polynomial regression model that incorporates the sample selection scheme into a stochastic monotone trend constraint, variable selection, and robustness against departures from the normality assumption. We present the basic theoretical properties of the proposed model that include its stochastic representation, sample selection bias quantification, and hierarchical model specification to deal with the stochastic monotone trend constraint in the nonparametric component, simple bias corrected estimation, and variable selection for the linear components. We then develop computationally feasible Markov chain Monte Carlo methods for semiparametric Bernstein polynomial functions with stochastically constrained parameter estimation and variable selection procedures. We demonstrate the finite-sample performance of the proposed model compared to existing methods using simulation studies and illustrate its use based on two real data applications.     

Multiple comparisons with ‘best’ for multivariate normal populations

Comparisons of multivariate normal populations are made using a mul-tivariate approach (instead of reducing the problem to a univariate one). A rather negative finding is that, for comparisons with the ‘best’ of each variate, repeated univariate comparisons appear to be almost as efficient as multivariate comparisons, at least for the bivariate case and, under certain circumstances, for higher dimensional cases. Investigations are done on comparisons with the ‘MAX-best’ population (that one having the largest maximum of the marginal means), the ‘MIN-best’ (having the largest minimum) and the ‘O-best’ (being closest to largest in all marginal means). Detailed results are given for the bivariate normal with extensions indicated for the multivariate.     

Sidak-type simultaneous confidence intervals for the risk measures rsmr,based on proportional mortality measures in epidemiologic 1 studies involving several competing risks of death

In the present paper, simultaneous confidence interval estimates are constructed for the mortality measures RSMR. based on propor¬tional mortality measures SPMR. in epidemiologic studies for several competing risks of death to which the individuals in the study are exposed. It is demonstrated that, under a reasonable assumption, the joint sampling distribution of the statistics X. = RSMR./SPMR. for M competing risks9 may be approximated by means of a multi-variafe normal distribution, Sidak's (1967, 1968) mulfivariate normal probability inequalities are applied to construct the simultaneous confidence intervals for the measures RSMR., i=l3 2, ..., M. These are valid regardless of the covariance structure among the risks, As a particular case if the risks may be assumed as independent, our confidence intervals reduce to those for a single measure RSMR., which are narrower than those of Kupper et al., (1978), In this sense, our paper generalizes the results presently available in the literature in two directions; first, to obtain narrower confidence limits, and second3 to discuss the case of competing risks of death irrespective of their covariance structure.     

Interval robust design under contaminated and non normal data

Abstract

Robust parameter design (RPD) is an effective tool, which involves experimental design and strategic modeling to determine the optimal operating conditions of a system. The usual assumptions of RPD are that normally distributed experimental data and no contamination due to outliers. And generally the parameter uncertainties in response models are neglected. However, using normal theory modeling methods for a skewed data and ignoring parameter uncertainties can create a chain of degradation in optimization and production phases such that misleading fit, poor estimated optimal operating conditions, and poor quality products. This article presents a new approach based on confidence interval (CI) response modeling for the process mean. The proposed interval robust design makes the system median unbiased for the mean and uses midpoint of the interval as a measure of location performance response. As an alternative robust estimator for the process variance response modeling, using biweight midvariance is proposed which is both resistant and robust of efficiency where normality is not met. The results further show that the proposed interval robust design gives a robust solution to the skewed structure of the data and to contaminated data. The procedure and its advantages are illustrated using two experimental design studies.     

On the Admissibility of Linear Estimators in a Multivariate Normal Distribution Under LINEX Loss Function

Consider an estimation problem of a linear combination of population means in a multivariate normal distribution under LINEX loss function. Necessary and sufficient conditions for linear estimators to be admissible are given. Further, it is shown that the result is an extension of the quadratic loss case as well as the univariate normal case.     

Sensitivity analysis of the t-distribution under truncated normal populations

In recent literature, the truncated normal distribution has been used to model the stochastic structure for a variety of random structures. In this paper, the sensitivity of the t-random variable under a left-truncated normal population is explored. Simulation results are used to assess the errors associated when applying the student t-distribution to the case of an underlying left-truncated normal population. The maximum errors are modelled as a linear function of the magnitude of the truncation and sample size. In the case of a left-truncated normal population, adjustments to standard inferences for the mean, namely confidence intervals and observed significance levels, based on the t-random variable are introduced.     

Using the singly truncated normal distribution to analyze satellite data

This paper proposes the singly truncated normal distribution as a model for estimating radiance measurements from satellite-borne infrared sensors. These measurements are made in order to estimate sea surface temperatures which can be related to radiances. Maximum likelihood estimation is used to provide estimates for the unknown parameters. In particular, a procedure is described for estimating clear radiances in the presence of clouds and the Kolmogorov-Smirnov statistic is used to test goodness-of-fit of the measurements to the singly truncated normal distribution. Tables of quantile values of the Kolmogorov-Smirnov statistic for several values of the truncation point are generated from Monie Carlo experiment Mnally a numerical emample using satetic data is presented to illustrate the application of the procedures.     

On the distribution of the maximum of bivariate normal random variables with general means and variances

A great amount of effort has been devoted to achieving exact expressions for moments of order statistics of independent normal random variables, as well as the dependent case with the same correlation coefficients, means and variances. It does not seem as if there are handy formulae for the order statistics of even the simple bivariate normal random variables when the means and variances are allowed to be different. In this paper we give an explicit formula for the Lanl ace-Stielties Transform of the maximum of bivariate normal random variables by which we obtain formulae for the first two moments in the standard way.