A nonparametric test for proving noninferiority in clinical trials with ordered categorical data

We consider the problem of proving noninferiority when the comparison is based on ordered categorical data. We apply a rank test based on the Wilcoxon–Mann–Whitney effect where the asymptotic variance is estimated consistently under the alternative and a small‐sample approximation is given. We give the associated 100(1?α)% confidence interval and propose a formula for sample size determination. Finally, we illustrate the procedure and possible choices of the noninferiority margin using data from a clinical trial. Copyright © 2003 John Wiley & Sons, Ltd.     

Similarity-based model for ordered categorical data

In a large variety of applications, the data for a variable we wish to explain are ordered and categorical. In this paper, we present a new similarity-based model for the scenario and investigate its properties. We establish that the process is ψ-mixing and strictly stationary and derive the explicit form of the autocorrelation function in some special cases. Consistency and asymptotic normality of the maximum likelihood estimator of the model’s parameters are proven. A simulation study supports our findings. The results are applied to the Netflix data set, comprised of a survey on users’ grading of movies.     

Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations

The trend test is often used for the analysis of 2×K ordered categorical data, in which K pre-specified increasing scores are used. There have been discussions on how to assign these scores and the impact of the outcomes on different scores. The scores are often assigned based on the data-generating model. When this model is unknown, using the trend test is not robust. We discuss the weighted average of a trend test over all scientifically plausible choices of scores or models. This approach is more computationally efficient than a commonly used robust test MAX when K is large. Our discussion is for any ordered 2×K table, but simulation and applications to real data are focused on case-control genetic association studies. Although there is no single test optimal for all choices of scores, our numerical results show that some score averaging tests can achieve the performance of MAX.     

The minimum discrimination information approach in analyzing categorical data

A brief review of the minimum discrimination information (MDI) approach in analyzing categorical data is presented in a question -answer format, An example is given to bring out situations in which the MDI approach is more useful. No new results are proved.     

A generalized ordered Probit model

Abstract

The ordered probit and logit models, based on the normal and logistic distributions, can yield biased and inconsistent estimators when the distributions are misspecified. A generalized ordered response model is introduced which can reduce the impact of distributional misspecification. An empirical exploration of various determinants of life satisfaction suggests possible benefits of allowing for diverse distributional characteristics. These improvements are confirmed using a Monte Carlo study to contrast the performance of the flexible parametric specifications to the probit and logit specifications.     

Generalised quasi‐symmetry models for ordinal contingency tables

This paper extends the ordinary quasi‐symmetry (QS) model for square contingency tables with commensurable classification variables. The proposed generalised QS model is defined in terms of odds ratios that apply to ordinal variables. In particular, we present QS models based on global, cumulative and continuation odds ratios and discuss their properties. Finally, the conditional generalised QS model is introduced for local and global odds ratios. These models are illustrated through the analysis of two data sets.     

A skew-normal random effects model for longitudinal ordinal categorical responses with missing data

Missing values are common in longitudinal data studies. The missing data mechanism is termed non-ignorable (NI) if the probability of missingness depends on the non-response (missing) observations. This paper presents a model for the ordinal categorical longitudinal data with NI non-monotone missing values. We assumed two separate models for the response and missing procedure. The response is modeled as ordinal logistic, whereas the logistic binary model is considered for the missing process. We employ these models in the context of so-called shared-parameter models, where the outcome and missing data models are connected by a common set of random effects. It is commonly assumed that the random effect follows the normal distribution in longitudinal data with or without missing data. This can be extremely restrictive in practice, and it may result in misleading statistical inferences. In this paper, we instead adopt a more flexible alternative distribution which is called the skew-normal distribution. The methodology is illustrated through an application to Schizophrenia Collaborative Study data [19 D. Hedeker, Generalized linear mixed models, in Encyclopedia of Statistics in Behavioral Science, B. Everitt and D. Howell, eds., John Wiley, London, 2005, pp. 729–738. [Google Scholar]] and a simulation.     

The validity of the chi-squared test when expected frequencies are small:A list of recent research references

A bibliography is given containing about 60 recent (chiefly post-1968) items on the validity of the chi-squared test for categorical data when the expected frequencies are small.     

Cumulative correspondence analysis of ordered categorical data from industrial experiments

Most studies of quality improvement deal with ordered categorical data from industrial experiments. Accounting for the ordering of such data plays an important role in effectively determining the optimal factor level of combination. This paper utilizes the correspondence analysis to develop a procedure to improve the ordered categorical response in a multifactor state system based on Taguchi's statistic. Users may find the proposed procedure in this paper to be attractive because we suggest a simple and also popular statistical tool for graphically identifying the really important factors and determining the levels to improve process quality. A case study for optimizing the polysilicon deposition process in a very large-scale integrated circuit is provided to demonstrate the effectiveness of the proposed procedure.     

CATANOVA for two-way cross classified categorical data

In this article we develop an extension of categorical analysis of variance for one response and two factors, based on a partitioning of a measure of predictability for three-way contingency tables, known as Gray and Williams's index. At the first instance moment the decomposition of this multiple measure of association in partial association measures is shown. Finally, for ordinal-scale variables, we propose an extension of this decomposition using a particular set of orthogonal polynomials.     

A univariate procedure for monitoring location and dispersion with ordered categorical data

The quality characteristic is usually measured by ordered attribute levels, such as good, general, and poor, which describe different magnitudes of the characteristic. The ordinal levels are determined by a continuous latent variable, the shifts of which are reflected by the observed counts in each level. This article devises a control procedure based on the discrepancy between observed average cumulative counts and their expected ones. Simulation results are shown to demonstrate its superior sensitivity in simultaneously detecting location and dispersion shifts of the latent variable. Flexibility in assigning the weight for each level can allow the chart to be more powerful.     

Marginal asymmetry model for square contingency tables with ordered categories

For the analysis of square contingency tables with ordered categories, this paper proposes a model which indicates the structure of marginal asymmetry. The model states that the absolute values of logarithm of ratio of the cumulative probability that an observation will fall in row category i or below and column category i+1 or above to the corresponding cumulative probability that the observation falls in column category i or below and row category i+1 or above are constant for every i. We deal with the estimation problem for the model parameter and goodness-of-fit tests. Also we discuss the relationships between the model and a measure which represents the degree of departure from marginal homogeneity. Examples are given.     

Imputation procedures for categorical data: their effects on the goodness-of-fit chi-square statistic

An imputation procedure is a procedure by which each missing value in a data set is replaced (imputed) by an observed value using a predetermined resampling procedure. The distribution of a statistic computed from a data set consisting of observed and imputed values, called a completed data set, is affecwd by the imputation procedure used. In a Monte Carlo experiment, three imputation procedures are compared with respect to the empirical behavior of the goodness-of- fit chi-square statistic computed from a completed data set. The results show that each imputation procedure affects the distribution of the goodness-of-fit chi-square statistic in 3. different manner. However, when the empirical behavior of the goodness-of-fit chi-square statistic is compared u, its appropriate asymptotic distribution, there are no substantial differences between these imputation procedures.     

Univaiuate anu multivariate categorical data analysis for block designs

Analysis for univariate and multivariate categorical data in block designs is given and illustrated through examples. The univariate analysis compares the treatments on the basis of their pooled frequency distributions (pooled over blocks). The test statistic used is called Q after Cochran (1950). The large sample null distribution of Q is a chi-square. Analysis of p-variate categorical data (kth variable having ck classes, K=1,...,p) can be done by treating it as a univariate categorical problem with [d] classes. Very often [d] is large in relation to the size of the experiment. This makes the expected frequencies for some of the cells very small, making the univariate method inapplicable. In these circumstances it may be reasonable to compare the treatments on the basis of marginal distributions up to the mth dimension, 1[d] , which is given in this paper. This method is also illustrated for missing observations     

Tests on asymmetry for ordered categorical variables

Skewness is a well-established statistical concept for continuous and, to a lesser extent, for discrete quantitative statistical variables. However, for ordered categorical variables, limited literature concerning skewness exists, although this type of variables is common for behavioral, educational, and social sciences. Suitable measures of skewness for ordered categorical variables have to be invariant with respect to the group of strictly increasing, continuous transformations. Therefore, they have to depend on the corresponding maximal-invariants. Based on these maximal-invariants, we propose a new class of skewness functionals, show that members of this class preserve a suitable ordering of skewness and derive the asymptotic distribution of the corresponding skewness statistic. Finally, we show the good power behavior of the corresponding skewness tests and illustrate these tests by applying real data examples.     

Effective directed tests for models with ordered categorical data

This paper offers a new method for testing one‐sided hypotheses in discrete multivariate data models. One‐sided alternatives mean that there are restrictions on the multidimensional parameter space. The focus is on models dealing with ordered categorical data. In particular, applications are concerned with R×C contingency tables. The method has advantages over other general approaches. All tests are exact in the sense that no large sample theory or large sample distribution theory is required. Testing is unconditional although its execution is done conditionally, section by section, where a section is determined by marginal totals. This eliminates any potential nuisance parameter issues. The power of the tests is more robust than the power of the typical linear tests often recommended. Furthermore, computer programs are available to carry out the tests efficiently regardless of the sample sizes or the order of the contingency tables. Both censored data and uncensored data models are discussed.     

Bayesian reconstruction of contingency tables with partially categorized data

This paper suggests a Bayesian approach to the reconstruction of a 2 × 2 contingency table where some of the observations are only partially categorized and others are fully categorized. In contrast, most previous Bayesian and non-Bayesian analyses of the partially categorized data problem have been concerned with estimation of the parameters that generated the data. We show in an example that estimates may not be extremely sensitive to the weight placed on prior information relative to the sample data.     

A latent variable regression model for asymmetric bivariate ordered categorical data

In many areas of medical research, especially in studies that involve paired organs, a bivariate ordered categorical response should be analyzed. Using a bivariate continuous distribution as the latent variable is an interesting strategy for analyzing these data sets. In this context, the bivariate standard normal distribution, which leads to the bivariate cumulative probit regression model, is the most common choice. In this paper, we introduce another latent variable regression model for modeling bivariate ordered categorical responses. This model may be an appropriate alternative for the bivariate cumulative probit regression model, when postulating a symmetric form for marginal or joint distribution of response data does not appear to be a valid assumption. We also develop the necessary numerical procedure to obtain the maximum likelihood estimates of the model parameters. To illustrate the proposed model, we analyze data from an epidemiologic study to identify some of the most important risk indicators of periodontal disease among students 15-19 years in Tehran, Iran.     

Two simple measures of variability for categorical data

This paper proposes two new variability measures for categorical data. The first variability measure is obtained as one minus the square root of the sum of the squares of the relative frequencies of the different categories. The second measure is obtained by standardizing the first measure. The measures proposed are functions of the variability measure proposed by Gini [Variabilitá e Mutuabilitá Contributo allo Studio delle Distribuzioni e delle Relazioni Statistiche, C. Cuppini, Bologna, 1912] and approximate the coefficient of nominal variation introduced by Kvålseth [Coefficients of variation for nominal and ordinal categorical data, Percept. Motor Skills 80 (1995), pp. 843–847] when the number of categories increases. Different mathematical properties of the proposed variability measures are studied and analyzed. Several examples illustrate how the variability measures can be interpreted and used in practice.     

A modified chi-square test of independence against a class of ordered alternatives in an r x c contingency table

A modified chi-square test statistic is constructed for testing the hypothesis of independence in a two-way contingency table against a class of ordered alternatives defined in terms of pooled cross-product ratios. The test procedure can also be used to test for positive quadrant dependence in a two-way contingency table. The asymptotic distribution of the test statistic under the null hypothesis is obtained. Some power comparisons with known test procedures are given. A numerical example is given to illustrate the use of this test.