Biological Underpinnings of Borderline Personality Disorder

SUMMARY

Biological understanding of a personality disorder is best achieved by examining the disorder's component dimensions, which for borderline personality disorder include impulsive aggression and affective instability. Current biological research into BPD aims to identify the neurotransmitters and brain regions implicated in each of these key domains. Because of advancing technologies and analytic strategies, structural and functional neuroimaging are at the forefront of such efforts. Structural neuroimaging, primarily in the form of magnetic resonance imaging (MRI) scans, gives information about the anatomy of the brain, while functional neuroimaging, primarily functional MRI (fMRI) and positron emission tomography (PET) scans, gives information about brain activity and neurotransmitter systems at the molecular level. BPD neuroimaging studies to date have implied the involvement of several neurotransmitter systems, principally serotonin, along with dysfunction of select brain regions, including the prefrontal cortex and amygdala, suggesting a “dualbrain pathology”: “hyperarousal-dyscontrol syndrome.” However, the exact mechanisms of all these putative etiologies remain unknown.     

Maternal Neurobiological Processing of Negative Adolescent Stimuli: Relations With Positive Parenting and Relationship Quality

We examined associations between maternal affective neurobiology and positive parenting in a study of 20 mothers of adolescents. Mothers underwent functional magnetic resonance imaging during an emotion image task, rated parent‐adolescent relationship quality, and completed an adolescent interaction task in which positive parenting behaviors were observed. Maternal structure was associated with lower responsivity in emotional processing regions in the general negative image contrast and was related to greater dorsolateral prefrontal cortex activation to negative adolescent images. Parent‐adolescent relationship quality was associated with lower precuneus activation to negative adolescent images. Findings are among the first to connect functional brain processing with observed parenting behaviors for parents of adolescent children, and underscore the relative importance of affective processing in parenting older children.     

The unconscious in economic decision-making: Convergent voices

Mainstream economics assumes that decision-making is a conscious cost-benefit process, ignoring the pervasive role of unconscious thought processes. Recent research in neuroimaging, genomics, and psychoanalysis exposes the role of unconscious and “nonconscious” processes, providing tools for analyzing economic decision-making. Neuroimaging reveals examples of brain function that modulate decision-making, but are not under conscious control. Psychoanalytic research provides evidence of the role of emotions and the unconscious in human behavior and decision-making. We advance the case for integrating psychoanalysis and neuroscience for a new perspective on the role of the mind in decision-making and economic behavior.     

Joint Attention,Self‐Recognition,and Neurocognitive Function in Toddlers

Recent studies have attempted to understand the processes involved in joint attention because of its relevance to both atypical and normal development. Data from a recent study of young children with autism suggests that performance on a delay nonmatch to sample (DNMS) task associated with ventromedial prefrontal functions, but not an A‐not‐B/delayed response task associated with dorsolateral prefrontal cortex, was related to joint attention skills (Dawson et al., 2002). Recent research also suggests that joint attention is associated with dorsalmedial brain systems linked to self‐monitoring (Mundy, 2003). This study investigated the relations among joint attention, DNMS, and self‐recognition performance in a longitudinal study of 39 normally developing toddlers from 14 to 18 months. The results indicated that development on the DNMS and self‐recognition tasks, but not a means end task, predicted joint attention at 18 months. Further analysis showed that the model was only significant for initiating joint attention (IJA). The implications of these results for the neuro‐development of IJA are discussed.     

Plasticity in Early Alzheimer's Disease: An Opportunity for Intervention

The scientific evidence of plasticity, or the brain's dynamic ability to alter its organization and activation throughout one's lifetime, has increased significantly over the last decade. This analytic review evaluates selected evidence regarding the persistence of plasticity in people with early-stage Alzheimer's disease (AD). Functional neuroimaging provides persuasive evidence of plasticity throughout aging as well as the early stages of dementia, including the possibility of a heightened response during the prodromal period of AD. Behavioral outcomes research demonstrates the ability of people with early-stage AD to relearn previously forgotten information or otherwise improve cognitive abilities following a cognition-focused intervention. Both of these bodies of evidence support the existence of compensatory processes at work, even in the presence of dementia-related pathology. This retained ability of the brain to adapt to neurodegenerative disease in an attempt to maintain function may provide a valuable opportunity for intervention, particularly in the prodromal or earliest stages of AD.     

The contribution of neuroscience to consumer research: A conceptual framework and empirical review

Following the development of advanced neuroimaging techniques, the growing interest in studying the brain’s response to marketing stimuli resulted in the birth of consumer neuroscience within the field of neuroeconomics. However, marketing scholars have remained reluctant to adopt the techniques of neuroscience and there is still uncertainty about the capacity of neuroimaging data to provide useful findings about consumer psychology and behaviour. In order to clarify the current scope and contribution of consumer neuroscience, we first develop a semantic cluster analysis of the boundaries of the field, followed by a comprehensive empirical review from 34 selected studies. We propose a novel approach to classify findings and facilitate the assessment of evidence around the topics of decision-making, rewards, memory and emotions. Finally, we discuss the possible role of several brain mechanisms in the processing of marketing stimuli as well as obstacles to the integration of these findings with classical consumer behaviour theories. We conclude that the contribution of neuroimaging remains too limited to replace existing consumer research techniques and provide recommendations for future research.     

Maternal Buffering of Adolescent Dysregulation in Socially Appetitive Contexts: From Behavior to the Brain

Adolescents are more susceptible to dysregulation in positive social contexts, compared to children. We investigated whether maternal presence would buffer these effects in adolescence. Fifty‐four adolescents and children (age range = 8–17 years, M_age = 13.38 years) completed a social go‐nogo task during an fMRI scan alone and in the presence of their mother. We found age‐related patterns, such that older relative to younger youth displayed more disinhibition toward socially appetitive than socially aversive stimuli, which was buffered by maternal presence. Furthermore, with age, maternal buffering in socially appetitive contexts elicited heightened activation in the ventromedial prefrontal cortex and amygdala–medial prefrontal cortex connectivity. Findings underscore the importance of caregivers in promoting the neural regulation of their offspring during adolescence.     

An fMRI Study of Responses to Sexual Stimuli as a Function of Gender and Sensation Seeking: A Preliminary Analysis

Although sexual cues produce stronger neural activation in men than in women, mechanisms underlying this differential response are unclear. We examined the relationship of sensation seeking and the brain’s response to sexual stimuli across gender in 27 subjects (14 men, M = 25.2 years, SD = 3.6, 85.2% Caucasian) who underwent functional magnetic resonance imaging (fMRI) while viewing sexual and nonsexual images. Whole-brain corrected significant clusters of regional activation were extracted and associated with gender, sensation seeking, and sexual behaviors. Men responded more to sexual than nonsexual images in the anterior cingulate/medial prefrontal cortex (ACC/mPFC), anterior insula/lateral orbitofrontal cortex, bilateral amygdala, and occipital regions. Sensation seeking related positively to ACC/mPFC (r = 0.65, p = 0.01) and left amygdala (r = 0.66, p = 0.01) response in men alone, with both of these correlations being significantly larger in men than in women (ps < 0.03). The relationship between brain responses and self-reported high-risk and low-risk sexual behaviors showed interesting, albeit nonsignificant, gender-specific trends. These findings suggest the relationship between sexual responsivity, sensation seeking, and sexual behavior is gender specific. This study indicates a need to identify the gender-specific mechanisms that underlie sexual responsivity and behaviors. In addition, it demonstrates that the nature of stimuli used to induce positive mood in imaging and other studies should be carefully considered.     

Loneliness and Adolescents’ Neural Processing of Self,Friends, and Teachers: Consequences for the School Self‐Concept

The present interdisciplinary study explored whether perceived loneliness is associated with ventromedial prefrontal cortex (vMPFC) activation during self‐ and social judgments (friends and teachers) in adolescents. Moreover, we examined how vMPFC activity is related to the academic self‐concept (ASC). Results of manifest path analysis indicated that high perceived loneliness was related to lower neural response to self‐judgments. In turn, high neural response to self‐judgments was positively associated with the ASC, whereas there was a trendwise negative association between high neural response to teacher‐related judgments and ASC. This study reveals associations between perceived loneliness and neural processing of the self, underlining the idea that feeling isolated from others may hinder self‐insight and, by extension, the formation of a stable academic self‐concept.     

A Neuropsychoanalytic Approach to Case Studies

Neuropsychoanalysis is an interdisciplinary field that attempts to generate links between psychoanalytic schools and the neurosciences. Historically speaking, neuropsychoanalysis emerged as a response to ‘cognitive’ views of the mind/brain problem, which tended to neglect the influence of emotional and instinctual processes in the constitution, and functioning, of the human mind. Since its origins, neuropsychoanalysis has used case studies, of brain injured individuals undergoing psychoanalytic treatment, to explore how focal damage to specific brain areas is related to changes in non-cognitive domains of the mind, such as emotion, motivation or personality. This approach is a useful contribution to the neurosciences since it allows observing, at the same time, objective and subjective aspects of the mind/brain, thus bridging third and first person methodologies. In this article a neuropsychoanalytic approach to case studies is introduced, describing both its historical roots as well as its present status. Then, a brief case study, of a man with focal damage to the left dorso-lateral prefrontal cortex, who presented with changes in his capacity to intrinsically regulate feelings, is used to exemplify this approach.     

Multiple Coordination Patterns in Infant and Adult Vocalizations

The study of vocal coordination between infants and adults has led to important insights into the development of social, cognitive, emotional, and linguistic abilities. We used an automatic system to identify vocalizations produced by infants and adults over the course of the day for fifteen infants studied longitudinally during the first 2 years of life. We measured three different types of vocal coordination: coincidence‐based, rate‐based, and cluster‐based. Coincidence‐based coordination and rate‐based coordination are established measures in the developmental literature. Cluster‐based coordination is new and measures the strength of matching in the degree to which vocalization events occur in hierarchically nested clusters. We investigated whether various coordination patterns differ as a function of vocalization type, whether different coordination patterns provide unique information about the dynamics of vocal interaction, and how the various coordination patterns each relate to infant age. All vocal coordination patterns displayed greater coordination for infant speech‐related vocalizations, adults adapted the hierarchical clustering of their vocalizations to match that of infants, and each of the three coordination patterns had unique associations with infant age. Altogether, our results indicate that vocal coordination between infants and adults is multifaceted, suggesting a complex relationship between vocal coordination and the development of vocal communication.     

Infants' ERP Responses to Novel and Familiar Stimuli Change Over Time: Implications for Novelty Detection and Memory

Detection of novelty is an important cognitive ability early in development, when infants must learn a great deal about their world. Work with adults has identified networks of brain areas involved in novelty detection; this study investigated electrophysiological correlates of detection of novelty and recognition of familiarity in 9‐month‐old infants, using event‐related potentials (ERPs). Infants were familiarized with an event in the laboratory, then ERPs were recorded as they viewed repeated presentations of pictures of this familiar event and a novel event, along with single presentations of 30 trial‐unique events. A middle‐latency negative component was sensitive to degree of novelty, differing in amplitude and latency by stimulus condition and across repeated presentations. Long‐latency slow‐wave activity also related to stimulus condition. Findings have implications for our understanding of infants' detection of novel information and the processes that render the novel familiar.     

Infants’ Lexical Processing Efficiency is Related to Vocabulary Size by One Year of Age

By 15–18 months, infants’ skill in interpreting familiar words, or lexical processing efficiency (LPE), improves substantially and is correlated with vocabulary size concurrently and several months later. Prior to this age LPE is quite poor, and to date there is little evidence that it is related to vocabulary size. If this relation only emerges once infants have relatively good LPE, and also know a substantial number of words, it could suggest that the processes that support the rapid growth in vocabulary commonly observed as infants approach age 2 may not yet be functional in the earlier stages of lexical development. However, using a modified LPE task we found that 12‐month‐olds with better LPE understood more words at that age and also produced more words several months later. These results suggest that meaningful individual differences in LPE are already emerging by 12 months and may support lexical development across the second year.     

Learning While Babbling: Prelinguistic Object‐Directed Vocalizations Indicate a Readiness to Learn

Two studies illustrate the functional significance of a new category of prelinguistic vocalizing—object‐directed vocalizations (ODVs)—and show that these sounds are connected to learning about words and objects. Experiment 1 tested 12‐month‐old infants’ perceptual learning of objects that elicited ODVs. Fourteen infants’ vocalizations were recorded as they explored novel objects. Infants learned visual features of objects that elicited the most ODVs but not of objects that elicited the fewest vocalizations. Experiment 2 assessed the role of ODVs in learning word–object associations. Forty infants aged 11.5 months played with a novel object and received a label either contingently on an ODV or on a look alone. Only infants who received labels in response to an ODV learned the association. Taken together, the findings suggest that infants’ ODVs signal a state of attention that facilitates learning.     

How Does Learning Impact Development in Infancy? The Case of Perceptual Organization

Pattern perception and organization are critical functions of the visual cognition system. Many organizational processes are available early in life, such that infants as young 3 months of age are able to readily utilize a variety of cues to organize visual patterns. However, other processes are not readily evident in young infants, and their development involves perceptual learning. We describe a theoretical framework that addresses perceptual learning in infancy and the manner in which it affects visual organization and development. It identifies five kinds of experiences that induce learning, and suggests that they work via attentional and unitization mechanisms to modify visual organization. In addition, the framework proposes that this kind of learning is abstract, domain general, functional at different ages in a qualitatively similar manner, and has a long‐term impact on development through a memory reactivation process. Although most models of development assume that experience is fundamental to development, very little is actually known about the process by which experience affects development. The proposed framework is an attempt to account for this process in the domain of perception.     

The Long‐Term Effects of Caregiving on Women's Health and Mortality

Caregivers experience numerous mental and physical health effects from the stress of providing care, but we know little about whether these problems persist in the long term and whether long‐term effects differ across caregiving contexts. Using the National Longitudinal Survey of Mature Women, we examined the relationship between caregiving and long‐term patterns of depressive symptoms, functional limitations, and mortality. We also explored the health effects of caregiving in‐home versus out‐of‐home and by caregiver/care‐recipient relationship. Analyses show that in‐home spousal and parental caregiving predict increased depressive symptoms and functional limitations in the long term but are unassociated with mortality, whereas caregiving outside the home is unassociated with later depression and functional limitations but predicts a lower risk of mortality. This study highlights the usefulness of approaching stressful experiences such as caregiving from the life course perspective, viewing them as processes that unfold over time within specific contexts that may carry delayed or cumulative consequences.     

Childhood Sexual Abuse and Brain Development: A Discussion of Associated Structural Changes and Negative Psychological Outcomes

The effects of traumatic exposure have been researched for many years and studies have shown that the parts of the brain affected by sexually traumatic experiences in childhood are also linked to many physical and psychological problems, such as depression, posttraumatic stress disorder, somatic complaints and suicide. Neuroimaging studies have provided a breadth of evidence that childhood sexual abuse is related to structural changes in the brain. Taken together, childhood sexual abuse affects brain development, leading to differences in brain anatomy and functioning that have lifelong consequences for mental health. Several limitations of neuroimaging research on childhood sexual abuse are discussed, including a lack of refined and sensitive neuroimaging measures and problems interpreting results of structural imaged subjects with associated psychiatric conditions. Future, large‐scale studies are warranted to examine the type and severity of the sexual abuse and how each of the levels of childhood sexual abuse contributes to structural and functional changes. Furthermore, future studies are needed to control for comorbid psychiatric conditions in order to disentangle the effects of childhood sexual abuse from psychiatric conditions that damage brain development. © 2018 John Wiley & Sons, Ltd.

‘Childhood sexual abuse affects brain development, leading to differences in brain anatomy and functioning that have lifelong consequences for mental health’

Key Practitioner Messages

• Childhood sexual abuse is linked to observable structural changes in the brain.
• These structural changes in the brain are associated with a myriad number of negative psychological effects.
• Research is limited in elucidating the role of childhood sexual abuse on brain development, as the bulk of the research has focused only broadly on child maltreatment.

     

14‐month‐olds exploit verbs’ syntactic contexts to build expectations about novel words

During their second year of life, infants develop a rudimentary understanding of grammatical categories based on their knowledge and use of frequent function words. The current study inquired whether, at only 14 months of age, infants can track co‐occurrence patterns between function words and content words (e.g., determiners can precede nouns, and pronouns can precede verbs), and use these previously encountered syntactic contexts to build expectations about which function words can co‐occur with novel words. Using a habituation paradigm, French‐learning 14‐month‐olds were presented with utterances containing two novel words preceded by function words (either two determiners in the Novel Nouns condition or two pronouns in the Novel Verbs conditions). We found that at test, infants looked longer during trials in which the novel words occurred in an unexpected syntactic context (following a pronoun for infants in the Novel Nouns condition and following a determiner for infants in the pooled analysis of the three Novel Verbs conditions). Hence, our results confirm previous findings on infants’ sensitivity to noun contexts and most importantly demonstrate that their sensitivity to the co‐occurrence of verbs with pronouns begins much earlier than previously understood.     

Developmental Changes in Infants’ Ability to Cope with Dialect Variation in Word Recognition

Toward the end of their first year of life, infants’ overly specified word representations are thought to give way to more abstract ones, which helps them to better cope with variation not relevant to word identity (e.g., voice and affect). This developmental change may help infants process the ambient language more efficiently, thus enabling rapid gains in vocabulary growth. One particular kind of variability that infants must accommodate is that of dialectal accent, because most children will encounter speakers from different regions and backgrounds. In this study, we explored developmental changes in infants’ ability to recognize words in continuous speech by familiarizing them with words spoken by a speaker of their own region (North Midland‐American English) or a different region (Southern Ontario Canadian English), and testing them with passages spoken by a speaker of the opposite dialectal accent. Our results demonstrate that 12‐ but not 9‐month‐olds readily recognize words in the face of dialectal variation.     

Can welfare and labour market regimes explain cross‐country differences in the unemployment of young people?

No single institution can reduce (long‐term) youth unemployment. Welfare and labour market institutions function as “bundles”, through multiple inter‐institutional synergies. Based on a focused literature review for theory and on cluster analysis for empirics, the author identifies five such regimes across the EU‐27 and estimates their effects on the youth unemployment ratio and on long‐term youth unemployment. The most helpful institutional arrangement for young people in the labour market would be a combination of strong dual apprenticeship embedded in a corporatist labour market regime with high levels of social security, active labour market policy, and spending on education and childcare.