Weak convergence for the conditional distribution function in a Koziol–Green model under dependent censoring

In this paper we consider the conditional Koziol–Green model of Braekers and Veraverbeke [2008. A conditional Koziol–Green model under dependent censoring. Statist. Probab. Lett., accepted for publication] in which they generalized the Koziol–Green model of Veraverbeke and Cadarso Suárez [2000. Estimation of the conditional distribution in a conditional Koziol–Green model. Test 9, 97–122] by assuming that the association between a censoring time and a time until an event is described by a known Archimedean copula function. They got in this way, an informative censoring model with two different types of informative censoring. Braekers and Veraverbeke [2008. A conditional Koziol–Green model under dependent censoring. Statist. Probab. Lett., accepted for publication] derived in this model a non-parametric Koziol–Green estimator for the conditional distribution function of the time until an event, for which they showed the uniform consistency and the asymptotic normality. In this paper we extend their results and prove the weak convergence of the process associated to this estimator. Furthermore we show that the conditional Koziol–Green estimator is asymptotically more efficient in this model than the general copula-graphic estimator of Braekers and Veraverbeke [2005. A copula-graphic estimator for the conditional survival function under dependent censoring. Canad. J. Statist. 33, 429–447]. As last result, we construct an asymptotic confidence band for the conditional Koziol–Green estimator. Through a simulation study, we investigate the small sample properties of this asymptotic confidence band. Afterwards we apply this estimator and its confidence band on a practical data set.     

Adjusted Hazard Rate Estimator Based on a Known Censoring Probability

In most reliability studies involving censoring, one assumes that censoring probabilities are unknown. We derive a nonparametric estimator for the survival function when information regarding censoring frequency is available. The estimator is constructed by adjusting the Nelson–Aalen estimator to incorporate censoring information. Our results indicate significant improvements can be achieved if available information regarding censoring is used. We compare this model to the Koziol–Green model, which is also based on a form of proportional hazards for the lifetime and censoring distributions. Two examples of survival data help to illustrate the differences in the estimation techniques.     

On progressive hybrid censored exponential distribution

In this paper, we introduce a new adaptive Type-I progressive hybrid censoring scheme, which has some advantages over the progressive hybrid censoring schemes already discussed in the literature. Based on an adaptive Type-I progressively hybrid censored sample, we derive the exact distribution of the maximum-likelihood estimator (MLE) of the mean lifetime of an exponential distribution as well as confidence intervals for the failure rate using exact distribution, asymptotic distribution, and three parametric bootstrap resampling methods. Furthermore, we provide computational formula for the expected number of failures and investigate the performance of the point and interval estimation for the failure rate in this case. An alternative simple form for the distribution of the MLE under adaptive Type-II progressive hybrid censoring scheme proposed by Ng et al. [Statistical analysis of exponential lifetimes under an adaptive Type-II progressive censoring scheme, Naval Res. Logist. 56 (2009), pp. 687–698] is obtained. Finally, from the exact distribution of the MLE, we establish the explicit expression for the Bayes risk of a sampling plan under adaptive Type-II progressive hybrid censoring scheme when a general loss function is used, and present some optimal Bayes solutions under four different progressive hybrid censoring schemes to illustrate the effectiveness of the proposed method.     

Additive risks regression model for middle censored exponentiated-exponential lifetime data

Jammalamadaka and Mangalam introduced middle censoring which refers to data arising in situations, where the exact lifetime becomes unobservable if it falls within a random censoring interval. In the present article, we propose an additive risks regression model for a lifetime data subject to middle censoring, where the lifetimes are assumed to follow exponentiated exponential distribution. The regression parameters are estimated using the Expectation-Maximization algorithm. Asymptotic normality of the estimator is proposed. We report a simulation study to assess the finite sample properties of the estimator. We then analyze a real-life data on survival times of larynx cancer patients studied by Karduan.     

Comparison of renewal function estimators for censored data

The computation of the renewal function when the distribution function is completely known has received much attention in the literature. However, in many cases the form of the distribution function is unknown and has to be estimated nonparametrically. A nonparametric estimator for the renewal function for complete data was suggested by Frees (1986). In many cases, however, censoring of the lifetime might occur. We shall present parametric and nonparametric estimators of the renewal function based on censored data. In a simulation study we compare the nonparametric estimators with parametric estimators for the Weibull and lognormal distribution. The study suggests that the nonparametric estimator is a viable alternative to the parametric estimators when the lifetime distribution is unknown. Also, the nonparametric estimator is computationally simpler than the parametric estimator.     

Estimation of average causal effect using the restricted mean residual lifetime as effect measure

Although mean residual lifetime is often of interest in biomedical studies, restricted mean residual lifetime must be considered in order to accommodate censoring. Differences in the restricted mean residual lifetime can be used as an appropriate quantity for comparing different treatment groups with respect to their survival times. In observational studies where the factor of interest is not randomized, covariate adjustment is needed to take into account imbalances in confounding factors. In this article, we develop an estimator for the average causal treatment difference using the restricted mean residual lifetime as target parameter. We account for confounding factors using the Aalen additive hazards model. Large sample property of the proposed estimator is established and simulation studies are conducted in order to assess small sample performance of the resulting estimator. The method is also applied to an observational data set of patients after an acute myocardial infarction event.     

Nonparametric maximum likelihood estimation for artificially truncated absence data

In manpower planning it is cornmoniy tue case tnat employees withuraw from active service for a period of time before returning to take up post at a later date. Such periods of absence are frequently of major concern to employers who are anxious to ensure that employees return as soon as possible. The distribution of duration of such periods of absence are therefore of considerable interest as is the probability that such employees will ever return to active service. In this paper we derive a nonparametric estimator for such a lifetime distribution based on renewal data which are subject to various forms of incompleteness, namely right censoring, left and right truncation, and forward recurrence. Artificial truncation is used to ensure that the data are time homogeneous. A nonparametric maximum likelihood estimator for the lifetime.     

Lifetime estimation from doubly censored data and dirichlet process prior knowledge on the observable random vector

The purpose of this paper is to present a nonparametric Bayesian procedure for estimating a survival curve in a double censoring situation. Assuming a proportional hazard rates model, we propose a consistent estimation of lifetime, based on a Dirichlet process prior knowledge on the observable random vector. Some large sample properties of this estimator are also derived, We prove strong consistency and asymptotic weak convergence to a Gaussian pro cess. Finally, a simulation study is presented in order to analyze the behavior of the proposed estimator, and establish some comparisons to other estimators.     

On Consistency of the Self-Consistent Estimator of Survival Functions with Interval-Censored Data

The self-consistent estimator is commonly used for estimating a survival function with interval-censored data. Recent studies on interval censoring have focused on case 2 interval censoring, which does not involve exact observations, and double censoring, which involves only exact, right-censored or left-censored observations. In this paper, we consider an interval censoring scheme that involves exact, left-censored, right-censored and strictly interval-censored observations. Under this censoring scheme, we prove that the self-consistent estimator is strongly consistent under certain regularity conditions.     

Non-parametric estimation of lifetime distribution of competing risk models when censoring times are missing

There are situations in the analysis of failure time or lifetime data where the censoring times of unfailed units are missing. The non-parametric estimator of the lifetime distribution for such data is available in literature. In this paper we consider an extension of this situation to the univariate and bivariate competing risk setups. The maximum likelihood and simple moment estimators of cause specific distribution functions in both univariate and bivariate situations are developed. A simulation study is carried out to assess the performance of the estimators. Finally, we illustrate the method with real data set.     

Investigation of the performance of trimmed estimators of life time distributions with censoring

For the lifetime (or negative) exponential distribution, the trimmed likelihood estimator has been shown to be explicit in the form of a β‐trimmed mean which is representable as an estimating functional that is both weakly continuous and Fréchet differentiable and hence qualitatively robust at the parametric model. It also has high efficiency at the model. The robustness is in contrast to the maximum likelihood estimator (MLE) involving the usual mean which is not robust to contamination in the upper tail of the distribution. When there is known right censoring, it may be perceived that the MLE which is the most asymptotically efficient estimator may be protected from the effects of ‘outliers’ due to censoring. We demonstrate that this is not the case generally, and in fact, based on the functional form of the estimators, suggest a hybrid defined estimator that incorporates the best features of both the MLE and the β‐trimmed mean. Additionally, we study the pure trimmed likelihood estimator for censored data and show that it can be easily calculated and that the censored observations are not always trimmed. The different trimmed estimators are compared by a modest simulation study.     

Statistical inference for discrete middle-censored data

In this paper we consider the discrete middle censoring where lifetime, lower bound and length of censoring interval are variables with geometric distribution. We obtain the likelihood function of observed data and derive the MLE of the unknown parameter using EM algorithm. Also we obtain the Bayes estimator of the unknown parameter under squared error loss (SEL) function and credible interval of unknown parameter using Monte Carlo methods.     

On estimation of frequency data with censored observations

The problem of the estimation of mean frequency of events in the presence of censoring is important in assessing the efficacy, safety and cost of therapies. The mean frequency is typically estimated by dividing the total number of events by the total number of patients under study. This method, referred to in this paper as the ‘naïve estimator’, ignores the censoring. Other approaches available for this problem require many assumptions that are rarely acceptable. These include the assumption of independence, constant hazard rate over time and other similar distributional assumptions. In this paper a simple non‐parametric estimator based on the sum of the products of Kaplan–Meier estimators is proposed as an estimator of mean frequency, and its approximate variance and standard error are derived. An illustration is provided to show the derivation of the proposed estimator. Although the clinical trial setting is used in this paper, the problem has applications in other areas where survival analysis is used and recurrent events are studied. Copyright © 2003 John Wiley & Sons, Ltd.     

Approximate self consistency for middle-censored data

Middle censoring refers to data that becomes unobservable if it falls within a random interval. The lifetime distribution of such data is defined via the self-consistency equation. We propose an approximation to this distribution function for which an estimator and its asymptotic properties are very easy to establish.     

Estimating stage occupation probabilities in non-Markov models

We study non-Markov multistage models under dependent censoring regarding estimation of stage occupation probabilities. The individual transition and censoring mechanisms are linked together through covariate processes that affect both the transition intensities and the censoring hazard for the corresponding subjects. In order to adjust for the dependent censoring, an additive hazard regression model is applied to the censoring times, and all observed counting and “at risk” processes are subsequently given an inverse probability of censoring weighted form. We examine the bias of the Datta–Satten and Aalen–Johansen estimators of stage occupation probability, and also consider the variability of these estimators by studying their estimated standard errors and mean squared errors. Results from different simulation studies of frailty models indicate that the Datta–Satten estimator is approximately unbiased, whereas the Aalen–Johansen estimator either under- or overestimates the stage occupation probability due to the dependent nature of the censoring process. However, in our simulations, the mean squared error of the latter estimator tends to be slightly smaller than that of the former estimator. Studies on development of nephropathy among diabetics and on blood platelet recovery among bone marrow transplant patients are used as demonstrations on how the two estimation methods work in practice. Our analyses show that the Datta–Satten estimator performs well in estimating stage occupation probability, but that the censoring mechanism has to be quite selective before a deviation from the Aalen-Johansen estimator is of practical importance. N. Gunnes—Supported by a grant from the Norwegian Cancer Society.     

Estimation for two-parameter weibull distribution and extreme-value distribution under multiply type-II censoring

Compared to Type-II censoring, multiply Type-II censoring is a more general, yet mathematically and numerically much more complicated censoring scheme. For multiply Type II censored data from a two-parameter Weibull distribution, we propose several estimators, including MLE, approximate MLE, and estimators corresponding to the BLUE and BLIE from estimating parameters in extreme-value distribution. An approximately unbiased estimator for the shape parameter is also proposed which has the smallest MSE. Numerical examples show that this estimator is the best in terms of bias and MSE. Numerical examples also show that the approximate MLE which admits a closed form is better for estimating the scale parameter.     

Wavelet estimation of density for censored data with censoring indicator missing at random

In this paper, we define the nonlinear wavelet estimator of density for the right censoring model with the censoring indicator missing at random (MAR), and develop its asymptotic expression for mean integrated squared error (MISE). Unlike for kernel estimator, the MISE expression of the estimator is not affected by the presence of discontinuities in the curve. Meanwhile, asymptotic normality of the estimator is established. The proposed estimator can reduce to the estimator defined by Li [Non-linear wavelet-based density estimators under random censorship. J Statist Plann Inference. 2003;117(1):35–58] when the censoring indicator MAR does not occur and a bandwidth in non-parametric estimation is close to zero. Also, we define another two nonlinear wavelet estimators of the density. A simulation is done to show the performance of the three proposed estimators.     

A copula‐graphic estimator for the conditional survival function under dependent censoring

Rivest Wells (2001) showed that in situations where the dependence between a lifetime and a censoring variable can be modeled by a given Archimedean copula, the copula‐graphic estimator of Zheng Klein (1995) has an explicit form. The authors extend this work to the fixed design regression case. They show that the copula‐graphic estimator then has an asymptotic representation and a Gaussian limit. They also assess the influence of a misspecified copula function on the performance of the estimator. Their developments are illustrated with data on the survival of the Atlantic halibut.     

A maximum likelihood estimator for left-truncated lifetimes based on probabilistic prior information about time of occurrence

In forestry, many processes of interest are binary and they can be modeled using lifetime analysis. However, available data are often incomplete, being interval- and right-censored as well as left-truncated, which may lead to biased parameter estimates. While censoring can be easily considered in lifetime analysis, left truncation is more complicated when individual age at selection is unknown. In this study, we designed and tested a maximum likelihood estimator that deals with left truncation by taking advantage of prior knowledge about the time when the individuals enter the experiment. Whenever a model is available for predicting the time of selection, the distribution of the delayed entries can be obtained using Bayes' theorem. It is then possible to marginalize the likelihood function over the distribution of the delayed entries in the experiment to assess the joint distribution of time of selection and time to event. This estimator was tested with continuous and discrete Gompertz-distributed lifetimes. It was then compared with two other estimators: a standard one in which left truncation was not considered and a second estimator that implemented an analytical correction. Our new estimator yielded unbiased parameter estimates with empirical coverage of confidence intervals close to their nominal value. The standard estimator leaded to an overestimation of the long-term probability of survival.