Nonparametric estimation of the conditional distribution function in a semiparametric censorship model

In this paper we propose a new nonparametric estimator of the conditional distribution function under a semiparametric censorship model. We establish an asymptotic representation of the estimator as a sum of iid random variables, balanced by some kernel weights. This representation is used for obtaining large sample results such as the rate of uniform convergence of the estimator, or its limit distributional law. We prove that the new estimator outperforms the conditional Kaplan–Meier estimator for censored data, in the sense that it exhibits lower asymptotic variance. Illustration through real data analysis is provided.     

Improving variance function estimation in semiparametric longitudinal data analysis

We propose an efficient and robust method for variance function estimation in semiparametric longitudinal data analysis. The method utilizes a local log‐linear approximation for the variance function and adopts a generalized estimating equation approach to account for within subject correlations. We show theoretically and empirically that our method outperforms estimators using working independence that ignores the correlations. The Canadian Journal of Statistics 39: 656–670; 2011. © 2011 Statistical Society of Canada     

Regression analysis for a summed missing data problem under an outcome‐dependent sampling scheme

In this paper, we consider a regression analysis for a missing data problem in which the variables of primary interest are unobserved under a general biased sampling scheme, an outcome‐dependent sampling (ODS) design. We propose a semiparametric empirical likelihood method for accessing the association between a continuous outcome response and unobservable interesting factors. Simulation study results show that ODS design can produce more efficient estimators than the simple random design of the same sample size. We demonstrate the proposed approach with a data set from an environmental study for the genetic effects on human lung function in COPD smokers. The Canadian Journal of Statistics 40: 282–303; 2012 © 2012 Statistical Society of Canada     

An estimated‐score approach for dealing with missing covariate data in matched case–control studies

Matched case–control designs are commonly used in epidemiological studies for estimating the effect of exposure variables on the risk of a disease by controlling the effect of confounding variables. Due to retrospective nature of the study, information on a covariate could be missing for some subjects. A straightforward application of the conditional logistic likelihood for analyzing matched case–control data with the partially missing covariate may yield inefficient estimators of the parameters. A robust method has been proposed to handle this problem using an estimated conditional score approach when the missingness mechanism does not depend on the disease status. Within the conditional logistic likelihood framework, an empirical procedure is used to estimate the odds of the disease for the subjects with missing covariate values. The asymptotic distribution and the asymptotic variance of the estimator when the matching variables and the completely observed covariates are categorical. The finite sample performance of the proposed estimator is assessed through a simulation study. Finally, the proposed method has been applied to analyze two matched case–control studies. The Canadian Journal of Statistics 38: 680–697; 2010 © 2010 Statistical Society of Canada     

Efficient estimation for the proportional hazards model with competing risks and current status data

The proportional hazards model is the most commonly used model in regression analysis of failure time data and has been discussed by many authors under various situations (Kalbfleisch & Prentice, 2002. The Statistical Analysis of Failure Time Data, Wiley, New York). This paper considers the fitting of the model to current status data when there exist competing risks, which often occurs in, for example, medical studies. The maximum likelihood estimates of the unknown parameters are derived and their consistency and convergence rate are established. Also we show that the estimates of regression coefficients are efficient and have asymptotically normal distributions. Simulation studies are conducted to assess the finite sample properties of the estimates and an illustrative example is provided. The Canadian Journal of Statistics © 2009 Statistical Society of Canada     

Consistency of maximum likelihood estimators in a large class of deconvolution models

We consider the maximum likelihood estimator $\hat{F}_n$ of a distribution function in a class of deconvolution models where the known density of the noise variable is of bounded variation. This class of noise densities contains in particular bounded, decreasing densities. The estimator $\hat{F}_n$ is defined, characterized in terms of Fenchel optimality conditions and computed. Under appropriate conditions, various consistency results for $\hat{F}_n$ are derived, including uniform strong consistency. The Canadian Journal of Statistics 41: 98–110; 2013 © 2012 Statistical Society of Canada     

Variance function estimation of a one-dimensional nonstationary process

We propose a flexible nonparametric estimation of a variance function from a one-dimensional process where the process errors are nonstationary and correlated. Due to nonstationarity a local variogram is defined, and its asymptotic properties are derived. We include a bandwidth selection method for smoothing taking into account the correlations in the errors. We compare the proposed difference-based nonparametric approach with Anderes and Stein(2011)’s local-likelihood approach. Our method has a smaller integrated MSE, easily fixes the boundary bias, and requires far less computing time than the likelihood-based method.     

Small area estimation of poverty indicators

The authors propose to estimate nonlinear small area population parameters by using the empirical Bayes (best) method, based on a nested error model. They focus on poverty indicators as particular nonlinear parameters of interest, but the proposed methodology is applicable to general nonlinear parameters. They use a parametric bootstrap method to estimate the mean squared error of the empirical best estimators. They also study small sample properties of these estimators by model‐based and design‐based simulation studies. Results show large reductions in mean squared error relative to direct area‐specific estimators and other estimators obtained by “simulated” censuses. The authors also apply the proposed method to estimate poverty incidences and poverty gaps in Spanish provinces by gender with mean squared errors estimated by the mentioned parametric bootstrap method. For the Spanish data, results show a significant reduction in coefficient of variation of the proposed empirical best estimators over direct estimators for practically all domains. The Canadian Journal of Statistics 38: 369–385; 2010 © 2010 Statistical Society of Canada     

Smoothed empirical likelihood confidence intervals for the relative distribution with left‐truncated and right‐censored data

The study of differences among groups is an interesting statistical topic in many applied fields. It is very common in this context to have data that are subject to mechanisms of loss of information, such as censoring and truncation. In the setting of a two‐sample problem with data subject to left truncation and right censoring, we develop an empirical likelihood method to do inference for the relative distribution. We obtain a nonparametric generalization of Wilks' theorem and construct nonparametric pointwise confidence intervals for the relative distribution. Finally, we analyse the coverage probability and length of these confidence intervals through a simulation study and illustrate their use with a real data set on gastric cancer. The Canadian Journal of Statistics 38: 453–473; 2010 © 2010 Statistical Society of Canada     

Analyzing panel count data with a dependent observation process and a terminal event

Panel count data occur in many fields and a number of approaches have been developed. However, most of these approaches are for situations where there is no terminal event and the observation process is independent of the underlying recurrent event process unconditionally or conditional on the covariates. In this paper, we discuss a more general situation where the observation process is informative and there exists a terminal event which precludes further occurrence of the recurrent events of interest. For the analysis, a semiparametric transformation model is presented for the mean function of the underlying recurrent event process among survivors. To estimate the regression parameters, an estimating equation approach is proposed in which an inverse survival probability weighting technique is used. The asymptotic distribution of the proposed estimates is provided. Simulation studies are conducted and suggest that the proposed approach works well for practical situations. An illustrative example is provided. The Canadian Journal of Statistics 41: 174–191; 2013 © 2012 Statistical Society of Canada     

Extending the empirical likelihood by domain expansion

We extend the empirical likelihood beyond its domain by expanding its contours nested inside the domain with a similarity transformation. The extended empirical likelihood achieves two objectives at the same time: escaping the “convex hull constraint” on the empirical likelihood and improving the coverage accuracy of the empirical likelihood ratio confidence region to $O(n^{-2})$ . The latter is accomplished through a special transformation which matches the extended empirical likelihood with the Bartlett corrected empirical likelihood. The extended empirical likelihood ratio confidence region retains the shape of the original empirical likelihood ratio confidence region. It also accommodates adjustments for dimension and small sample size, giving it good coverage accuracy in large and small sample situations. The Canadian Journal of Statistics 41: 257–274; 2013 © 2013 Statistical Society of Canada     

Nonparametric regression with cross‐classified responses

In this article, we develop regression models with cross‐classified responses. Conditional independence structures can be explored/exploited through the selective inclusion/exclusion of terms in a certain functional ANOVA decomposition, and the estimation is done nonparametrically via the penalized likelihood method. A cohort of computational and data analytical tools are presented, which include cross‐validation for smoothing parameter selection, Kullback–Leibler projection for model selection, and Bayesian confidence intervals for odds ratios. Random effects are introduced to model possible correlations such as those found in longitudinal and clustered data. Empirical performances of the methods are explored in simulation studies of limited scales, and a real data example is presented using some eyetracking data from linguistic studies. The techniques are implemented in a suite of R functions, whose usage is briefly described in the appendix. The Canadian Journal of Statistics 39: 591–609; 2011. © 2011 Statistical Society of Canada     

Nonparametric likelihood and doubly robust estimating equations for marginal and nested structural models

This article considers Robins's marginal and nested structural models in the cross‐sectional setting and develops likelihood and regression estimators. First, a nonparametric likelihood method is proposed by retaining a finite subset of all inherent and modelling constraints on the joint distributions of potential outcomes and covariates under a correctly specified propensity score model. A profile likelihood is derived by maximizing the nonparametric likelihood over these joint distributions subject to the retained constraints. The maximum likelihood estimator is intrinsically efficient based on the retained constraints and weakly locally efficient. Second, two regression estimators, named hat and tilde, are derived as first‐order approximations to the likelihood estimator under the propensity score model. The tilde regression estimator is intrinsically and weakly locally efficient and doubly robust. The methods are illustrated by data analysis for an observational study on right heart catheterization. The Canadian Journal of Statistics 38: 609–632; 2010 © 2010 Statistical Society of Canada     

Restricted maximum likelihood estimation of joint mean‐covariance models

The class of joint mean‐covariance models uses the modified Cholesky decomposition of the within subject covariance matrix in order to arrive to an unconstrained, statistically meaningful reparameterisation. The new parameterisation of the covariance matrix has two sets of parameters that separately describe the variances and correlations. Thus, with the mean or regression parameters, these models have three sets of distinct parameters. In order to alleviate the problem of inefficient estimation and downward bias in the variance estimates, inherent in the maximum likelihood estimation procedure, the usual REML estimation procedure adjusts for the degrees of freedom lost due to the estimation of the mean parameters. Because of the parameterisation of the joint mean covariance models, it is possible to adapt the usual REML procedure in order to estimate the variance (correlation) parameters by taking into account the degrees of freedom lost by the estimation of both the mean and correlation (variance) parameters. To this end, here we propose adjustments to the estimation procedures based on the modified and adjusted profile likelihoods. The methods are illustrated by an application to a real data set and simulation studies. The Canadian Journal of Statistics 40: 225–242; 2012 © 2012 Statistical Society of Canada     

Fully efficient estimation of coefficients of correlation in the presence of imputed survey data

Marginal imputation, that consists of imputing items separately, generally leads to biased estimators of bivariate parameters such as finite population coefficients of correlation. To overcome this problem, two main approaches have been considered in the literature: the first consists of using customary imputation methods such as random hot‐deck imputation and adjusting for the bias at the estimation stage. This approach was studied in Skinner & Rao 2002 . In this paper, we extend the results of Skinner & Rao 2002 to the case of arbitrary sampling designs and three variants of random hot‐deck imputation. The second approach consists of using an imputation method, which preserves the relationship between variables. Shao & Wang 2002 proposed a joint random regression imputation procedure that succeeds in preserving the relationships between two study variables. One drawback of the Shao–Wang procedure is that it suffers from an additional variability (called the imputation variance) due to the random selection of residuals, resulting in potentially inefficient estimators. Following Chauvet, Deville, & Haziza 2011 , we propose a fully efficient version of the Shao–Wang procedure that preserves the relationship between two study variables, while virtually eliminating the imputation variance. Results of a simulation study support our findings. An application using data from the Workplace and Employees Survey is also presented. The Canadian Journal of Statistics 40: 124–149; 2012 © 2011 Statistical Society of Canada