An iterative approach to distance correlation-based sure independence screening

Feature screening and variable selection are fundamental in analysis of ultrahigh-dimensional data, which are being collected in diverse scientific fields at relatively low cost. Distance correlation-based sure independence screening (DC-SIS) has been proposed to perform feature screening for ultrahigh-dimensional data. The DC-SIS possesses sure screening property and filters out unimportant predictors in a model-free manner. Like all independence screening methods, however, it fails to detect the truly important predictors which are marginally independent of the response variable due to correlations among predictors. When there are many irrelevant predictors which are highly correlated with some strongly active predictors, the independence screening may miss other active predictors with relatively weak marginal signals. To improve the performance of DC-SIS, we introduce an effective iterative procedure based on distance correlation to detect all truly important predictors and potentially interactions in both linear and nonlinear models. Thus, the proposed iterative method possesses the favourable model-free and robust properties. We further illustrate its excellent finite-sample performance through comprehensive simulation studies and an empirical analysis of the rat eye expression data set.     

Censored cumulative residual independent screening for ultrahigh-dimensional survival data

For complete ultrahigh-dimensional data, sure independent screening methods can effectively reduce the dimensionality while retaining all the active variables with high probability. However, limited screening methods have been developed for ultrahigh-dimensional survival data subject to censoring. We propose a censored cumulative residual independent screening method that is model-free and enjoys the sure independent screening property. Active variables tend to be ranked above the inactive ones in terms of their association with the survival times. Compared with several existing methods, our model-free screening method works well with general survival models, and it is invariant to the monotone transformation of the responses, as well as requiring substantially weaker moment conditions. Numerical studies demonstrate the usefulness of the censored cumulative residual independent screening method, and the new approach is illustrated with a gene expression data set.     

Model-free slice screening for ultrahigh-dimensional survival data

For ultrahigh-dimensional data, independent feature screening has been demonstrated both theoretically and empirically to be an effective dimension reduction method with low computational demanding. Motivated by the Buckley–James method to accommodate censoring, we propose a fused Kolmogorov–Smirnov filter to screen out the irrelevant dependent variables for ultrahigh-dimensional survival data. The proposed model-free screening method can work with many types of covariates (e.g. continuous, discrete and categorical variables) and is shown to enjoy the sure independent screening property under mild regularity conditions without requiring any moment conditions on covariates. In particular, the proposed procedure can still be powerful when covariates are strongly dependent on each other. We further develop an iterative algorithm to enhance the performance of our method while dealing with the practical situations where some covariates may be marginally unrelated but jointly related to the response. We conduct extensive simulations to evaluate the finite-sample performance of the proposed method, showing that it has favourable exhibition over the existing typical methods. As an illustration, we apply the proposed method to the diffuse large-B-cell lymphoma study.     

Independent feature screening for ultrahigh-dimensional models with interactions

Feature selection is an important technique for ultrahigh-dimensional data analysis. Most feature selection methods such as SIS and its relevant versions heavily depend on the specified model structures. Furthermore, feature interactions are usually not taken into account in the existing literature. In this paper, we present a novel feature selection method for the model with variable interactions, without the use of structure assumption. Thus, the new ranking criterion is flexible and can deal with the models that contain interactions. Moreover, the new screening procedures are not complex, consequently, they are computationally efficient and the theoretical properties such as the ranking consistency and sure screening properties can be easily obtained. Several real and simulation examples are presented to illustrate the methodology.     

Feature screening in ultrahigh-dimensional additive Cox model

The additive Cox model is flexible and powerful for modelling the dynamic changes of regression coefficients in the survival analysis. This paper is concerned with feature screening for the additive Cox model with ultrahigh-dimensional covariates. The proposed screening procedure can effectively identify active predictors. That is, with probability tending to one, the selected variable set includes the actual active predictors. In order to carry out the proposed procedure, we propose an effective algorithm and establish the ascent property of the proposed algorithm. We further prove that the proposed procedure possesses the sure screening property. Furthermore, we examine the finite sample performance of the proposed procedure via Monte Carlo simulations, and illustrate the proposed procedure by a real data example.     

Variable screening for survival data in the presence of heterogeneous censoring

Variable screening for censored survival data is most challenging when both survival and censoring times are correlated with an ultrahigh-dimensional vector of covariates. Existing approaches to handling censoring often make use of inverse probability weighting by assuming independent censoring with both survival time and covariates. This is a convenient but rather restrictive assumption which may be unmet in real applications, especially when the censoring mechanism is complex and the number of covariates is large. To accommodate heterogeneous (covariate-dependent) censoring that is often present in high-dimensional survival data, we propose a Gehan-type rank screening method to select features that are relevant to the survival time. The method is invariant to monotone transformations of the response and of the predictors, and works robustly for a general class of survival models. We establish the sure screening property of the proposed methodology. Simulation studies and a lymphoma data analysis demonstrate its favorable performance and practical utility.     

Entropy-based model-free feature screening for ultrahigh-dimensional multiclass classification

Most feature screening methods for ultrahigh-dimensional classification explicitly or implicitly assume the covariates are continuous. However, in the practice, it is quite common that both categorical and continuous covariates appear in the data, and applicable feature screening method is very limited. To handle this non-trivial situation, we propose an entropy-based feature screening method, which is model free and provides a unified screening procedure for both categorical and continuous covariates. We establish the sure screening and ranking consistency properties of the proposed procedure. We investigate the finite sample performance of the proposed procedure by simulation studies and illustrate the method by a real data analysis.     

Ultrahigh-dimensional sufficient dimension reduction for censored data with measurement error in covariates

In this paper, we consider the ultrahigh-dimensional sufficient dimension reduction (SDR) for censored data and measurement error in covariates. We first propose the feature screening procedure based on censored data and the covariates subject to measurement error. With the suitable correction of mismeasurement, the error-contaminated variables detected by the proposed feature screening procedure are the same as the truly important variables. Based on the selected active variables, we develop the SDR method to estimate the central subspace and the structural dimension with both censored data and measurement error incorporated. The theoretical results of the proposed method are established. Simulation studies are reported to assess the performance of the proposed method. The proposed method is implemented to NKI breast cancer data.     

Variable screening for ultrahigh dimensional censored quantile regression

Quantile regression is a flexible approach to assessing covariate effects on failure time, which has attracted considerable interest in survival analysis. When the dimension of covariates is much larger than the sample size, feature screening and variable selection become extremely important and indispensable. In this article, we introduce a new feature screening method for ultrahigh dimensional censored quantile regression. The proposed method can work for a general class of survival models, allow for heterogeneity of data and enjoy desirable properties including the sure screening property and the ranking consistency property. Moreover, an iterative version of screening algorithm has also been proposed to accommodate more complex situations. Monte Carlo simulation studies are designed to evaluate the finite sample performance under different model settings. We also illustrate the proposed methods through an empirical analysis.     

Quantile-adaptive variable screening in ultra-high dimensional varying coefficient models

The varying-coefficient model is an important nonparametric statistical model since it allows appreciable flexibility on the structure of fitted model. For ultra-high dimensional heterogeneous data it is very necessary to examine how the effects of covariates vary with exposure variables at different quantile level of interest. In this paper, we extended the marginal screening methods to examine and select variables by ranking a measure of nonparametric marginal contributions of each covariate given the exposure variable. Spline approximations are employed to model marginal effects and select the set of active variables in quantile-adaptive framework. This ensures the sure screening property in quantile-adaptive varying-coefficient model. Numerical studies demonstrate that the proposed procedure works well for heteroscedastic data.     

A model-free feature screening approach based on kernel density estimation

In this article, a new model-free feature screening method named after probability density (mass) function distance (PDFD) correlation is presented for ultrahigh-dimensional data analysis. We improve the fused-Kolmogorov filter (F-KOL) screening procedure through probability density distribution. The proposed method is also fully nonparametric and can be applied to more general types of predictors and responses, including discrete and continuous random variables. Kernel density estimate method and numerical integration are applied to obtain the estimator we proposed. The results of simulation studies indicate that the fused-PDFD performs better than other existing screening methods, such as F-KOL filter, sure-independent screening (SIS), sure independent ranking and screening (SIRS), distance correlation sure-independent screening (DCSIS) and robust ranking correlation screening (RRCS). Finally, we demonstrate the validity of fused-PDFD by a real data example.     

How to Make Model‐free Feature Screening Approaches for Full Data Applicable to the Case of Missing Response?

It is quite a challenge to develop model‐free feature screening approaches for missing response problems because the existing standard missing data analysis methods cannot be applied directly to high dimensional case. This paper develops some novel methods by borrowing information of missingness indicators such that any feature screening procedures for ultrahigh‐dimensional covariates with full data can be applied to missing response case. The first method is the so‐called missing indicator imputation screening, which is developed by proving that the set of the active predictors of interest for the response is a subset of the active predictors for the product of the response and missingness indicator under some mild conditions. As an alternative, another method called Venn diagram‐based approach is also developed. The sure screening property is proven for both methods. It is shown that the complete case analysis can also keep the sure screening property of any feature screening approach with sure screening property.     

Robust sure independence screening for nonpolynomial dimensional generalized linear models

We consider the problem of variable screening in ultra-high-dimensional generalized linear models (GLMs) of nonpolynomial orders. Since the popular SIS approach is extremely unstable in the presence of contamination and noise, we discuss a new robust screening procedure based on the minimum density power divergence estimator (MDPDE) of the marginal regression coefficients. Our proposed screening procedure performs well under pure and contaminated data scenarios. We provide a theoretical motivation for the use of marginal MDPDEs for variable screening from both population as well as sample aspects; in particular, we prove that the marginal MDPDEs are uniformly consistent leading to the sure screening property of our proposed algorithm. Finally, we propose an appropriate MDPDE-based extension for robust conditional screening in GLMs along with the derivation of its sure screening property. Our proposed methods are illustrated through extensive numerical studies along with an interesting real data application.     

Stable feature screening for ultrahigh dimensional data

This paper is concerned with the stable feature screening for the ultrahigh dimensional data. To deal with the ultrahigh dimensional data problem and screen the important features, a set-averaging measurement is proposed. The model averaging technique and the conditional quantile method are used to construct the weighted set-averaging feature screening procedure to identify the relationships between the possible predictors and the response variable. The proposed screening method is model free, stable and possesses the sure screening property under some regular conditions. Some Monte Carlo simulations and a real data application are conducted to evaluate the performance of the proposed procedure.     

Investigation about a screening step in model selection

In many studies a large number of variables is measured and the identification of relevant variables influencing an outcome is an important task. For variable selection several procedures are available. However, focusing on one model only neglects that there usually exist other equally appropriate models. Bayesian or frequentist model averaging approaches have been proposed to improve the development of a predictor. With a larger number of variables (say more than ten variables) the resulting class of models can be very large. For Bayesian model averaging Occam’s window is a popular approach to reduce the model space. As this approach may not eliminate any variables, a variable screening step was proposed for a frequentist model averaging procedure. Based on the results of selected models in bootstrap samples, variables are eliminated before deriving a model averaging predictor. As a simple alternative screening procedure backward elimination can be used. Through two examples and by means of simulation we investigate some properties of the screening step. In the simulation study we consider situations with fifteen and 25 variables, respectively, of which seven have an influence on the outcome. With the screening step most of the uninfluential variables will be eliminated, but also some variables with a weak effect. Variable screening leads to more applicable models without eliminating models, which are more strongly supported by the data. Furthermore, we give recommendations for important parameters of the screening step.     

A robust variable screening method for high-dimensional data

In practice, the presence of influential observations may lead to misleading results in variable screening problems. We, therefore, propose a robust variable screening procedure for high-dimensional data analysis in this paper. Our method consists of two steps. The first step is to define a new high-dimensional influence measure and propose a novel influence diagnostic procedure to remove those unusual observations. The second step is to utilize the sure independence screening procedure based on distance correlation to select important variables in high-dimensional regression analysis. The new influence measure and diagnostic procedure that we developed are model free. To confirm the effectiveness of the proposed method, we conduct simulation studies and a real-life data analysis to illustrate the merits of the proposed approach over some competing methods. Both the simulation results and the real-life data analysis demonstrate that the proposed method can greatly control the adverse effect after detecting and removing those unusual observations, and performs better than the competing methods.     

Feature screening for case‐cohort studies with failure time outcome

Case‐cohort design has been demonstrated to be an economical and efficient approach in large cohort studies when the measurement of some covariates on all individuals is expensive. Various methods have been proposed for case‐cohort data when the dimension of covariates is smaller than sample size. However, limited work has been done for high‐dimensional case‐cohort data which are frequently collected in large epidemiological studies. In this paper, we propose a variable screening method for ultrahigh‐dimensional case‐cohort data under the framework of proportional model, which allows the covariate dimension increases with sample size at exponential rate. Our procedure enjoys the sure screening property and the ranking consistency under some mild regularity conditions. We further extend this method to an iterative version to handle the scenarios where some covariates are jointly important but are marginally unrelated or weakly correlated to the response. The finite sample performance of the proposed procedure is evaluated via both simulation studies and an application to a real data from the breast cancer study.     

Variable selection in linear regression analysis with alternative Bayesian information criteria using differential evaluation algorithm

In statistical analysis, one of the most important subjects is to select relevant exploratory variables that perfectly explain the dependent variable. Variable selection methods are usually performed within regression analysis. Variable selection is implemented so as to minimize the information criteria (IC) in regression models. Information criteria directly affect the power of prediction and the estimation of selected models. There are numerous information criteria in literature such as Akaike Information Criteria (AIC) and Bayesian Information Criteria (BIC). These criteria are modified for to improve the performance of the selected models. BIC is extended with alternative modifications towards the usage of prior and information matrix. Information matrix-based BIC (IBIC) and scaled unit information prior BIC (SPBIC) are efficient criteria for this modification. In this article, we proposed a combination to perform variable selection via differential evolution (DE) algorithm for minimizing IBIC and SPBIC in linear regression analysis. We concluded that these alternative criteria are very useful for variable selection. We also illustrated the efficiency of this combination with various simulation and application studies.     

A sure independence screening procedure for ultra-high dimensional partially linear additive models

We introduce a two-step procedure, in the context of ultra-high dimensional additive models, which aims to reduce the size of covariates vector and distinguish linear and nonlinear effects among nonzero components. Our proposed screening procedure, in the first step, is constructed based on the concept of cumulative distribution function and conditional expectation of response in the framework of marginal correlation. B-splines and empirical distribution functions are used to estimate the two above measures. The sure screening property of this procedure is also established. In the second step, a double penalization based procedure is applied to identify nonzero and linear components, simultaneously. The performance of the designed method is examined by several test functions to show its capabilities against competitor methods when the distribution of errors is varied. Simulation studies imply that the proposed screening procedure can be applied to the ultra-high dimensional data and well detect the influential covariates. It also demonstrate the superiority in comparison with the existing methods. This method is also applied to identify most influential genes for overexpression of a G protein-coupled receptor in mice.     

Doubly robust weighted composite quantile regression based on SCAD-L2

In this article, a robust variable selection procedure based on the weighted composite quantile regression (WCQR) is proposed. Compared with the composite quantile regression (CQR), WCQR is robust to heavy-tailed errors and outliers in the explanatory variables. For the choice of the weights in the WCQR, we employ a weighting scheme based on the principal component method. To select variables with grouping effect, we consider WCQR with SCAD-L₂ penalization. Furthermore, under some suitable assumptions, the theoretical properties, including the consistency and oracle property of the estimator, are established with a diverging number of parameters. In addition, we study the numerical performance of the proposed method in the case of ultrahigh-dimensional data. Simulation studies and real examples are provided to demonstrate the superiority of our method over the CQR method when there are outliers in the explanatory variables and/or the random error is from a heavy-tailed distribution.