Two-sample empirical likelihood method for difference between coefficients in linear regression model

The empirical likelihood method is proposed to construct the confidence regions for the difference in value between coefficients of two-sample linear regression model. Unlike existing empirical likelihood procedures for one-sample linear regression models, as the empirical likelihood ratio function is not concave, the usual maximum empirical likelihood estimation cannot be obtained directly. To overcome this problem, we propose to incorporate a natural and well-explained restriction into likelihood function and obtain a restricted empirical likelihood ratio statistic (RELR). It is shown that RELR has an asymptotic chi-squared distribution. Furthermore, to improve the coverage accuracy of the confidence regions, a Bartlett correction is applied. The effectiveness of the proposed approach is demonstrated by a simulation study.     

Generalized empirical likelihood inference in partial linear regression model for longitudinal data

In this paper, empirical likelihood inference for longitudinal data within the framework of partial linear regression models are investigated. The proposed procedures take into consideration the correlation within groups without involving direct estimation of nuisance parameters in the correlation matrix. The empirical likelihood method is used to estimate the regression coefficients and the baseline function, and to construct confidence intervals. A nonparametric version of Wilk's theorem for the limiting distribution of the empirical likelihood ratio is derived. Compared with methods based on normal approximations, the empirical likelihood does not require consistent estimators for the asymptotic variance and bias. The finite sample behaviour of the proposed method is evaluated with simulation and illustrated with an AIDS clinical trial data set.     

A test for the linearity of the nonparametric part of a semiparametric logistic regression model

A semiparametric logistic regression model is proposed in which its nonparametric component is approximated with fixed-knot cubic B-splines. To assess the linearity of the nonparametric component, we construct a penalized likelihood ratio test statistic. When the number of knots is fixed, the null distribution of the test statistic is shown to be asymptotically the distribution of a linear combination of independent chi-squared random variables, each with one degree of freedom. We set the asymptotic null expectation of this test statistic equal to a value to determine the smoothing parameter value. Monte Carlo experiments are conducted to investigate the performance of the proposed test. Its practical use is illustrated with a real-life example.     

Relative risk regression for current status data in case‐cohort studies

We propose using the weighted likelihood method to fit a general relative risk regression model for the current status data with missing data as arise, for example, in case‐cohort studies. The missingness probability is either known or can be reasonably estimated. Asymptotic properties of the weighted likelihood estimators are established. For the case of using estimated weights, we construct a general theorem that guarantees the asymptotic normality of the M‐estimator of a finite dimensional parameter in a class of semiparametric models, where the infinite dimensional parameter is allowed to converge at a slower than parametric rate, and some other parameters in the objective function are estimated a priori. The weighted bootstrap method is employed to estimate the variances. Simulations show that the proposed method works well for finite sample sizes. A motivating example of the case‐cohort study from an HIV vaccine trial is used to demonstrate the proposed method. The Canadian Journal of Statistics 39: 557–577; 2011. © 2011 Statistical Society of Canada     

Guaranteed Local Maximum Likelihood Detection of a Change Point in Nonparametric Logistic Regression

We consider nonparametric logistic regression and propose a generalized likelihood test for detecting a threshold effect that indicates a relationship between some risk factor and a defined outcome above the threshold but none below it. One important field of application is occupational medicine and in particular, epidemiological studies. In epidemiological studies, segmented fully parametric logistic regression models are often threshold models, where it is assumed that the exposure has no influence on a response up to a possible unknown threshold, and has an effect beyond that threshold. Finding efficient methods for detection and estimation of a threshold is a very important task in these studies. This article proposes such methods in a context of nonparametric logistic regression. We use a local version of unknown likelihood functions and show that under rather common assumptions the asymptotic power of our test is one. We present a guaranteed non asymptotic upper bound for the significance level of the proposed test. If applying the test yields the acceptance of the conclusion that there was a change point (and hence a threshold limit value), we suggest using the local maximum likelihood estimator of the change point and consider the asymptotic properties of this estimator.     

Continuous threshold models with two-way interactions in survival analysis

Proportional hazards model with the biomarker–treatment interaction plays an important role in the survival analysis of the subset treatment effect. A threshold parameter for a continuous biomarker variable defines the subset of patients who can benefit or lose from a certain new treatment. In this article, we focus on a continuous threshold effect using the rectified linear unit and propose a gradient descent method to obtain the maximum likelihood estimation of the regression coefficients and the threshold parameter simultaneously. Under certain regularity conditions, we prove the consistency, asymptotic normality and provide a robust estimate of the covariance matrix when the model is misspecified. To illustrate the finite sample properties of the proposed methods, we simulate data to evaluate the empirical biases, the standard errors and the coverage probabilities for both the correctly specified models and misspecified models. The proposed continuous threshold model is applied to a prostate cancer data with serum prostatic acid phosphatase as a biomarker.     

Semiparametric Approach to a Random Effects Quantile Regression Model

We consider a random effects quantile regression analysis of clustered data and propose a semiparametric approach using empirical likelihood. The random regression coefficients are assumed independent with a common mean, following parametrically specified distributions. The common mean corresponds to the population-average effects of explanatory variables on the conditional quantile of interest, while the random coefficients represent cluster specific deviations in the covariate effects. We formulate the estimation of the random coefficients as an estimating equations problem and use empirical likelihood to incorporate the parametric likelihood of the random coefficients. A likelihood-like statistical criterion function is yield, which we show is asymptotically concave in a neighborhood of the true parameter value and motivates its maximizer as a natural estimator. We use Markov Chain Monte Carlo (MCMC) samplers in the Bayesian framework, and propose the resulting quasi-posterior mean as an estimator. We show that the proposed estimator of the population-level parameter is asymptotically normal and the estimators of the random coefficients are shrunk toward the population-level parameter in the first order asymptotic sense. These asymptotic results do not require Gaussian random effects, and the empirical likelihood based likelihood-like criterion function is free of parameters related to the error densities. This makes the proposed approach both flexible and computationally simple. We illustrate the methodology with two real data examples.     

Weighted composite quantile regression method via empirical likelihood for non linear models

In this paper, we investigate empirical likelihood (EL) inferences via weighted composite quantile regression for non linear models. Under regularity conditions, we establish that the proposed empirical log-likelihood ratio is asymptotically chi-squared, and then the confidence intervals for the regression coefficients are constructed. The proposed method avoids estimating the unknown error density function involved in the asymptotic covariance matrix of the estimators. Simulations suggest that the proposed EL procedure is more efficient and robust, and a real data analysis is used to illustrate the performance.     

Linear regression analysis with inequality constraints on the regression parameters via empirical likelihood

An empirical likelihood ratio test is developed for testing for or against inequality constraints on regression parameters in linear regression analysis. The proposed approach imposes no parametric model nor identically distributing assumption on the random errors. The asymptotic distribution of the proposed test statistic under null hypothesis is shown to be of chi-bar-squared type. The asymptotic power under contiguous alternatives is also briefly discussed. Moreover, an adjusted empirical likelihood method is adopted to improve the small sample size behaviour of the proposed test. Several simulation studies are carried out to assess the finite sample performance of the proposed tests. The results reveal that the proposed tests could be valuable for improving inference efficiency. A real-life example is discussed to illustrate the theoretical results.     

Empirical likelihood inference for partial functional linear model with missing responses

In this paper, we consider the empirical likelihood inferences of the partial functional linear model with missing responses. Two empirical log-likelihood ratios of the parameters of interest are constructed, and the corresponding maximum empirical likelihood estimators of parameters are derived. Under some regularity conditions, we show that the proposed two empirical log-likelihood ratios are asymptotic standard Chi-squared. Thus, the asymptotic results can be used to construct the confidence intervals/regions for the parameters of interest. We also establish the asymptotic distribution theory of corresponding maximum empirical likelihood estimators. A simulation study indicates that the proposed methods are comparable in terms of coverage probabilities and average lengths of confidence intervals. An example of real data is also used to illustrate our proposed methods.     

Statistical Inference in Partially Linear Varying-Coefficient Models with Missing Responses at Random

This article considers statistical inference for partially linear varying-coefficient models when the responses are missing at random. We propose a profile least-squares estimator for the parametric component with complete-case data and show that the resulting estimator is asymptotically normal. To avoid to estimate the asymptotic covariance in establishing confidence region of the parametric component with the normal-approximation method, we define an empirical likelihood based statistic and show that its limiting distribution is chi-squared distribution. Then, the confidence regions of the parametric component with asymptotically correct coverage probabilities can be constructed by the result. To check the validity of the linear constraints on the parametric component, we construct a modified generalized likelihood ratio test statistic and demonstrate that it follows asymptotically chi-squared distribution under the null hypothesis. Then, we extend the generalized likelihood ratio technique to the context of missing data. Finally, some simulations are conducted to illustrate the proposed methods.     

Statistical inference in partially time-varying coefficient models

A partially time-varying coefficient time series model is introduced to characterize the nonlinearity and trending phenomenon. To estimate the regression parameter and the nonlinear coefficient function, the profile least squares approach is applied with the help of local linear approximation. The asymptotic distributions of the proposed estimators are established under mild conditions. Meanwhile, the generalized likelihood ratio test is studied and the test statistics are demonstrated to follow asymptotic χ²-distribution under the null hypothesis. Furthermore, some extensions of the proposed model are discussed and several numerical examples are provided to illustrate the finite sample behavior of the proposed methods.     

Testing symmetry based on empirical likelihood

In this paper, we propose a general kth correlation coefficient between the density function and distribution function of a continuous variable as a measure of symmetry and asymmetry. We first propose a root-n moment-based estimator of the kth correlation coefficient and present its asymptotic results. Next, we consider statistical inference of the kth correlation coefficient by using the empirical likelihood (EL) method. The EL statistic is shown to be asymptotically a standard chi-squared distribution. Last, we propose a residual-based estimator of the kth correlation coefficient for a parametric regression model to test whether the density function of the true model error is symmetric or not. We present the asymptotic results of the residual-based kth correlation coefficient estimator and also construct its EL-based confidence intervals. Simulation studies are conducted to examine the performance of the proposed estimators, and we also use our proposed estimators to analyze the air quality dataset.     

Inference in Semi‐Parametric Dynamic Models for Repeated Count Data

This paper deals with a longitudinal semi‐parametric regression model in a generalised linear model setup for repeated count data collected from a large number of independent individuals. To accommodate the longitudinal correlations, we consider a dynamic model for repeated counts which has decaying auto‐correlations as the time lag increases between the repeated responses. The semi‐parametric regression function involved in the model contains a specified regression function in some suitable time‐dependent covariates and a non‐parametric function in some other time‐dependent covariates. As far as the inference is concerned, because the non‐parametric function is of secondary interest, we estimate this function consistently using the independence assumption‐based well‐known quasi‐likelihood approach. Next, the proposed longitudinal correlation structure and the estimate of the non‐parametric function are used to develop a semi‐parametric generalised quasi‐likelihood approach for consistent and efficient estimation of the regression effects in the parametric regression function. The finite sample performance of the proposed estimation approach is examined through an intensive simulation study based on both large and small samples. Both balanced and unbalanced cluster sizes are incorporated in the simulation study. The asymptotic performances of the estimators are given. The estimation methodology is illustrated by reanalysing the well‐known health care utilisation data consisting of counts of yearly visits to a physician by 180 individuals for four years and several important primary and secondary covariates.     

Cressie–Read Power-Divergence Statistics for Non-Gaussian Vector Stationary Processes

Abstract.  For a class of vector-valued non-Gaussian stationary processes, we develop the Cressie–Read power-divergence (CR) statistic approach which has been proposed for the i.i.d. case. The CR statistic includes empirical likelihood as a special case. Therefore, by adopting this CR statistic approach, the theory of estimation and testing based on empirical likelihood is greatly extended. We use an extended Whittle likelihood as score function and derive the asymptotic distribution of the CR statistic. We apply this result to estimation of autocorrelation and the AR coefficient, and get narrower confidence intervals than those obtained by existing methods. We also consider the power properties of the test based on asymptotic theory. Under a sequence of contiguous local alternatives, we derive the asymptotic distribution of the CR statistic. The problem of testing autocorrelation is discussed and we introduce some interesting properties of the local power.     

Empirical likelihood ratio tests for the linear regression model with inequality constraints

Abstract

In this article, empirical likelihood is applied to the linear regression model with inequality constraints. We prove that asymptotic distribution of the adjusted empirical likelihood ratio test statistic is a weighted mixture of chi-square distribution.     

Empirical Likelihood Ratio Test for a Change-Point in Linear Regression Model

A nonparametric method based on the empirical likelihood is proposed to detect the change-point in the coefficient of linear regression models. The empirical likelihood ratio test statistic is proved to have the same asymptotic null distribution as that with classical parametric likelihood. Under some mild conditions, the maximum empirical likelihood change-point estimator is also shown to be consistent. The simulation results show the sensitivity and robustness of the proposed approach. The method is applied to some real datasets to illustrate the effectiveness.     

Inferences in dynamic logit models in semi-parametric setup for repeated binary data

Binary dynamic fixed and mixed logit models are extensively studied in the literature. These models are developed to examine the effects of certain fixed covariates through a parametric regression function as a part of the models. However, there are situations where one may like to consider more covariates in the model but their direct effect is not of interest. In this paper we propose a generalization of the existing binary dynamic logit (BDL) models to the semi-parametric longitudinal setup to address this issue of additional covariates. The regression function involved in such a semi-parametric BDL model contains (i) a parametric linear regression function in some primary covariates, and (ii) a non-parametric function in certain secondary covariates. We use a simple semi-parametric conditional quasi-likelihood approach for consistent estimation of the non-parametric function, and a semi-parametric likelihood approach for the joint estimation of the main regression and dynamic dependence parameters of the model. The finite sample performance of the estimation approaches is examined through a simulation study. The asymptotic properties of the estimators are also discussed. The proposed model and the estimation approaches are illustrated by reanalysing a longitudinal infectious disease data.     

On multivariate quantile regression

To detect the dependence on the covariates in the lower and upper tails of the response distribution, regression quantiles are very useful tools in linear model problems with univariate response. We consider here a notion of regression quantiles for problems with multivariate responses. The approach is based on minimizing a loss function equivalent to that in the case of univariate response. To construct an affine equivariant notion of multivariate regression quantiles, we have considered a transformation retransformation procedure based on ‘data-driven coordinate systems’. We indicate some algorithm to compute the proposed estimates and establish asymptotic normality for them. We also, suggest an adaptive procedure to select the optimal data-driven coordinate system. We discuss the performance of our estimates with the help of a finite sample simulation study and to illustrate our methodology, we analyzed an interesting data-set on blood pressures of a group of women and another one on the dependence of sales performances on creative test scores.     

Wavelet-based estimators of multivariable mean regression function with long-memory data

Wavelet analysis has been proved to be a powerful statistical technique in the non parametric regression. In this paper, we propose non linear wavelet-based estimators for multivariable mean regression function with long-memory data. We also provide an asymptotic expansion for the mean integrated squared error (MISE) of the function estimators. This MISE expansion still works even when the underlying mean regression function is only piecewise smooth. This paper extends the corresponding results in the literature for single variable to multivariable case.