Failure Inference and Optimization for Step Stress Model Based on Bivariate Wiener Model

In this article, we consider the situation under a life test, in which the failure time of the test units are not related deterministically to an observable stochastic time varying covariate. In such a case, the joint distribution of failure time and a marker value would be useful for modeling the step stress life test. The problem of accelerating such an experiment is considered as the main aim of this article. We present a step stress accelerated model based on a bivariate Wiener process with one component as the latent (unobservable) degradation process, which determines the failure times and the other as a marker process, the degradation values of which are recorded at times of failure. Parametric inference based on the proposed model is discussed and the optimization procedure for obtaining the optimal time for changing the stress level is presented. The optimization criterion is to minimize the approximate variance of the maximum likelihood estimator of a percentile of the products’ lifetime distribution.     

Starting Values for EM Estimation of Latent Class Joint Model

Latent class model is one of the important latent variable methods for joint modeling longitudinal and survival data. Latent class joint model can handle underlying heterogeneous population, discover subpopulation structure, and incorporate correlated non normally distributed outcomes. The maximum likelihood estimates of parameters in latent class joint model are generally obtained by the EM algorithm. Finding the starting values is one of the major issues to implement the EM algorithm successfully. In this article, initial value formulas are provided, a simulation study is conducted to show that the proposed starting values perform very well, and two illustrative examples are presented.     

A latent process model for dementia and psychometric tests

We jointly model longitudinal values of a psychometric test and diagnosis of dementia. The model is based on a continuous-time latent process representing cognitive ability. The link between the latent process and the observations is modeled in two phases. Intermediate variables are noisy observations of the latent process; scores of the psychometric test and diagnosis of dementia are obtained by categorizing these intermediate variables. We propose maximum likelihood inference for this model and we propose algorithms for performing this task. We estimated the parameters of such a model using the data of the 5 year follow-up of the PAQUID study. In particular this analysis yielded interesting results about the effect of educational level on both latent cognitive ability and specific performance in the mini mental test examination. The predictive ability of the model is illustrated by predicting diagnosis of dementia at the 8 year follow-up of the PAQUID study based on the information from the first 5 years.     

On limiting likelihood ratio processes of some change-point type statistical models

Different change-point type models encountered in parametric statistical inference give rise to different limiting likelihood ratio processes. In this paper we consider two such likelihood ratios. The first one is an exponential functional of a two-sided Poisson process driven by some parameter, while the second one is an exponential functional of a two-sided Brownian motion. We establish that for sufficiently small values of the parameter, the Poisson type likelihood ratio can be approximated by the Brownian type one. As a consequence, several statistically interesting quantities (such as limiting variances of different estimators) related to the first likelihood ratio can also be approximated by those related to the second one. Finally, we discuss the asymptotics for large values of the parameter and illustrate the results by numerical simulations.     

Explaining the behavior of joint and marginal Monte Carlo estimators in latent variable models with independence assumptions

In latent variable models parameter estimation can be implemented by using the joint or the marginal likelihood, based on independence or conditional independence assumptions. The same dilemma occurs within the Bayesian framework with respect to the estimation of the Bayesian marginal (or integrated) likelihood, which is the main tool for model comparison and averaging. In most cases, the Bayesian marginal likelihood is a high dimensional integral that cannot be computed analytically and a plethora of methods based on Monte Carlo integration (MCI) are used for its estimation. In this work, it is shown that the joint MCI approach makes subtle use of the properties of the adopted model, leading to increased error and bias in finite settings. The sources and the components of the error associated with estimators under the two approaches are identified here and provided in exact forms. Additionally, the effect of the sample covariation on the Monte Carlo estimators is examined. In particular, even under independence assumptions the sample covariance will be close to (but not exactly) zero which surprisingly has a severe effect on the estimated values and their variability. To address this problem, an index of the sample’s divergence from independence is introduced as a multivariate extension of covariance. The implications addressed here are important in the majority of practical problems appearing in Bayesian inference of multi-parameter models with analogous structures.     

产品缺陷数不可被精确观测过程的加权似然比控制图

基于Zhou等提出的加权似然比控制图(WEWMA),给出3种对应的控制图方案,即基于极大似然估计的控制图方案、基于非线性方程估计的控制图方案和基于相关系数矩阵估计的控制图方法,以解决产品缺陷数不可被精确观测过程的在线监控问题。数值模拟显示,基于相关系数矩阵估计构造的控制图方案表现良好,尤其是在核查人员之间的确存在相关性的时候,有更明显的优势。随机生成一个例子,说明了相关系数矩阵控制图的使用方法。     

Latent variable model for mixed correlated power series and ordinal longitudinal responses with non ignorable missing values

We propose a joint model based on a latent variable for analyzing mixed power series and ordinal longitudinal data with and without missing values. A bivariate probit regression model is used for the missing mechanisms. Random effects are used to take into account the correlation between longitudinal responses. A full likelihood-based approach is used to yield maximum-likelihood estimates of the model parameters. Our model is applied to a medical data set, obtained from an observational study on women where the correlated responses are the ordinal response of osteoporosis of the spine and the power series response of the number of joint damages. Sensitivity analysis is also performed to study the influence of small perturbations of the parameters of the missing mechanisms and overdispersion of the model on likelihood displacement.     

Point predictors of the latent failure times of censored units in progressively Type-II censored competing risks data from the exponential distributions

In this paper, we discuss the problem of predicting times to the latent failures of units censored in multiple stages in a progressively Type-II censored competing risks model. It is assumed that the lifetime distribution of the latent failure times are independent and exponential-distributed with the different scale parameters. Several classical point predictors such as the maximum likelihood predictor, the best unbiased predictor, the best linear unbiased predictor, the median unbiased predictor and the conditional median predictor are obtained. The Bayesian point predictors are derived under squared error loss criterion. Moreover, the point estimators of the unknown parameters are obtained using the observed data and different point predictors of the latent failure times. Finally, Monte-Carlo simulations are carried out to compare the performances of the different methods of prediction and estimation and one real data is used to illustrate the proposed procedures.     

Estimation and prediction of the Kumaraswamy distribution based on record values and inter-record times

ABSTRACT

The maximum likelihood and Bayesian approaches for estimating the parameters and the prediction of future record values for the Kumaraswamy distribution has been considered when the lower record values along with the number of observations following the record values (inter-record-times) have been observed. The Bayes estimates are obtained based on a joint bivariate prior for the shape parameters. In this case, Bayes estimates of the parameters have been developed by using Lindley's approximation and the Markov Chain Monte Carlo (MCMC) method due to the lack of explicit forms under the squared error and the linear-exponential loss functions. The MCMC method has been also used to construct the highest posterior density credible intervals. The Bayes and the maximum likelihood estimates are compared by using the estimated risk through Monte Carlo simulations. We further consider the non-Bayesian and Bayesian prediction for future lower record values arising from the Kumaraswamy distribution based on record values with their corresponding inter-record times and only record values. The comparison of the derived predictors are carried out by using Monte Carlo simulations. Real data are analysed for an illustration of the findings.     

Regression analysis of longitudinal data with outcome‐dependent sampling and informative censoring

We consider a regression analysis of longitudinal data in the presence of outcome‐dependent observation times and informative censoring. Existing approaches commonly require a correct specification of the joint distribution of longitudinal measurements, the observation time process, and informative censoring time under the joint modeling framework and can be computationally cumbersome due to the complex form of the likelihood function. In view of these issues, we propose a semiparametric joint regression model and construct a composite likelihood function based on a conditional order statistics argument. As a major feature of our proposed methods, the aforementioned joint distribution is not required to be specified, and the random effect in the proposed joint model is treated as a nuisance parameter. Consequently, the derived composite likelihood bypasses the need to integrate over the random effect and offers the advantage of easy computation. We show that the resulting estimators are consistent and asymptotically normal. We use simulation studies to evaluate the finite‐sample performance of the proposed method and apply it to a study of weight loss data that motivated our investigation.     

Maximum likelihood drift estimation for a threshold diffusion

We study the maximum likelihood estimator of the drift parameters of a stochastic differential equation, with both drift and diffusion coefficients constant on the positive and negative axis, yet discontinuous at zero. This threshold diffusion is called drifted oscillating Brownian motion. For this continuously observed diffusion, the maximum likelihood estimator coincides with a quasi-likelihood estimator with constant diffusion term. We show that this estimator is the limit, as observations become dense in time, of the (quasi)-maximum likelihood estimator based on discrete observations. In long time, the asymptotic behaviors of the positive and negative occupation times rule the ones of the estimators. Differently from most known results of the literature, we do not restrict ourselves to the ergodic framework: indeed, depending on the signs of the drift, the process may be ergodic, transient, or null recurrent. For each regime, we establish whether or not the estimators are consistent; if they are, we prove the convergence in long time of the properly rescaled difference of the estimators towards a normal or mixed normal distribution. These theoretical results are backed by numerical simulations.     

Dynamic latent trait models with mixed hidden Markov structure for mixed longitudinal outcomes

We propose a general Bayesian joint modeling approach to model mixed longitudinal outcomes from the exponential family for taking into account any differential misclassification that may exist among categorical outcomes. Under this framework, outcomes observed without measurement error are related to latent trait variables through generalized linear mixed effect models. The misclassified outcomes are related to the latent class variables, which represent unobserved real states, using mixed hidden Markov models (MHMMs). In addition to enabling the estimation of parameters in prevalence, transition and misclassification probabilities, MHMMs capture cluster level heterogeneity. A transition modeling structure allows the latent trait and latent class variables to depend on observed predictors at the same time period and also on latent trait and latent class variables at previous time periods for each individual. Simulation studies are conducted to make comparisons with traditional models in order to illustrate the gains from the proposed approach. The new approach is applied to data from the Southern California Children Health Study to jointly model questionnaire-based asthma state and multiple lung function measurements in order to gain better insight about the underlying biological mechanism that governs the inter-relationship between asthma state and lung function development.     

The proportional hazards model with covariate measurement error

The proportional hazards regression model is commonly used to evaluate the relationship between survival and covariates. Covariates are frequently measured with error. Substituting mismeasured values for the true covariates leads to biased estimation. Hu et al. (Biometrics 88 (1998) 447) have proposed to base estimation in the proportional hazards model with covariate measurement error on a joint likelihood for survival and the covariate variable. Nonparametric maximum likelihood estimation (NPMLE) was used and simulations were conducted to assess the asymptotic validity of this approach. In this paper, we derive a rigorous proof of asymptotic normality of the NPML estimators.     

Stochastically Curtailed Tests Under Fractional Brownian Motion

Stochastic curtailment has been considered for the interim monitoring of group sequential trials (Davis and Hardy, 1994). Statistical boundaries in Davis and Hardy (1994) were derived using theory of Brownian motion. In some clinical trials, the conditions of forming a Brownian motion may not be satisfied. In this paper, we extend the computations of Brownian motion based boundaries, expected stopping times, and type I and type II error rates to fractional Brownian motion (FBM). FBM includes Brownian motion as a special case. Designs under FBM are compared to those under Brownian motion and to those of O’Brien–Fleming type tests. One- and two-sided boundaries for efficacy and futility monitoring are also discussed. Results show that boundary values decrease and error rates deviate from design levels when the Hurst parameter increases from 0.1 to 0.9, these changes should be considered when designing a study under FBM.     

Estimation and prediction of the Burr type XII distribution based on record values and inter-record times

The maximum likelihood and Bayesian approaches for parameter estimations and prediction of future record values have been considered for the two-parameter Burr Type XII distribution based on record values with the number of trials following the record values (inter-record times). Firstly, the Bayes estimates are obtained based on a joint bivariate prior for the shape parameters. In this case, the Bayes estimates of the parameters have been developed by using Lindley's approximation and the Markov Chain Monte Carlo (MCMC) method due to the lack of explicit forms under the squared error and the linear-exponential loss functions. The MCMC method has been also used to construct the highest posterior density credible intervals. Secondly, the Bayes estimates are obtained with respect to a discrete prior for the first shape parameter and a conjugate prior for other shape parameter. The Bayes and the maximum likelihood estimates are compared in terms of the estimated risk by the Monte Carlo simulations. We further consider the non-Bayesian and Bayesian prediction for future lower record arising from the Burr Type XII distribution based on record data. The comparison of the derived predictors is carried out by using Monte Carlo simulations. A real data are analysed for illustration purposes.     

A tampered Brownian motion process model for partial step-stress accelerated life testing

In partial step-stress accelerated life testing, models extrapolating data obtained under more severe conditions to infer the lifetime distribution under normal use conditions are needed. Bhattacharyya (Invited paper for 46th session of the ISI, 1987) proposed a tampered Brownian motion process model and later derived the probability distribution from a decay process perspective without linear assumption. In this paper, the model is described and the features of the failure time distribution are discussed. The maximum likelihood estimates of the parameters in the model and their asymptotic properties are presented. An application of models for step-stress accelerated life test to fields other than engineering is described and illustrated by applying the tampered Brownian motion process model to data taken from a clinical trial.     

Operating Characteristics for Group Sequential Trials Monitored Under Fractional Brownian Motion

Brownian motion has been used to derive stopping boundaries for group sequential trials, however, when we observe dependent increment in the data, fractional Brownian motion is an alternative to be considered to model such data. In this article we compared expected sample sizes and stopping times for different stopping boundaries based on the power family alpha spending function under various values of Hurst coefficient. Results showed that the expected sample sizes and stopping times will decrease and power increases when the Hurst coefficient increases. With same Hurst coefficient, the closer the boundaries are to that of O'Brien-Fleming, the higher the expected sample sizes and stopping times are; however, power has a decreasing trend for values start from H = 0.6 (early analysis), 0.7 (equal space), 0.8 (late analysis). We also illustrate study design changes using results from the BHAT study.     

Pointwise and functional approximations in Monte Carlo maximum likelihood estimation

We consider the use of Monte Carlo methods to obtain maximum likelihood estimates for random effects models and distinguish between the pointwise and functional approaches. We explore the relationship between the two approaches and compare them with the EM algorithm. The functional approach is more ambitious but the approximation is local in nature which we demonstrate graphically using two simple examples. A remedy is to obtain successively better approximations of the relative likelihood function near the true maximum likelihood estimate. To save computing time, we use only one Newton iteration to approximate the maximiser of each Monte Carlo likelihood and show that this is equivalent to the pointwise approach. The procedure is applied to fit a latent process model to a set of polio incidence data. The paper ends by a comparison between the marginal likelihood and the recently proposed hierarchical likelihood which avoids integration altogether.     

Estimation with the generalized exponential distribution based on record values and inter-record times

The maximum likelihood and Bayesian approaches have been considered for the two-parameter generalized exponential distribution based on record values with the number of trials following the record values (inter-record times). The maximum likelihood estimates are obtained under the inverse sampling and the random sampling schemes. It is shown that the maximum likelihood estimator of the shape parameter converges in mean square to the true value when the scale parameter is known. The Bayes estimates of the parameters have been developed by using Lindley's approximation and the Markov Chain Monte Carlo methods due to the lack of explicit forms under the squared error and the linear-exponential loss functions. The confidence intervals for the parameters are constructed based on asymptotic and Bayesian methods. The Bayes and the maximum likelihood estimators are compared in terms of the estimated risk by the Monte Carlo simulations. The comparison of the estimators based on the record values and the record values with their corresponding inter-record times are performed by using Monte Carlo simulations.     

A joint-modeling approach to assess the impact of biomarker variability on the risk of developing clinical outcome

In some clinical trials and epidemiologic studies, investigators are interested in knowing whether the variability of a biomarker is independently predictive of clinical outcomes. This question is often addressed via a naïve approach where a sample-based estimate (e.g., standard deviation) is calculated as a surrogate for the “true” variability and then used in regression models as a covariate assumed to be free of measurement error. However, it is well known that the measurement error in covariates causes underestimation of the true association. The issue of underestimation can be substantial when the precision is low because of limited number of measures per subject. The joint analysis of survival data and longitudinal data enables one to account for the measurement error in longitudinal data and has received substantial attention in recent years. In this paper we propose a joint model to assess the predictive effect of biomarker variability. The joint model consists of two linked sub-models, a linear mixed model with patient-specific variance for longitudinal data and a full parametric Weibull distribution for survival data, and the association between two models is induced by a latent Gaussian process. Parameters in the joint model are estimated under Bayesian framework and implemented using Markov chain Monte Carlo (MCMC) methods with WinBUGS software. The method is illustrated in the Ocular Hypertension Treatment Study to assess whether the variability of intraocular pressure is an independent risk of primary open-angle glaucoma. The performance of the method is also assessed by simulation studies.