Asymptotic theory for bent-cable regression—the basic case

We use what we call the bent-cable model to describe potential change-point phenomena. The class of bent cables includes the commonly used broken stick (a bent cable without a bend segment). Theory for least-squares (LS) estimation is developed for the basic bent cable, whose incoming and outgoing linear phases have slopes 0 and 1, respectively, and are joined smoothly by a quadratic bend. Conditions on the design are given to ensure regularity of the estimation problem, despite non-differentiability of the model's first partial derivatives (with respect to the covariate and model parameters). Under such conditions, we show that the LS estimators (i) are consistent, regardless of a zero or positive true bend width; and (ii) asymptotically follow a bivariate normal distribution, if the underlying cable has all three segments. In the latter case, we show that the deviance statistic has an asymptotic chi-squared distribution with two degrees of freedom.     

A modified generalized mixed regression estimator when disturbances are nonnormal

A generalized mixed regression estimator for the estimation of the regression coefficients in the linear regression model with incomplete prior information is proposed and its properties are studied considering the risk under the general quadratic loss function when the disturbances are small and non normal.     

Therapeutic Hypothermia: Quantification of the Transition of Core Body Temperature Using the Flexible Mixture Bent‐Cable Model for Longitudinal Data

Hypothermia which is induced by reducing core body temperature is a therapeutic tool used to prevent brain damage resulting from physical trauma. However, all physiological systems begin to slow down due to hypothermia and this can result in increased risk of mortality. Therefore quantification of the transition of core body temperature to early hypothermia is of great clinical interest. Conceptually core body temperature may exhibit an either gradual or abrupt transition. Bent‐cable regression is an appealing statistical tool to model such data due to the model's flexibility and readily interpretable regression coefficients. It handles more flexibly models that traditionally have been handled by low‐order polynomial models (for gradual transition) or piecewise linear changepoint models (for abrupt change). We consider a rat model to quantify the temporal trend of core body temperature primarily to address the question: What is the critical time point associated with a breakdown in the compensatory mechanisms following the start of hypothermia therapy? To this end, we develop a Bayesian modelling framework for bent‐cable regression of longitudinal data to simultaneously account for gradual and abrupt transitions. Our analysis reveals that: (i) about 39% of rats exhibit a gradual transition in core body temperature; (ii) the critical time point is approximately the same regardless of transition type; and (iii) both transition types show a significant increase of core body temperature followed by a significant decrease.     

Bayesian Single Changepoint Estimation in a Parameter‐driven Model

In this paper, we consider the problem of estimating a single changepoint in a parameter‐driven model. The model – an extension of the Poisson regression model – accounts for serial correlation through a latent process incorporated in its mean function. Emphasis is placed on the changepoint characterization with changes in the parameters of the model. The model is fully implemented within the Bayesian framework. We develop a RJMCMC algorithm for parameter estimation and model determination. The algorithm embeds well‐devised Metropolis–Hastings procedures for estimating the missing values of the latent process through data augmentation and the changepoint. The methodology is illustrated using data on monthly counts of claimants collecting wage loss benefit for injuries in the workplace and an analysis of presidential uses of force in the USA.     

Smooth piecewise linear regression splines with hyperbolic covariates

We-propose the use of hyperbolas as covariates in piecewise linear regression splines to fit data exhibiting a multi-phase linear response with smooth transitions between phases. The hyperbolic regression spline model, fitted by non-linear regression, provides an intuitive and easy way to extend to multiple phases the two-phase hyperbolic response model previously proposed by others. The small additional effort required to fit non-linear, as opposed to linear, regression models is particularly worthwhile when investigators are unwilling to assume that the slope of the response changes abruptly at the join points. Furthermore, undue influence on the join point and slope estimates, resulting from points in the transition region, may be avoided by using the hyperbolic regression spline. Two examples illustrate the use of this method.     

Asymptotic distribution of regression correlation coefficient for Poisson regression model

This study treats an asymptotic distribution for measures of predictive power for generalized linear models (GLMs). We focus on the regression correlation coefficient (RCC) that is one of the measures of predictive power. The RCC, proposed by Zheng and Agresti is a population value and a generalization of the population value for the coefficient of determination. Therefore, the RCC is easy to interpret and familiar. Recently, Takahashi and Kurosawa provided an explicit form of the RCC and proposed a new RCC estimator for a Poisson regression model. They also showed the validity of the new estimator compared with other estimators. This study discusses the new statistical properties of the RCC for the Poisson regression model. Furthermore, we show an asymptotic normality of the RCC estimator.     

Ordered Regressions

There are often situations where two or more regression functions are ordered over a range of covariate values. In this paper, we develop efficient constrained estimation and testing procedures for such models. Specifically, necessary and sufficient conditions for ordering generalized linear regressions are given and shown to unify previous results obtained for simple linear regression, for polynomial regression and in the analysis of covariance models. We show that estimating the parameters of ordered linear regressions requires either quadratic programming or semi‐infinite programming, depending on the shape of the covariate space. A distance‐type test for order is proposed. Simulations demonstrate that the proposed methodology improves the mean square error and power compared with the usual, unconstrained, estimation and testing procedures. Improvements are often substantial. The methodology is extended to order generalized linear models where convex semi‐infinite programming plays a role. The methodology is motivated by, and applied to, a hearing loss study.     

Variable selection for high-dimensional generalized linear models with the weighted elastic-net procedure

High-dimensional data arise frequently in modern applications such as biology, chemometrics, economics, neuroscience and other scientific fields. The common features of high-dimensional data are that many of predictors may not be significant, and there exists high correlation among predictors. Generalized linear models, as the generalization of linear models, also suffer from the collinearity problem. In this paper, combining the nonconvex penalty and ridge regression, we propose the weighted elastic-net to deal with the variable selection of generalized linear models on high dimension and give the theoretical properties of the proposed method with a diverging number of parameters. The finite sample behavior of the proposed method is illustrated with simulation studies and a real data example.     

A note on the Cook''s distance

A modification of the classical Cook's distance is proposed, providing us with a generalized Mahalanobis distance in the context of multivariate elliptical linear regression models. We establish the exact distribution of a pivotal type statistics based on this generalized Mahalanobis distance, which provides critical points for the identification of outlier data points. Based on the equivalence between the modified Cook's distance and what is called the mean-shift multivariate outlier elliptical model, twelve new modifications are proposed for the Cook's distance. We also describe the explicit relationship between the Cook's distance and the likelihood displacement with the modified Cook's distance. We illustrate the procedure with some examples, in the context of multiple and multivariate linear regression.     

Estimated estimating equations: semiparametric inference for clustered and longitudinal data

Summary.  We introduce a flexible marginal modelling approach for statistical inference for clustered and longitudinal data under minimal assumptions. This estimated estimating equations approach is semiparametric and the proposed models are fitted by quasi-likelihood regression, where the unknown marginal means are a function of the fixed effects linear predictor with unknown smooth link, and variance–covariance is an unknown smooth function of the marginal means. We propose to estimate the nonparametric link and variance–covariance functions via smoothing methods, whereas the regression parameters are obtained via the estimated estimating equations. These are score equations that contain nonparametric function estimates. The proposed estimated estimating equations approach is motivated by its flexibility and easy implementation. Moreover, if data follow a generalized linear mixed model, with either a specified or an unspecified distribution of random effects and link function, the model proposed emerges as the corresponding marginal (population-average) version and can be used to obtain inference for the fixed effects in the underlying generalized linear mixed model, without the need to specify any other components of this generalized linear mixed model. Among marginal models, the estimated estimating equations approach provides a flexible alternative to modelling with generalized estimating equations. Applications of estimated estimating equations include diagnostics and link selection. The asymptotic distribution of the proposed estimators for the model parameters is derived, enabling statistical inference. Practical illustrations include Poisson modelling of repeated epileptic seizure counts and simulations for clustered binomial responses.     

Goodness-of-link tests for multivariate regression models

ABSTRACT

This note presents an approximation to multivariate regression models which is obtained from a first-order series expansion of the multivariate link function. The proposed approach yields a variable-addition approximation of regression models that enables a multivariate generalization of the well-known goodness-of-link specification test, available for univariate generalized linear models. Application of this general methodology is illustrated with models of multinomial discrete choice and multivariate fractional data, in which context it is shown to lead to well-established approximation and testing procedures.     

Segmental modeling of changing immunologic response for CD4 data with skewness,missingness and dropout

In clinical practice, the profile of each subject's CD4 response from a longitudinal study may follow a ‘broken stick’ like trajectory, indicating multiple phases of increase and/or decline in response. Such multiple phases (changepoints) may be important indicators to help quantify treatment effect and improve management of patient care. Although it is a common practice to analyze complex AIDS longitudinal data using nonlinear mixed-effects (NLME) or nonparametric mixed-effects (NPME) models in the literature, NLME or NPME models become a challenge to estimate changepoint due to complicated structures of model formulations. In this paper, we propose a changepoint mixed-effects model with random subject-specific parameters, including the changepoint for the analysis of longitudinal CD4 cell counts for HIV infected subjects following highly active antiretroviral treatment. The longitudinal CD4 data in this study may exhibit departures from symmetry, may encounter missing observations due to various reasons, which are likely to be non-ignorable in the sense that missingness may be related to the missing values, and may be censored at the time of the subject going off study-treatment, which is a potentially informative dropout mechanism. Inferential procedures can be complicated dramatically when longitudinal CD4 data with asymmetry (skewness), incompleteness and informative dropout are observed in conjunction with an unknown changepoint. Our objective is to address the simultaneous impact of skewness, missingness and informative censoring by jointly modeling the CD4 response and dropout time processes under a Bayesian framework. The method is illustrated using a real AIDS data set to compare potential models with various scenarios, and some interested results are presented.     

Changepoint Estimation in a Segmented Linear Regression via Empirical Likelihood

For a segmented regression system with an unknown changepoint over two domains of a predictor, a new empirical likelihood ratio statistic is proposed to test the null hypothesis of no change. Under the null hypothesis of no change, the proposed test statistic is shown empirically to be Gumbel distributed with robust location and scale estimators against various parameter settings and error distributions. A power analysis is conducted to illustrate the performance of the test. Under the alternative hypothesis with a changepoint, the test statistic is utilized to estimate the changepoint between the two domains. A comparison of the frequency distributions between the proposed estimator and two parametric methods indicates that the proposed method is effective in capturing the true changepoint.     

Mixtures of regressions with changepoints

We introduce an extension to the mixture of linear regressions model where changepoints are present. Such a model provides greater flexibility over a standard changepoint regression model if the data are believed to not only have changepoints present, but are also believed to belong to two or more unobservable categories. This model can provide additional insight into data that are already modeled using mixtures of regressions, but where the presence of changepoints has not yet been investigated. After discussing the mixture of regressions with changepoints model, we then develop an Expectation/Conditional Maximization (ECM) algorithm for maximum likelihood estimation. Two simulation studies illustrate the performance of our ECM algorithm and we analyze a real dataset.     

Semiparametric errors-in-variables models A Bayesian approach

Regression models incorporating measurement error have received much attention in the recent literature. Measurement error can arise both in the explanatory variables and in the response. We introduce a fairly general model which permits both types of errors. The model naturally arises as a hierarchical structure involving three distinct regressions. For each regression, a semiparametric generalized linear model is introduced utilizing an unknown monotonic function. By transformation, such a function can be viewed as a c.d.f. We model an unknown c.d.f. using mixtures of Beta c.d.f.'s, noting that such mixtures are dense within the class of all continuous distributions on [0,1]. Thus, the overall model incorporates nonparametric links or calibration curves along with customary regression coefficients clarifying its semiparametric nature. Fully Bayesian fitting of such a model using sampling-based methods is proposed. We indicate numerous attractive advantages which our model and its fitting provide. A simulation example demonstrates quantitatively the potential benefit.     

Exponential-Bound Property of Estimators and Variable Selection in Generalized Additive Models

In this article, utilizing a scale mixture of skew-normal distribution in which mixing random variable is assumed to follow a mixture model with varying weights for each observation, we introduce a generalization of skew-normal linear regression model with the aim to provide resistant results. This model, which also includes the skew-slash distribution in a particular case, allows us to accommodate and detect outlying observations under the skew-normal linear regression model. Inferences about the model are carried out through the empirical Bayes approach. The conditions for propriety of the posterior and for existence of posterior moments are given under the standard noninformative priors for regression and scale parameters as well as proper prior for skewness parameter. Then, for Bayesian inference, a Markov chain Monte Carlo method is described. Since posterior results depend on the prior hyperparameters, we estimate them adopting the empirical Bayes method as well as using a Monte Carlo EM algorithm. Furthermore, to identify possible outliers, we also apply the Bayes factor obtained through the generalized Savage-Dickey density ratio. Examining the proposed approach on simulated instance and real data, it is found to provide not only satisfactory parameter estimates rather allow identifying outliers favorably.     

Generalized symmetrical partial linear model

In this work, we propose a new model called generalized symmetrical partial linear model, based on the theory of generalized linear models and symmetrical distributions. In our model the response variable follows a symmetrical distribution such a normal, Student-t, power exponential, among others. Following the context of generalized linear models we consider replacing the traditional linear predictors by the more general predictors in whose case one covariate is related with the response variable in a non-parametric fashion, that we do not specified the parametric function. As an example, we could imagine a regression model in which the intercept term is believed to vary in time or geographical location. The backfitting algorithm is used for estimating the parameters of the proposed model. We perform a simulation study for assessing the behavior of the penalized maximum likelihood estimators. We use the quantile residuals for checking the assumption of the model. Finally, we analyzed real data set related with pH rivers in Ireland.     

Asymptotic distributions of quadratic forms occurring in changepoint problems

A stochastic-process approach is used to derive the asymptotic distributions of quadratic forms occurring in the analysis of changepoint data.     

Statistical Inference and Applications of Mixture of Varying Coefficient Models

In this paper, we consider a new mixture of varying coefficient models, in which each mixture component follows a varying coefficient model and the mixing proportions and dispersion parameters are also allowed to be unknown smooth functions. We systematically study the identifiability, estimation and inference for the new mixture model. The proposed new mixture model is rather general, encompassing many mixture models as its special cases such as mixtures of linear regression models, mixtures of generalized linear models, mixtures of partially linear models and mixtures of generalized additive models, some of which are new mixture models by themselves and have not been investigated before. The new mixture of varying coefficient model is shown to be identifiable under mild conditions. We develop a local likelihood procedure and a modified expectation–maximization algorithm for the estimation of the unknown non‐parametric functions. Asymptotic normality is established for the proposed estimator. A generalized likelihood ratio test is further developed for testing whether some of the unknown functions are constants. We derive the asymptotic distribution of the proposed generalized likelihood ratio test statistics and prove that the Wilks phenomenon holds. The proposed methodology is illustrated by Monte Carlo simulations and an analysis of a CO₂‐GDP data set.     

Bayesian modelling of the mean and covariance matrix in normal nonlinear models

An important problem in statistics is the study of longitudinal data taking into account the effect of other explanatory variables such as treatments and time. In this paper, a new Bayesian approach for analysing longitudinal data is proposed. This innovative approach takes into account the possibility of having nonlinear regression structures on the mean and linear regression structures on the variance–covariance matrix of normal observations, and it is based on the modelling strategy suggested by Pourahmadi [M. Pourahmadi, Joint mean-covariance models with applications to longitudinal data: Unconstrained parameterizations, Biometrika, 87 (1999), pp. 667–690.]. We initially extend the classical methodology to accommodate the fitting of nonlinear mean models then we propose our Bayesian approach based on a generalization of the Metropolis–Hastings algorithm of Cepeda [E.C. Cepeda, Variability modeling in generalized linear models, Unpublished Ph.D. Thesis, Mathematics Institute, Universidade Federal do Rio de Janeiro, 2001]. Finally, we illustrate the proposed methodology by analysing one example, the cattle data set, that is used to study cattle growth.