Analysis of ordered probit model with surrogate response data and measurement error in covariates

ABSTRACT

Often in data arising out of epidemiologic studies, covariates are subject to measurement error. In addition ordinal responses may be misclassified into a category that does not reflect the true state of the respondents. The goal of the present work is to develop an ordered probit model that corrects for the classification errors in ordinal responses and/or measurement error in covariates. Maximum likelihood method of estimation is used. Simulation study reveals the effect of ignoring measurement error and/or classification errors on the estimates of the regression coefficients. The methodology developed is illustrated through a numerical example.     

An Exact Corrected Log-Likelihood Function for Cox's Proportional Hazards Model under Measurement Error and Some Extensions

Abstract.  This paper studies Cox's proportional hazards model under covariate measurement error. Nakamura's [ Biometrika 77 (1990) 127] methodology of corrected log-likelihood will be applied to the so-called Breslow likelihood, which is, in the absence of measurement error, equivalent to partial likelihood. For a general error model with possibly heteroscedastic and non-normal additive measurement error, corrected estimators of the regression parameter as well as of the baseline hazard rate are obtained. The estimators proposed by Nakamura [Biometrics 48 (1992) 829], Kong et al. [ Scand. J. Statist. 25 (1998) 573] and Kong & Gu [ Statistica Sinica 9 (1999) 953] are re-established in the special cases considered there. This sheds new light on these estimators and justifies them as exact corrected score estimators. Finally, the method will be extended to some variants of the Cox model.     

Confidence Interval Estimation in Ultrastructural Model

The present article proposes a methodology to construct confidence interval for slope parameter and joint confidence region for intercept term and slope parameter in an ultra-structural model with equation error and correlated measurement errors.     

Mixture models in measurement error problems, with reference to epidemiological studies

Summary. The paper focuses on a Bayesian treatment of measurement error problems and on the question of the specification of the prior distribution of the unknown covariates. It presents a flexible semiparametric model for this distribution based on a mixture of normal distributions with an unknown number of components. Implementation of this prior model as part of a full Bayesian analysis of measurement error problems is described in classical set-ups that are encountered in epidemiological studies: logistic regression between unknown covariates and outcome, with a normal or log-normal error model and a validation group. The feasibility of this combined model is tested and its performance is demonstrated in a simulation study that includes an assessment of the influence of misspecification of the prior distribution of the unknown covariates and a comparison with the semiparametric maximum likelihood method of Roeder, Carroll and Lindsay. Finally, the methodology is illustrated on a data set on coronary heart disease and cholesterol levels in blood.     

Bayesian Estimators for Small Area Models when Auxiliary Information is Measured with Error

Small area estimators in linear models are typically expressed as a convex combination of direct estimators and synthetic estimators from a suitable model. When auxiliary information used in the model is measured with error, a new estimator, accounting for the measurement error in the covariates, has been proposed in the literature. Recently, for area‐level model, Ybarra & Lohr (Biometrika, 95, 2008, 919) suggested a suitable modification to the estimates of small area means based on Fay & Herriot (J. Am. Stat. Assoc., 74, 1979, 269) model where some of the covariates are measured with error. They used a frequentist approach based on the method of moments. Adopting a Bayesian approach, we propose to rewrite the measurement error model as a hierarchical model; we use improper non‐informative priors on the model parameters and show, under a mild condition, that the joint posterior distribution is proper and the marginal posterior distributions of the model parameters have finite variances. We conduct a simulation study exploring different scenarios. The Bayesian predictors we propose show smaller empirical mean squared errors than the frequentist predictors of Ybarra & Lohr (Biometrika, 95, 2008, 919), and they seem also to be more stable in terms of variability and bias. We apply the proposed methodology to two real examples.     

On diagnostics in multivariate measurement error models under asymmetric heavy-tailed distributions

In this paper, we discuss the extension of some diagnostic procedures to multivariate measurement error models with scale mixtures of skew-normal distributions (Lachos et?al., Statistics 44:541?C556, 2010c). This class provides a useful generalization of normal (and skew-normal) measurement error models since the random term distributions cover symmetric, asymmetric and heavy-tailed distributions, such as skew-t, skew-slash and skew-contaminated normal, among others. Inspired by the EM algorithm proposed by Lachos et?al. (Statistics 44:541?C556, 2010c), we develop a local influence analysis for measurement error models, following Zhu and Lee??s (J R Stat Soc B 63:111?C126, 2001) approach. This is because the observed data log-likelihood function associated with the proposed model is somewhat complex and Cook??s well-known approach can be very difficult to apply to achieve local influence measures. Some useful perturbation schemes are also discussed. In addition, a score test for assessing the homogeneity of the skewness parameter vector is presented. Finally, the methodology is exemplified through a real data set, illustrating the usefulness of the proposed methodology.     

Improved Monte Carlo inference for models with additive error

Some statistical models defined in terms of a generating stochastic mechanism have intractable distribution theory, which renders parameter estimation difficult. However, a Monte Carlo estimate of the log-likelihood surface for such a model can be obtained via computation of nonparametric density estimates from simulated realizations of the model. Unfortunately, the bias inherent in density estimation can cause bias in the resulting log-likelihood estimate that alters the location of its maximizer. In this paper a methodology for radically reducing this bias is developed for models with an additive error component. An illustrative example involving a stochastic model of molecular fragmentation and measurement is given.     

The identification of logistic regression models with errors in the variables

The simple logistic regression model with normal measurement error and normal regressor is shown to be identifiable without any extra information about the measurement error. The multiple logistic regression model with more than one regressor variable measured with error is not identifiable. If the covariance matrix of the measurement error is known up to a scalar factor, the model is identified. Further we discuss why in spite of the identifiability the models cannot be estimated in a reasonable way without extra information about the measurement error.     

SEMIPARAMETRIC REGRESSION AND GRAPHICAL MODELS

Semiparametric regression models that use spline basis functions with penalization have graphical model representations. This link is more powerful than previously established mixed model representations of semiparametric regression, as a larger class of models can be accommodated. Complications such as missingness and measurement error are more naturally handled within the graphical model architecture. Directed acyclic graphs, also known as Bayesian networks, play a prominent role. Graphical model-based Bayesian 'inference engines', such as bugs and vibes , facilitate fitting and inference. Underlying these are Markov chain Monte Carlo schemes and recent developments in variational approximation theory and methodology.     

Statistical analysis of controlled calibration model with replicates

In this work, we generalize the controlled calibration model by assuming replication on both variables. Likelihood-based methodology is used to estimate the model parameters and the Fisher information matrix is used to construct confidence intervals for the unknown value of the regressor variable. Further, we study the local influence diagnostic method which is based on the conditional expectation of the complete-data log-likelihood function related to the EM algorithm. Some useful perturbation schemes are discussed. A simulation study is carried out to assess the effect of the measurement error on the estimation of the parameter of interest. This new approach is illustrated with a real data set.     

Regression model checking with Berkson measurement errors

This paper discusses asymptotically distribution free tests for the lack-of-fit of a parametric regression model in the Berkson measurement error model. These tests are based on a martingale transform of a certain marked empirical process of calibrated residuals. A simulation study is included to assess the effect of measurement error on the proposed test. It is observed that empirical level is more stable across the chosen measurement error variances when fitting a linear model compared to when fitting a nonlinear model, while, in both cases, the empirical power decreases as this error variance increases, against all chosen alternatives.     

Oracle GMM estimation for misspecified models via thresholding

We propose a thresholding generalized method of moments (GMM) estimator for misspecified time series moment condition models. This estimator has the following oracle property: its asymptotic behavior is the same as of any efficient GMM estimator obtained under the a priori information that the true model were known. We propose data adaptive selection methods for thresholding parameter using multiple testing procedures. We determine the limiting null distributions of classical parameter tests and show the consistency of the corresponding block-bootstrap tests used in conjunction with thresholding GMM inference. We present the results of a simulation study for a misspecified instrumental variable regression model and for a vector autoregressive model with measurement error. We illustrate an application of the proposed methodology to data analysis of a real-world dataset.     

Estimation of dependence between paired correlated failure times in the presence of covariate measurement error

Summary. In many biomedical studies, covariates are subject to measurement error. Although it is well known that the regression coefficients estimators can be substantially biased if the measurement error is not accommodated, there has been little study of the effect of covariate measurement error on the estimation of the dependence between bivariate failure times. We show that the dependence parameter estimator in the Clayton–Oakes model can be considerably biased if the measurement error in the covariate is not accommodated. In contrast with the typical bias towards the null for marginal regression coefficients, the dependence parameter can be biased in either direction. We introduce a bias reduction technique for the bivariate survival function in copula models while assuming an additive measurement error model and replicated measurement for the covariates, and we study the large and small sample properties of the dependence parameter estimator proposed.     

A Bayesian semiparametric accelerated failure time model for arbitrarily censored data with covariates subject to measurement error

A flexible Bayesian semiparametric accelerated failure time (AFT) model is proposed for analyzing arbitrarily censored survival data with covariates subject to measurement error. Specifically, the baseline error distribution in the AFT model is nonparametrically modeled as a Dirichlet process mixture of normals. Classical measurement error models are imposed for covariates subject to measurement error. An efficient and easy-to-implement Gibbs sampler, based on the stick-breaking formulation of the Dirichlet process combined with the techniques of retrospective and slice sampling, is developed for the posterior calculation. An extensive simulation study is conducted to illustrate the advantages of our approach.     

Analysis of error-prone survival data under additive hazards models: measurement error effects and adjustments

Covariate measurement error occurs commonly in survival analysis. Under the proportional hazards model, measurement error effects have been well studied, and various inference methods have been developed to correct for error effects under such a model. In contrast, error-contaminated survival data under the additive hazards model have received relatively less attention. In this paper, we investigate this problem by exploring measurement error effects on parameter estimation and the change of the hazard function. New insights of measurement error effects are revealed, as opposed to well-documented results for the Cox proportional hazards model. We propose a class of bias correction estimators that embraces certain existing estimators as special cases. In addition, we exploit the regression calibration method to reduce measurement error effects. Theoretical results for the developed methods are established, and numerical assessments are conducted to illustrate the finite sample performance of our methods.     

Analysis of rounded data in measurement error regression

The measurement error model (MEM) is an important model in statistics because in a regression problem, the measurement error of the explanatory variable will seriously affect the statistical inferences if measurement errors are ignored. In this paper, we revisit the MEM when both the response and explanatory variables are further involved with rounding errors. Additionally, the use of a normal mixture distribution to increase the robustness of model misspecification for the distribution of the explanatory variables in measurement error regression is in line with recent developments. This paper proposes a new method for estimating the model parameters. It can be proved that the estimates obtained by the new method possess the properties of consistency and asymptotic normality.     

Double sampling for exact values in the normal discriminant model with application to binary regression

Increasing attention is being given to problems involving binary outcomes with covariates subject to measurement error. Here, we consider the two group normal discriminant model where a subset of the continuous variates are subject to error and will typically be replaced by a vector of surrogates, perhaps of different dimension. Correcting for the measurement error is made possible by a double sampling scheme in which the surrogates are collected on all units and true values are obtained on a random subset of units. Such a scheme allows us to consider a rich set of measurement error models which extend the traditional additive error model. Maximum likelihood estimators and their asymptotic properties are derived under a variety of models for the relationship between true values and the surrogates. Specific attention is given to the coefficients in the resulting logistic regression model. Optimal allocations are derived which minimize the variance of the estimated slope subject to cost constraints for the case where there is a univariate covariate but a possibly multivariate surrogate.     

On the skew-normal calibration model

In this article, we present the EM-algorithm for performing maximum likelihood estimation of an asymmetric linear calibration model with the assumption of skew-normally distributed error. A simulation study is conducted for evaluating the performance of the calibration estimator with interpolation and extrapolation situations. As one application in a real data set, we fitted the model studied in a dimensional measurement method used for calculating the testicular volume through a caliper and its calibration by using ultrasonography as the standard method. By applying this methodology, we do not need to transform the variables to have symmetrical errors. Another interesting aspect of the approach is that the developed transformation to make the information matrix nonsingular, when the skewness parameter is near zero, leaves the parameter of interest unchanged. Model fitting is implemented and the best choice between the usual calibration model and the model proposed in this article was evaluated by developing the Akaike information criterion, Schwarz’s Bayesian information criterion and Hannan–Quinn criterion.     

Effect of Berkson measurement error on parameter estimates in Cox regression models

We study the effect of additive and multiplicative Berkson measurement error in Cox proportional hazard model. By plotting the true and the observed survivor function and the true and the observed hazard function dependent on the exposure one can get ideas about the effect of this type of error on the estimation of the slope parameter corresponding to the variable measured with error. As an example, we analyze the measurement error in the situation of the German Uranium Miners Cohort Study both with graphical methods and with a simulation study. We do not see a substantial bias in the presence of small measurement error and in the rare disease case. Even the effect of a Berkson measurement error with high variance, which is not unrealistic in our example, is a negligible attenuation of the observed effect. However, this effect is more pronounced for multiplicative measurement error.     

Bias corrected estimation for generalized probit regression with covariate measurement error and censored responses

In this paper, we propose a bias corrected estimate of the regression coefficient for the generalized probit regression model when the covariates are subject to measurement error and the responses are subject to interval censoring. The main improvement of our method is that it reduces most of the bias that the naive estimates have. The great advantage of our method is that it is baseline and censoring distribution free, in a sense that the investigator does not need to calculate the baseline or the censoring distribution to obtain the estimator of the regression coefficient, an important property of Cox regression model. A sandwich estimator for the variance is also proposed. Our procedure can be generalized to general measurement error distribution as long as the first four moments of the measurement error are known. The results of extensive simulations show that our approach is very effective in eliminating the bias when the measurement error is not too large relative to the error term of the regression model.