A Comparison of Approaches to Interval Estimation of Mediated Effects in Linear Regression Models

A novel approach based on the concepts of a generalized pivotal quantity (GPQ) is developed to construct confidence intervals for the mediated effect. Thereafter, its performance is compared with six interval estimation approaches in terms of empirical coverage probability and expected length via simulation and two real examples. The results show that the GPQ-based and bootstrap percentile methods outperform other methods when mediated effects exist in small and medium samples. Moreover, the GPQ-based method exhibits a more stable performance in small and non-normal samples. A discussion on how to choose the best interval estimation method for mediated effects is presented.     

Profile Likelihood Based Confidence Intervals for Common Intraclass Correlation Coefficient

In this article, we propose an approach for estimating the confidence interval of the common intraclass correlation coefficient based on the profile likelihood. Comparisons are made with a procedure using the concept of generalized pivots. The method presented is less computationally demanding than the method using generalized pivots. The approach also provides better coverage, and shorter lengths of confidence intervals for the case when the value of the common intraclass correlation coefficient is low. The lengths of confidence intervals given by both methods are quite comparable for high but less realistic values of the common intraclass correlation coefficient.     

Point and Interval Estimation for a Generalized Logistic Distribution Under Progressive Type II Censoring

The likelihood equations based on a progressively Type II censored sample from a Type I generalized logistic distribution do not provide explicit solutions for the location and scale parameters. We present a simple method of deriving explicit estimators by approximating the likelihood equations appropriately. We examine numerically the bias and variance of these estimators and show that these estimators are as efficient as the maximum likelihood estimators (MLEs). The probability coverages of the pivotal quantities (for location and scale parameters) based on asymptotic normality are shown to be unsatisfactory, especially when the effective sample size is small. Therefore we suggest using unconditional simulated percentage points of these pivotal quantities for the construction of confidence intervals. A wide range of sample sizes and progressive censoring schemes have been considered in this study. Finally, we present a numerical example to illustrate the methods of inference developed here.     

Generalized Confidence Interval Estimation for the Difference in Paired Areas Under the ROC Curves in the Absence of a Gold Standard

Receiver operating characteristic (ROC) curves can be used to assess the accuracy of tests measured on ordinal or continuous scales. The most commonly used measure for the overall diagnostic accuracy of diagnostic tests is the area under the ROC curve (AUC). A gold standard (GS) test on the true disease status is required to estimate the AUC. However, a GS test may be too expensive or infeasible. In many medical researches, the true disease status of the subjects may remain unknown. Under the normality assumption on test results from each disease group of subjects, we propose a heuristic method of estimating confidence intervals for the difference in paired AUCs of two diagnostic tests in the absence of a GS reference. This heuristic method is a three-stage method by combining the expectation-maximization (EM) algorithm, bootstrap method, and an estimation based on asymptotic generalized pivotal quantities (GPQs) to construct generalized confidence intervals for the difference in paired AUCs in the absence of a GS. Simulation results show that the proposed interval estimation procedure yields satisfactory coverage probabilities and expected interval lengths. The numerical example using a published dataset illustrates the proposed method.     

Sample Sizes in the Interval Estimation of the Correlation Coefficient

An expression is derived for the maximum length of the interval estimator of the correlation coefficient, p, under bivariate normal assumptions. The prespecification of this minimum attainable precision and the confidence level results in an expression for the sample size required. An approximate expression for the sample size is proposed and is numerically shown to be as good as or better than that based on the Fisher's Z transformation.     

Empirical Likelihood-based Inference for Stationary-ergodicity of the Generalized Random Coefficient Autoregressive Model

In this article, we consider the application of the empirical likelihood method to the generalized random coefficient autoregressive (GRCA) model. When the order of the model is 1, we derive an empirical likelihood ratio test statistic to test the stationary-ergodicity. Some simulation studies are also conducted to investigate the finite sample performances of the proposed test.     

Performance of Interval Estimators for the Inverse Hypergeometric Distribution

The inverse hypergeometric distribution is of interest in applications of inverse sampling without replacement from a finite population where a binary observation is made on each sampling unit. Thus, sampling is performed by randomly choosing units sequentially one at a time until a specified number of one of the two types is selected for the sample. Assuming the total number of units in the population is known but the number of each type is not, we consider the problem of estimating this parameter. We use the Delta method to develop approximations for the variance of three parameter estimators. We then propose three large sample confidence intervals for the parameter. Based on these results, we selected a sampling of parameter values for the inverse hypergeometric distribution to empirically investigate performance of these estimators. We evaluate their performance in terms of expected probability of parameter coverage and confidence interval length calculated as means of possible outcomes weighted by the appropriate outcome probabilities for each parameter value considered. The unbiased estimator of the parameter is the preferred estimator relative to the maximum likelihood estimator and an estimator based on a negative binomial approximation, as evidenced by empirical estimates of closeness to the true parameter value. Confidence intervals based on the unbiased estimator tend to be shorter than the two competitors because of its relatively small variance but at a slight cost in terms of coverage probability.     

Interval Estimation for the Scaled Half-Logistic Distribution Under Progressive Type-II Censoring

In this article, we propose an exact confidence interval and an exact test for the scale parameter of the scaled half-logistic distribution based on progressively Type-II censored sample. Using the Monte Carlo method, we compare the expected length of the proposed confidence interval with one of confidence interval proposed by Balakrishnan and Asgharzadeh (2005 Balakrishnan , N. , Asgharzadeh , A. ( 2005 ). Inference for the scaled half-logistic distribution based on progressively Type-II censored sample . Commun. Statist. Theor. Meth. 34 : 73 – 87 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). The simulation results show that the proposed confidence interval performs better. Finally, we present a numerical example to illustrate the proposed procedures.     

Empirical likelihood inference for the bivariate survival function under univariate censoring

In this article, we apply the empirical likelihood method to make inference on the bivariate survival function of paired failure times by estimating the survival function of censored time with the Kaplan–Meier estimator. Adjusted empirical likelihood (AEL) confidence intervals for the bivariate survival function are developed. We conduct a simulation study to compare the proposed AEL method with other methods. The simulation study shows the proposed AEL method has better performance than other existing methods. We illustrate the proposed method by analyzing the skin graft data.     

Empirical Likelihood for Linear Models Under Linear Process Errors

In this article, we study the construction of confidence intervals for regression parameters in a linear model under linear process errors by using the blockwise technique. It is shown that the blockwise empirical likelihood (EL) ratio statistic is asymptotically χ²-type distributed. The result is used to obtain EL based confidence regions for regression parameters. The finite-sample performance of the method is evaluated through a simulation study.     

Weighted empirical likelihood for generalized linear models with longitudinal data

In this paper, we introduce the empirical likelihood (EL) method to longitudinal studies. By considering the dependence within subjects in the auxiliary random vectors, we propose a new weighted empirical likelihood (WEL) inference for generalized linear models with longitudinal data. We show that the weighted empirical likelihood ratio always follows an asymptotically standard chi-squared distribution no matter which working weight matrix that we have chosen, but a well chosen working weight matrix can improve the efficiency of statistical inference. Simulations are conducted to demonstrate the accuracy and efficiency of our proposed WEL method, and a real data set is used to illustrate the proposed method.     

Confidence Interval Estimation in Ultrastructural Model

The present article proposes a methodology to construct confidence interval for slope parameter and joint confidence region for intercept term and slope parameter in an ultra-structural model with equation error and correlated measurement errors.     

An Approach of Stocks Substitution Strategy Using Fuzzy Interval Correlation Coefficient

The classical Pearson's correlation coefficient has been widely adopted in various fields of application. However, when the data are composed of fuzzy interval values, it is not feasible to use such a traditional approach to evaluate the correlation coefficient. In this study, we propose the specific calculation of fuzzy interval correlation coefficient with fuzzy interval data to measure the relationship between various stocks. As such, the study is able to offer an improving measure of investment strategy for stocks substitution via the analysis of the fuzzy interval correlation. In addition, we use empirical studies to verify the validity of our proposal on fuzzy interval correlation coefficient using data from companies in electric machinery and plastic sectors in Taiwan.     

Interval estimation for conformance proportions of multiple quality characteristics

A conformance proportion is an important and useful index to assess industrial quality improvement. Statistical confidence limits for a conformance proportion are usually required not only to perform statistical significance tests, but also to provide useful information for determining practical significance. In this article, we propose approaches for constructing statistical confidence limits for a conformance proportion of multiple quality characteristics. Under the assumption that the variables of interest are distributed with a multivariate normal distribution, we develop an approach based on the concept of a fiducial generalized pivotal quantity (FGPQ). Without any distribution assumption on the variables, we apply some confidence interval construction methods for the conformance proportion by treating it as the probability of a success in a binomial distribution. The performance of the proposed methods is evaluated through detailed simulation studies. The results reveal that the simulated coverage probability (cp) for the FGPQ-based method is generally larger than the claimed value. On the other hand, one of the binomial distribution-based methods, that is, the standard method suggested in classical textbooks, appears to have smaller simulated cps than the nominal level. Two alternatives to the standard method are found to maintain their simulated cps sufficiently close to the claimed level, and hence their performances are judged to be satisfactory. In addition, three examples are given to illustrate the application of the proposed methods.     

Empirical likelihood inference for probability density functions under association

In this paper, we consider to apply the empirical likelihood method to a probability density function under an associated sample. It is shown that the empirical likelihood ratio statistic is asymptotically χ²-type distributed under some mild conditions. The result is used to construct empirical likelihood-based confidence intervals on the probability density function.     

On empirical likelihood for linear models with missing responses

Suppose that we have a linear regression model Y=X^′β+_ν0(X)ε$Y=X^{\prime }\beta +{\nu }_0(X)\epsilon$ with random error ε$\epsilon$, where X is a random design variable and is observed completely, and Y is the response variable and some Y-values are missing at random (MAR). In this paper, based on the ‘complete’ data set for Y after inverse probability weighted imputation, we construct empirical likelihood statistics on EY   and β$\beta$ which have the χ²${\chi }^2$-type limiting distributions under some new conditions compared with Xue (2009). Our results broaden the applicable scope of the approach combined with Xue (2009).     

Empirical likelihood based confidence regions for first order parameters of heavy-tailed distributions

Let X₁,…,X_n be some i.i.d. observations from a heavy-tailed distribution F, i.e. the common distribution of the excesses over a high threshold u_n can be approximated by a generalized Pareto distribution G_γ,σn with γ>0. This paper deals with the problem of finding confidence regions for the couple (γ,σ_n): combining the empirical likelihood methodology with estimation equations (close but not identical to the likelihood equations) introduced by Zhang (2007), asymptotically valid confidence regions for (γ,σ_n) are obtained and proved to perform better than Wald-type confidence regions (especially those derived from the asymptotic normality of the maximum likelihood estimators). By profiling out the scale parameter, confidence intervals for the tail index are also derived.     

Interval Estimation by Frequentist Model Averaging

An important contribution to the literature on frequentist model averaging (FMA) is the work of Hjort and Claeskens (2003 Hjort , N. L. , Claeskens , G. ( 2003 ). Frequestist model average estimators . J. Amer. Statist. Assoc. 98 : 879 – 899 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), who developed an asymptotic theory for frequentist model averaging in parametric models based on a local mis-specification framework. They also proposed a simple method for constructing confidence intervals of the unknown parameters. This article shows that the confidence intervals based on the FMA estimator suggested by Hjort and Claeskens (2003 Hjort , N. L. , Claeskens , G. ( 2003 ). Frequestist model average estimators . J. Amer. Statist. Assoc. 98 : 879 – 899 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) are asymptotically equivalent to that obtained from the full model under both parametric and the varying-coefficient partially linear models. Thus, as long as interval estimation rather than point estimation is concerned, the confidence interval based on the full model already fulfills the objective and model averaging provides no additional useful information.     

Semi-empirical likelihood inference for the ROC curve with missing data

The receiver operating characteristic (ROC) curve is one of the most commonly used methods to compare the diagnostic performance of two or more laboratory or diagnostic tests. In this paper, we propose semi-empirical likelihood based confidence intervals for ROC curves of two populations, where one population is parametric and the other one is non-parametric and both have missing data. After imputing missing values, we derive the semi-empirical likelihood ratio statistic and the corresponding likelihood equations. It is shown that the log-semi-empirical likelihood ratio statistic is asymptotically scaled chi-squared. The estimating equations are solved simultaneously to obtain the estimated lower and upper bounds of semi-empirical likelihood confidence intervals. We conduct extensive simulation studies to evaluate the finite sample performance of the proposed empirical likelihood confidence intervals with various sample sizes and different missing probabilities.     

Nonparametric Interval Estimation in One-Way Random-Effects Models

The structural method provided by Hannig et al. (2006 Hannig , J. , Iyer , H. , Patterson , P. (2006). Fiducial generalized confidence intervals. J. Amer. Statist. Assoc. 101:254–269.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) has proved to be a useful tool for constructing confidence intervals. However, it is difficult to apply this method to nonparametric problems since the pivotal quantity required in using it exists only in some special parametric models. Based on an extended structural method, this article discusses nonparametric interval estimation for smooth functions of the variances in one-way random-effects models. We use the bootstrap distribution estimator of a statistic to construct an approximate pivotal equation, and prove that the confidence interval derived by the approximate pivotal equation has asymptotically correct coverage probability. Simulation results are presented and show that the normal fiducial interval is not robust against non normality and that the proposed confidence interval has better finite-sample behaviors than the naive interval based on normal approximation.