D s -optimal designs for Kozak's tree taper model

In this work, we study D _s -optimal design for Kozak's tree taper model. The approximate D _s -optimal designs are found invariant to tree size and hence create a ground to construct a general replication-free D _s -optimal design. Even though the designs are found not to be dependent on the parameter value p of the Kozak's model, they are sensitive to the s×1 subset parameter vector values of the model. The 12 points replication-free design (with 91% efficiency) suggested in this study is believed to reduce cost and time for data collection and more importantly to precisely estimate the subset parameters of interest.     

Optimal designs for second-degree Kronecker model mixture experiments

The paper investigates optimal designs in the second-degree Kronecker model for mixture experiments. Three groups of novel results are presented: (i) characterization of feasible weighted centroid designs for a maximum parameter system, (ii) derivations of D-, A-, and E-optimal weighted centroid designs, and (iii) numerically φ_p-optimal weighted centroid designs. Results on a quadratic subspace of invariant symmetric matrices containing the information matrices involved in the design problem serve as a main tool throughout the analysis.     

On optimality properties of simple block designs in the approximate design theory

Optimality properties of approximate block designs are studied under variations of (1) the class of competing designs, (2) the optimality criterion, (3) the parametric function of interest, and (4) the statistical model. The designs which are optimal turn out to be the product of their treatment and block marginals, and uniform designs when the support is specified in advance. Optimality here means uniform, universal, and simultaneous j_p-optimality. The classical balanced incomplete block designs are embedded into this approach, and shown to be simultaneously j_p-optimal for a maximal system of identifiable parameters. A geometric account of universal optimality is given which applies beyond the context of block designs.     

Optimal selection and ordering of columns in supersaturated designs

Two methods to select columns for assigning factors to work on supersaturated designs are proposed. The focus of interest is the degree of non-orthogonality between the selected columns. One method is the exhaustive enumeration of selections of p columns from all k columns to find the exact optimality, while the other is intended to find an approximate solution by applying techniques used in the corresponding analysis, aiming for ease of use as well as a reduction in the large computing time required for large k with the first method. Numerical illustrations for several typical design matrices reveal that the resulting “approximately” optimal assignments of factors to their columns are exactly optimal for any p. Ordering the columns in E(s²)-optimal designs results in promising new findings including a large number of E(s²)-optimal designs.     

Addition of runs to a two-level supersaturated design

The purpose of this article is to introduce a new class of extended E(s²)-optimal two level supersaturated designs obtained by adding runs to an existing E(s²)-optimal two level supersaturated design. The extended design is a union of two optimal SSDs belonging to different classes. New lower bound to E(s²) has been obtained for the extended supersaturated designs. Some examples and a small catalogue of E(s²)-optimal SSDs are also included.     

Optimal designs for statistical analysis with Zernike polynomials

The Zernike polynomials arise in several applications such as optical metrology or image analysis on a circular domain. In the present paper, we determine optimal designs for regression models which are represented by expansions in terms of Zernike polynomials. We consider two estimation methods for the coefficients in these models and determine the corresponding optimal designs. The first one is the classical least squares method and Φ _p -optimal designs in the sense of Kiefer [Kiefer, J., 1974, General equivalence theory for optimum designs (approximate theory). Annals of Statistics, 2 849–879.] are derived, which minimize an appropriate functional of the covariance matrix of the least squares estimator. It is demonstrated that optimal designs with respect to Kiefer's Φ _p -criteria (p>?∞) are essentially unique and concentrate observations on certain circles in the experimental domain. E-optimal designs have the same structure but it is shown in several examples that these optimal designs are not necessarily uniquely determined. The second method is based on the direct estimation of the Fourier coefficients in the expansion of the expected response in terms of Zernike polynomials and optimal designs minimizing the trace of the covariance matrix of the corresponding estimator are determined. The designs are also compared with the uniform designs on a grid, which is commonly used in this context.     

An algorithm for calculating D-optimal designs for polynomial regression through a fixed point

Optimal designs are required to make efficient statistical experiments. By using canonical moments, in 1980, Studden found D_s-optimal designs for polynomial regression models. On the other hand, integrable systems are dynamical systems whose solutions can be written down concretely. In this paper, polynomial regression models through a fixed point are discussed. In order to calculate D-optimal designs for these models, a useful relationship between canonical moments and discrete integrable systems is introduced. By using canonical moments and discrete integrable systems, a new algorithm for calculating D-optimal designs for these models is proposed.     

Locally optimal designs for some dose–response models with continuous endpoints

We consider the problem of constructing static (or non sequential), approximate optimal designs for a class of dose–response models with continuous outcomes. We obtain conditions for a design being D-optimal or c-optimal. The designs are locally optimal in that they depend on the model parameters. The efficiency studies show that these designs have high efficiency when the mis-specification of the initial values of model parameters is not severe. A case study indicates that using an optimal design may result in a significant saving of resources.     

On representing maximin efficient designs by Taylor series

This paper considers exponential and rational regression models that are nonlinear in some parameters. Recently, locally D-optimal designs for such models were investigated in [Melas, V. B., 2005. On the functional approach to optimal designs for nonlinear models. J. Statist. Plann. Inference 132, 93–116] based upon a functional approach. In this article a similar method is applied to construct maximin efficient D-optimal designs. This approach allows one to represent the support points of the designs by Taylor series, which gives us the opportunity to construct the designs by hand using tables of the coefficients of the series. Such tables are provided here for models with two nonlinear parameters. Furthermore, the recurrent formulas for constructing the tables for arbitrary numbers of parameters are introduced.     

On D-optimal robust designs for lifetime improvement experiments

Locating the optimal operating conditions of the process parameters is critical in a lifetime improvement experiment. For log-normal lifetime distribution with compound error structure (i.e., symmetry, inter-class and intra-class correlation error structures), we have developed methods for construction of D-optimal robust first order designs. It is shown that D-optimal robust first order designs are always robust first order rotatable but the converse is not always true.     

Highly Efficient Designs for Logistic Models with Categorical Variables

Optimal designs for logistic models generally require prior information about the values of the regression parameters. However, experimenters usually do not have full knowledge of these parameters. We propose a design that is D-optimal on a restricted design region. This design assigns an equal weight to design points that contain more information and ignores those design points that contain less information about the regression parameters. The design can be constructed in practice by means of the rank order of the outcome variances. A numerical study compares the proposed design with the D-optimal and completely balanced designs in terms of efficiency.     

E-optimal design in irregular BIBD settings

When the necessary conditions for a BIBD are satisfied, but no BIBD exists, there is no simple answer for the optimal design problem. This paper identifies the E-optimal information matrices for any such irregular BIBD setting when the number of treatments is no larger than 100. A- and D-optimal designs are typically not E-optimal. An E-optimal design for 15 treatments in 21 blocks of size 5 is found.     

A new characterization of Elfving's method for high dimensional computation

We give a new characterization of Elfving's (1952) method for computing c-optimal designs in k dimensions which gives explicit formulae for the k unknown optimal weights and k unknown signs in Elfving's characterization. This eliminates the need to search over these parameters to compute c-optimal designs, and thus reduces the computational burden from solving a family of optimization problems to solving a single optimization problem for the optimal finite support set. We give two illustrative examples: a high dimensional polynomial regression model and a logistic regression model, the latter showing that the method can be used for locally optimal designs in nonlinear models as well.     

On D-optimal robust second order slope-rotatable designs

Das and Park (2006) introduced slope-rotatable designs overall directions for correlated observations which is known as A-optimal robust slope-rotatable designs. This article focuses D-optimal slope-rotatable designs for second-order response surface model with correlated observations. It has been established that robust second-order rotatable designs are also D-optimal robust slope-rotatable designs. A class of D-optimal robust second-order slope-rotatable designs has been derived for special correlation structures of errors.     

D- and V-optimal population designs for the quadratic regression model with a random intercept term

In this paper D- and V-optimal population designs for the quadratic regression model with a random intercept term and with values of the explanatory variable taken from a set of equally spaced, non-repeated time points are considered. D-optimal population designs based on single-point individual designs were readily found but the derivation of explicit expressions for designs based on two-point individual designs was not straightforward and was complicated by the fact that the designs now depend on ratio of the variance components. Further algebraic results pertaining to d-point D-optimal population designs where d≥3 and to V-optimal population designs proved elusive. The requisite designs can be calculated by careful programming and this is illustrated by means of a simple example.     

Extension and necessity of Cheng and Wu conditions

Repeated Measurement Designs, with two treatments, n (experimental) units and p periods are examined. The model examined is with uncorrelated observations following a continuous distribution with constant variance and the parameters of interest are (i) the difference of direct effects and (ii) the difference of residual effects. In this paper (a) the difference of Universal optimality and Φ-optimality is clarified and (b) the sufficient conditions of Cheng and Wu (1980) are extended to include the case n=2 mod 4, p even, (c) also it is shown that these conditions are also necessary for Φ-optimality for estimating direct as well as residual effects, and (d) a method is proposed to construct Φ-optimal designs and examples are given when n even and p=3, n=0 mod 4 and p=4, n=2 mod 4 and p=4. In the last case the estimated parameters in the optimal design are correlated.     

The analytic construction of D-optimal designs for the two-variable binary logistic regression model without interaction

Candidate locally D-optimal designs for the binary two-variable logistic model with no interaction, which comprise 3 and 4 support points lying in the first quadrant of the two-dimensional Euclidean space, were introduced by Haines et al. (D-optimal designs for logistic regression in two variables. In: Lopez-Fidalgo J, Rodrigez-Diaz JM, Torsney B, editors. MODA8 – advances in model-oriented designs and analysis. Heidelberg: Physica-Verlag; 2007. p. 91–98). The authors proved algebraically the global D-optimality of the 3-point design for the special case in which the intercept parameter is equal to?1.5434. However for other selected values of the intercept parameter, the global D-optimality of the proposed 3- and 4-point designs was only demonstrated numerically. In this paper, we provide analytical proofs of the D-optimality of these 3- and 4-point designs for all negative and zero intercept parameters of the binary two-variable logistic model with no interaction. The results are extended to the construction of D-optimal designs on a rectangular design space and illustrated by means of two examples of which one is a real example taken from the literature.     

Optimal designs for discriminating between some extensions of the Michaelis–Menten model

In this paper some results on the computation of optimal designs for discriminating between nonlinear models are provided. In particular, some typical deviations of the Michaelis–Menten model are considered. A common deviation of this pharmacokinetic model consists on adding a linear term. If two linear models differ in one parameter the T-optimal design for discriminating between them is c-optimal for estimating the added linear term. This is not the case for nonlinear models.     

Optimal foldover designs

An obvious strategy for obtaining a Doptimal foldover design for p factors at two levels each in 2N runs is to fold a Doptimal main effects plan. We show that this strategy works except when N = 4t + 2 and s is even In that case there are two different classes of D-optimal main effects plans with N runs that have the same determinant. However folding them gives two different values foi the D-optimality criteiion One set of designs is D-optimal The other is not.