Estimation of error rate in multiple group logistic discrimination. the approximate leaving-one-out method

We present an approximate leaving-one-out technique for estimating the error rate in logistic discrimination. The new measure is based on the one-step approximation of a(i), the maximum likelihood estimate of the parameter vector based on the sample without the ith case. Some inequalities between the resubstitution error rate, the approximate and exact leaving-one-out error rates for the multiple group logistic model are investigated. Monte-Carlo simulations assess the adequacy of the approximate leaving-one-out method as an estimate of the actual error rate. The usefulness of this approach is demonstrated by means of two medical examples.     

Computation aspects of the parameter estimates of linear mixed effects model in multivariate repeated measures set-up

The number of parameters mushrooms in a linear mixed effects (LME) model in the case of multivariate repeated measures data. Computation of these parameters is a real problem with the increase in the number of response variables or with the increase in the number of time points. The problem becomes more intricate and involved with the addition of additional random effects. A multivariate analysis is not possible in a small sample setting. We propose a method to estimate these many parameters in bits and pieces from baby models, by taking a subset of response variables at a time, and finally using these bits and pieces at the end to get the parameter estimates for the mother model, with all variables taken together. Applying this method one can calculate the fixed effects, the best linear unbiased predictions (BLUPs) for the random effects in the model, and also the BLUPs at each time of observation for each response variable, to monitor the effectiveness of the treatment for each subject. The proposed method is illustrated with an example of multiple response variables measured over multiple time points arising from a clinical trial in osteoporosis.     

Efficiency of the generalized-difference-based weighted mixed almost unbiased two-parameter estimator in partially linear model

In this paper, a generalized difference-based estimator is introduced for the vector parameter β in partially linear model when the errors are correlated. A generalized-difference-based almost unbiased two-parameter estimator is defined for the vector parameter β. Under the linear stochastic constraint r = Rβ + e, we introduce a new generalized-difference-based weighted mixed almost unbiased two-parameter estimator. The performance of this new estimator over the generalized-difference-based estimator and generalized- difference-based almost unbiased two-parameter estimator in terms of the MSEM criterion is investigated. The efficiency properties of the new estimator is illustrated by a simulation study. Finally, the performance of the new estimator is evaluated for a real dataset.     

A variance shift model for detection of outliers in the linear mixed measurement error models

ABSTRACT

In this paper, we extend a variance shift model, previously considered in the linear mixed models, to the linear mixed measurement error models using the corrected likelihood of Nakamura (1990 Nakamura, T. (1990). Corrected score function for errors in variables models: methodology and application to generalized linear models. Biometrika 77:127–137.[Crossref], [Web of Science ®] , [Google Scholar]). This model assumes that a single outlier arises from an observation with inflated variance. We derive the score test and the analogue of the likelihood ratio test, to assess whether the ith observation has inflated variance. A parametric bootstrap procedure is implemented to obtain empirical distributions of the test statistics. Finally, results of a simulation study and an example of real data are presented to illustrate the performance of proposed tests.