Estimation in semiparametric models using an auxiliary model

Two classes of semiparametric and nonparametric mixture models are defined to represent general kinds of prior information. For these models the nonparametric maximum likelihood estimator (NPMLE) of an unknown probability distribution is derived and is shown to be consistent and relative efficient. Linear functionals are used for the estimation of parameters. Their consistency is proved, the gain of efficiency is derived and asymptotical distributions are given.     

A Class of Semiparametric Transformation Models for Doubly Censored Failure Time Data

Doubly censored failure time data occur in many areas including demographical studies, epidemiology studies, medical studies and tumorigenicity experiments, and correspondingly some inference procedures have been developed in the literature (Biometrika, 91, 2004, 277; Comput. Statist. Data Anal., 57, 2013, 41; J. Comput. Graph. Statist., 13, 2004, 123). In this paper, we discuss regression analysis of such data under a class of flexible semiparametric transformation models, which includes some commonly used models for doubly censored data as special cases. For inference, the non‐parametric maximum likelihood estimation will be developed and in particular, we will present a novel expectation–maximization algorithm with the use of subject‐specific independent Poisson variables. In addition, the asymptotic properties of the proposed estimators are established and an extensive simulation study suggests that the proposed methodology works well for practical situations. The method is applied to an AIDS study.     

Estimation of the Association for Bivariate Interval-censored Failure Time Data

Abstract.  Multivariate failure time data frequently occur in medical studies and the dependence or association among survival variables is often of interest ( Biometrics , 51 , 1995, 1384; Stat. Med. , 18 , 1999, 3101; Biometrika , 87 , 2000, 879; J. Roy. Statist. Soc. Ser. B , 65 , 2003, 257). We study the problem of estimating the association between two related survival variables when they follow a copula model and only bivariate interval-censored failure time data are available. For the problem, a two-stage estimation procedure is proposed and the asymptotic properties of the proposed estimator are established. Simulation studies are conducted to assess the finite sample properties of the presented estimate and the results suggest that the method works well for practical situations. An example from an acquired immunodeficiency syndrome clinical trial is discussed.     

An Adjustment to Improve the Bivariate Survivor Function Repaired NPMLE

We recently proposed a representation of the bivariate survivor function as a mapping of the hazard function for truncated failure time variates. The representation led to a class of estimators that includes van der Laan’s repaired nonparametric maximum likelihood estimator (NPMLE) as an important special case. We proposed a Greenwood-like variance estimator for the repaired NPMLE but found somewhat poor agreement between the empirical variance estimates and these analytic estimates for the sample sizes and bandwidths considered in our simulation study. The simulation results also confirmed those of others in showing slightly inferior performance for the repaired NPMLE compared to other competing estimators as well as a sensitivity to bandwidth choice in moderate sized samples. Despite its attractive asymptotic properties, the repaired NPMLE has drawbacks that hinder its practical application. This paper presents a modification of the repaired NPMLE that improves its performance in moderate sized samples and renders it less sensitive to the choice of bandwidth. Along with this modified estimator, more extensive simulation studies of the repaired NPMLE and Greenwood-like variance estimates are presented. The methods are then applied to a real data example. This revised version was published online in September 2005 with a correction to the second author's name.     

Semiparametric estimation for the dispersion parameter in the analysis of over- or underdispersed count data

This paper investigates several semiparametric estimators of the dispersion parameter in the analysis of over- or underdispersed count data when there is no likelihood available. In the context of estimating the dispersion parameter, we consider the double-extended quasi-likelihood (DEQL), the pseudo-likelihood and the optimal quadratic estimating (OQE) equations method and compare them with the maximum likelihood method, the method of moments and the extended quasi-likelihood through simulation study. The simulation study shows that the estimator based on the DEQL has superior bias and efficiency property for moderate and large sample size, and for small sample size the estimator based on the OQE equations outperforms the other estimators. Three real-life data sets arising in biostatistical practices are analyzed, and the findings from these analyses are quite similar to what are found from the simulation study.     

Estimation under Cox proportional hazards model with covariates missing not at random

This paper considers likelihood-based estimation under the Cox proportional hazards model in the situations where some covariate entries are missing not at random. Assuming the conditional distribution of the missing entries is known, we demonstrate the existence of the semiparametric maximum likelihood estimator of the model parameters, establish the consistency and weak convergence. By simulation, we examine the finite-sample performance of the estimation procedure, and compare the SPMLE with the one resulted from using an estimated conditional distribution of the missing entries. We analyze the data from a tuberculosis (TB) study applying the proposed approach for illustration.     

Fisher’s observed information matrix for location and scale parameters under type i censoring

An expression for Fisher's observed information matrix is given under type I censoring for any location-scale distribution under mild requirements. It is illustrated on a data set which has been analyzed by several authors.     

Hierarchical likelihood approach for the Weibull frailty model

In this article, the proportional hazard model with Weibull frailty, which is outside the range of the exponential family, is used for analysing the right-censored longitudinal survival data. Complex multidimensional integrals are avoided by using hierarchical likelihood to estimate the regression parameters and to predict the realizations of random effects. The adjusted profile hierarchical likelihood is adopted to estimate the parameters in frailty distribution, during which the first- and second-order methods are used. The simulation studies indicate that the regression-parameter estimates in the Weibull frailty model are accurate, which is similar to the gamma frailty and lognormal frailty models. Two published data sets are used for illustration.     

An alpha-power extension for the Birnbaum–Saunders distribution

Data on fatigue to exceed a critical value (or to grow to a critical level at which failure is likely to occur) is typically adjusted using the Birnbaum–Saunders (BS) distribution [see Birnbaum ZW, Saunders SC. A new family of life distributions. J Appl Probab. 1969a;6:319–327]. Although this type of distribution is asymmetric, in some cases the degree of skewness and/or kurtosis are outside the distributional range allowed by the BS distribution. Thus, a more adequate distribution model for better adjusting such unexpected deviations is called for. With this in mind, the main object of this paper is to propose an extension of the BS distribution based on the asymmetric alpha-power family of distributions [see Pewsey A, Gómez HW, Bolfarine H. Likelihood-based inference for power distributions. Test. 2012;21(4):775–789]. This extension is called the exponentiated BS distribution. We expect that by replacing the normal distribution by such more general family, a more flexible BS family is obtained. Asymmetry in the alpha-power family is controlled by a shape parameter, which also presents a similar performance in the extended BS family. The paper presents the density function for the extended BS and derives closed-form expressions for moments. Estimation is dealt with by using maximum likelihood estimators. Large sample inference can be conducted by using the Fisher information matrix derived in the paper. Estimation performance is studied by using a small scale simulation study. Results of a real application illustrates the good performance of the proposed approach.     

A comparison of estimation procedures for the parameters of the star model

A simulation experiment compares the accuracy and precision of three alternate estimation techniques for the parameters of the STARMA model. Maximum likelihood estimation, in most ways the "best" estimation procedure, involves a large amount of computational effort so that two approximate techniques, exact least squares and conditional maximum likelihood, are often proposed for series of moderate lengths. This simulation experiment compares the accuracy of these three estimation procedures for simulated series of various lengths, and discusses the appropriateness of the three procedures as a function of the length of the observed series.     

Generalized Additive Models for Current Status Data

Current status data arise in studies where the target measurement is the time of occurrence of some event, but observations are limited to indicators of whether or not the event has occurred at the time the sample is collected - only the current status of each individual with respect to event occurrence is observed. Examples of such data arise in several fields, including demography, epidemiology, econometrics and bioassay. Although estimation of the marginal distribution of times of event occurrence is well understood, techniques for incorporating covariate information are not well developed. This paper proposes a semiparametric approach to estimation for regression models of current status data, using techniques from generalized additive modeling and isotonic regression. This procedure provides simultaneous estimates of the baseline distribution of event times and covariate effects. No parametric assumptions about the form of the baseline distribution are required. The results are illustrated using data from a demographic survey of breastfeeding practices in developing countries, and from an epidemiological study of heterosexual Human Immunodeficiency Virus (HIV) transmission. This revised version was published online in July 2006 with corrections to the Cover Date.     

The exponentiated-log-logistic geometric distribution: Dual activation

ABSTRACT

The log-logistic distribution is commonly used to model lifetime data. We propose a wider distribution, named the exponentiated log-logistic geometric distribution, based on a double activation approach. We obtain the quantile function, ordinary moments, and generating function. The method of maximum likelihood is used to estimate the model parameters. We propose a new extended regression model based on the logarithm of the exponentiated log-logistic geometric distribution. This regression model can be very useful in the analysis of real data and could provide better fits than other special regression models. The potentiality of the new models is illustrated by means of two applications to real lifetime data sets.     

Consistency of the GMLE with Mixed Case Interval-Censored Data

In this paper we consider an interval censorship model in which the endpoints of the censoring intervals are determined by a two stage experiment. In the first stage the value k of a random integer is selected; in the second stage the endpoints are determined by a case k interval censorship model. We prove the strong consistency in the L ₁( μ )-topology of the non-parametric maximum likelihood estimate of the underlying survival function for a measure μ which is derived from the distributions of the endpoints. This consistency result yields strong consistency for the topologies of weak convergence, pointwise convergence and uniform convergence under additional assumptions. These results improve and generalize existing ones in the literature.