Comparison of Statistical Methods for Pretest–Posttest Designs in Terms of Type I Error Probability and Statistical Power

The pretest–posttest design is widely used to investigate the effect of an experimental treatment in biomedical research. The treatment effect may be assessed using analysis of variance (ANOVA) or analysis of covariance (ANCOVA). The normality assumption for parametric ANOVA and ANCOVA may be violated due to outliers and skewness of data. Nonparametric methods, robust statistics, and data transformation may be used to address the nonnormality issue. However, there is no simultaneous comparison for the four statistical approaches in terms of empirical type I error probability and statistical power. We studied 13 ANOVA and ANCOVA models based on parametric approach, rank and normal score-based nonparametric approach, Huber M-estimation, and Box–Cox transformation using normal data with and without outliers and lognormal data. We found that ANCOVA models preserve the nominal significance level better and are more powerful than their ANOVA counterparts when the dependent variable and covariate are correlated. Huber M-estimation is the most liberal method. Nonparametric ANCOVA, especially ANCOVA based on normal score transformation, preserves the nominal significance level, has good statistical power, and is robust for data distribution.     

Non parametric double generally weighted moving average sign charts based on process proportion

Non parametric control charts have received increasing attention in the field of statistical process control. This paper presents a non parametric double generally weighted moving average (DGWMA) sign chart for monitoring small deviations when the quality characteristics of a process are unknown. The statistical performance of the non parametric DGWMA sign chart is evaluated and compared with those of other charts, including the exponentially weighted moving average (EWMA), generally weighted moving average (GWMA), and double EWMA (DEWMA) sign charts. Simulation studies indicate that the non parametric DGWMA sign chart with a large design and median adjustment parameters is always more sensitive than other charts in detecting small changes.     

Robust non-parametric smoothing of non-stationary time series

Motivated by the need of extracting local trends and low frequency components in non-stationary time series, this paper discusses methods of robust non-parametric smoothing. Basic approach is the combination of the parametric M-estimation with kernel and local polynomial regression methods. The result is an iterative estimator that retains a linear structure, but has kernel weights also in the direction of the prediction errors. The design of smoothing coefficients is carried out with robust cross-validation criteria and rules of thumb. The method works well both to remove the influence of patches of outliers and to detect the local breaks and persistent structural change in time series.     

Non‐parametric Regression Tests Using Dimension Reduction Techniques

Abstract. Testing for parametric structure is an important issue in non‐parametric regression analysis. A standard approach is to measure the distance between a parametric and a non‐parametric fit with a squared deviation measure. These tests inherit the curse of dimensionality from the non‐parametric estimator. This results in a loss of power in finite samples and against local alternatives. This article proposes to circumvent the curse of dimensionality by projecting the residuals under the null hypothesis onto the space of additive functions. To estimate this projection, the smooth backfitting estimator is used. The asymptotic behaviour of the test statistic is derived and the consistency of a wild bootstrap procedure is established. The finite sample properties are investigated in a simulation study.     

Inference in Semi‐Parametric Dynamic Models for Repeated Count Data

This paper deals with a longitudinal semi‐parametric regression model in a generalised linear model setup for repeated count data collected from a large number of independent individuals. To accommodate the longitudinal correlations, we consider a dynamic model for repeated counts which has decaying auto‐correlations as the time lag increases between the repeated responses. The semi‐parametric regression function involved in the model contains a specified regression function in some suitable time‐dependent covariates and a non‐parametric function in some other time‐dependent covariates. As far as the inference is concerned, because the non‐parametric function is of secondary interest, we estimate this function consistently using the independence assumption‐based well‐known quasi‐likelihood approach. Next, the proposed longitudinal correlation structure and the estimate of the non‐parametric function are used to develop a semi‐parametric generalised quasi‐likelihood approach for consistent and efficient estimation of the regression effects in the parametric regression function. The finite sample performance of the proposed estimation approach is examined through an intensive simulation study based on both large and small samples. Both balanced and unbalanced cluster sizes are incorporated in the simulation study. The asymptotic performances of the estimators are given. The estimation methodology is illustrated by reanalysing the well‐known health care utilisation data consisting of counts of yearly visits to a physician by 180 individuals for four years and several important primary and secondary covariates.     

Outlier detection using difference-based variance estimators in multiple regression

In this article, we propose an outlier detection approach in a multiple regression model using the properties of a difference-based variance estimator. This type of a difference-based variance estimator was originally used to estimate error variance in a non parametric regression model without estimating a non parametric function. This article first employed a difference-based error variance estimator to study the outlier detection problem in a multiple regression model. Our approach uses the leave-one-out type method based on difference-based error variance. The existing outlier detection approaches using the leave-one-out approach are highly affected by other outliers, while ours is not because our approach does not use the regression coefficient estimator. We compared our approach with several existing methods using a simulation study, suggesting the outperformance of our approach. The advantages of our approach are demonstrated using a real data application. Our approach can be extended to the non parametric regression model for outlier detection.     

Mean response estimation with missing response in the presence of high-dimensional covariates

This paper studies the problem of mean response estimation where missingness occurs to the response but multiple-dimensional covariates are observable. Two main challenges occur in this situation: curse of dimensionality and model specification. The non parametric imputation method relieves model specification but suffers curse of dimensionality, while some model-based methods such as inverse probability weighting (IPW) and augmented inverse probability weighting (AIPW) methods are the opposite. We propose a unified non parametric method to overcome the two challenges with the aiding of sufficient dimension reduction. It imposes no parametric structure on propensity score or conditional mean response, and thus retains the non parametric flavor. Moreover, the estimator achieves the optimal efficiency that a double robust estimator can attain. Simulations were conducted and it demonstrates the excellent performances of our method in various situations.     

Generalised quasi‐likelihood inference in a semi‐parametric binary dynamic mixed logit model

There exists a recent study where dynamic mixed‐effects regression models for count data have been extended to a semi‐parametric context. However, when one deals with other discrete data such as binary responses, the results based on count data models are not directly applicable. In this paper, we therefore begin with existing binary dynamic mixed models and generalise them to the semi‐parametric context. For inference, we use a new semi‐parametric conditional quasi‐likelihood (SCQL) approach for the estimation of the non‐parametric function involved in the semi‐parametric model, and a semi‐parametric generalised quasi‐likelihood (SGQL) approach for the estimation of the main regression, dynamic dependence and random effects variance parameters. A semi‐parametric maximum likelihood (SML) approach is also used as a comparison to the SGQL approach. The properties of the estimators are examined both asymptotically and empirically. More specifically, the consistency of the estimators is established and finite sample performances of the estimators are examined through an intensive simulation study.     

Statistical test based on intuitionistic fuzzy hypotheses

In this paper, the classical statistical test based on intuitionistic fuzzy hypotheses in relation to the underlying population parametric is extended. In this approach, the type-I, type-II, power of test, and p-value are extended for intuitionistic fuzzy hypotheses. Throughout the paper, some applied examples are provided for both parametric and non parametric cases to clarify the discussions.     

Robust estimation and model identification for longitudinal data varying-coefficient model

It is well known that M-estimation is a widely used method for robust statistical inference and the varying coefficient models have been widely applied in many scientific areas. In this paper, we consider M-estimation and model identification of bivariate varying coefficient models for longitudinal data. We make use of bivariate tensor-product B-splines as an approximation of the function and consider M-type regression splines by minimizing the objective convex function. Mean and median regressions are included in this class. Moreover, with a double smoothly clipped absolute deviation (SCAD) penalization, we study the problem of simultaneous structure identification and estimation. Under approximate conditions, we show that the proposed procedure possesses the oracle property in the sense that it is as efficient as the estimator when the true model is known prior to statistical analysis. Simulation studies are carried out to demonstrate the methodological power of the proposed methods with finite samples. The proposed methodology is illustrated with an analysis of a real data example.     

Variable selection in finite mixture of semi-parametric regression models

Abstract

In this paper we are concerned with variable selection in finite mixture of semiparametric regression models. This task consists of model selection for non parametric component and variable selection for parametric part. Thus, we encountered separate model selections for every non parametric component of each sub model. To overcome this computational burden, we introduced a class of variable selection procedures for finite mixture of semiparametric regression models using penalized approach for variable selection. It is shown that the new method is consistent for variable selection. Simulations show that the performance of proposed method is good, and it consequently improves pervious works in this area and also requires much less computing power than existing methods.     

A Class of Weighted Estimating Equations for Semiparametric Transformation Models with Missing Covariates

In survival analysis, covariate measurements often contain missing observations; ignoring this feature can lead to invalid inference. We propose a class of weighted estimating equations for right‐censored data with missing covariates under semiparametric transformation models. Time‐specific and subject‐specific weights are accommodated in the formulation of the weighted estimating equations. We establish unified results for estimating missingness probabilities that cover both parametric and non‐parametric modelling schemes. To improve estimation efficiency, the weighted estimating equations are augmented by a new set of unbiased estimating equations. The resultant estimator has the so‐called ‘double robustness’ property and is optimal within a class of consistent estimators.     

Prediction Regions for Bivariate Extreme Events

This paper suggests using a mixture of parametric and non‐parametric methods to construct prediction regions in bivariate extreme‐value problems. The non‐parametric part of the technique is used to estimate the dependence function, or copula, and the parametric part is employed to estimate the marginal distributions. A bootstrap calibration argument is suggested for reducing coverage error. This combined approach is compared with a more parametric one, relative to which it has the advantages of being more flexible and simpler to implement. It also enjoys these features relative to predictive likelihood methods. The paper shows how to construct both compact and semi‐infinite bivariate prediction regions, and it treats the problem of predicting the value of one component conditional on the other. The methods are illustrated by application to Australian annual maximum temperature data.     

A Non‐parametric Test of Exchangeability for Extreme‐Value and Left‐Tail Decreasing Bivariate Copulas

Abstract. A non‐parametric rank‐based test of exchangeability for bivariate extreme‐value copulas is first proposed. The two key ingredients of the suggested approach are the non‐parametric rank‐based estimators of the Pickands dependence function recently studied by Genest and Segers, and a multiplier technique for obtaining approximate p‐values for the derived statistics. The proposed approach is then extended to left‐tail decreasing dependence structures that are not necessarily extreme‐value copulas. Large‐scale Monte Carlo experiments are used to investigate the level and power of the various versions of the test and show that the proposed procedure can be substantially more powerful than tests of exchangeability derived directly from the empirical copula. The approach is illustrated on well‐known financial data.     

BOOTSTRAP TESTS FOR THE ERROR DISTRIBUTION IN LINEAR AND NONPARAMETRIC REGRESSION MODELS

In this paper we investigate several tests for the hypothesis of a parametric form of the error distribution in the common linear and non‐parametric regression model, which are based on empirical processes of residuals. It is well known that tests in this context are not asymptotically distribution‐free and the parametric bootstrap is applied to deal with this problem. The performance of the resulting bootstrap test is investigated from an asymptotic point of view and by means of a simulation study. The results demonstrate that even for moderate sample sizes the parametric bootstrap provides a reliable and easy accessible solution to the problem of goodness‐of‐fit testing of assumptions regarding the error distribution in linear and non‐parametric regression models.     

Difference-based estimation and model identification for panel data semiparametric models with cross-section dependence

Abstract

In this article, we consider a panel data partially linear regression model with fixed effect and non parametric time trend function. The data can be dependent cross individuals through linear regressor and error components. Unlike the methods using non parametric smoothing technique, a difference-based method is proposed to estimate linear regression coefficients of the model to avoid bandwidth selection. Here the difference technique is employed to eliminate the non parametric function effect, not the fixed effects, on linear regressor coefficient estimation totally. Therefore, a more efficient estimator for parametric part is anticipated, which is shown to be true by the simulation results. For the non parametric component, the polynomial spline technique is implemented. The asymptotic properties of estimators for parametric and non parametric parts are presented. We also show how to select informative ones from a number of covariates in the linear part by using smoothly clipped absolute deviation-penalized estimators on a difference-based least-squares objective function, and the resulting estimators perform asymptotically as well as the oracle procedure in terms of selecting the correct model.     

Model‐Based Non‐parametric Variance Estimation for Systematic Sampling

Abstract. Systematic sampling is frequently used in surveys, because of its ease of implementation and its design efficiency. An important drawback of systematic sampling, however, is that no direct estimator of the design variance is available. We describe a new estimator of the model‐based expectation of the design variance, under a non‐parametric model for the population. The non‐parametric model is sufficiently flexible that it can be expected to hold at least approximately in many situations with continuous auxiliary variables observed at the population level. We prove the model consistency of the estimator for both the anticipated variance and the design variance under a non‐parametric model with a univariate covariate. The broad applicability of the approach is demonstrated on a dataset from a forestry survey.     

Comparison of spline estimator at various levels of autocorrelation in smoothing spline non parametric regression for longitudinal data

The purpose of this research are: (1) to obtain spline function estimation in non parametric regression for longitudinal data with and without considering the autocorrelation between data of observation within subject, (2) to develop the algorithm that generates simulation data with certain autocorrelation level based on size of sample (N) and error variance (EV), and (3) to establish shape of spline estimator in non parametric regression for longitudinal data to simulation with various level of autocorrelation, as well as compare DM and TM approaches in predicting spline estimator in the data simulation with different of autocorrelation observational data on within subject. The results of the application are as follows: (a) implementation of smoothing spline with penalized weighted least square (PWLS) approach with or without consideration of autocorrelation in general (in all sizes and all error variances levels) provides significantly different spline estimator when the autocorrelation level >0.8; (b) based on size comparison, spline estimator in non parametric regression smoothing spline with PLS approach with (DM), or without (DM) consideration of autocorrelation showed significantly different result in level of autocorrelation > 0.8 (in overall size, moderate and large sample size), and > 0.7 (in small sample size); (c) based on level of variance, spline estimator in non parametric regression smoothing spline with PLS approach with (DM), or without (DM) consideration of autocorrelation showed significantly different result in level of autocorrelation > 0.8 (in overall level of variance, moderate and large variance), and > 0.7 (in small variance).     

Single-index regression models with right-censored responses

In this article, we propose some new generalizations of M-estimation procedures for single-index regression models in presence of randomly right-censored responses. We derive consistency and asymptotic normality of our estimates. The results are proved in order to be adapted to a wide range of techniques used in a censored regression framework (e.g. synthetic data or weighted least squares). As in the uncensored case, the estimator of the single-index parameter is seen to have the same asymptotic behavior as in a fully parametric scheme. We compare these new estimators with those based on the average derivative technique of Lu and Burke [2005. Censored multiple regression by the method of average derivatives. J. Multivariate Anal. 95, 182–205] through a simulation study.     

Local linear double and asymmetric kernel estimation of conditional quantiles

Abstract

In this work, we propose and investigate a family of non parametric quantile regression estimates. The proposed estimates combine local linear fitting and double kernel approaches. More precisely, we use a Beta kernel when covariate’s support is compact and Gamma kernel for left-bounded supports. Finite sample properties together with asymptotic behavior of the proposed estimators are presented. It is also shown that these estimates enjoy the property of having finite variance and resistance to sparse design.