Comparison of Frailty Models for Acute Leukemia Data under Gompertz Baseline Distribution

In this article, we consider two different shared frailty regression models under the assumption of Gompertz as baseline distribution. Mostly assumption of gamma distribution is considered for frailty distribution. To compare the results with gamma frailty model, we consider the inverse Gaussian shared frailty model also. We compare these two models to a real life bivariate survival data set of acute leukemia remission times (Freireich et al., 1963 Freireich, E.J., Gehan, E., Frei, E., Schroeder, L.R., Wolman, I.J., Anbari, R., Burgert, E.O., Mills, S.D., Pinkel, D., Selawry, O.S., Moon, J.H., Gendel, B.R., Spurr, C.L., Storrs, R., Haurani, F., Hoogstraten, B., Lee, S. (1963). The effect of 6-mercaptopurine on the duration of steroid-induced remissions in acute leukemia: a model for evaluation of other potentially useful therapy. Blood 21:699–716.[Web of Science ®] , [Google Scholar]). Analysis is performed using Markov Chain Monte Carlo methods. Model comparison is made using Bayesian model selection criterion and a well-fitted model is suggested for the acute leukemia data.     

Improved strategy to collect sensitive data by using geometric distribution as a randomization device

Abstract

In this article, we improvise Singh and Grewal (2013 Singh, S., and I. S. Grewal. 2013. Geometric distribution as a randomization device implemented in the Kuk’s model. International Journal of Contemporary Mathematical Sciences 8:243–8.[Crossref] , [Google Scholar]) and Hussain et al. (2016 Hussain, Z., J. Shabbir, Z. Pervez, S. F. Shah, and M. Khan. 2016. Generalized geometric distribution of order k: A flexible choice to randomize the response. Communications in Statistics: Simulation and Computation 46:4708–21.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) techniques by introducing a new two-stage randomization response process. Using the proposed new technique, we achieve better efficiency and increasing protection of privacy of respondents than the Kuk (1990 Kuk, A. Y. C. 1990. Asking sensitive questions indirectly. Biometrika 77 (2):436–8.[Crossref], [Web of Science ®] , [Google Scholar]), Singh and Grewal (2013 Singh, S., and I. S. Grewal. 2013. Geometric distribution as a randomization device implemented in the Kuk’s model. International Journal of Contemporary Mathematical Sciences 8:243–8.[Crossref] , [Google Scholar]) and Hussain et al. (2016 Hussain, Z., J. Shabbir, Z. Pervez, S. F. Shah, and M. Khan. 2016. Generalized geometric distribution of order k: A flexible choice to randomize the response. Communications in Statistics: Simulation and Computation 46:4708–21.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) models. The relative efficiency and protection of the respondents of the proposed two-stage randomization device have been investigated through simulation study, and the situations are reported where the proposed estimator performs better than its competitors. The SAS code used to investigate the performance of the proposed strategy are also provided.     

Marginal correlation from an extended random-effects model for repeated and overdispersed counts

Vangeneugden et al. [15 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C. and Sotto, C. 2007. Marginal correlation in longitudinal binary data based on generalized linear mixed models, Tech. Rep., Hasselt University. submitted for publication [Google Scholar]] derived approximate correlation functions for longitudinal sequences of general data type, Gaussian and non-Gaussian, based on generalized linear mixed-effects models (GLMM). Their focus was on binary sequences, as well as on a combination of binary and Gaussian sequences. Here, we focus on the specific case of repeated count data, important in two respects. First, we employ the model proposed by Molenberghs et al. [13 Molenberghs, G., Verbeke, G. and Demétrio, C. G.B. 2007. An extended random-effects approach to modeling repeated, overdispersed count data. Lifetime Data Anal., 13: 513–531. [Crossref], [PubMed], [Web of Science ®] [Google Scholar]], which generalizes at the same time the Poisson-normal GLMM and the conventional overdispersion models, in particular the negative-binomial model. The model flexibly accommodates data hierarchies, intra-sequence correlation, and overdispersion. Second, means, variances, and joint probabilities can be expressed in closed form, allowing for exact intra-sequence correlation expressions. Next to the general situation, some important special cases such as exchangeable clustered outcomes are considered, producing insightful expressions. The closed-form expressions are contrasted with the generic approximate expressions of Vangeneugden et al. [15 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C. and Sotto, C. 2007. Marginal correlation in longitudinal binary data based on generalized linear mixed models, Tech. Rep., Hasselt University. submitted for publication [Google Scholar]]. Data from an epileptic-seizures trial are analyzed and correlation functions derived. It is shown that the proposed extension strongly outperforms the classical GLMM.     

Robust Bayesian inference via γ-divergence

Abstract

This paper presents the robust Bayesian inference based on the γ-divergence which is the same divergence as “type 0 divergence” in Jones et al. (2001 Jones, M. C., N. L. Hjort, I. R. Harris, and A. Basu. 2001. A comparison of related density-based minimum divergence estimators. Biometrika 88(3):865–73.[Crossref], [Web of Science ®] , [Google Scholar]) on the basis of Windham (1995 Windham, M. P. 1995. Robustifying model fitting. Journal of the Royal Statistical Society B57:599–609. [Google Scholar]). It is known that the minimum γ-divergence estimator works well to estimate the probability density for heavily contaminated data, and to estimate the variance parameters. In this paper, we propose a robust posterior distribution against outliers based on the γ-divergence and show the asymptotic properties of the proposed estimator. We also discuss some robustness properties of the proposed estimator and illustrate its performances in some simulation studies.     

Adaptive tangent distance classifier on recognition of handwritten digits

Simard et al. [16 Simard, P. Y., LeCun, Y., Denker, J. S. and Victorri, B. 2000. Transformation invariance in pattern recognition: Tangent distance and tangent propagation. J. Imaging Syst. Technol., 11: 181–197.  [Google Scholar] 17 Sona, D., Sperduti, A. and Starita, A. 1997. A constructive learning algorithm for discriminant tangent models. Advances in Neural Information Processing Systems. 1997, Cambridge, MA. Edited by: Mozer, M. C., Jordan, M. I. and Petsche, T. Vol. 9, pp.786–792. MIT Press.  [Google Scholar]] proposed a transformation distance called “tangent distance” (TD) which can make pattern recognition be efficient. The key idea is to construct a distance measure which is invariant with respect to some chosen transformations. In this research, we provide a method using adaptive TD based on an idea inspired by “discriminant adaptive nearest neighbor” [7 Hastie, T., Tibshirani, R. and Friedman, J. 2009. The Elements of Statistical Learning, Data Mining, Inference, and Prediction, 2, New York, Berlin, Heidelberg: Springer. Available at http://www-stat.stanford.edu/ElemStatLearn [Google Scholar]]. This method is relatively easy compared with many other complicated ones. A real handwritten recognition data set is used to illustrate our new method. Our results demonstrate that the proposed method gives lower classification error rates than those by standard implementation of neural networks and support vector machines and is as good as several other complicated approaches.     

SECOND-ORDER ASYMPTOTICS FOR SCORE TESTS IN HETEROSKEDASTIC t REGRESSION MODELS

ABSTRACT

This paper develops corrected score tests for heteroskedastic t regression models, thus generalizing results by Cordeiro, Ferrari and Paula[1] Cordeiro, G.M., Ferrari, S.L.P. and Paula, G.A. 1993. Improved Score Tests for Generalized Linear Models. Journal of the Royal Statistical Society B, 55: 661–674.  [Google Scholar] and Cribari-Neto and Ferrari[2] Cribari-Neto, F. and Ferrari, S.L.P. 1995. Second-order Asymptotics for Score Tests in Generalised Linear Models. Biometrika, 82: 426–432. [Crossref], [Web of Science ®] , [Google Scholar] for normal regression models and by Ferrari and Arellano-Valle[3] Ferrari, S.L.P. and Arellano-Valle, R. 1996. Modified Likelihood Ratio and Score Tests in Linear Regression Models Using the t Distribution. Brazilian Journal of Probability and Statistics, 10: 15–33.  [Google Scholar] for homoskedastic t regression models. We present, in matrix notation, Bartlett-type correction formulae to improve score tests in this class of models. The corrected score statistics have a chi-squared distribution to order n ^?1, where n is the sample size. We apply our main result to a few special models and present simulation results comparing the performance of the usual score tests and their corrected versions.     

On Complete Convergence in Marcinkiewicz-Zygmund Type SLLN for END Random Variables and Its Applications

Abstract

In this paper, the complete convergence for maximal weighted sums of extended negatively dependent (END, for short) random variables is investigated. Some sufficient conditions for the complete convergence and some applications to a nonparametric model are provided. The results obtained in the paper generalize and improve the corresponding ones of Wang et al. (2014 Wang, X. J., X. Deng, L. L. Zheng, and S. H. Hu. 2014. Complete convergence for arrays of rowwise negatively superadditive-dependent random variables and its applications. A Journal of Theoretical and Applied Statistics 48(4):834–50. [Google Scholar]b) and Shen, Xue, and Wang (2017 Shen, A., M. Xue, and W. Wang. 2017. Complete convergence for weighted sums of extended negatively dependent random variables. Communications in Statistics – Theory and Methods 46(3):1433–44.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]).     

On Fitting Transformation Model to Survey Data

In this article, we consider fitting a semiparametric linear model to survey data with censored observations. The specific goal of the paper is to extend the methods of Cheng et al. (1995 Cheng, S.C., Wei, L.J., Ying, Z. (1995). Analysis of transformation models with censored data. Biometrika 82(4):835–845.[Crossref], [Web of Science ®] , [Google Scholar]) and Chen et al. (2002 Chen, K., Jin, Z. Ying, Z. (2002). Semiparametric analysis of transformation models with censored data. Biometrika 89:659–668.[Crossref], [Web of Science ®] , [Google Scholar]) to the case when the sample has been drawn from a population using a complex sampling design. Similar to the approach of Lin (2000 Lin, D.Y. (2000). On fitting Cox’s proportional hazards models to survey data. Biometrika 87:37–47.[Crossref], [Web of Science ®] , [Google Scholar]), we regard the survey population as a random sample from an infinite universe and accounts for this randomness in the statistical inference. A simulation study is conducted to investigate the performance of the proposed estimators.     

Comparison of cumulative incidence functions of current status competing risks data with discrete observation times

Abstract

Competing risks data with current status censoring arise frequently from transversal studies in demography, epidemiology and reliability theory; where the only information about lifetime is whether the event of interest has occurred or not before a monitoring time. In practice, the monitoring times are discrete, but most of the studies consider them as continuous in nature. In the present paper, we propose a non parametric test for comparing cumulative incidence functions of current status competing risks data while the observation (monitoring) times are discrete. Asymptotic distribution of the test statistic is also derived. A simulation study is conducted to assess the finite sample behavior of the test statistic. The practical utility of the procedure is well demonstrated using a real-life data set on menopausal history of 2423 women given in Jewell, van der Laan, and Henneman (2003 Jewell, N. P., M. van der Laan, and T. Henneman. 2003. Nonparametric estimation from current status data with competing risks. Biometrika 90 (1):183–197. doi: 10.1093/biomet/90.1.183.[Crossref], [Web of Science ®] , [Google Scholar]).     

Population Attributable Fraction as a Measure of Heritability in Dichotomous Twin Data

In many genetic analyses of dichotomous twin data, odds ratios have been used to test hypotheses on heritability and shared common environment effects of a given disease (Lichtenstein et al., 2000 Lichtenstein , P. , Holm , N. , Verkasalo , P. , Iliadou , A. , Kaprio , J. , Koskenvuo , M. , Pukkala , E. , Skytthe , A. , Hemminki , K. ( 2000 ). Environmental and heritable factors in the causation of cancer . New England Journal of Medicine 343 : 78 – 85 .[Crossref], [Web of Science ®] , [Google Scholar]; Ahlbom et al., 1997 Ahlbom , A. , Lichtenstein , P. , Malmström , H. , Feychting , M. , Hemminki , K. , Pedersen , N. L. ( 1997 ). Cancer in twins: genetic and nongenetic familial risk factors . Journal of the National Cancer Institute 89 : 287 – 93 . [Google Scholar]; Ramakrishnan et al., 1992 Ramakrishnan , V. , Goldberg , J. , Henderson , W. , Elsen , S. , True , W. , Lyons , M. , Tsuang , M. ( 1992 ). Elementary methods for the analysis of dichotomous outcomes in unselected samples of twins . Genetic Epidemiology 9 : 273 – 287 . [Google Scholar], 4). However, estimates of these two effects have not been dealt with in the literature. In epidemiology, the attributable fraction (AF), a function of the odds ratio and the prevalence of the risk factor has been used to describe the contribution of a risk factor to a disease in a given population (Leviton, 1973 Leviton , A. ( 1973 ). Definitions of attributable risk . American Journal of Epidemiology 98 : 231 . [Google Scholar]). In this article, we adapt the AF to quantify the heritability and the shared common environment. Twin data on cancer, gallstone disease and phobia are used to illustrate the applicability of the AF estimate as a measure of heritability.     

Optimal Halton Sequence via Inversive Scrambling

In this article, we develop the Halton sequence of generating quasi-random numbers to an optimal sequence which has the inversive property. The new constructed quasi-random number generator satisfies the extra uniformity condition on [0, 1]. We finally present the performances of this generator in contrast to the former optimal Halton sequence in Chi et al. (2005 Chi, H., Mascagni, M. and Warnock, T. 2005. On the Optimal Halton Sequences. Math. Comput. in Simul., 70(1): 9–21. [Crossref], [Web of Science ®] , [Google Scholar]) and modified optimal Halton sequence in Fathi et al. (2009 Fathi, B., Samimi, H. and Eskandari, A. 2009. A New Efficient Algorithm for Linear Scrambling Halton Sequence. International Journal of Applied Mathematics, 22(7): 1059–1065.  [Google Scholar]).     

A NEW VERSION OF THE LOCAL CONSTANT M-SMOOTHER

ABSTRACT

In the case of the equally spaced fixed design nonparametric regression, the local constant M-smoother (LCM) in Chu, Glad, Godtliebsen, and Marron [1] Chu, C.K., Glad, I., Godtliebsen, F. and Marron, J.S. 1998. Edge-Preserving Smoothers for Image Processing (with discussion). Journal of the American Statistical Association, 93: 526–556. [Taylor & Francis Online], [Web of Science ®] , [Google Scholar] has the interesting property of jump-preserving. However, it suffers from the problem of boundary effects. To correct for such adverse effects on the LCM, Rue, Chu, Godtliebsen, and Marron [2] Rue, H., Chu, C.K., Godtliebsen, F. and Marron, J.S. 2001. M-smoother with Local Linear Fit. To appear in Journal of Nonparametric Statistics [Google Scholar] apply the local linear fit to the “inside” of the kernel function, and propose the local linear M-smoother (LLM). Unfortunately, the LLM is more sensitive to random fluctuations, since an extra tuning parameter is included. To avoid such a practical drawback to the LLM, we propose a new version of the LCM by applying the local linear fit to the “outside” of the kernel function. Our proposed estimator employs both the same tuning parameter associated with the ordinary LCM and the same weights assigned to the observations by the local linear smoother in Fan 3-4 Fan, J. 1992. Design-adaptive Nonparametric Regression. Journal of the American Statistical Association, 87: 998–1004. Fan, J. 1993. Local Linear Regression Smoothers and Their Minimax Efficiencies. Annals of Statistics, 21: 196–216.  . It has the same asymptotic mean square error as the LLM. In practice, it can be calculated by using the fast computation algorithm designed for the ordinary LCM by Chu et al. [1] Chu, C.K., Glad, I., Godtliebsen, F. and Marron, J.S. 1998. Edge-Preserving Smoothers for Image Processing (with discussion). Journal of the American Statistical Association, 93: 526–556. [Taylor & Francis Online], [Web of Science ®] , [Google Scholar], and does not suffer from the drawback to the LLM. More importantly, our results obtained for the new version of the LCM in the one-dimensional case can be extended directly to the multidimensional case. Simulation studies demonstrate that the asymptotic effects hold for reasonable sample sizes.     

Selection of Binary Variables and Classification by Boosting

We adopt boosting for classification and selection of high-dimensional binary variables for which classical methods based on normality and non singular sample dispersion are inapplicable. Boosting seems particularly well suited for binary variables. We present three methods of which two combine boosting with the relatively classical variable selection methods developed in Wilbur et al. (2002 Wilbur , J. D. , Ghosh , J. K. , Nakatsu , C. H. , Brouder , S. M. , Doerge , R. W. ( 2002 ). Variable selection in high-dimensional multivariate binary data with application to the analysis of microbial community DNA fingerprints . Biometrics 58 : 378 – 386 . [Google Scholar]). Our primary interest is variable selection in classification with small misclassification error being used as validation of proposed method for variable selection. Two of the new methods perform uniformly better than Wilbur et al. (2002 Wilbur , J. D. , Ghosh , J. K. , Nakatsu , C. H. , Brouder , S. M. , Doerge , R. W. ( 2002 ). Variable selection in high-dimensional multivariate binary data with application to the analysis of microbial community DNA fingerprints . Biometrics 58 : 378 – 386 . [Google Scholar]) in one set of simulated and three real life examples.     

An improved estimation in stratified random sampling

ABSTRACT

The article suggests a class of estimators of population mean in stratified random sampling using auxiliary information with its properties. In addition, various known estimators/classes of estimators are identified as members of the suggested class. It has been shown that the suggested class of estimators under optimum condition performs better than the usual unbiased, usual combined ratio, usual combined regression, Kadilar and Cingi (2005 Kadilar, C., Cingi, H. (2005). A new ratio estimator in stratified sampling. Commun. Stat. Theory Methods 34:597–602.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Singh and Vishwakarma (2006 Singh, H.P., Vishwakarma, G.K. (2006). Combined ratio-product estimator of finite population mean in stratified sampling. Metodologia de Encuestas Monografico: Incidencias en el trabjo de Campo 7(1):32–40. [Google Scholar]) estimators and the members belonging to the classes of estimators envisaged by Kadilar and Cingi (2003 Kadilar, C., Cingi, H. (2003). Ratio estimator in stratified sampling. Biomet. J. 45:218–225.[Crossref], [Web of Science ®] , [Google Scholar]), Singh, Tailor et al. (2008 Singh, H.P., Agnihotri, N. (2008). A general procedure of estimating population mean using auxiliary information in sample surveys. Stat. Trans. 9(1):71–87. [Google Scholar]), Singh et al. (2009 Singh, R., Kumar, M., Chaudhary, M.K., Kadilar, C. (2009). Improved exponential estimator in stratified random sampling. Pak. J. Stat. Oper. Res. 5(2):67–82.[Crossref] , [Google Scholar]), Singh and Vishwakarma (2010 Singh, H.P., Vishwakarma, G.K. (2010). A general procedure for estimating the population mean in stratified sampling using auxiliary information. METRON 67(1):47–65.[Crossref] , [Google Scholar]) and Koyuncu and Kadilar (2010) Koyuncu, N., Kadilar, C. (2010). On improvement in estimating population mean in stratified random sampling. J. Appl. Stat. 37(6):999–1013.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar].     

A Comparison of Procedures for Controlling the False Discovery Rate in the Presence of Small Variance Genes: A Simulation Study

The Significance Analysis of Microarrays (SAM; Tusher et al., 2001 Tusher , V. G. , Tibshirani , R. , Chu , G. ( 2001 ). Significance analysis of microarrys applied to the ionizing radiation response . Proceedings of the National Academy of Sciences 98 : 5116 – 5121 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) method is widely used in analyzing gene expression data while controlling the FDR by using resampling-based procedure in the microarray setting. One of the main components of the SAM procedure is the adjustment of the test statistic. The introduction of the fudge factor to the test statistic aims at deflating the large value of test statistics due to the small standard error of gene-expression. Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) pointed out that the fudge factor does not effectively improve the power and the control of the FDR as compared to the SAM procedure without the fudge factor in the presence of small variance genes. Motivated by the simulation results presented in Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), in this article, we extend our study to compare several methods for choosing the fudge factor in the modified t-type test statistics and use simulation studies to investigate the power and the control of the FDR of the considered methods.     

Regression M-estimators with One Modified Form of Doubly Censored Data

In this article, we consider the M-estimators for the linear regression model when both response and covariate variables are subject to double censoring. The proposed estimators are constructed as some functional of three types of estimators for a bivariate survival distribution. The first two estimators are the generalizations of the Campbell and Földes (1982 Campbell, G. and Földes, A. 1982. “Large sample properties of nonparametric statistical inference”. In Nonparametric Statistical Inference., Edited by: Gnredenko, B. V., Puri, M. L. and Vineze, I. 103–122. Amsterdam: North-Holland.  [Google Scholar]) and Dabrowska (1988 Dabrowska, D. M. 1988. Kaplan-Meier estimate on the plane. Annals of Statistics, 18: 1475–1489. [Crossref], [Web of Science ®] , [Google Scholar]) estimators proposed by Shen (2009 Shen, P. S. 2009. Nonparametric estimation of the bivariate survival function one modified form of doubly censored data. Computational Statistics, 25: 203–313. [Crossref], [Web of Science ®] , [Google Scholar]). The third estimator is the generalization of the Prentice and Cai (1992 Prentice, R. L. and Cai, J. 1992. Covariance and survivor function estimation using censored multivariate failure time data. Biometrika, 79: 495–512. [Crossref], [Web of Science ®] , [Google Scholar]) estimator. The consistency of the proposed M-estimators is established. A simulation study is conducted to investigate the performance of the proposed estimators. Furthermore, the simple bootstrap methods are used to estimate standard deviations and construct interval estimators.     

A Bottom-Up Dynamic Model of Portfolio Credit Risk with Stochastic Intensities and Random Recoveries

In Bielecki et al. (2014a Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014a ). Dynamic hedging of portfolio credit risk in a markov copula model . J. Optimiz. Theor. Applic . doi: DOI 10.1007/s10957-013-0318-4 (forthcoming) .[Crossref] , [Google Scholar]), the authors introduced a Markov copula model of portfolio credit risk where pricing and hedging can be done in a sound theoretical and practical way. Further theoretical backgrounds and practical details are developed in Bielecki et al. (2014b Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014b ). A bottom-up dynamic model of portfolio credit risk - Part I: Markov copula perspective . In: Recent Adv. Fin. Eng. 2012 , World Scientific (preprint version available at http://dx.doi.org/10.2139/ssrn.1844574) . [Google Scholar],c) where numerical illustrations assumed deterministic intensities and constant recoveries. In the present paper, we show how to incorporate stochastic default intensities and random recoveries in the bottom-up modeling framework of Bielecki et al. (2014a Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014a ). Dynamic hedging of portfolio credit risk in a markov copula model . J. Optimiz. Theor. Applic . doi: DOI 10.1007/s10957-013-0318-4 (forthcoming) .[Crossref] , [Google Scholar]) while preserving numerical tractability. These two features are of primary importance for applications like CVA computations on credit derivatives (Assefa et al., 2011 Assefa , S. , Bielecki , T. R. , Crépey , S. , Jeanblanc , M. ( 2011 ). CVA computation for counterparty risk assessment in credit portfolios . In: Bielecki , T.R. , Brigo , D. , Patras , F. , Eds., Credit Risk Frontiers . Hoboken : Wiley/Bloomberg-Press . [Google Scholar]; Bielecki et al., 2012 Bielecki , T. R. , Crépey , S. , Jeanblanc , M. , Zargari , B. ( 2012 ). Valuation and Hedging of CDS counterparty exposure in a markov copula model . Int. J. Theoret. Appl. Fin. 15 ( 1 ): 1250004 .[Crossref] , [Google Scholar]), as CVA is sensitive to the stochastic nature of credit spreads and random recoveries allow to achieve satisfactory calibration even for “badly behaved” data sets. This article is thus a complement to Bielecki et al. (2014a Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014a ). Dynamic hedging of portfolio credit risk in a markov copula model . J. Optimiz. Theor. Applic . doi: DOI 10.1007/s10957-013-0318-4 (forthcoming) .[Crossref] , [Google Scholar]), Bielecki et al. (2014b Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014b ). A bottom-up dynamic model of portfolio credit risk - Part I: Markov copula perspective . In: Recent Adv. Fin. Eng. 2012 , World Scientific (preprint version available at http://dx.doi.org/10.2139/ssrn.1844574) . [Google Scholar]) and Bielecki et al. (2014c Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014c ). A bottom-up dynamic model of portfolio credit risk - Part II: Common-shock interpretation, calibration and hedging issues . Recent Adv. Fin. Eng. 2012 , World Scientific (preprint version available at http://dx.doi.org/10.2139/ssrn.2245130) . [Google Scholar]).     

Estimating Incidence Rate on Current Status Data with Application to a Phase IV Cancer Trial

New drug discovery in the pediatrics has dramatically improved survival, but with long- term adverse events. This motivates the examination of adverse outcomes such as long-term toxicity in a phase IV trial. An ideal approach to monitor long-term toxicity is to systematically follow the survivors, which is generally not feasible. Instead, cross-sectional surveys are conducted in Hudson et al. (2007 Hudson , M. M. , Rai , S. N. , Nunez , C. , Merchant , T. E. , Marina , N. M. , Zalamea , N. , Cox , C. , Phipps , S. , Pompeu , R. , Rosenthal , D. ( 2007 ). Noninvasive evaluation of late anthracycline cardiac toxicity in childhood cancer survivors . J. Clin. Oncol. 25 : 3635 – 3643 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), with one of the objectives to estimate the cumulative incidence rates along with specific interest in fixed-term (5 or 10 year) rates. We present inference procedures based on current status data to our motivating example with very interesting findings.     

Likelihood based inference for the ratio of gamma means

Inference concerning the ratio of two means based two independent two-parameter gamma models with common shape parameter was examined in Booth et al. (1999 Booth, J. G., Hobert, J. P. and Ohman, P. A. (1999). On the probable error of the ratio of two gamma means. Biometrika, 86: 439–452.  [Google Scholar]) and a computationally intensive bootstrap calibration method was developed. In this paper, a likelihood based method is proposed for small sample inference about the ratio of two means of the two-parameter gamma models when the shape parameters may or may not be equal. The proposed method is very simple to use and, as illustrated in simulation studies, gives extremely accurate results.     

Monotone Log-Odds Rate Distributions in Reliability Analysis

Abstract

Monotone failure rate models [Barlow Richard, E., Marshall, A. W., Proschan, Frank. (1963 Barlow Richard, E., Marshall, A. W. and Proschan, Frank. 1963. Properties of probability distributions with monotone failure rate. Annals of Mathematical Statistics, 34: 375–389.  [Google Scholar]). Properties of probability distributions with monotone failure rate. Annals of Mathematical Statistics 34:375–389, and Barlow Richard, E., Proschan, Frank. (1965 Barlow Richard, E. and Proschan, Frank. 1965. Mathematical Theory of Reliability New York: John Wiley.  [Google Scholar]). Mathematical Theory of Reliability. New York: John Wiley & Sons, Barlow Richard, E., Proschan, Frank. (1966a Barlow Richard, E. and Proschan, Frank. 1966a. Tolerance and confidence limits for classes of distributions based on failure rate. Annals of Mathematical Statistics, 37(6): 1593–1601.  [Google Scholar]). Tolerance and confidence limits for classes of distributions based on failure rate. Annals of Mathematical Statistics 37(6):1593–1601, Barlow Richard, E., Proschan, Frank. (1966b Barlow Richard, E. and Proschan, Frank. 1966b. Inequalities for linear combinations of order statistics from restricted families. Annals of Mathematical Statistics, 37(6): 1574–1592.  [Google Scholar]). Inequalities for linear combinations of order statistics from restricted families. Annals of Mathematical Statistics 37(6):1574–1592, Barlow Richard, E., Proschan, Frank. (1975 Barlow Richard, E. and Proschan, Frank. 1975. Statistical Theory of Reliability and Life Testing New York: Holt, Rinehart and Winston, Inc..  [Google Scholar]). Statistical Theory of Reliability and Life Testing. New York: Holt, Rinehart and Winston, Inc.] have become one of the most important models of failure time for reliability practitioners to consider and use. The above authors also developed models and bounds for monotone increasing failure rates (IFR) and for monotone decreasing failure rates (DFR). The IFR models and bounds appear to be especially useful for describing and bounding the hazard of aging. This article extends a new model for time to failure based onthe log odds rate [Zimmer William, J., Wang Yao, Pathak, P. K. (1998 Zimmer William, J., Wang, F. K. and Keats, J. Bert. 1998. The Burr XII distribution in reliability analysis. Journal of Quality Technology, 30(4): 386–394.  [Google Scholar]). Log-odds rate and monotone log-odds rate distributions. Journal of Quality Technology 30(4):376–385.] which is comparable to the model based on the failure rate. It is shown that in the case of increasing log odds rate (ILOR) in terms of log time (ln t), the model is less stringent than the IFR model for aging. The characterization of distributions of failure time by log odds rate is also derived. It is shown that the logistic distribution has the property of constant log odds rate over time and that the log logistic distribution has the property of constant log odds rate with respect to ln t. Some other properties of ILOR distributions are presented and bounds based on the relationship to the log logistic distribution are provided for distributions which are ILOR with respect to ln t. Motivational examples are provided. The ILOR bounds are compared to the more stringent bounds based on the IFR model. Bounds on system reliability are also provided for certain systems.