首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 687 毫秒
1.
Oil and gas exploration and production activities are carried out in hazardous environments in many parts of the world. Recent events in the Gulf of Mexico highlight those risks and underline the importance of considering human factors during facility design. Ergonomic factors such as machinery design, facility and accommodation layout and the organization of work activities have been systematically considered over the past twenty years on a limited number of offshore facility design projects to a) minimize the occupational risks to personnel, b) support operations and maintenance tasks and c) improve personnel wellbeing. During this period, several regulators and industry bodies such as the American Bureau of Shipping (ABS), the American Society of Testing and Materials (ASTM), the UK's Health and Safety Executive (HSE), Oil and Gas Producers (OGP), and Norway's Petroleum Safety Authority (PSA) have developed specific HFE design standards and guidance documents for the application of Human Factors Engineering (HFE) to the design and operation of Oil and Gas projects. However, despite the existence of these guidance and recommended design practise documents, and documented proof of their value in enhancing crew safety and efficiency, HFE is still not well understood across the industry and application across projects is inconsistent. This paper summarizes the key Oil and Gas industry bodies' HFE guidance documents, identifies recurring themes and current trends in the use of these standards, provides examples of where and how these HFE standards have been used on past major offshore facility design projects, and suggests criteria for selecting the appropriate HFE strategy and tasks for future major oil and gas projects. It also provides a short history of the application of HFE to the offshore industry, beginning with the use of ASTM F 1166 to a major operator's Deepwater Gulf of Mexico facility in 1990 and the application of HFE to diverse world regions. This latter point highlights the need to consider user populations when selecting HFE design criteria, an aspect strongly emphasized in current industry guidance.  相似文献   

2.
The measurement of walkway slip resistance is required to assess the risk of slipping. Unlike other countries, the U.S. has not decided upon a single approach to the measurement of slip resistance. Several types of tribometers are available to measure slip resistance however, the measured value of the slip resistance of a given surface has been found to be tribometer specific. The introduction of ASTM International Standard F2508 Standard Practice for Validation and Calibration of Walkway Tribometers Using Reference Surfaces, has produced a method which allows validation of each type of tribometer and the values generated during testing.  相似文献   

3.
Testosterone is the predominant gonadal androgen in men. Low testosterone levels are found to be associated with an increased in metabolic risk and systematic inflammation. Since adipose tissue is a source of inflammatory cytokines, testosterone may regulate inflammation by acting on adipose tissue. This review aimed to explore the role of testosterone in inflammation and its mechanism of action. Both animal studies and human studies showed that (1) testosterone deficiency was associated with an increase in pro-inflammatory cytokines; (2) testosterone substitution reduced pro-inflammatory cytokines. The suppression of inflammation by testosterone were observed in patients with coronary artery disease, prostate cancer and diabetes mellitus through the increase in anti-inflammatory cytokines (IL-10) and the decrease in pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). Despite these, some studies also reported a non-significant relationship. In conclusion, testosterone may possess anti-inflammatory properties but its magnitude is debatable. More evidence is needed to validate the use of testosterone as a marker and in the management of chronic inflammatory diseases.  相似文献   

4.
The ability to compare the genetics of aging in multiple model organisms is a powerful tool to dissect the biology of aging. Although the fruit fly has only about half again as many genes as the nematode worm, its tissue organization is much more complex. The emerging importance of tissue specificity and endocrine signaling in aging makes the fly a natural choice for many researchers interested in unraveling the next level of complexity of the aging process. This Perspective provides an overview of research related to aging that was described at the annual Drosophila conference held in Chicago in March 2003.  相似文献   

5.
$\underline{Objective}$: Investigate effects of interactions between biomechanical, psychosocial and individual risk factors on the body's immune inflammatory responses. $\underline{Background}$: Current theories for low back pain causation do not fully account for the body's response to tissue loading and tissue trauma. $\underline{Methods}$: Two groups possessing a preference for the sensor or intuitor personality trait performed repetitive lifting combined with high or low mental workload on separate occasions. Spinal loading was assessed using an EMG-assisted subject-specific biomechanical model and immune markers were collected before and after exposure. $\underline{Results}$: Mental workload was associated with a small decrease in AP shear. Both conditions were characterized by a regulated time-dependent immune response making use of markers of inflammation, tissue trauma and muscle damage. Intuitors' creatine kinase levels were increased following low mental workload compared to that observed in Sensors with the opposite trend occurring for high mental workload. $\underline{Conclusions}$: A temporally regulated immune response to lifting combined with mental workload exists. This response is influenced by personality and mental workload.  相似文献   

6.
The most striking age-related change in the human adrenal cortex is the decline in secretion of dehydroepiandrosterone and its sulfate, steroids synthesized by the inner zone of the cortex, the zona reticularis. Because these steroids are of essentially unknown function, the importance of this age-related change is the subject of considerable debate. It is likely that the age-related change in these steroids results from loss of zona reticularis cells or impairment of their function. During aging, cumulative damage to the zona reticularis could occur through ischemia-related infarcts and other causes of cell death. Cellular senescence could contribute to a loss of the ability of the tissue to replace lost cells. In contrast, feedback mechanisms that regulate adrenocortical growth cause compensatory local tissue hyperplasias called nodules. The effect of imperfect repair of damage combined with compensatory overgrowth in the form of nodules leads to an increasingly abnormal tissue architecture.  相似文献   

7.
Cartilage aging can contribute to the development of osteoarthritis (OA), the most common cause of chronic pain and disability in older adults. Articular cartilage is a unique tissue from the perspective of aging in that the cells (chondrocytes) and the majority of the extracellular matrix proteins experience little turnover, resulting in a tissue that must withstand years of use and can also accumulate years of aging-associated changes. Accumulation of advanced glycation end products (AGEs) occurs in cartilage, and the potential role of AGEs in the development of OA is being investigated. An age-associated reduction in growth factor signaling and an increase in oxidative stress may also play an important role in the age-OA connection. Further elucidation of mechanisms that affect chondrocyte function with aging should lead to novel interventions designed to slow the aging process in cartilage with the goal of preventing age-associated OA.  相似文献   

8.
SUMMARY. The following is an account of a research project exploring the recollections of seven fathers at the time of the birth of their children with Down's Syndrome. It discusses the disclosure of diagnosis and subsequent contacts the fathers made both professionally and socially during the period following both in the hospital and at home. This is combined with the personal recollections of one father, not part of the original study, whose child was born with special needs. The implications for both professional practice and fathers are highlighted. Whilst there is an acknowledgement that the project was small scale, the conclusions will raise challenging issues for further discussion both among professionals and individual members of families.  相似文献   

9.
《The aging male》2013,16(2):65-74
The aim of the study was to evaluate the independent ‘net’ effects of hormonal variables (estradiol, free testosterone and dehydroepiandrosterone sulfate (DHEAS) levels) and lifestyle variables (alcohol consumption, coffee drinking, cigarette smoking, physical activity and muscle strength) on trabecular, cortical and total bone mineral content (BMC) in a group of 236 healthy males, aged 22–67 years. The men were occupationally active inhabitants of the city of Wroclaw, Lower Silesia, Poland. Trabecular, cortical and total bone mineral content, at the distal radius of the non-dominant hand, were assessed by peripheral quantitative computed tomography (pQCT) using the Stratec 960 apparatus. Sex steroids levels were measured using standard immunoassays. Data on lifestyle variables (alcohol consumption, cigarette smoking, coffee drinking and physical activity) were obtained through a questionnaire. Hand-grip strength of the dominant hand was assessed using a standard dynamometer. All statistical analyses were made separately in two subgroups, younger males (aged 22–39 years) and older males (aged 40 years and over). The impact of a particular independent variable on BMC and the extent of determination on BMC by the complex of chosen variables were evaluated using a path analysis. In younger males, the effects of physical activity and muscle strength were the most important among all the factors that influenced BMC, as they contributed to 16.2%, 16.9% and 16.5% of the variability of trabecular, cortical and total BMC, respectively. Taking into consideration cigarette smoking, alcohol and coffee drinking together, the coefficients of determination of the variability in trabecular, cortical and total BMC were 10.6%, 11.3% and 16.1%, respectively. The variances in trabecular, cortical and total BMC levels were determined in only 5.8%, 11.5% and 13.0% by sex steroids, respectively. The influence of free testosterone on trabecular BMC was greater compared with that of dehydroepiandrosterone sulfate (DHEAS) and estradiol; for cortical BMC, the impacts of estradiol and DHEAS were similar and greater than that of free testosterone, and the variability of total BMC was affected mainly by estradiol. In contrast, in older men the effects of physical activity and muscular strength were the least important among all the complexes of independent variables, as they contributed to 4.5%, 7.8% and 7.0% of the variability in trabecular, cortical and total BMC, respectively. Taking into consideration the influences of cigarette smoking, alcohol and coffee drinking, the coefficients of determination of the variability in trabecular, cortical and total BMC were 16.5%, 14.8% and 17.4%, respectively. Among the older men, the variances in trabecular, cortical and total BMC were determined in only 9.4%, 6.3% and 13.6% by sex steroid levels, respectively. The influence of DHEAS on trabecular BMC was greater when compared with that of estradiol and free testosterone, whereas the variability of both cortical and total BMC in older men was affected mainly by estradiol. It is quite striking that, in younger healthy subjects, both physical activity and muscle strength contributed to a greater extent to BMC variance when compared with sex steroids levels, whereas, in older men, physical activity and muscular strength were less important than androgen- estrogen activity in determining the variability of BMC. This may suggest that the tropic effect of mechanical force influences bone structure mainly in younger men; probably male bone tissue becomes less prone to mechanical stimuli during aging. It is astonishing that both in younger and older men the coefficients of determination of physical activity and muscle strength were the highest for cortical BMC, which would indicate the greatest response of that part of the bone tissue to mechanical force. It is worth noting that the coefficients of determination of the complex of lifestyle factors (alcohol consumption, cigarette smoking and coffee drinking) were higher in older men compared to younger Polish males. This can be explained by the longer exposure of male bone to environmental influences (ethanol, nicotine, caffeine) during a lifetime. Our study revealed that all the evaluated variables were related to the variability in BMC in healthy Polish men, but the coefficients of determination differed depending on the age of the examined subject and on the BMC of a particular bone component. This suggests that the responsiveness of male bone tissue to environmental factors changes with age, and that these effects vary significantly between particular parts of the male bone structure.  相似文献   

10.
11.
This paper describes the evolution of a university–community child welfare learning collaborative based on an adaptation of the teaching hospital concept. This partnership between an agency providing a range of child and family welfare services and two university units, the school of social work and outreach, was intended to accomplish multiple agency, university and community goals: implement best practices in the agency, enhance social work education, increase staff resources in child welfare, influence public policy, and improve the lives of children and families in the child welfare system. The major strategy was ‘Grand Rounds’ modeled after the system used to train medical students through multiple transactions with experts in a clinical setting. The first year was very successful, with students, agency staff and faculty giving the sessions high ratings in content, quality and utility. One key to the success of the initiative was that it was an agency‐driven process and was based on working relationships of mutual respect and trust. Building such relationships takes both time and effort. Future challenges will include garnering the resources, both human and financial, to sustain the collaboration over time.  相似文献   

12.
The effect of dysphoria on husbands' and wives' later marital adjustment was examined in a sample of 264 white couples about to marry who responded to advertisements. Relationship satisfaction and level of dysphoria were assessed in both spouses prior to marriage, 6 months after marriage, and 18 months after marriage. Premarital dysphoria was associated with later marital dissatisfaction. Husbands' premarital dysphoria, regardless of chronicity, was associated with greater deterioration in both their own and their partners' marital satisfaction. Wives' premarital dysphoria was associated with greater deterioration in marital satisfaction only if it was chronic. Results suggest that premarital dysphoria is associated with subsequent deterioration of marital relationships.  相似文献   

13.
The Eugenic Protection Law, which regulated sterilisation and abortion in Japan, had two aspects: one was to prevent the birth of people with specific diseases and impairments, and the other was to permit women to have an abortion for specified reasons. This law was criticised by both disabled people and feminists, and finally amended in 1996. Another eugenic practice related to both disabled people and women is prenatal screening. One prenatal diagnostic check, serum screening is a simple blood test carried out on the mother with little risk and no need for sophisticated techniques. It became very widespread in Japan around 1996 and was used with too little thought. As a result, it led to controversy. This paper discusses Japanese eugenics by reference to the Eugenic Protection Law and prenatal screening from the standpoint of both women and disabled people.  相似文献   

14.
The relationship between premarital cohabitation and marital dysfunction was examined with a total sample of 1,425 spouses in two U.S. marriage cohorts: those married between 1964 and 1980 (when cohabitation was less common) and those married between 1981 and 1997 (when cohabitation was more common). Spouses in both cohorts who cohabited prior to marriage reported poorer marital quality and greater marital instability. When selection factors for cohabitation and subsequent marital instability were included in the statistical model, cohabitors in both cohorts continued to exhibit poorer marital quality and greater marital instability. These findings lend stronger support to an experience of cohabitation perspective than to a selection perspective as an explanation for why couples who cohabit before marriage tend to have more troubled relationships.  相似文献   

15.
Mitochondrial defects have been related to obesity and prostate cancer. We investigated if Mexican–Mestizo men presenting this type of cancer, exhibited somatic mutations of ATP6 and/or ND3.Body mass index (BMI) was determined; the degree of prostate cancer aggressiveness was demarcated by the Gleason score. DNA from tumor tissue and from blood leukocytes was amplified by the polymerase chain reaction and ATP6 and ND3 were sequenced. We included 77 men: 20 had normal BMI, 38 were overweight and 19 had obesity; ages ranged from 52 to 83. After sequencing ATP6 and ND3, from DNA obtained from leukocytes and tumor tissue, we did not find any somatic mutations. All changes observed, in both genes, were polymorphisms. In ATP6 we identified, in six patients, two non-synonymous nucleotide changes and in ND3 we observed that twelve patients presented non-synonymous polymorphisms. To our knowledge, this constitutes the first report where the complete sequences of the ATP6 and ND3 have been analyzed in Mexican–Mestizo men with prostate cancer and diverse BMI. Our results differ with those reported in Caucasian populations, possibly due to ethnic differences.  相似文献   

16.
In this article a White Jewish-American therapist shares what she learned from her work with an African-American couple using a semi-structured protocol for planned short-term marital therapy. Twenty-eight months after the original treatment, the author met again with the couple for an audiotaped follow-up interview. Marital satisfaction for both partners was tracked with an Index of Marital Satisfaction over the course of the treatment and the follow-up process. The empirical findings augment the story of the couple and the therapist. During the middle phase, the therapy reached an impasse. With the goal of creating a cognitive shift, the therapist used the couple's culture as a resource for therapeutic change. The cultural metaphor is considered as the vital step in overcoming the treatment impasse. The major finding is that cultural responsiveness does not end with the engagement and assessment of clients. The culture of the clients and the culture of the therapist provide powerful metaphors and rich resources to introduce change possibilities. With this couple, when culture was combined with an appreciation of the intersubjective meanings for both clients and therapist, culturally responsive and effective therapy became possible.  相似文献   

17.
Gunilla Stenberg 《Infancy》2013,18(5):873-904
Why infants prefer to look at and use information provided by some informants over others was examined in four experiments. In each experiment, 52 12‐month‐old infants participated. In Experiment 1, a familiar expert and a familiar nonexpert and in Experiment 2, a novel expert and a novel nonexpert presented an ambiguous object and provided positive information. In both experiments, the infants preferred to look at the expert and regulated their behavior more in accordance with positive information provided by the expert, regardless of she was novel or more familiar. In Experiment 3, a familiar expert and a familiar nonexpert and in Experiment 4, a novel expert and a novel nonexpert presented an ambiguous object and provided negative information. In both experiments, the infants looked more at the expert and regulated their behavior more in accordance with negative information provided by the expert, regardless of she was novel or more familiar. The results support an expertise perspective of infant behavior in social‐referencing situations.  相似文献   

18.
It is well known that people that sit or lie down for prolonged periods change their posture on a regular basis. Even when people are asleep on average 20-40 postural can be observed during an 8 hours period of night rest. One of the reasons that can be found in literature for this 'urge to move' is that these movements are necessary to persevere the blood flow in the tissue. The aim of this paper is to study the relation between tissue perfusion and pressure on the tissue and frequency of the load cycle. Each subject is subjected to a treatment scheme that varies in pressure and frequency of the load on the tissue. The pressure levels that are used are 2.7 kPa, 4.0 kPa and 5.3 kPa and the frequency levels that are used are loading/unloading at intervals of 5 min., 10 min., 15 min. Statistics shows that for 2.7 kPa there is a significant reduction of blood flow between time intervals of 5 min. and 10 min. (P=0.028), and 5 min. and 15 min. (p=0.009). Statistics also shows that there is no significant reduction in blood flow at the time interval of 10 minutes, for every level of pressure. This series of measurements seems to suggest that at the time interval of 10 minutes for every level of pressure the blood flow does not decrease compared to the start situation.  相似文献   

19.
The presence of large numbers of Protestants within the nineteenth century Irish exodus to the USA ensured that the integrity of the Orange/Green dispute continued in the adopted homeland. The Catholic majority amongst Irish immigrants was nevertheless a minority within Protestant American society. The struggle between Orange and Green in New York thus gave each faction both a majority and a minority status. Fear of Catholicism within America meant that the commonality between Irish Orangemen and native born Protestants was a classic example of an internal ethnic dispute having a relevance to the whole society. This common Protestantism was able to straddle, to an extent, the ethnic barrier. The clash between Fenians and Orangemen in New York thus gained an inflated significance for both state and national politics.  相似文献   

20.
Post-qualifying courses for social workers offer unique access to large numbers of practising social workers. Therefore, they present an opportunity to gather research data about current practice concerns. Asking students on post-qualifying courses to take part in research activity can also enable reflections upon the links between research and practice. However, ideally, any research activity should also contain an educational element so that students will directly gain from taking part. This paper describes a study in which Q-sort methodology was used as a method of both gathering data and as an educational tool. The study was an exploration of the links between views about both 'good enough' parenting and decision-making in child care and protection work. Subjects were students attending post-qualifying child protection courses. The methodology was successful both in gathering meaningful data and in stimulating lively debate about the issue. This paper will describe the study, briefly set out the research findings and discuss the advantages of the methodology as an educational tool.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号