Growth hormone in anti-aging medicine: a critical review

Insulin-like growth factor 1 (IGF-1) signaling modulation has been associated with increased lifespan in model organisms, while high levels of circulating interleukin-6 (IL-6) are a marker of disability and mortality. In the prospective, population-based “Treviso Longeva”? TRELONG Study from Italy (n?=?668, age range 70–105.5 years at baseline, followed for seven years) we investigated the effects of survival on the IGF-1 receptor (IGF-1R) gene polymorphism rs2229765, the IL-6 gene promoter polymorphism rs1800795, and plasma concentrations of IGF-1 and IL-6, alone or in combination. We found a sex-dependent effect for the IGF-1R rs2229765 polymorphism, as male carriers of the homozygous A/A genotype survived longer, while the IL-6 rs1800795 genotype did not influence overall or sex-specific longevity. Higher IL-6 levels were more detrimental for survival among males than females, while IGF-1 had no dose–response effect. These findings sustain the hypothesis that sex-specific longevity relies on detectable differences in genetic and biochemical parameters between males and females.     

Murine models of life span extension

Mice are excellent experimental models for genetic research and are being used to investigate the genetic component of organismal aging. Several mutant mice are known to possess defects in the growth hormone/insulin-like growth factor 1 (GH/IGF-1) neurohormonal pathway and exhibit dwarfism together with extended life span. Their phenotypes resemble those of mice subjected to caloric restriction. Targeted mutations that affect components of this pathway, including the GH receptor, p66Shc, and the IGF-1 receptor (IGF-1R), also extend life span; mutations that affect IGF-1R or downstream components of the pathway decouple longevity effects from dwarfism. These effects on life span may result from an increased capacity to resist oxidative damage.     

Gender differentials in poverty-mortality well-being

"This paper explores the application of a life table approach to the analysis of poverty [in the United States]. After reviewing trends in gender differentials in poverty and mortality, we investigate an indicator of poverty-mortality well-being. The rationale for this approach is that to some extent poverty and mortality are causally interrelated phenomena which are both fundamental to well-being. The empirical results indicate that females are expected to live more years in poverty than are males, but females are expected to live more years in nonpoverty as well. Although the gender differential in poverty rates has increased to the disadvantage of females, and although most of the greater poverty of females cannot be attributed to their greater longevity, the gender differential in poverty-mortality well-being has nonetheless not deteriorated to the disadvantage of women in recent decades."     

Why females live longer than males: control of longevity by sex hormones

Females live longer than males in many species, including humans. We have traced a possible explanation for this phenomenon to the beneficial action of estrogens, which bind to estrogen receptors and increase the expression of longevity-associated genes, including those encoding the antioxidant enzymes superoxide dismutase and glutathione peroxidase. As a result, mitochondria from females produce fewer reactive oxygen species than those from males. Administering estrogens has serious drawbacks, however--they are feminizing (and thus cannot be administered to males) and may increase the incidence of serious diseases such as uterine cancer in postmenopausal women. Phytoestrogens, which are present in soy or wine, may have some of the favorable effects of estrogens without their undesirable effects. Study of gender differences in longevity may help us to understand the basic processes of aging and to devise practical strategies to increase the longevity of both females and males.     

Characteristics of cocaine users in a private inpatient treatment setting.

Patient records were reviewed from an eighteen-month period of a private hospital adult addictive disease unit. Of 667 consecutive admissions, sixty-five (49 males, 16 females) were diagnosed with cocaine abuse or dependence; 38 percent were from rural areas. Although mean age of males and females was similar, males had a longer duration of use (8.2 years versus 5.8 years), however, females used an average of 14 grams per week versus 9.5 grams per week for males. African-American patients were over-represented among the cocaine using sample and also among the sample who chose smoking as their route of administration. A larger percentage of males had legal problems and admitted to "dealing," when compared to females. Those from rural areas were more likely to be married and less apt to have legal problems.     

Does anti-aging equal anti-microbial?

Aging is the dominant risk factor for human disease in developed countries. Could it be that a wide variety of disease states all have their origins in a common mechanism? Major signaling pathways that determine the rate of aging, such as the insulin/insulin-like growth factor 1 (IGF-1) pathway, might give clues to the nature of this major disease risk factor. It has now been shown that insulin/IGF-1 signaling influences Caenorhabditis elegans resistance to bacteria in such a way that long-lived worms are stress-resistant and slow to succumb to infection. Perhaps enhanced innate immunity is a feature of genetically determined longevity.     

Gene expression of insulin receptor,insulin-like growth factor increases and insulin-like growth factor-binding protein-3 reduces with increase in prostate size in benign prostatic hyperplasia

Introduction: Although the role of insulin in the development of benign prostatic hyperplasia (BPH) is well established, there are no studies regarding alteration in the gene expression of components of insulin-signaling pathway and their association with prostate size in BPH. Hence, the study was designed to analyze the gene and protein expression of insulin receptor and its related components in patients with BPH.

Materials and methods: Twenty-seven BPH patients aged between 55 and 75 years were recruited in the study and prostatic tissues were obtained after transurethral resection of the prostate. Gene expression levels of Insulin receptor (IR), insulin receptor substrate (IRS), insulin-like growth factor (IGF) and insulin-like growth factor-binding protein-3 (IGFBP-3) were assessed by q-PCR.

Results: Insulin receptor (IR-A and B) and insulin-like growth factors (IGF-1 and IGF-2) gene expression were significantly increased and IGFBP-3 gene expression was reduced in BPH patients with larger prostate size. Also, serum insulin was significantly increased and IGFBP-3 was significantly reduced in patients with larger prostate size.

Conclusion: Increased expression of IR-A, B and IGF-1, 2 genes and reduced IGFBP-3 gene expression was associated with larger prostate size in BPH.     

Updates of the Prevalence of Problem Gambling in Romanian Teenagers

The aim of this study was to find out what is the prevalence of pathological in Romanian teenagers. We questioned one thousand thirty-two teenagers in Cluj-Napoca and Harghita counties. Participants completed a questionnaire with 40 items including gamblers anonymous twenty questions. The sample included teenagers aged 11–19 years; 65.57% were male and 34.43% were female. The subjects were divided into three groups: non-gambling/recreational gambling or occasional gambling (0–1 positive answers —Level 1)—753 subjects (72.96%) [316 females and 437 males]; problem gambling (2–6 points—Level 2)—243 subjects (23.54%) [43 females and 200 males]; pathological gambling (above 7 points—Level 3)—36 subjects (3.48%) [3 females and 33 males]. The mean age of pathological gamblers was 16.48 years. Gender differences were as expected, males engaging in pathological gambling (91.66% from pathological gamblers) more than females did (8.33% from pathological gamblers). Data revealed that the most encountered games practiced weekly were sport bets and slot machines in the case of 36.11% of the pathological gamblers; lotto, internet casino and pool bets each with 25%, followed by roulette and black-jack with 22.22%.From those who reported practicing gambling at a pathological level 66.66% engaged in alcohol consumption, 13.88% illicit drug use and 19.44% licit drugs. Just 16.66% smoke cigarettes. Data revealed higher rates of prevalence in Romanian teenagers than in other Central and Eastern European countries. A prevalence study at a national level should be designed.     

The political economy of urban homicide: assessing the relative impact of gender inequality on sex-specific victimization

This research examines the ways in which the changing political economy of urban areas has contributed differently to the homicide victimization rates of females and males across US cities. Recent research, while relatively limited, has presented disparate results regarding the effect of gender inequality on urban sex-specific victimization. Our work further explores this relationship by taking into account relative gender disparities in income, education, labor market opportunities, and politics in an examination of sex-specific homicide victimization in 1990. Key to this current investigation is the evaluation of feminist and lifestyle arguments that suggest that structural gender inequality has a unique effect on female victimization. Overall, our findings reveal gender inequality to be a significant predictor of both male and female urban homicide. While these findings suggest mixed support for theoretical arguments regarding gender inequality, further analyses reveal significant differences in specific types of gender inequality on victimization patterns across genders. These additional results highlight the need for greater attention toward both methodological and theoretical issues when examining the interconnections between gender, political economy, and violence in research.     

Sex-specific effects of interventions that extend fly life span

Genetic and environmental interventions that extend life span are a current focus in research on the biology of aging. Most of this work has focused on differences among genotypes and species. A recent study on fruit flies shows that life span extension because of dietary restriction can be highly sex-specific. Here we review the literature on sex-specific effects of 56 genetic and 41 environmental interventions that extend life span in Drosophila melanogaster. We found that only one-sixth of the experiments provided statistical tests of differences in response between males and females, suggesting that sex-specific effects have been largely ignored. When measured, the life span extension was female-biased in 8 of 16 cases, male-biased in 5 of 16 cases, and not significantly different in only 3 of 16 cases. We discuss possible explanations for the sex-specific differences and suggest various ways in which we might test these hypotheses. We argue that understanding sex differences in the response to life span-extending manipulations should lead to new insights about the basic mechanisms that underlie the biology of aging in both sexes.     

The Driving Vengeance Questionnaire (DVQ): the development of a scale to measure deviant drivers' attitudes

The Driving Vengeance Questionnaire (DVQ) was developed and administered to assess drivers' use of vengeance when faced with common driving situations. Subjects in the development of the scale were 266 male and female university students. The scale was then administered to 271 university students (both male and female) and 74 male inmates who were classified as either violent or nonviolent offenders on the basis of the amount of force used in committing the offence. A Cronbach alpha of .83 (M = 40.76, n = 310) indicated a high level of internal consistency for the DVQ. Younger drivers (18-23 years old) indicated higher levels of vengeance while driving than did older drivers (24-66 years old, M = 44.35 and 37.81, respectively). Those with less driving experience (0-6 years) expressed higher levels of vengeance while driving than more experienced drivers (6+ years, M = 42.95 and 38.81, respectively). Male drivers responded with greater vengeance to the questionnaire items than females (M = 42.07 and 39.62, respectively). The level of force used in commission of crime failed to correlate with the DVQ. A factor analysis was performed with a different sample of subjects using a slightly modified version of the DVQ to deal with the issue of whether horn honking constituted an appropriate measure of aggression. When the two relevant DVQ items were changed to read "leaning on horn" rather than mere honking, a strong, single factor of vengeance was found to characterize the scale. Suggestions were made for the use of DVQ in the screening of driving license applicants and in the study of problem drivers.     

Personal space invasions: What happens when the invader asks permission?

Male or female college students seated outdoors and alone on a university campus were approached by a same-sexed invader who sat 9 inches or 18 inches away. The invader asked permission before sitting down or said nothing. An unobtrusive observer recorded (1) the amount of time before subjects left and (2) the presence of compensatory reactions (moving away, interposing barriers, orienting away, leaning away, or leaning forward). Results showed that males left more quickly with silent invaders; females tended to leave more quickly if permission was asked. Compensation was greatest among closely invaded subjects who remained in their seats longest (males who were asked; females who were not asked). These findings agree with equilibrium theory. They have implications for the concept of personal space.This paper was presented at the 1976 conference of the American Psychological Association in Washington, D.C.The authors would like to thank Andy Derryberry, Cheryl Haley, Jeffrey Lewis, and Patricia Seipp for acting as invaders.     

Relationship functioning and sexuality among people with multiple sclerosis

This study was concerned with how the sexuality and relationships of people with Multiple Sclerosis (MS) are different from those of people from the general population. Three‐hundred eighty‐one respondents (144 males, 237 females) with MS and 291 respondents (101 males, 190 females) from the general population participated in the study. Sexual satisfaction, sexual dysfunction, relationship satisfaction, and coping style were assessed among all respondents. Information was also obtained from people with MS regarding age of onset and diagnosis of symptoms, as well as severity of symptoms. Overall, males with MS experienced a higher frequency of sexual dysfunction than males from the general population, while females with MS only differed from females from the general population in their levels of masturbation and numbness of the genital area. Coping strategies and levels of cognitive functioning were important predictors of sexual satisfaction, sexual dysfunction, and relationship satisfaction for women with MS, but there were fewer coping or health‐related factors that predicted these variables among men with MS. The results of this study are discussed in terms of factors related to sexual satisfaction and positive interpersonal relationships. There is a need to conduct further research in this area so that professionals working with people with MS are informed on strategies to improve the sexuality and relationships of their clients' lives.     

Effects of a multimodal exercise program in pedal dexterity and balance: study with Portuguese older adults of different contexts

This study investigated the effects of a multimodal exercise program (MEP) on pedal dexterity and balance in two groups of older adult participants (65–92 years of age) from a psychiatric hospital center (HC), a residential care home (RCH), and a daily living center (DLC). The experimental group (EG) trained three times per week for 12 months, and the control group (CG) maintained their normal activities. The Mini-Mental State Examination and the Modified Baecke Questionnaire, as well as the Pedal Dexterity and the Tinetti tests, were applied to all subjects before and after the experimental protocol. Furthermore, the foot preference was controlled using the Lateral Preference Questionnaire proposed by Coren [10]. In the EG, the results from the Pedal Dexterity test showed that both males and females from the RCH and DLC improved their performances after the MEP. In the HC, the males slightly decreased their performance with both feet, contrarily to females. Both males and females from the CG decreased their pedal dexterity performance, namely, with the non-preferred foot. Concerning the Tinetti test, the EG of both males and females from the HC, the RCH (males were better than females regarding the gender factor), and the DLC improved their balance after the MEP. In the CG, no significant effects or interactions were found for any of the context groups.     

Sex differences in empathy and its relation to juvenile offending

Implicit in most theoretical accounts of sex differences in offending is the assumption that females are less likely than males to engage in crime--especially serious, violent crime--in part because of their comparatively higher levels of concern for others and stronger affiliative ties. Much research suggests that significant sex differences in both empathy and serious offending emerge in adolescence, with females displaying notably higher levels of empathy and males engaging in notably higher levels of serious offending. However, there has been little empirical work assessing the degree to which sex differences in empathy among adolescents can account for sex differences in offending. This research uses data from a sample of adolescents attending public high schools in Philadelphia (n = 425) and a sample of adolescents incarcerated in the California Youth Authority (CYA) (n = 232) to examine the relation between empathy and serious offending. Results suggest that empathy acts as a protective factor for both males and females but that there are subtle differences among males and females in the relation between empathy and offending.     

Raccoon use of the urban matrix in the Baltimore Metropolitan Area, Maryland

The raccoon is often considered a synanthropic species; however, most urban research on this species has been restricted to urban parks or green spaces. Little is known about the persistence of synanthropic characteristics in the raccoon within the urban matrix. We examined density, den selection, home range size, habitat selection, and survival for adult raccoons (Procyon lotor) during summer (June?CAugust) and autumn (September?CNovember) in two residential neighborhoods, Linthicum located inland, and Riviera Beach on a peninsula in the Potomac river, in Southern Maryland. Den site selection varied by gender (P?=?0.0002) and study site (P?=?0.052), and study site interacted with gender (P?=?0.0063), with female raccoons denning preferentially on the ground and male raccoons in human structures in Riviera Beach while in Linthicum females denned preferentially in trees and males avoided human structures. Seasonal home range size was larger for males (P?<?0.0001) than females at both sites. Habitat selection varied at different hierarchical levels, and between gender, season and site. Intersite differences in habitat selection were apparent at the second order and third order scale. Aquatic and urban habitat was ranked high and woodland consistently lowest in second order scale at Riviera Beach while urban habitat was consistently ranked lowest at Linthicum where woodland ranked highest. Between the hierarchal scales (2nd and 3rd order) a difference in habitat selection occurred at Linthicum only where urban habitats ranked lowest at 3rd order. The differences in patterns of habitat selection we observed between two urban sites at different hierarchical scales suggest that resource selection is dependent upon the specific characteristics of the site and that raccoons exhibit variable responses to changes in landscape features. Finally, male survival tended to be lower (P?=?0.079) than female survival in both study sites. Our results reveal that raccoons can continue to exhibit synanthropic characteristics within the urban matrix even in areas with little natural habitat. This ability to adjust to different levels of development allows the raccoon to occur throughout most parts of the urban landscape, which has important management implications for human-raccoon conflicts and disease management.     

Gambling among Croatian young people: an exploratory study of the relationship between psychopathic traits,risk-taking tendencies and gambling-related problems

The present study investigated the relationship between psychopathic traits, risk-taking tendencies and gambling problem severity and if these associations varied by gender in a community sample of Croatian adolescents (N = 282; 148 males). Results of the regression analyses showed that the Impulsive-Irresponsible behavioural style (YPI-II) and the Grandiose-Manipulative interpersonal style (YPI-GM) were the strongest postdictors of gambling-related problems. Surprisingly, independently of the YPI-II dimension, the Callous-Unemotional traits were negatively associated to gambling-related problems. By, contrast, independently of the psychopathic traits, risk-tendencies were not significant postdictors of gambling problem severity. With respect to gender differences, higher levels of the YPI-II and YPI-GM dimensions were related to more severe gambling-related problems only in males, not in females. Furthermore, while the CU traits exhibited protective features against gambling-related problems in both genders, the effect was stronger for males than for females.     

Suicide ideation,attempts and abuse among incarcerated gang and nongang delinquents

The present study examines suicide ideation and attempts as well as reported levels of physical and sexual abuse among gang and nongang-involved incarcerated youth. The self-report survey data were collected from 334 males and 61 females who were incarcerated in Nevada youth correctional facilities in the summer of 1994. Over half (58.3 percent) of the males and nearly half (45.2 percent) of the females reported being gang members. Surprisingly high rates of abuse (more than 70 percent for both physical and sexual abuse) were found among the incarcerated females of this study. Females reported significantly more suicide attempts and were more likely to have been physically and sexually abused than males. Nongang males reported significantly more suicide attempts and were more likely to report sexual abuse than gang-involved males. Among the gang-involved delinquents, females reported significantly more suicide attempts than males. In addition, gang members who reported sexual abuse were more likely to have higher levels of suicide ideationand to have attempted suicide. Implications for youth correction specialists and social workers are discussed.The data for this study were collected under Grant #000616 from the Nevada Agricultural Experiment Station.     

NEIGHBORHOOD CONTEXT AND THE GENDER GAP IN ADOLESCENT VIOLENT CRIME

Although researchers consistently demonstrate that females engage in less criminal behavior than males across the life course, research on the variability of the gender gap across contexts is sparse. To address this issue, we examine the gender gap in self-reported violent crime among adolescents across neighborhoods. Multilevel models using data from the Project of Human Development in Chicago Neighborhoods (PHDCN) indicate that the gender gap in violent crime decreases as levels of neighborhood disadvantage increase. Further, the narrowing of the gender gap is explained by gender differences in peer influence on violent offending. Neighborhood disadvantage increases exposure to peer violence for both sexes, but peer violence has a stronger impact on violent offending for females than for males, producing the reduction in the gender gap at higher levels of disadvantage. We also find that the gender difference in the relationship between peer violence and offending is explained, in part, by (1) the tendency for females to have more intimate friendships than males, and (2) the moderating effect of peer intimacy on the relationship between peer violence and self-reported violent behavior.