Subfield history: use of model organisms in the search for human aging genes

The National Institute on Aging (NIA) started a program in 1993 to identify genes involved in the regulation of longevity in a variety of species, including yeast, nematodes, fruit flies, and mice. The initial success of this program has attracted the interest of many investigators working with these organisms. Of primary interest are single-gene mutants that have identified genes and processes involved in longevity regulation across species. These processes include the insulin-like signaling pathway, stress resistance, and most recently, chromosome and nuclear architecture. Mutations in genes that regulate these processes indirectly are also being identified in this program. The ultimate goal of this program is to extend these results to humans to identify the major biological risk factors for age-related decline of function in human physiological systems.     

Briefly Noted

The National Institutes of Health (NIH) will award 12 grants to form the Justice Community Opioid Innovation Network (JCOIN) to support research on quality addiction treatment for opioid use disorder (OUD) in criminal justice settings nationwide, with a total of $155 million from the National Institute on Drug Abuse. One focus will be on finding new medications. There will be 10 research institutions and two centers. JCOIN is part of the NIH HEAL (Helping to End Addiction Long‐term) initiative launched last year. Funded institutions and the site locations are: the New York State Psychiatric Institute (New York), Baystate Medical Center (Massachusetts), Friends Research Institute Inc. (Maryland), Texas Christian University (Illinois, New Mexico, Texas), the New York University School of Medicine (Connecticut, Delaware, New Hampshire, New York, Oregon), Brown University (North Carolina, Pennsylvania, Rhode Island), the University of Chicago (Illinois), Chestnut Health Systems Inc. (Illinois), the University of Kentucky (Kentucky), and Yale University (Connecticut, Minnesota, New York, North Carolina, Puerto Rico). George Mason University in Fairfax, Virginia, will serve as the JCOIN coordination and translation center. For more information, go to https://www.nih.gov/research‐training/medical‐research‐initiatives/heal‐initiative/justice‐community‐opioid‐innovation‐network .     

NASADAD to NIDA: Connect research to practice

When the National Institute on Drug Abuse (NIDA) sought input on its five‐year plan, the people responsible for publicly funded prevention, treatment and recovery — state directors — called for returning to the days of communication between federal agencies like the Substance Abuse and Mental Health Services Administration (SAMHSA) and between NIDA researchers and the service delivery system. In an Aug. 7 letter to NIDA's strategic planning team, Robert I.L. Morrison, executive director of the National Association of State Alcohol and Drug Abuse Directors (NASADAD), noted that each state alcohol and drug agency has a critical role to play in NIDA initiatives. This role includes.     

Get High and Get Stupid: The Effect of Alcohol and Marijuana Use on Teen Sexual Behavior

Numerous studies have documented a strong correlation between substance use and teen sexual behavior, and this empirical relationship has given rise to a widespread belief that substance use causes teens to engage in risky sex. This causal link is often used by advocates to justify policies targeted at reducing substance use. Here, we argue that previous research has not produced sufficient evidence to substantiate a causal relationship between substance use and teen sexual behavior. Accordingly, we attempt to estimate causal effects using two complementary research approaches. Our findings suggest that substance use is not causally related to teen sexual behavior, although we cannot definitively rule out that possibility.Research for this paper was supported by grant number 5 R01 DA12692 from the National Institute on Drug Abuse to the National Bureau of Economic Research. We are indebted to Inas Rashad and Nasreen Khan for research assistance. We wish to thank Donald Kenkel, Jody Sindelar, David Salkever, David Bishai, Eric Slade, and two anonymous referees for helpful comments and suggestions. Our research is based in part on the Add Health project, a program project designed by J. Richard Udry (PI) and Peter Bearman, and funded by grant PO1-HD31921 from the National Institute of Child Health and Human Development to the Carolina Population Center, University of North Carolina at Chapel Hill, with cooperative funding participation by the National Cancer Institute; the National Institute of Alcohol Abuse and Alcoholism; the National Institute on Deafness and Other Communication Disorders; the National Institute on Drug Abuse; the National Institute of General Medical Sciences; the National Institute of Mental Health; the National Institute of Nursing Research; the Office of AIDS Research, NIH; The Office of Behavior and Social Science Research, NIH; the Office of the Director, NIH; the Office of Research on Womens Health, NIH; the Office of Population Affairs, DHHS; the National Center for Health Statistics, Centers for Disease Control and Prevention, DHHS; the Office of Minority Health, Center for Disease Control and Prevention, DHHS; the Office of Minority Health, Office of Public Health and Science, DHHS; the Office of the Assistant Secretary for Planning and Evaluation, DHHS; and the National Science Foundation. Persons interested in obtaining data files from The National Longitudinal Study of Adolescent Health should contact Add Health Project, Carolina Population Center, 123 West Franklin Street, Chapel Hill, NC 27516-3997 (email: addhealth@unc.edu). This paper has not undergone the review accorded to official NBER publications; in particular, it has not been submitted for approval by the Board of Directors. Any opinions expressed are those of the authors and not those of NIDA or NBER.JEL Classification: I10, I11     

Biomarkers of aging

As a subgenre of biogerontology, biomarker research has developed a thoroughly tarnished reputation, and those who believe that biomarker studies should be a major focus in experimental aging research must now try to prove to their doubting colleagues that under the tarnish lies true metal, rather than more layers of tarnish. In this Perspective, the author argues that the discovery of biomarkers of aging is possible.     

Meeting summary--cell biology of Parkinson's disease and related neurodegenerative disorders

Parkinsonian disorders (idiopathic Parkinson's disease and clinically similar disorders) are characterized by impaired movements caused by the degeneration of brain centers involved in regulating normal and smooth movements of the body and its extremities. The mechanisms that cause such degeneration are unknown. This Perspective summarizes research described at a meeting held in June 2003, which was organized by the National Institute of Neurological Disorders and Stroke and the National Institute on Aging to provide an update on recent advances in the cell biology of parkinsonian disorders.     

Re-branding the NHL: Building the league through the “My NHL” integrated marketing campaign

This article is a case study examining promotional efforts undertaken by the National Hockey League (NHL) via integrated marketing initiatives launched during the 2005–2006 season. Following the 2004–2005 season player lockout², the NHL worked to promote itself to both fervent and casual fans. By briefly assessing past marketing efforts and the dwindling popularity of the league in recent years, the article provides a fuller picture of how professional hockey was marketed in North America when the NHL returned to play. The focus is on “My NHL” and the league's re-branding efforts as part of its new integrated communications plan. This research reveals that in its attempts to revive the sport the NHL has done a better job than with past efforts, however the current campaign must be aggressively maintained in order to successfully re-brand the league.     

Youth Program Quality Survey: Youth Assessment of Program Quality

The Youth Program Quality survey, a 24-item survey of youth participant perceptions of program quality, based on program elements identified by the National Research Council (NRC) and Institute of Medicine, was developed and piloted with 614 younger teens (ages 10–13 years) and 486 older teens (ages 14–17 years) who attended 4-H camps and conferences. Evidence is presented for content and construct validity. In addition, the overall instrument demonstrated high reliability, as measured by Cronbach's alpha, generally ranging from .70 to .96, and moderate subscale reliability of .60 or higher on four factors in the younger sample (α=.60 or higher on four factors in the older sample). Results are discussed in terms of goodness of fit to the National Research Council model, the significance of youth voice in assessment of program quality, developmental differences in perceptions of quality, and programming design. Recommendations are offered for practice, research, and policy.     

Transnational halal networks: INHART and the Islamic cultural economy in Malaysia and beyond

The concern for piety among contemporary middle-class Muslims has led to efforts to establish a halal (permissible according to Islamic principles) economy. This can be seen in the thriving Islamic cultural economy in Malaysia, which refers to the links between Islamic culture and economic practices. Malaysia tops the Global Islamic Economy indicator, which serves as the dominant framework for evaluating and measuring the global halal economy. This was achieved through various initiatives, such as establishing research centres, of which the International Institute for Halal Research and Training (INHART) is among the most prominent. Drawing on ethnographic fieldwork and digital ethnography, this article focuses on INHART initiatives for building transnational halal networks. This article aims to explore how halal interpretations and practices travel across borders. I argue that halal research centres, such as INHART, signify both the decentring and centring of power transnationally and economically in terms of the global flow of halal knowledge and practices.     

Explaining Family Change and Variation: Challenges for Family Demographers

Twenty years ago, the National Institute of Child Health and Human Development (NICHD) issued a request for proposals that resulted in the National Survey of Families and Households (NSFH), a unique survey valuable to a wide range of family scholars. This paper describes the efforts of an interdisciplinary group of family demographers to build on the progress enabled by the NSFH and many other theoretical and methodological innovations. Our work, also supported by NICHD, will develop plans for research and data collection to address the central question of what causes family change and variation. We outline the group's initial assessments of orienting frameworks, key aspects of family life to study, and theoretical and methodological challenges for research on family change. Finally, we invite family scholars to follow our progress and to help develop this shared public good.     

The adoption of external networking by American schools

Hypotheses from diffusion and resource dependence theory are applied to the explanation of participation in external networking (inter-networking) by schools. A national probability sample of 571 U.S. K-12 schools was used to test factors predicting schools’ use of external networks for instructional purposes. Early (vs late) adoption of computers did not predict later involvement in networking. Neither school spending nor rural region predicted network participation, except through the intervening variable of computer density. Thus, no matter how a school has acquired computers, once the base has been established it serves as an essential ingredient in taking the next step into external networking. The results were disappointing for diffusion theory and certainly point toward further investigation of this phenomenon. The findings also point to the importance of building a technological infrastructure in order to boost and leverage many of the instructional reform initiatives in education. where he has been since completing his Ph.D. at Stanford University in 1970. His primary specialty has been computing: developing computer-related methods in sociology as well as doing research on the social aspects of information technology. Shon Magnan is a Ph.D. candidate in sociology at the University of Minnesota and a research analyst at Questar Data Systems in Eagan Minnesota. This material is based on work supported by the National Science Foundation under grant number SED-9154511. Any opinions, findings, and conclusions expressed in this article do not necessarily reflect those of the National Science Foundation.     

Age-Friendly Portland: A University-City-Community Partnership

This article addresses the question of how creating an age-friendly city has come to be an important policy and planning issue in Portland, Oregon. In 2006, researchers from Portland State University's Institute on Aging examined the meanings of age friendliness among a broad range of participants in Portland, Oregon. The research was conducted in conjunction with the World Health Organization's (WHO) Age-Friendly Cities project and followed the completion of two earlier non–WHO-related projects. The city of Portland, through the Institute on Aging, was one of nine original members to apply for and be accepted into the WHO Global Network of Age-Friendly Cities and Communities. An Age-Friendly Portland Advisory Council was formed to guide the development of an action plan, monitor progress over time, and suggest additional research. To understand how Portland's age-friendly policy effort has developed over time, we use Kingdon's (1984) agenda-setting framework to explain how the policy problem was formulated, how solutions were developed, and the influence of local politics. The policy actors, including individuals and organizations working within and outside of government, are described. The Portland experience provides a case study that other cities, especially those with a strong commitment to community-engaged urban planning, may find useful as they develop age-friendly initiatives.     

Developing a research agenda in biogerontology: physiological systems

The Biology of Aging Program (BAP) at the National Institute on Aging supports research in many areas, including processes of cell senescence and apoptosis, genetic influences on aging, and how aging leads to tissue dysfunction. Several approaches to research on aging physiological systems are described, along with BAP programmatic efforts to enhance and support that research. Understanding the relation between aging and tissue dysfunction has led to new insights into how health can be improved for aged individuals.     

President's proposed budget would slash treatment and prevention funding

We had a feeling of déjà vu when the White House sent its proposed budget to Congress last week. Similar to past years, the Office of National Drug Control Policy (ONDCP) would be decimated, moving the $100 million Drug‐Free Communities program to the Center for Substance Abuse Prevention (CSAP) at the Substance Abuse and Mental Health Services Administration (SAMHSA). There's no additional money in the Substance Abuse Prevention and Treatment (SAPT) block grant and cuts to the National Institute on Drug Abuse, the National Institute on Alcohol Abuse and Alcoholism, CSAP and SAMHSA's Center for Substance Abuse Treatment.     

Family structure,family organization,and quality of family life

This study examines how family organization is associated with the quality of family life for parents in first marriages, remarriages with biological children, and several types of stepfamilies. Data are drawn from the 1987–1988 National Survey of Families and Households; only married couples in which both spouses participated in the survey and who had children under age 19 in the household are considered (N=3,120). Results indicate that respondents in different family structures differ in the perceived quality of parent-child relationships, that differences in family structure are not related to differences in family organization, and that some aspects of family organization are related to marital quality and the quality of parent-chil relationships. Hierarchical multiple regression analyses indicate that family structure and family organization are independently related to the quality of family life. This research was supported by National Institute of Child Health and Human Development Grant R15 HD28198-01. The National Survey of Families and Households was funded by a grant (HD21009) from the Center for Population Research of the National Institute of Child Health and Human Development. The survey was designed and carried out at the Center for Demography and Ecology at the University of Wisconsin-Madison under the direction of Larry Bumpass and James Sweet. The fieldwork was done by the Institute for Survey Research at Temple University. A previous version of this article was presented at the annual meeting of the National Council on Family Relations, Orlando, November 1992. Her research interests include the work/family interface and family policy. She received her Ph.D. from Wayne State University. His research interests include the effects of divorce and remarriage on parents and children. He received his Ph.D. from Ohio State University. Her research interests include adolescents and adoption. She received her Ph.D. from the University of Delaware.     

‘I’m not really sure but I hope it’s better’: early thoughts of parents and carers in a regional trial site for the Australian National Disability Insurance Scheme

The National Disability Insurance Scheme (NDIS) is one of the most significant initiatives in Australian social policy history. Its complexity has been compounded by a fast-paced introduction and ongoing refinement throughout the initial trial phase. Parents and carers of very young disabled children face particular challenges accessing and navigating NDIS systems. This article presents findings from a mixed-method pilot study examining the perspectives of parents and carers of disabled children in one NDIS trial site – the Hunter Region of New South Wales. The research highlights a number of policy assumptions potentially impacting on NDIS take up for young disabled children and their families in regional contexts. Based on research findings a number of policy suggestions and improvements for disabled children and their families entering the NDIS and other individualised funding schemes are outlined.     

The situational logic of entrepreneurship: a realist approach to national policy

National policy initiatives to encourage entrepreneurial behaviour are often developed with limited knowledge of the contextual constraints and causal factors. In this paper, we adopt a social realist approach, generally associated with critical realism, as a framework for analysing levels of entrepreneurial behaviour. The trigger for our study is the apparent anomaly of low levels of German entrepreneurship. We apply the morphogenetic framework of the sociologist Margaret Archer to Germany and then compare this to the United States. We conclude that particular so-called situational logics at the intersection of structure and culture constitute mechanisms which provide strategic direction for the decisions of potential entrepreneurs. We argue that a social realist stance based upon Archer’s sociology provides a practical grounding for research and policy development.     

Police bargaining,arbitration, and fringe benefits

Data from a national sample of 500 to 600 U.S. cities with over 25,000 in population indicated that the practice of police collective bargaining has a positive, strong association with fringe benefits (measured by city contributions for police retirement and insurance benefits per police officer). The availability of arbitration, however, seems to have little or no influence on the dollar amount of police fringes, and neither the current nor the prior use of arbitration (i.e., actually receiving an arbitration award) has any consistent association with police fringes. The results indicate that collective bargaining and regional location influence the level of police fringes more than do other variables. We are grateful to Steve Kawakami, Mark Phillips, Joe Schimansky, and Dick Williams for some excellent research assistance. We are also grateful to the National Institute of Justice of the U.S. Department of Justice for financially supporting this research. Such support does not mean that the Institute or Department necessarily agrees with our methods or conclusions.     

Committee on national statistics the not-for-profit sector of the economy: measurement and presentation in federal statistics

The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competencies and with regard for appropriate balance.This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering and the Institute of Medicine.