THE USE OF AGGREGATE DATA TO ESTIMATE GOMPERTZ‐TYPE OLD‐AGE MORTALITY IN HETEROGENEOUS POPULATIONS

We consider two related aspects of the study of old‐age mortality. One is the estimation of a parameterized hazard function from grouped data, and the other is its possible deceleration at extreme old age owing to heterogeneity described by a mixture of distinct sub‐populations. The first is treated by half of a logistic transform, which is known to be free of discretization bias at older ages, and also preserves the increasing slope of the log hazard in the Gompertz case. It is assumed that data are available in the form published by official statistical agencies, that is, as aggregated frequencies in discrete time. Local polynomial modelling and weighted least squares are applied to cause‐of‐death mortality counts. The second, related, problem is to discover what conditions are necessary for population mortality to exhibit deceleration for a mixture of Gompertz sub‐populations. The general problem remains open but, in the case of three groups, we demonstrate that heterogeneity may be such that it is possible for a population to show decelerating mortality and then return to a Gompertz‐like increase at a later age. This implies that there are situations, depending on the extent of heterogeneity, in which there is at least one age interval in which the hazard function decreases before increasing again.     

The forecasting performance of mortality models

Mortality projections are of special interest in many applications. For example, they are essential in life insurances to determine the annual contributions of their members as well as for population predictions. Due to their importance, there exists a huge variety of mortality forecasting models from which to seek the best approach. In the demographic literature, statements about the quality of the various models are mostly based on empirical ex-post examinations of mortality data for very few populations. On the basis of such a small number of observations, it is impossible to precisely estimate statistical forecasting measures. We use Monte Carlo (MC) methods here to generate time trajectories of mortality tables, which form a more comprehensive basis for estimating the root-mean-square error (RMSE) of different mortality forecasts.     

Distributions of the ratio of two ranges of samples from nonnormal populations

The probability density function of the ratio of two ranges of samples from a population represented by an Edgeworth series is developed. The corrective functions arising due to nonnormality are tabulated for the upper 5 and 1 percent normal theory points and compared with those of F‐distribution. Indications are that both the variance ratio and the range ratio test are affected by nonnormality almost to the same extent. If there is any numerical difference for larger samples (say, n_:1 = n₂ >= 5), it is in the cases of symmetrical populations. The theoretical results are compared with those obtained from Monte Carlo sampling from x² and t‐distributions with various shape parameters.     

Basis risk modelling: a cointegration-based approach

ABSTRACT

In this paper we propose a multivariate approach for forecasting pairwise mortality rates of related populations. The need for joint modelling of mortality rates is analysed using a causality test. We show that for the datasets considered, the inclusion of national mortality information enhances predictions on its subpopulations. The investigated approach links national population mortality to that of a subset population, using an econometric model that captures a long-term relationship between the two mortality dynamics. This model does not focus on the correlation between the mortality rates of the two populations, but rather their long-term behaviour, which suggests that the two times series cannot wander off in opposite directions for long before mean reverting, which is consistent with biological reasoning. The model can additionally capture short-term adjustments in the mortality dynamics of the two populations. An empirical comparison of the forecast of one-year death probabilities for policyholders is performed using both a classical factor-based model and the proposed approach. The robustness of the model is tested on mortality rate data for England and Wales, alongside the Continuous Mortality Investigation assured lives dataset, representing the subpopulation.     

Rank procedures in many population forced discrimination problems

In this paper the rank method for forced discrimination in two population problems, introduced by Randies, Broffitt, Ramberg and Hogg (1978), is extended to cover settings involving more than two populations. Several methods of ranking are compared to the normal theory procedure in a Monte Carlo study. Asymptotic theory is included which confirms that the rank method does balance the limiting probabilities of misclassification in a two population setting.     

Graphical modelling and the Mahalanobis distance

I consider the problem of estimating the Mahalanobis distance between multivariate normal populations when the population covariance matrix satisfies a graphical model. In addition to providing a clear understanding of the dependencies in a multivariate data set, the use of graphical models can reduce the variability of the estimated distances and improve inferences. I derive the asymptotic distribution of the estimated Mahalanobis distance under a general covariance model, which includes graphical models as a special case. Two examples are discussed.     

Multistate recapture models: Modelling incomplete individual histories

Multistate capture-recapture models are a natural generalization of the usual one-site recapture models. Similarly, individuals are sampled on discrete occasions, at which they may be captured or not. However, contrary to the one-site case, the individuals can move within a finite set of states between occasions. The growing interest in spatial aspects of population dynamics presently contributes to making multistate models a very promising tool for population biology. We review first the interest and the potential of multistate models, in particular when they are used with individual states as well as geographical sites. Multistate models indeed constitute canonical capture-recapture models for individual categorical covariates changing over time, and can be linked to longitudinal studies with missing data and models such as hidden Markov chains. Multistate models also provide a promising tool for handling heterogeneity of capture, provided states related to capturability can be defined and used. Such an approach could be relevant for population size estimation in closed populations. Multistate models also constitute a natural framework for mixtures of information in individual history data. Presently, most models can be fit using program MARK. As an example, we present a canonical model for multisite accession to reproduction, which fully generalizes a classical one-site model. In the generalization proposed, one can estimate simultaneously age-dependent rates of accession to reproduction, natal and breeding dispersal. Finally, we discuss further generalizations - such as a multistate generalization of growth rate models and models for data where the state in which an individual is detected is known with uncertainty - and prospects for software development.     

Multistate recapture models: modelling incomplete individual histories

Multistate capture-recapture models are a natural generalization of the usual one-site recapture models. Similarly, individuals are sampled on discrete occasions, at which they may be captured or not. However, contrary to the one-site case, the individuals can move within a finite set of states between occasions. The growing interest in spatial aspects of population dynamics presently contributes to making multistate models a very promising tool for population biology. We review first the interest and the potential of multistate models, in particular when they are used with individual states as well as geographical sites. Multistate models indeed constitute canonical capture-recapture models for individual categorical covariates changing over time, and can be linked to longitudinal studies with missing data and models such as hidden Markov chains. Multistate models also provide a promising tool for handling heterogeneity of capture, provided states related to capturability can be defined and used. Such an approach could be relevant for population size estimation in closed populations. Multistate models also constitute a natural framework for mixtures of information in individual history data. Presently, most models can be fit using program MARK. As an example, we present a canonical model for multisite accession to reproduction, which fully generalizes a classical one-site model. In the generalization proposed, one can estimate simultaneously age-dependent rates of accession to reproduction, natal and breeding dispersal. Finally, we discuss further generalizations - such as a multistate generalization of growth rate models and models for data where the state in which an individual is detected is known with uncertainty - and prospects for software development.     

Exploring Parameter Relations for Multi‐Stage Models in Stage‐Wise Constant and Time Dependent Hazard Rates

Single cohort stage‐frequency data are considered when assessing the stage reached by individuals through destructive sampling. For this type of data, when all hazard rates are assumed constant and equal, Laplace transform methods have been applied in the past to estimate the parameters in each stage‐duration distribution and the overall hazard rates. If hazard rates are not all equal, estimating stage‐duration parameters using Laplace transform methods becomes complex. In this paper, two new models are proposed to estimate stage‐dependent maturation parameters using Laplace transform methods where non‐trivial hazard rates apply. The first model encompasses hazard rates that are constant within each stage but vary between stages. The second model encompasses time‐dependent hazard rates within stages. Moreover, this paper introduces a method for estimating the hazard rate in each stage for the stage‐wise constant hazard rates model. This work presents methods that could be used in specific types of laboratory studies, but the main motivation is to explore the relationships between stage maturation parameters that, in future work, could be exploited in applying Bayesian approaches. The application of the methodology in each model is evaluated using simulated data in order to illustrate the structure of these models.     

Focused Information Criterion for Capture–Recapture Models for Closed Populations

Abstract. We propose a criterion for selecting a capture–recapture model for closed populations, which follows the basic idea of the focused information criterion (FIC) of Claeskens and Hjort. The proposed criterion aims at selecting the model which, among the available models, leads to the smallest mean‐squared error (MSE) of the resulting estimator of the population size and is based on an index which, up to a constant term, is equal to the asymptotic MSE of the estimator. Two alternative approaches to estimate this FIC index are proposed. We also deal with multimodel inference; in this case, the population size is estimated by using a weighted average of the estimates coming from different models, with weights chosen so as to minimize the MSE of the resulting estimator. The proposed model selection approach is compared with more common approaches through a series of simulations. It is also illustrated by an application based on a dataset coming from a live‐trapping experiment.     

A UNIFIED FRAMEWORK FOR MODELLING WILDLIFE POPULATION DYNAMICS†

This paper proposes a unified framework for defining and fitting stochastic, discrete‐time, discrete‐stage population dynamics models. The biological system is described by a state‐space model, where the true but unknown state of the population is modelled by a state process, and this is linked to survey data by an observation process. All sources of uncertainty in the inputs, including uncertainty about model specification, are readily incorporated. The paper shows how the state process can be represented as a generalization of the standard Leslie or Lefkovitch matrix. By dividing the state process into subprocesses, complex models can be constructed from manageable building blocks. The paper illustrates the approach with a model of the British grey seal metapopulation, using sequential importance sampling with kernel smoothing to fit the model.     

Estimating the prevalence of male clients of prostitute women in Vancouver with a simple capture–recapture method

Summary.  Capture–recapture techniques are widely used to estimate the size of difficult-to-count human populations. Applications often focus on the overlap between two or more samples, but another type of data that is encountered in human studies involves only the number of times that particular individuals were encountered in the study period. We present a method for estimating the population size in this situation. This method is simple and technically accessible and allows for entries and exits by individuals and for a difference between probabilities of initial and subsequent contacts. We apply the method to arrest data on male clients of prostitute women in Vancouver.     

MULTIPLE-RECORD SYSTEMS ESTIMATION USING LATENT CLASS MODELS

Capture–recapture methods (also referred to as 'multiple-record systems') have been widely used in enumerating human populations in the fields of epidemiology and public health. In this article, we introduce latent class models into multiple-record systems to account for unobserved heterogeneity in the population. Two approaches, the full and the conditional likelihood, are proposed to estimate the unknown population abundance. We also suggest rules to diagnose identifiability of the proposed latent class models. The methodologies are illustrated by two real examples: the first is to count the undercount of homelessness in the Adelaide central business district, and the second concerns the incidence of diabetes in a small Italian town.     

Sampling strategy for optimal classification into one of two correlated normal populations

A unit ω is to be classified into one of two correlated homoskedastic normal populations by linear discriminant function known as W classification statistic [T.W. Anderson, An asymptotic expansion of the distribution of studentized classification statistic, Ann. Statist. 1 (1973), pp. 964–972; T.W. Anderson, An Introduction to Multivariate Statistical Analysis, 2nd edn, Wiley, New York, 1984; G.J. Mclachlan, Discriminant Analysis and Statistical Pattern Recognition, John Wiley and Sons, New York, 1992]. The two populations studied here are two different states of the same population, like two different states of a disease where the population is the population of diseased patient. When a sample unit is observed in both the states (populations), the observations made on it (which form a pair) become correlated. A training sample is unbalanced when not all sample units are observed in both the states. Paired and also unbalanced samples are natural in studies related to correlated populations. S. Bandyopadhyay and S. Bandyopadhyay [Choosing better training sample for classifying an individual into one of two correlated normal populations, Calcutta Statist. Assoc. Bull. 54(215–216) (2003), pp. 167–180] studied the effect of unbalanced training sample structure on the performance of W statistics in the univariate correlated normal set-up for finding optimal sampling strategy for a better classification rate. In this study, the results are extended to the multivariate case with discussion on application in real scenario.     

Variance estimation for integrated population models

State-space models are widely used in ecology. However, it is well known that in practice it can be difficult to estimate both the process and observation variances that occur in such models. We consider this issue for integrated population models, which incorporate state-space models for population dynamics. To some extent, the mechanism of integrated population models protects against this problem, but it can still arise, and two illustrations are provided, in each of which the observation variance is estimated as zero. In the context of an extended case study involving data on British Grey herons, we consider alternative approaches for dealing with the problem when it occurs. In particular, we consider penalised likelihood, a method based on fitting splines and a method of pseudo-replication, which is undertaken via a simple bootstrap procedure. For the case study of the paper, it is shown that when it occurs, an estimate of zero observation variance is unimportant for inference relating to the model parameters of primary interest. This unexpected finding is supported by a simulation study.     

Max‐infinitely divisible models and inference for spatial extremes

For many environmental processes, recent studies have shown that the dependence strength is decreasing when quantile levels increase. This implies that the popular max‐stable models are inadequate to capture the rate of joint tail decay, and to estimate joint extremal probabilities beyond observed levels. We here develop a more flexible modeling framework based on the class of max‐infinitely divisible processes, which extend max‐stable processes while retaining dependence properties that are natural for maxima. We propose two parametric constructions for max‐infinitely divisible models, which relax the max‐stability property but remain close to some popular max‐stable models obtained as special cases. The first model considers maxima over a finite, random number of independent observations, while the second model generalizes the spectral representation of max‐stable processes. Inference is performed using a pairwise likelihood. We illustrate the benefits of our new modeling framework on Dutch wind gust maxima calculated over different time units. Results strongly suggest that our proposed models outperform other natural models, such as the Student‐t copula process and its max‐stable limit, even for large block sizes.     

Alternating event processes during lifetimes: population dynamics and statistical inference

In the literature studying recurrent event data, a large amount of work has been focused on univariate recurrent event processes where the occurrence of each event is treated as a single point in time. There are many applications, however, in which univariate recurrent events are insufficient to characterize the feature of the process because patients experience nontrivial durations associated with each event. This results in an alternating event process where the disease status of a patient alternates between exacerbations and remissions. In this paper, we consider the dynamics of a chronic disease and its associated exacerbation-remission process over two time scales: calendar time and time-since-onset. In particular, over calendar time, we explore population dynamics and the relationship between incidence, prevalence and duration for such alternating event processes. We provide nonparametric estimation techniques for characteristic quantities of the process. In some settings, exacerbation processes are observed from an onset time until death; to account for the relationship between the survival and alternating event processes, nonparametric approaches are developed for estimating exacerbation process over lifetime. By understanding the population dynamics and within-process structure, the paper provide a new and general way to study alternating event processes.     

Modelling paired categorical outcomes in clinical trials

The goal of this paper is to discuss methods for testing the homogeneity of treatment‐induced changes in trials with paired categorical responses. Widely used marginal homogeneity tests ignore the information contained in concordant pairs of observations and become highly underpowered for configurations of parameters encountered in real trials. This paper considers models for paired binary or ordinal outcomes based on both discordant and concordant pairs that provide a natural extension of marginal models. Likelihood‐ratio tests associated with these models are developed and are demonstrated to be at least as powerful as or more powerful than marginal homogeneity tests. The proposed models are easy to fit using standard statistical software. Copyright © 2003 John Wiley & Sons, Ltd.     

A NONPARAMETRIC MIXED‐EFFECTS MODEL FOR CANCER MORTALITY

There are several ways to handle within‐subject correlations with a longitudinal discrete outcome, such as mortality. The most frequently used models are either marginal or random‐effects types. This paper deals with a random‐effects‐based approach. We propose a nonparametric regression model having time‐varying mixed effects for longitudinal cancer mortality data. The time‐varying mixed effects in the proposed model are estimated by combining kernel‐smoothing techniques and a growth‐curve model. As an illustration based on real data, we apply the proposed method to a set of prefecture‐specific data on mortality from large‐bowel cancer in Japan.     

Adaptive Cluster Sampling in Two‐stage Sampling

Adaptive cluster sampling can be a useful design for surveying rare and clustered populations. Here we present a new development in adaptive cluster sampling where we use a two‐stage design and extend the complete allocation sampling method. In the proposed new design the primary sample units are selected and, depending on the value of a preset condition, the entire primary unit is surveyed, as in complete allocation sampling. In the next step, if a second condition is met, the surrounding primary sample units are selected. We review the efficiency of the proposed design for sampling the New Zealand Castle Hill buttercups and provide unbiased estimators for the population total and sampling variance.