Some new lower bounds to various discrepancies on combined designs

The foldover is a useful technique in construction of two-level factorial designs. A foldover design is the follow-up experiment generated by reversing the sign(s) of one or more factors in the initial design. The full design obtained by joining the runs in the foldover design to those of the initial design is called the combined design. In this article, some new lower bounds of various discrepancies of combined designs, such as the centered, symmetric, and wrap-around L₂-discrepancies, are obtained, which can be used as a better benchmark for searching optimal foldover plans. Our results provide a theoretical justification for optimal foldover plans in terms of uniformity criterion.     

A lower bound for the centred L 2-discrepancy on combined designs under the asymmetric factorials

The foldover is a useful technique in the construction of two-level factorial designs for follow-up experiments. To search an optimal foldover plans is an important issue. In this paper, for a set of asymmetric fractional factorials such as the original designs, a lower bound for centred L ₂-discrepancy of combined designs under a general foldover plan is obtained, which can be used as a benchmark for searching optimal foldover plans. All of our results are the extended ones of Ou et al. [Lower bounds of various discrepancies on combined designs, Metrika 74 (2011), pp. 109–119] for symmetric designs to asymmetric designs. Moreover, it also provides a theoretical justification for optimal foldover plans in terms of uniformity criterion.     

TABLES OF SMALL OPTIMAL REPEATED MEASUREMENTS DESIGNS

This paper presents tables of the optimal repeated measurements designs for the estimation of direct effects and of residual effects for a model with independent errors, for up to n = 10 experimental units, for t= 2 treatments and p= 2, 3 or 4 periods, and for t= 3 treatments and p= 2 or 3 periods.     

Optimal foldover designs

An obvious strategy for obtaining a Doptimal foldover design for p factors at two levels each in 2N runs is to fold a Doptimal main effects plan. We show that this strategy works except when N = 4t + 2 and s is even In that case there are two different classes of D-optimal main effects plans with N runs that have the same determinant. However folding them gives two different values foi the D-optimality criteiion One set of designs is D-optimal The other is not.     

A new look on optimal foldover plans in terms of uniformity criteria

In this paper, we develop a new mechanism for finding the optimal foldover plans (OFPs) which is based on the uniformity criteria measured by Lee discrepancy, wrap-around L₂-discrepancy, and centered L₂-discrepancy. For three-level fractional factorials as the original designs, general foldover plans and combined designs are defined, and lower bounds of these three discrepancies of combined designs under general foldover plans are also obtained, which can be used as benchmarks for searching OFPs. Illustrative examples with a comparison study between the foldover plans under these discrepancies are provided. Our results provide a theoretical justification for OFPs of three-level designs in terms of uniformity criteria.     

Reverse Foldovers for Blocked 2 m−k Fractional Factorial Designs

Two-level regular fractional factorial designs are often used in industry as screening designs to help identify early on in an experimental process those experimental or system variables which have significant effects on the process being studied. When the experimental material to be used in the experiment is heterogenous or the experiment must be performed over several well-defined time periods, blocking is often used as a means to improve experimental efficiency by removing the possible effects of heterogenous experimental material or possible time period effects. In a recent article, Li and Jacroux (2007 Li , F. , Jacroux , M. (2007). Optimal foldover plans for blocked 2 ^m?k fractional factorial designs. J. Statsist. Plann. Infer 137:2434–2452. [Google Scholar]) suggested a strategy for constructing optimal follow-up designs for blocked fractional factorial designs using the well-known foldover technique in conjunction with several optimality criteria. In this article, we consider the reverse foldover problem for blocked fractional factorial designs. In particular, given a 2^(m+p)?(p+k) blocked fractional factorial design D, we derive simple sufficient conditions which can be used to determine if there exists a 2^{(m+p?1)?(p?1+k+1)} initial fractional factorial design d which yields D as a foldover combined design as well how to generate all such d. Such information is useful in developing an overall experimental strategy in situations where an experimenter wants an overall blocked fractional factorial design with “desirable” properties but also wants the option of analyzing the observed data at the halfway mark to determine if the significant experimental variables are obvious (and the experiment can be terminated) or if a different path of experimentation should be taken from that initially planned.     

OPTIMAL DESIGNS FOR 2 k PAIRED COMPARISON EXPERIMENTS

In this paper we establish the form of the optimal paired comparison design when there are k attributes, each with two levels, for testing for main effects, for main effects and two factor interactions and for main effects and two and three factor interactions. In all cases we assume that all pairs with the same number of attributes different appear equally often. In this setting the D and A optimal designs for main effects are the foldover pairs and those for main effects and two factor interactions have pairs in which about half the attributes are different.     

A Lower Bound for the Wrap-around L2-discrepancy on Combined Designs of Mixed Two- and Three-level Factorials

The objective of this article is to study the issue of employing the uniformity criterion measured by wrap-around L₂-discrepancy to assess the optimal foldover plans. For mixed two- and three-level fractional factorials as the original designs, general foldover plan and combined design under a foldover plan are defined, and the equivalence between any foldover plan and its complementary foldover plan is investigated. A lower bound of wrap-around L₂-discrepancy of combined designs under a general foldover plan is obtained, which can be used as a benchmark for searching optimal foldover plans. Moreover, it also provides a theoretical justification for optimal foldover plans in terms of uniformity criterion.     

OPTIMAL DESIGNS FOR FITTING A PROPORTIONAL HAZARDS REGRESSION MODEL TO DATA SUBJECT TO CENSORING

Suppose the probability model for failure time data, subject to censoring, is specified by the hazard function λ(t)exp(β_T x), where x is a vector of covariates. Analytical difficulties involved in finding the optimal design are avoided by assuming that λ is completely specified and by using D-optimality based on the information matrix for β Optimal designs are found to depend on β, but some results of practical consequence are obtained. It is found that censoring does not affect the choice of design appreciably when β^T x ≥ 0 for all points of the feasible region, but may have an appreciable effect when β_ix_i 0, for all i and all points in the feasible experimental region. The nature of the effect is discussed in detail for the cases of one and two parameters. It is argued that in practical biomedical situations the optimal design is almost always the same as for uncensored data.     

Optimal blocking and foldover plans for nonregular two-level designs

This paper discusses the issue of choosing optimal designs when both blocking and foldover techniques are simultaneously employed to nonregular two-level fractional factorial designs. By using the indicator function, the treatment and block generalized wordlength patterns of the combined blocked design under a general foldover plan are defined. Some general properties of combined block designs are also obtained. Our results extend the findings of Ai et al. (2010) from regular designs to nonregular designs. Based on these theoretical results, a catalog of optimal blocking and foldover plans in terms of the generalized aberration criterion for nonregular initial design with 12, 16 and 20 runs is tabulated, respectively.     

On Sampling Designs for Integral Estimation of a Random Process

Abstract

In this paper the problem of finding exactly optimal sampling designs for estimating the weighted integral of a stochastic process with a product covariance structure (R(s,t)=u(s)v(t), s<t) is discussed. The sampling designs for certain standard processes belonging to the product class are calculated. An asymptotic solution to the design problem also follows as a consequence.     

The existence of the strong combined-optimal design

The technique of fold-over is useful for conducting follow-up experiments. Based on the minimum aberration criterion, Li and Lin (2003) developed an algorithm and used computer to search the corresponding optimal foldover designs for 16 and 32 runs in the 2 ^k-p design. In their study, they found that the 2¹⁰⁻⁶ design is the only one that is not a strong combined-optimal design among all the designs. However, they did not interpret the reason causing the phenomenon. This article will explore under what kind of conditions, that the strong combined-optimal design will exist, and the solutions of the related problems.     

A note on the selection of optimal foldover plans for 16- and 32-run fractional factorial designs

The minimum aberration criterion has been advocated for ranking foldovers of 2^k−p$2^{k-p}$ fractional factorial designs (Li and Lin, 2003); however, a minimum aberration design may not maximize the number of clear low-order effects. We propose using foldover plans that sequentially maximize the number of clear low-order effects in the combined (initial plus foldover) design and investigate the extent to which these foldover plans differ from those that are optimal under the minimum aberration criterion. A small catalog is provided to summarize the results.     

A powerful and efficient algorithm for breaking the links between aliased effects in asymmetric designs

Fractional factorial (FF) designs are no doubt the most widely used designs in experimental investigations due to their efficient use of experimental runs. One price we pay for using FF designs is, clearly, our inability to obtain estimates of some important effects (main effects or second order interactions) that are separate from estimates of other effects (usually higher order interactions). When the estimate of an effect also includes the influence of one or more other effects the effects are said to be aliased. Folding over an FF design is a method for breaking the links between aliased effects in a design. The question is, how do we define the foldover structure for asymmetric FF designs, whether regular or nonregular? How do we choose the optimal foldover plan? How do we use optimal foldover plans to construct combined designs which have better capability of estimating lower order effects? The main objective of the present paper is to provide answers to these questions. Using the new results in this paper as benchmarks, we can implement a powerful and efficient algorithm for finding optimal foldover plans which can be used to break links between aliased effects.     

Search for optimal designs in a three stagenested random model

In this paper we define a class of unbalanced designs, denoted by C_k,s,t, for estimating the components of variance in a k-stage nested random effects linear model. This class contains many of the designs proposed in the literature for nested components of variance models. We focus on the three-state model and discuss the determination of locally optimal designs within this class using a systematic computer search. For large sample sizes we show that approximate optimal designs may be obtained using a limit argument combined with numerical optimization. A comparison of our designs with previously published designs suggests that, in many cases, our designs result in substantial gains in efficiency.     

Efficient three-level screening designs using weighing matrices

Screening is the first stage of many industrial experiments and is used to determine efficiently and effectively a small number of potential factors among a large number of factors which may affect a particular response. In a recent paper, Jones and Nachtsheim [A class of three-level designs for definitive screening in the presence of second-order effects. J. Qual. Technol. 2011;43:1–15] have given a class of three-level designs for screening in the presence of second-order effects using a variant of the coordinate exchange algorithm as it was given by Meyer and Nachtsheim [The coordinate-exchange algorithm for constructing exact optimal experimental designs. Technometrics 1995;37:60–69]. Xiao et al. [Constructing definitive screening designs using conference matrices. J. Qual. Technol. 2012;44:2–8] have used conference matrices to construct definitive screening designs with good properties. In this paper, we propose a method for the construction of efficient three-level screening designs based on weighing matrices and their complete foldover. This method can be considered as a generalization of the method proposed by Xiao et al. [Constructing definitive screening designs using conference matrices. J. Qual. Technol. 2012;44:2–8]. Many new orthogonal three-level screening designs are constructed and their properties are explored. These designs are highly D-efficient and provide uncorrelated estimates of main effects that are unbiased by any second-order effect. Our approach is relatively straightforward and no computer search is needed since our designs are constructed using known weighing matrices.     

Highly Efficient Designs for Logistic Models with Categorical Variables

Optimal designs for logistic models generally require prior information about the values of the regression parameters. However, experimenters usually do not have full knowledge of these parameters. We propose a design that is D-optimal on a restricted design region. This design assigns an equal weight to design points that contain more information and ignores those design points that contain less information about the regression parameters. The design can be constructed in practice by means of the rank order of the outcome variances. A numerical study compares the proposed design with the D-optimal and completely balanced designs in terms of efficiency.     

Optimal blocked main effects plans

In this paper, we consider the construction of optimal blocked main effects designs where m two-level factors are to be studied in N runs which are partitioned into b blocks of equal size. For N ≡ 2±od4 sufficient conditions are derived for a design to be Φ _f optimal among all designs having main effects occurring equally often at their high and low levels within blocks and then this result is extended to the class of all designs for the case when the block size is two. Methods of constructing designs satisfying the sufficient conditions derived are also given.     

Optimal designs for calibration of orientations

This paper concerns designed experiments involving observations of orientations following the models of Prentice (1989) and Rivest &Chang (2006). The authors state minimal conditions on the designs for consistent least squares estimation of the matrix parameters in these models. The conditions are expressed in terms of the axes and rotation angles of the design orientations. The authors show that designs satisfying U₁ + … + U_n = 0 are optimal in the sense of minimizing the estimation error average angular distance. The authors give constructions of optimal n‐point designs when n ≥ 4 and they compare the performance of several designs through approximations and simulation.     

Optimal designs for statistical analysis with Zernike polynomials

The Zernike polynomials arise in several applications such as optical metrology or image analysis on a circular domain. In the present paper, we determine optimal designs for regression models which are represented by expansions in terms of Zernike polynomials. We consider two estimation methods for the coefficients in these models and determine the corresponding optimal designs. The first one is the classical least squares method and Φ _p -optimal designs in the sense of Kiefer [Kiefer, J., 1974, General equivalence theory for optimum designs (approximate theory). Annals of Statistics, 2 849–879.] are derived, which minimize an appropriate functional of the covariance matrix of the least squares estimator. It is demonstrated that optimal designs with respect to Kiefer's Φ _p -criteria (p>?∞) are essentially unique and concentrate observations on certain circles in the experimental domain. E-optimal designs have the same structure but it is shown in several examples that these optimal designs are not necessarily uniquely determined. The second method is based on the direct estimation of the Fourier coefficients in the expansion of the expected response in terms of Zernike polynomials and optimal designs minimizing the trace of the covariance matrix of the corresponding estimator are determined. The designs are also compared with the uniform designs on a grid, which is commonly used in this context.