A Bayesian Approach to the Estimation of Expected Cell Counts by Using Log-Linear Models

ABSTRACT

In this article, Bayesian estimation of the expected cell counts for log-linear models is considered. The prior specified for log-linear parameters is used to determine a prior for expected cell counts, by means of the family and parameters of prior distributions. This approach is more cost-effective than working directly with cell counts because converting prior information into a prior distribution on the log-linear parameters is easier than that of on the expected cell counts. While proceeding from the prior on log-linear parameters to the prior of the expected cell counts, we faced with a singularity problem of variance matrix of the prior distribution, and added a new precision parameter to solve the problem. A numerical example is also given to illustrate the usage of the new parameter.     

High breakdown point robust estimators with missing data

In this paper, we propose a new procedure to estimate the distribution of a variable y when there are missing data. To compensate the presence of missing responses, it is assumed that a covariate vector x is observed and that y and x are related by means of a semi-parametric regression model. Observed residuals are combined with predicted values to estimate the missing response distribution. Once the responses distribution is consistently estimated, we can estimate any parameter defined through a continuous functional T using a plug in procedure. We prove that the proposed estimators have high breakdown point.     

Questions & Answers: The Role of Mathematical Models in Clinical Research

Given any generalized inverse (X'X)^? appropriate to normal equations X'Xb ⁰ = X'y for the linear model y = Xb + e, a procedure is given for obtaining from it a generalized inverse appropriate to a restricted model having restrictions P'b = 0 for P'b nonestimable.     

A classifier under the strongly spiked eigenvalue model in high-dimension,low-sample-size context

Abstract

We consider the classification of high-dimensional data under the strongly spiked eigenvalue (SSE) model. We create a new classification procedure on the basis of the high-dimensional eigenstructure in high-dimension, low-sample-size context. We propose a distance-based classification procedure by using a data transformation. We also prove that our proposed classification procedure has consistency property for misclassification rates. We discuss performances of our classification procedure in simulations and real data analyses using microarray data sets.     

Combined synthetic and |S| chart for monitoring process dispersion

This article proposes a multivariate control chart, the syn-|S| chart, which comprises a standard |S| subchart and a multivariate synthetic sample generalized variance |S| (synthetic |S|) subchart, for detecting shifts in the covariance matrix of a multivariate normally distributed process. A procedure for the optimal design of the syn-|S| chart by minimizing the average extra quadratic loss is provided. The syn-|S| chart has better overall performance compared to the synthetic |S| chart and the standard |S| chart, based on the zero-state and steady-state modes. An example is given to illustrate the operation of the synthetic |S| chart.     

Information approach for a lifetime change-point model based on the exponential-logarithmic distribution

ABSTRACT

The exponential-logarithmic distribution is a distribution which has a decreasing failure function and various applications such as in biological and engineering fields. In this paper, we study a change-point problem of this distribution. A procedure based on Schwarz information criterion is proposed to detect changes in parameters of this distribution. Simulations are conducted to indicate the performance of the proposed procedure under different scenarios. Applications on two real data are provided to illustrate the detection procedure.     

Optimal designs of multivariate synthetic |S| control chart based on median run length

The multivariate synthetic generalized sample variance |S| (synthetic |S|) chart is a combination of the |S| sub-chart and the conforming run length sub-chart. A procedure for optimal designs of the synthetic |S| chart, based on the median run length (MRL), for both zero and steady-state modes are provided by minimizing the out-of-control MRL. The comparative results show that the synthetic |S| chart performs better than the standard |S| chart for detecting shifts in the covariance matrix of a multivariate normally distributed process, in terms of the MRL. An example is given to illustrate the operation of the synthetic |S| chart.     

A note on successive comparisons between several ordered variances

ABSTRACT

In this article, a procedure for comparisons between k (k ? 3) successive populations with respect to the variance is proposed when it is reasonable to assume that variances satisfy simple ordering. Critical constants required for the implementation of the proposed procedure are computed numerically and selected values of the computed critical constants are tabulated. The proposed procedure for normal distribution is extended for making comparisons between successive exponential populations with respect to scale parameter. A comparison between the proposed procedure and its existing competitor procedures is carried out, using Monte Carlo simulation. Finally, a numerical example is given to illustrate the proposed procedure.     

Maximum likelihood estimation for germination-growth processes with application to neurotransmitters data

A maximum likelihood procedure is given for estimating parameters in a germination-growth process, based on germination times only or on both times and locations. The process is assumed to be driven by a Poisson process whose intensity is of known analytical form. The procedure is shown to perform well on simulated data with unnormalised gamma intensity and is also applied to data on release of neurotransmitter at a synapse.     

FAST DOUBLE BOOTSTRAP TESTS OF NONNESTED LINEAR REGRESSION MODELS

ABSTRACT

It has been shown in previous work that bootstrapping the J test for nonnested linear regression models dramatically improves its finite-sample performance. We provide evidence that a more sophisticated bootstrap procedure, which we call the fast double bootstrap, produces a very substantial further improvement in cases where the ordinary bootstrap does not work as well as it might. This FDB procedure is only about twice as expensive as the usual single bootstrap.     

On Calculations Involving the Maximum Cell Frequency

We describe a method of computing the cumulative distribution function of the maximum and minimum cell frequencies in sampling distributions commonly encountered in the analysis of categorical data.The procedure is efficient for exact or approximate calculation in both homogeneous and non-homogeneous cases, is non-recursive, and does not require Dirichlet integrals.Some related statistical problems are also discussed.     

MOSUM monitoring for variance change in nonparametric regression models

ABSTRACT

This article considers the monitoring for variance change in nonparametric regression models. First, the local linear estimator of the regression function is given. A moving square cumulative sum procedure is proposed based on residuals of the estimator. And the asymptotic results of the statistic under the null hypothesis and the alternative hypothesis are obtained. Simulations and Application support our procedure.     

Asymptotic results in gamma kernel regression

Abstract

Based on the Gamma kernel density estimation procedure, this article constructs a nonparametric kernel estimate for the regression functions when the covariate are nonnegative. Asymptotic normality and uniform almost sure convergence results for the new estimator are systematically studied, and the finite performance of the proposed estimate is discussed via a simulation study and a comparison study with an existing method. Finally, the proposed estimation procedure is applied to the Geyser data set.     

Multiple comparison procedures for finding non-maximum normal means

Abstract

In this study, we discuss multiple comparison procedures for finding normal means which are not maximum among several normal means. Specifically, we propose the single step procedure, the sequentially rejective step down procedure and the step up procedure. For the single step procedure we determine the critical value for a specified significance level. For the sequentially rejective step down procedure and the step up procedure we determine the critical value at each step of the test for a specified significance level. For three procedures we formulate the power of the test under a specified alternative hypothesis. We give some numerical examples regarding critical values and power of the test intended to compare three procedures.     

A nonparametric coherent confidence procedure

ABSTRACT

Holm's step-down testing procedure starts with the smallest p-value and sequentially screens larger p-values without any information on confidence intervals. This article changes the conventional step-down testing framework by presenting a nonparametric procedure that starts with the largest p-value and sequentially screens smaller p-values in a step-by-step manner to construct a set of simultaneous confidence sets. We use a partitioning approach to prove that the new procedure controls the simultaneous confidence level (thus strongly controlling the familywise error rate). Discernible features of the new stepwise procedure include consistency with individual inference, coherence, and confidence estimations for follow-up investigations. In a simple simulation study, the proposed procedure (treated as a testing procedure), is more powerful than Holm's procedure when the correlation coefficient is large, and vice versa when it is small. In the data analysis of a medical study, the new procedure is able to detect the efficacy of Aspirin as a cardiovascular prophylaxis in a nonparametric setting.     

Truncation invariant copulas and a testing procedure

ABSTRACT

The class of bivariate copulas that are invariant under truncation with respect to one variable is considered. A simulation algorithm for the members of the class and a novel construction method are presented. Moreover, inspired by a stochastic interpretation of the members of such a class, a procedure is suggested to check whether the dependence structure of a given data set is truncation invariant. The overall performance of the procedure has been illustrated on both simulated and real data.     

On the estimation of non linear functions in stochastic volatility models

Abstract

This paper focuses on the inference of suitable generally non linear functions in stochastic volatility models. In this context, in order to estimate the variance of the proposed estimators, a moving block bootstrap (MBB) approach is suggested and discussed. Under mild assumptions, we show that the MBB procedure is weakly consistent. Moreover, a methodology to choose the optimal length block in the MBB is proposed. Some examples and simulations on the model are also made to show the performance of the proposed procedure.     

ADAPTIVE GROUP SEQUENTIAL PROCEDURES FOR MULTIPLE COMPARISON OF TREATMENTS

ABSTRACT

We present a flexible group sequential procedure for comparing several treatments to a control. Though longitudinal data corresponding to a two stage mixed effects model are considered, ranges of application include any process with independent increments. The procedure allows the experimenter to drop the inferior treatments from the trial as soon as they are detected. It control strongly the familywise error rate. We also discuss a new error spending function (ESF) and study the performance of the procedure using various ESFs and time scales. Finally, the procedure is illustrated on a real example and implementation considerations are discussed.     

Partly linear models on Riemannian manifolds

In partly linear models, the dependence of the response y on (x ^T, t) is modeled through the relationship y=x ^T β+g(t)+?, where ? is independent of (x ^T, t). We are interested in developing an estimation procedure that allows us to combine the flexibility of the partly linear models, studied by several authors, but including some variables that belong to a non-Euclidean space. The motivating application of this paper deals with the explanation of the atmospheric SO₂ pollution incidents using these models when some of the predictive variables belong in a cylinder. In this paper, the estimators of β and g are constructed when the explanatory variables t take values on a Riemannian manifold and the asymptotic properties of the proposed estimators are obtained under suitable conditions. We illustrate the use of this estimation approach using an environmental data set and we explore the performance of the estimators through a simulation study.     

Empirical likelihood-based serial correlation testing in partially varying coefficient single-index models

ABSTRACT

Partially varying coefficient single-index models (PVCSIM) are a class of semiparametric regression models. One important assumption is that the model error is independently and identically distributed, which may contradict with the reality in many applications. For example, in the economical and financial applications, the observations may be serially correlated over time. Based on the empirical likelihood technique, we propose a procedure for testing the serial correlation of random error in PVCSIM. Under some regular conditions, we show that the proposed empirical likelihood ratio statistic asymptotically follows a standard χ² distribution. We also present some numerical studies to illustrate the performance of our proposed testing procedure.