Semiparametric ROC surface estimation for continuous diagnostic tests via polytomous logistic regression procedures

In this paper, we propose a semiparametric method of estimating receiver operating characteristic (ROC) surfaces for continuous diagnostic tests under density ratio models. Implementation of our method is easy since the usual polytomous logistic regression procedures in many statistical software packages can be employed. A simulated example is provided to facilitate the implementation of our method. Simulation results show that the proposed semiparametric ROC surface estimator is more efficient than the nonparametric counterpart and the parametric counterpart whether the normality assumption of data holds or not. Moreover, some simulation results on the underlying semiparametric distribution function estimators are also reported. In addition, some discussions on the proposed method as well as analysis of a real data set are provided.     

Optimum treatment allocation for dual-objective clinical trials with binary outcomes

A common problem in randomized controlled clinical trials is the optimal assignment of patients to treatment protocols, The traditional optimal design assumes a single criterion, although in reality, there are usually more than one objective in a clinical trial. In this paper, optimal treatment allocation schemes are found for a dual-objective clinical trial with a binary response. A graphical method for finding the optimal strategy is proposed and illustrative examples are discussed.     

Water cycle algorithm for solving the reliability-redundancy allocation problem with a choice of redundancy strategies

Abstract

This paper proposes a new mathematical model for the reliability-redundancy allocation problem (RRAP) with a choice of redundancy strategies. To maximize the reliability of a system, this model chooses the best redundancy strategy from among both active and standby ones for each subsystem. For those with a standby strategy, a continuous time Markov chain model is used to calculate the exact reliability values. In order to solve the proposed mixed-integer non-linear programing model, a powerful evolutionary algorithm, called water cycle algorithm (WCA), is developed and implemented on three famous benchmark problems. Finally, the results of different benchmark problems are compared with those previously reported to show the superiority of the proposed model and the efficiency of WCA.     

Nonparametric statistical procedures for the changepoint problem

Let X₁,…,X_r?1,X_r,X_r+1,…,X_n be independent, continuous random variables such that X_i, i = 1,…,r, has distribution function F(x), and X_i, i = r+1,…,n, has distribution function F(x?Δ), with -∞ <Δ< ∞. When the integer r is unknown, this is refered to as a change point problem with at most one change. The unknown parameter Δ represents the magnitude of the change and r is called the changepoint. In this paper we present a general review discussion of several nonparametric approaches for making inferences about r and Δ.     

Adjusting ROC curves for covariates in the presence of verification bias

The ROC (receiver operating characteristic) curve is frequently used for describing effectiveness of a diagnostic marker or test. Classical estimation of the ROC curve uses independent identically distributed samples taken randomly from the healthy and diseased populations. Frequently not all subjects undergo a definitive gold standard assessment of disease status (verification). Estimation of the ROC curve based on data only from subjects with verified disease status may be badly biased (verification bias). In this work we investigate the properties of the doubly robust (DR) method for estimating the ROC curve adjusted for covariates (ROC regression) under verification bias. We develop the estimator's asymptotic distribution and examine its finite sample size properties via a simulation study. We apply this procedure to fingerstick postprandial blood glucose measurement data adjusting for age.     

Testing for violations of the homogeneity needed for conditional logistic regression

In epidemiologic studies where the outcome is binary, the data often arise as clusters, as when siblings, friends or neighbors are used as matched controls in a case-control study. Conditional logistic regression (CLR) is typically used for such studies to estimate the odds ratio for an exposure of interest. However, CLR assumes the exposure coefficient is the same in every cluster, and CLR-based inference can be badly biased when homogeneity is violated. Existing methods for testing goodness-of-fit for CLR are not designed to detect such violations. Good alternative methods of analysis exist if one suspects there is heterogeneity across clusters. However, routine use of alternative robust approaches when there is no appreciable heterogeneity could cause loss of precision and be computationally difficult, particularly if the clusters are small. We propose a simple non-parametric test, the test of heterogeneous susceptibility (THS), to assess the assumption of homogeneity of a coefficient across clusters. The test is easy to apply and provides guidance as to the appropriate method of analysis. Simulations demonstrate that the THS has reasonable power to reveal violations of homogeneity. We illustrate by applying the THS to a study of periodontal disease.     

Comparative analysis of modern optimization tools for the p-median problem

This paper develops a study on different modern optimization techniques to solve the p-median problem. We analyze the behavior of a class of evolutionary algorithm (EA) known as cellular EA (cEA), and compare it against a tailored neural network model and against a canonical genetic algorithm for optimization of the p-median problem. We also compare against existing approaches including variable neighborhood search and parallel scatter search, and show their relative performances on a large set of problem instances. Our conclusions state the advantages of using a cEA: wide applicability, low implementation effort and high accuracy. In addition, the neural network model shows up as being the more accurate tool at the price of a narrow applicability and larger customization effort.     

Response-based multiple imputation method for minimizing the impact of covariate detection limit in logistic regression

Abstract

Presence of detection limit (DL) in covariates causes inflated bias and inaccurate mean squared error to the estimators of the regression parameters. This paper suggests a response-driven multiple imputation method to correct the deleterious impact introduced by the covariate DL in the estimators of the parameters of simple logistic regression model. The performance of the method has been thoroughly investigated, and found to outperform the existing competing methods. The proposed method is computationally simple and easily implementable by using three existing R libraries. The method is robust to the violation of distributional assumption for the covariate of interest.     

Likelihood-based cross-validation score for selecting the smoothing parameter in maximum penalized likelihood estimation

Maximum penalized likelihood estimation is applied in non(semi)-para-metric regression problems, and enables us exploratory identification and diagnostics of nonlinear regression relationships. The smoothing parameter A controls trade-off between the smoothness and the goodness-of-fit of a function. The method of cross-validation is used for selecting A, but the generalized cross-validation, which is based on the squared error criterion, shows bad be¬havior in non-normal distribution and can not often select reasonable A. The purpose of this study is to propose a method which gives more suitable A and to evaluate the performance of it.

A method of simple calculation for the delete-one estimates in the likeli¬hood-based cross-validation (LCV) score is described. A score of similar form to the Akaike information criterion (AIC) is also derived. The proposed scores are compared with the ones of standard procedures by using data sets in liter¬atures. Simulations are performed to compare the patterns of selecting A and overall goodness-of-fit and to evaluate the effects of some factors. The LCV-scores by the simple calculation provide good approximation to the exact one if λ is not extremeiy smaii Furthermore the LCV scores by the simple size it possible to select X adaptively They have the effect, of reducing the bias of estimates and provide better performance in the sense of overall goodness-of fit. These scores are useful especially in the case of small sample size and in the case of binary logistic regression.     

On the existence of maximum likelihood estimates for weighted logistic regression

The problems of existence and uniqueness of maximum likelihood estimates for logistic regression were completely solved by Silvapulle in 1981 and Albert and Anderson in 1984. In this paper, we extend the well-known results by Silvapulle and by Albert and Anderson to weighted logistic regression. We analytically prove the equivalence between the overlap condition used by Albert and Anderson and that used by Silvapulle. We show that the maximum likelihood estimate of weighted logistic regression does not exist if there is a complete separation or a quasicomplete separation of the data points, and exists and is unique if there is an overlap of data points. Our proofs and results for weighted logistic apply to unweighted logistic regression.     

A nonparametric statistical procedure for the detection of marine pollution

This paper is devoted to the estimation of the derivative of the regression function in fixed-design nonparametric regression. We establish the almost sure convergence as well as the asymptotic normality of our estimate. We also provide concentration inequalities which are useful for small sample sizes. Numerical experiments on simulated data show that our nonparametric statistical procedure performs very well. We also illustrate our approach on high-frequency environmental data for the study of marine pollution.     

Approximating the risk score for disease diagnosis using MARS

In disease screening and diagnosis, often multiple markers are measured and combined to improve the accuracy of diagnosis. McIntosh and Pepe [Combining several screening tests: optimality of the risk score, Biometrics 58 (2002), pp. 657–664] showed that the risk score, defined as the probability of disease conditional on multiple markers, is the optimal function for classification based on the Neyman–Pearson lemma. They proposed a two-step procedure to approximate the risk score. However, the resulting receiver operating characteristic (ROC) curve is only defined in a subrange (L, h) of false-positive rates in (0,1) and the determination of the lower limit L needs extra prior information. In practice, most diagnostic tests are not perfect, and it is usually rare that a single marker is uniformly better than the other tests. Using simulation, I show that multivariate adaptive regression spline is a useful tool to approximate the risk score when combining multiple markers, especially when ROC curves from multiple tests cross. The resulting ROC is defined in the whole range of (0,1) and is easy to implement and has intuitive interpretation. The sample code of the application is shown in the appendix.     

On a bayesian approach for the shiftpoint problem

Using a direct resampling process, a Bayesian approach is developed for the analysis of the shiftpoint problem. In many problems it is straight forward to isolate the marginal posterior distribution of the shift-point parameter and the conditional distribution of some of the parameters given the shift point and the other remaining parameters. When this is possible, a direct sampling approach is easily implemented whereby standard random number generators can be used to generate samples from the joint posterior distribution of aii the parameters in the model. This technique is illustrated with examples involving one shift for Poisson processes and regression models.     

An Automatic Test for the Umbrella Alternatives

The paper proposes a new test for detecting the umbrella pattern under a general non‐parametric scheme. The alternative asserts that the umbrella ordering holds while the hypothesis is its complement. The main focus is put on controlling the power function of the test outside the alternative. As a result, the asymptotic error of the first kind of the constructed solution is smaller than or equal to the fixed significance level α on the whole set where the umbrella ordering does not hold. Also, under finite sample sizes, this error is controlled to a satisfactory extent. A simulation study shows, among other things, that the new test improves upon the solution widely recommended in the literature of the subject. A routine, written in R, is attached as the Supporting Information file.     

Graphical displays for clarifying how allocation ratio affects total sample size for the two sample logrank test

For time‐to‐event data, the power of the two sample logrank test for the comparison of two treatment groups can be greatly influenced by the ratio of the number of patients in each of the treatment groups. Despite the possible loss of power, unequal allocations may be of interest due to a need to collect more data on one of the groups or to considerations related to the acceptability of the treatments to patients. Investigators pursuing such designs may be interested in the cost of the unbalanced design relative to a balanced design with respect to the total number of patients required for the study. We present graphical displays to illustrate the sample size adjustment factor, or ratio of the sample size required by an unequal allocation compared to the sample size required by a balanced allocation, for various survival rates, treatment hazards ratios, and sample size allocation ratios. These graphical displays conveniently summarize information in the literature and provide a useful tool for planning sample sizes for the two sample logrank test. Copyright © 2010 John Wiley & Sons, Ltd.     

On the small sample properties of norm-restricted maximum likelihood estimators for logistic regression models

This paper develops alternatives to maximum likelihood estimators (MLE) for logistic regression models and compares the mean squared error (MSE) of the estimators. The MLE for the vector of underlying success probabilities has low MSE only when the true probabilities are extreme (i.e., near 0 or 1). Extreme probabilities correspond to logistic regression parameter vectors which are large in norm. A competing “restricted” MLE and an empirical version of it are suggested as estimators with better performance than the MLE for central probabilities. An approximate EM-algorithm for estimating the restriction is described. As in the case of normal theory ridge estimators, the proposed estimators are shown to be formally derivable by Bayes and empirical Bayes arguments. The small sample operating characteristics of the proposed estimators are compared to the MLE via a simulation study; both the estimation of individual probabilities and of logistic parameters are considered.     

An adaptive allocation sampling design for which the conventional stratified estimator is an appropriate estimator

Adaptive allocations in stratified sampling design are suitable for studying Biological and Environmental populations. Biologists tend to use the conventional stratified estimator for an adaptive allocation sampling design in spite of its adaptive nature. In this paper, we have introduced an adaptive allocation sampling design for which the conventional stratified estimator has some desired statistical properties. We conduct a simulation study on a real population. The results show that the conventional stratified estimator for the introduced adaptive allocation sampling design is more efficient than other available estimators.