高含水期油藏层间压力结构差异量化方法研究

由于长期注水开发和层间非均质性影响，高含水期油藏各小层层间压力结构差异严重，掌握差异状况是合理调整的重要依据。针对现场分层测压资料少，单层压力资料获取困难的情况，应用渗流力学原理建立了高含水期地层层间压力结构差异量化数学模型，模型的关键参数可以通过生产数据计算获得。枣园油田的实例验证表明，高含水油藏层间压力存在明显差异，该方法能够确定各小层的压力差异状况。量化计算结果和实测资料相接近，有利于认清开发矛盾，为合理调整提供技术依据。     

领导干部党性修养评价机制研究

建立健全领导干部党性修养评价机制,是加强党的执政能力建设,建设高素质执政骨干队伍的客观需要。坚定的政治信念、牢固的党纪意识、严谨的自律能力、优秀的道德品质和勤勉的工作作风是评价领导干部党性修养的主要内容。要明确评价领导干部党性修养的指导思想、评价主体和评价原则,要建立健全领导干部党性修养的评价指标体系,不断探索科学的评价领导干部党性修养的方式方法。     

支书和他的村庄——基于生命历程理论视角

在详细梳理西村张书记生命历程的基础上,利用生命历程理论的分析范式,将张书记的个人生命历程置于广阔的社会背景下进行研究,探讨了宏观社会背景、社会力量对张书记个人生命历程发展的影响,同时也阐述和强调了张书记个人主观能动性的发挥对自己生命轨迹和整个村庄经济收入、产业结构调整、农业技术推广、村民日常生活等带来的深刻变化。     

休闲活动与大学生心理健康

大学生对休闲活动认知有误区。参与休闲活动自觉性差、层次低、能力不够强。应积极引导、改变观念、提升层次、注重技能养成,丰富休闲方式,从而促进广大学生投身于休闲活动之中,达到心身健康教育与培养目的。     

Inference and Decision Making for 21st-Century Drug Development and Approval

ABSTRACT

The cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making.     

自杀和生命的意义——来自脑科学研究的解读

生命本身是一个随机事件，并不具有高尚的意义。进化的结果使人类可通过工作、家庭和人际关系等给予自己的生命以意义感。当我们的生活方式使脑内奖赏系统获得刺激，就会带来生命具有意义的感受，这种感受给人带来更好的生存机会。生存的欲望是一切生物体最具特征的属性，一些精神疾病患者缺乏这种欲望。自杀主要发生于精神疾病患者，它并非是基于自由意志的行为。抗精神病治疗和适当的社会交往可以预防自杀。由于不同个体有着不同的大脑，人们的生活方式就应该去适应各自大脑的特征。只要人们的生活方式不对他人造成过多的伤害，政府就应该允许和保护人们自由地按照各自的方式生活。     

Changing Frameworks in Attitudes Toward Abortion

For more than two decades, legal abortion has been the subject of heated political debate and adversarial social movement activity; however, national polls have shown little change in aggregate levels of support for abortion. This analysis examines how the determinants of abortion attitudes have changed between 1977 and 1996, using data from the General Social Surveys. While in early time periods, whites were more approving of abortion than blacks, that pattern had reversed by the late 1980s. After controlling for other factors, older people are more accepting of abortion throughout the two decades, while gender is generally unrelated to abortion views. Catholic religion weakens slightly as a predictor of abortion attitudes, while religious fundamentalism and political liberalism increase in explanatory power. The associations between attitudinal correlates and abortion approval also change over this time period. Religiosity becomes a less powerful predictor of abortion attitudes, while respondents' attitude toward sexual freedom and belief in the sanctity of human life increase in their predictive power. Support for gender inequality remains a weak but stable predictor of abortion attitudes. This pattern of results suggests that the public is influenced more by the pro-life framework of viewing abortion than by the pro-choice perspective.