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This article demonstrates statistical models to quantify the interaction between a carbamate insecticide and acetylcholinesterase. Carbamates are a class of chemicals that inhibit the activity of acetylcholinesterase in humans, an enzyme involved in the regulation of the neurotransmitter acetylcholine. Following exposure to a carbamate insecticide, we specifically address (1) if acetylcholinesterase activity recovers to its level of preexposure activity; (2) the level of inhibition of acetylcholinesterase activity; (3) the recovery time of acetylcholinesterase activity to its preexposure level for a typical individual; and (4) the upper percentiles of the recovery time of acetycholinesterase activity across individuals. A nonlinear mixed-effects model is fitted to data from a repeated measures experiment conducted with human volunteers randomly assigned to a control and four dose groups. Repeated measurements were taken prior to exposure and at 1, 2, 4, 6, 8, and 21 hours after exposure to the carbamate aldicarb. It was found that full recovery did occur. Inhibition at 1 hour was estimated with maximum inhibition most likely occurring prior to 1-hour postexposure. In addition, recovery was rapid even for sensitive individuals. Given this information, the potential effect from exposure to a carbamate consumed in the diet during a day can be quantitatively assessed. 相似文献
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Herbert J. Abraham 《Social Studies》2013,104(3):123-125
Abstract The family is the foundation of our society. By learning about family life in other countries, we learn about our own lives and we realize that we all belong to one big family—the family of mankind. … [Studying families of the world] could help us to get closer to people in distant countries and support the knowledge that “we are one.” — Liv Ullmann, UNICEF Goodwill Ambassador 相似文献
65.
Abraham Katharine G.; Maitland Aaron; Bianchi Suzanne M. 《Public opinion quarterly》2006,70(5):676-703
This article examines nonresponse in a large government survey,the American Time Use Survey (ATUS), which interviews personsin households previously interviewed in the Current PopulationSurvey. The response rate for the ATUS has been below 60 percentfor the first two years of its existence, raising questionsabout whether the results can be generalized to the target population.The article begins with an analysis of the types of nonresponseencountered in the ATUS. Noncontact accounts for roughly 60percent of ATUS nonresponse, with refusals accounting for roughly40 percent. We find little support for the hypothesis that busypeople are less likely to respond to the ATUS but find considerablesupport for the hypothesis that people who are weakly integratedinto their communities are less likely to respond, mostly becausethey are less likely to be contacted. When we compare aggregateestimates of time use calculated using the ATUS base weightswithout any adjustment for nonresponse, estimates calculatedusing the ATUS final weights with a nonresponse adjustment,and estimates calculated using weights that incorporate ourown nonresponse adjustment based on a propensity model, we findsome modest differences, but the three sets of estimates arebroadly similar. The article ends with suggestions for furtherresearch and analysis. 相似文献
66.
This study examined how leaders create the impetus for creativity at work. One hundred ninety-three employees occupying a variety of jobs in Israeli organizations completed surveys at two points in time to assess their perceptions of the quality of their relationship with their leader (LMX), their level of energy, and their creative work involvement. SEM and regression analyses showed that LMX was positively related to employees' feelings of energy, which in turn were related to a high level of involvement in creative work. Factors that leaders should take into consideration in promoting followers' creative behaviors are discussed. 相似文献
67.
Niels G. Becker & Abraham M. Hasofer 《Journal of the Royal Statistical Society. Series B, Statistical methodology》1997,59(2):415-429
The construction of estimating equations by martingale methods is generalized to yield estimators with explicit expressions for the parameters of the birth-and-death and the general epidemic processes when only partial observations are available. (For the birth-and-death process the death process is observed but the number of births is observed only at the end and for the general epidemic process only the removal process is observed.) For large populations, the use of the martingale central limit theorem yields asymptotic confidence regions for the parameters. Explicit expressions are derived for estimators of the variances of the large sample distributions. The range of validity and usefulness of the new estimators is determined by simulation. 相似文献
68.
Itty Abraham 《Globalizations》2015,12(6):913-927
AbstractThe mutiny that took place in Singapore in February 1915 is usually dismissed as a footnote in the history of empire. One reason why it is marginalized is because the mutiny does not conform to a politics that seeks the formation of an independent territorial nation-state as its inevitable conclusion. This article returns to that initial moment of insurgency to argue that the mutiny offers a unique window into the political imaginaries of British Indian soldiers, seen as military migrant workers. A close reading of soldiers’ letters against the Rowlatt Committee's Sedition Report suggests a politics of equality and emancipation uncontaminated by the desire for national liberation. Two kinds of insurgency thus become visible: international space as an unsettled zone of attraction and desire and a nascent political subjectivity that rejects the disciplines of imperial military labor. The primary causes of these transformations, I argue, are the insurgent effects of long-distance travel. 相似文献
69.
Unsupervised Curve Clustering using B-Splines 总被引:5,自引:0,他引:5
C. Abraham P. A. Cornillon E. Matzner-Løber N. Molinari 《Scandinavian Journal of Statistics》2003,30(3):581-595
Data in many different fields come to practitioners through a process naturally described as functional. Although data are gathered as finite vector and may contain measurement errors, the functional form have to be taken into account. We propose a clustering procedure of such data emphasizing the functional nature of the objects. The new clustering method consists of two stages: fitting the functional data by B‐splines and partitioning the estimated model coefficients using a k‐means algorithm. Strong consistency of the clustering method is proved and a real‐world example from food industry is given. 相似文献
70.