Psychosocial Interventions for Maltreated and Violence-Exposed Children

Child sexual, physical, and emotional abuse as well as child neglect and domestic violence, community violence, and Childhood Traumatic Grief may result in significant and long-lasting emotional and behavioral difficulties. This article reviews randomized controlled studies that have assessed child mental health outcomes for maltreated and violence-exposed children. Key points of this review include the following: (1) maltreated and violence-exposed children typically experience more than one of these types of traumas; (2) effective psychosocial treatments are available to address Posttraumatic Stress Disorder (PTSD), depression, anxiety, and behavioral problems in these children; (3) it is likely that treatments which effectively reduce mental health symptoms in children exposed to one type of child maltreatment or violence exposure will also be effective for other or multiple types; and (4) mental health outcomes are not the only important outcomes to address in future treatment or intervention efforts. These future directions for treatment intervention research are addressed.     

An Exposure‐Response Threshold for Lung Diseases and Lung Cancer Caused by Crystalline Silica

Whether crystalline silica (CS) exposure increases risk of lung cancer in humans without silicosis, and, if so, whether the exposure‐response relation has a threshold, have been much debated. Epidemiological evidence is ambiguous and conflicting. Experimental data show that high levels of CS cause lung cancer in rats, although not in other species, including mice, guinea pigs, or hamsters; but the relevance of such animal data to humans has been uncertain. This article applies recent insights into the toxicology of lung diseases caused by poorly soluble particles (PSPs), and by CS in particular, to model the exposure‐response relation between CS and risk of lung pathologies such as chronic inflammation, silicosis, fibrosis, and lung cancer. An inflammatory mode of action is described, having substantial empirical support, in which exposure increases alveolar macrophages and neutrophils in the alveolar epithelium, leading to increased reactive oxygen species (ROS) and nitrogen species (RNS), pro‐inflammatory mediators such as TNF‐alpha, and eventual damage to lung tissue and epithelial hyperplasia, resulting in fibrosis and increased lung cancer risk among silicotics. This mode of action involves several positive feedback loops. Exposures that increase the gain factors around such loops can create a disease state with elevated levels of ROS, TNF‐alpha, TGF‐beta, alveolar macrophages, and neutrophils. This mechanism implies a “tipping point” threshold for the exposure‐response relation. Applying this new model to epidemiological data, we conclude that current permissible exposure levels, on the order of 0.1 mg/m³, are probably below the threshold for triggering lung diseases in humans.     

Correlational biases in mean response latency differences

Multifarious psychological constructs are indexed by the mean latency difference (MLD), the within-subject difference between mean response latency on two tasks. Two associations consistently emerge in mean latency data. Firstly, across subjects, mean latencies on distinct tasks are positively correlated. This correlation arises from individual differences in general rates of information processing that are a shared influence on response latency in diverse tasks. Secondly, across tasks, the mean and variance of mean latency are positively correlated. Compared to a simple task, a complex task has both a larger average mean latency and a larger variance of mean latency, across subjects. Taken together, these associations make the interpretation of the MLD problematic by biasing correlations between the MLD and (a) task mean latencies, (b) the average of the mean latencies, (c) external criteria, and (d) other MLDs. A variety of mean latency transformations were evaluated and, while they differed in their effectiveness, they did not satisfactorily rectify MLD biases. An alternative approach, focusing on scale invariant contrasts of within-subject response latency distributions, is introduced in the conclusion.     

The Impossibility of Naturalism: The Antinomies of Bhaskar's Realism

From the publication of The Possibility of Naturalism, Bhaskar's critical naturalism or realism has argued for a dualistic social ontology of interpreting individuals and objective, 'real' social structures. In arguing for a dualistic ontology, Bhaskar commits himself to two antinomies; he insists that society is dependent on individuals but also independent of them, and that social action is always intentional but it also has non-intentional, material features. These antinomies are apparently resolved by appeals to emergence. In fact, the appeal to emergence is merely a disguised regression into reification and the only genuine path out of these antinomies is the adoption of a fully hermeneutic social theory in line with the positions of Winch and Gadamer.     

A cautionary tale

Anthony Edwards wrote this cautionary tale for genetics students at Stanford University whom he was teaching in 1965. It has not previously been published. "Its appearance now is due to my having been asked whether a copy from the papers of the Nobel Laureate Joshua Lederberg might be put on the web by the US National Library of Medicine", he says. "Lederberg was Professor of Genetics at Stanford at the time and I must have given him a copy. More remarkably, he thought it worth keeping." It concerns what is known as Simpson's paradox.     

An Observational Study of Early Heterosexual Interaction at Middle School Dances

In this longitudinal, observational study of heterosexual interaction at middle school dances we examined the degree to which boys' and girls' groups became more gender integrated over time. The results show groups became more integrated over time with the pattern differing by gender. Boys had a relatively low level of contact with girls over the early months with an accelerated increase in the latter months. Girls had an increase in contact with boys over the early months but then a decrease in contact over the latter months. Further, changes in the dynamic covariate, aggression, were associated with changes in integration, and the static covariate, initial physical attractiveness, was predictive of integration trajectories. Physical attractiveness and aggression did relate to gender integration, but counter to our hypotheses, each strategy did not vary by gender, as predicted by sexual selection theory. Results are discussed in terms of different methods in assessing the roles of aggression and physical attractiveness in gender integration.