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The availability of the next generation sequencing (NGS) technology in today's biomedical research has provided new opportunities in scientific discovery of genetic information. The high-throughput NGS technology, especially DNA-seq, is particularly useful in profiling a genome for the analysis of DNA copy number variants (CNVs). The read count (RC) data resulting from NGS technology are massive and information rich. How to exploit the RC data for accurate CNV detection has become a computational and statistical challenge. We provide a statistical online change point method to help detect CNVs in the sequencing RC data in this paper. This method uses the idea of online searching for change point (or breakpoint) with a Markov chain assumption on the breakpoints loci and an iterative computing process via a Bayesian framework. We illustrate that an online change-point detection method is particularly suitable for identifying CNVs in the RC data. The algorithm is applied to the publicly available NCI-H2347 lung cancer cell line sequencing reads data for locating the breakpoints. Extensive simulation studies have been carried out and results show the good behavior of the proposed algorithm. The algorithm is implemented in R and the codes are available upon request. 相似文献
74.
The present study investigated possible Type C personality–quality of life (QOL) relationship, and the moderating role of perceived social support in this relation among 101 postoperative breast cancer patients. Participants were from different cities in Turkey but receiving treatment in the capital, Ankara. Obtained data were analyzed by moderated regression analysis. According to the results, Type C personality was not related to the QOL of participants, however, higher perceived social support was associated with better QOL in patients. Also, perceived social support moderated Type C personality–QOL relation. Accordingly, patients high on Type C personality and perceived social support had the highest QOL. In contrast, patients high on Type C personality and low on perceived social support had the lowest QOL. Findings, as well as the strengths and limitations of the study, were discussed in the light of the relevant literature. As a possible clinical implication, enhancement of social support networks of the patients were suggested. 相似文献
75.
中华书局 1982年出版的冀勤点校的《元稹集》 ,是 2 0世纪惟一的点校本 ,但是这个点校本却存在较多的不足之处 :一是录校不精 ,二是误校太多 ,三是失校太多 ,四是对前人成果的借鉴不够合理、充分 ,五是轻率校改 ,六是误收与误补 ,七是标点失误 ,八是未能广参异本。为此我们对《元稹集》应有一个基本正确的认识 ,以便日后谨慎正确的利用 ,并藉此为以后重新整理《元稹集》获得些微的经验教训 相似文献
76.
The Value of Safety as Revealed in the Swedish Car Market: An Application of the Hedonic Pricing Approach 总被引:1,自引:0,他引:1
In this article the hedonic regression technique is used to estimate the value of traffic safety, using information from the Swedish market for automobiles. The results from the study show that the market price of an automobile is negatively correlated with its inherent risk level, i.e. Swedish car consumers pay a safety premium for safer cars. In comparison to previous Swedish stated-preference studies, this study reveals a lower willingness to pay for additional car safety, which might be a result of the interaction between government interventions and individual self-insurance and self-protection.JEL Classification: C51, D61, J28 相似文献
77.
Bahar Bayraktar-Sağlam Bayraktar-Sağlam 《Social indicators research》2018,137(1):231-256
Using panel data from 102 countries in 1975–2010, this paper explores the dynamic interaction among health, education and growth by applying panel VAR techniques. Empirical findings reveal that the predictive pattern among health, education and economic growth is not stable in the cross section of countries. While health has positive contribution to growth for all countries, education has benefited only higher middle income and high-income OECD countries. Economic growth has predictive power for the components of human development in the high-income OECD countries. Further, econometric evidence reveals that bi-directional relationship between health and education should be supported to reap the benefits of human development on economic growth. 相似文献
78.
Three separate issues concerning the relation between age and satisfaction with sex life are addressed in this article. The first issue was concerned with the age generalizability of the factor structure produced by responses to the Satisfaction with Sex Life Scale (SWSLS). The second issue was to examine whether there were differences in the satisfaction with sex life according to certain background characteristics, namely age. Finally, the relationship between scores on the SWSLS with those on other relational constructs was explored. Data collection involved completion of a questionnaire. The sample consisted of 1,144 participants. The mean ages of the sample were 38.99 years in (SD = 16.91); ages ranged from 20 to 80. The data indicated that the factor structure of responses to the SWSLS were highly similar through adult life. Religious involvement, marital status, and love status influenced satisfaction with sex life. Expected correlations with measures of other relationship constructs were found. The strongest predictor of satisfaction with sex live across the adult life span was love satisfaction. Suggestions concerning the use of the SWSLS for research and clinical purposes are offered. 相似文献
79.
Word clouds constitute one of the most popular statistical tools for the visual analysis of text documents because they provide users with a quick and intuitive understanding of the content. Despite their popularity for visualizing single documents, word clouds are not appropriate to compare different text documents. Independently generating word clouds for each document leads to configurations where the same word is typically located in widely different positions. This makes it very difficult to compare two or more word clouds. This paper introduces COWORDS, a new stochastic algorithm to create multiple word clouds, including one for each document. The shared words in multiple documents are placed in the same position in all clouds. Similar documents produce similar and compact clouds, making it easier to simultaneously compare and interpret several word clouds. The algorithm is based on a probability distribution in which the most probable configurations are those with a desirable visual aspect, such as a low value for the total distance between the words in all clouds. The algorithm output is a set of word clouds that are randomly selected from this probability distribution. The selection procedure uses a Markov chain Monte Carlo simulation method. We present several examples that illustrate the performance and visual results that can be obtained by our algorithm. 相似文献
80.
Aylin Göçoğlu 《Journal of Statistical Computation and Simulation》2019,89(14):2694-2710
In this paper, proportion estimators and associated variance estimators are proposed for a binary variable with a concomitant variable based on modified ranked set sampling methods, which are extreme ranked set sampling (ERSS), median ranked set sampling (MRSS), percentile ranked set sampling (Per-RSS) and L ranked set sampling (LRSS) methods. The Monte Carlo simulation study is performed to compare the performance of the estimators based on bias, mean squared error, and relative efficiency for different levels of correlation coefficient, set and cycle sizes under normal and log-normal distributions. Moreover, the study is supported with real data application. 相似文献