Daily rhythm of salivary IL-1ß, cortisol and melatonin in day and night workers

Shiftwork-induced sleep deprivation and circadian disruption probably leads to an increase in the production of cytokines and dysregulation of innate immune system, respectively. This project aims evaluating changes in salivary IL-1 beta, cortisol, and melatonin in night workers. Method. Two day and three night healthy workers participated in this study. Sleep was evaluated by actimetry and activity protocols. Saliva was collected at waking and bedtime the last workday and the following two days-off and was analyzed by ELISA. Results. Neither sleep duration nor efficiency showed any association with salivary IL-1beta. IL-1beta levels were higher at waking than at bedtime during working days for all workers, but only one day and one night-worker maintained this pattern and hormone rhythms during days off. For this night worker, melatonin levels were shifted to daytime. A second one presented clear alterations in IL-1beta and hormone rhythms on days-off. Conclusions. Our preliminary results suggest that night work can disturb the variation pattern of salivary IL-1beta. No association of this variation with sleep was observed. It seems that disruption in hormone rhythms interfere with salivary IL-1beta production. IL- 1beta production pattern seems to be maintained when rhythms are present, in spite of a shift in melatonin secretion.     

The hierarchy of needs to inclusive design

This paper focuses Design importance in the development of effectively inclusive products based on Design Emotional approach, allowing children with disabilities to experience playing in the childhood as an instrument for social integration. The methodology used to develop this study was based on literature review, considering the following themes: emotional design, accessibility and inclusion, emotion and development of children. As a result, we propose a new level of need to model the hierarchy of needs, of Jordan ("usability", "functionality" and "pleasure"), level with the inclusion of "dignity."     

The traveling salesman problem on grids with forbidden neighborhoods

We introduce the traveling salesman problem with forbidden neighborhoods (TSPFN). This is an extension of the Euclidean TSP in the plane where direct connections between points that are too close are forbidden. The TSPFN is motivated by an application in laser beam melting. In the production of a workpiece in several layers using this method one hopes to reduce the internal stresses of the workpiece by excluding the heating of positions that are too close. The points in this application are often arranged in some regular (grid) structure. In this paper we study optimal solutions of TSPFN instances where the points in the Euclidean plane are the points of a regular grid. Indeed, we explicitly determine the optimal values for the TSPFN and its associated path version on rectangular regular grids for different minimal distances of the points visited consecutively. For establishing lower bounds on the optimal values we use combinatorial counting arguments depending on the parities of the grid dimensions. Furthermore we provide construction schemes for optimal TSPFN tours for the considered cases.     

Effort-reward imbalance,overcommitment and sleep in a working population

The relationship between workplace characteristics and nocturnal sleep in a working population was investigated. Data from 709 employees (mean age=39 years; 87% men) from two German companies were analysed at the entry of the longitudinal cohort study (overall accrual 73%). We investigated the association between the effort-reward imbalance model at work (Siegrist, ) and self-reported sleep quality and sleep disturbances, as assessed by the Jenkins Sleep Quality Index. Effort and overcommitment were found to be higher, and reward was lower in participants with lower (N=328) vs. higher sleep quality (N=381), as well as in participants with (N=217) vs. without (N=492) disturbed sleep (all ps<.001). In regression analyses, lower sleep quality (R ²=.33) and sleep disturbances (R ² _Nagelkerke=.33) were predicted by older age, female gender (only significant for sleep disturbances), shift-work, lower physical and mental health functioning, and higher overcommitment. Individuals were 1.7 times more likely to report disturbed sleep per standard deviation increase in overcommitment. Gender-stratified analyses revealed that higher overcommitment was associated with unfavourable sleep in men, while in women poor sleep was related to lower reward. The findings suggest that overcommitment at work interferes with restful sleep in men, while in women disturbed sleep may be associated with the amount of overcommitment and perceived job reward and sleep quality associated with the perceived reward.     

Implications of population growth and urbanization on agricultural risks in China

Growing population, rapid urbanization, rising incomes, and changing consumption preferences stimulate intensification of livestock production and excessive fertilization of crops in China. We present an innovative approach that sheds light on options to prevent negative environmental consequences of food production. Trends indicate that agricultural production expansion will take place in “profitable” locations around densely populated areas, where there are generally insufficient natural resources to recycle production wastes. This will likely lead to increased environmental impacts and risks to human health, with the largest impacts in close proximity to population hotspots. We identify trends in Chinese agricultural production and devise and compare feasible mitigation scenarios. We present a spatial allocation procedure that facilitates management of agricultural production expansion, accounting for environmental and health constraints. This procedure, based on behavioral principles, uses a spatial risk preference structure induced by local conditions, including environment, production, and demand, with important research and policy implications.     

Contract Structure,Risk‐Sharing,and Investment Choice

Few microfinance‐funded businesses grow beyond subsistence entrepreneurship. This paper considers one possible explanation: that the structure of existing microfinance contracts may discourage risky but high‐expected‐return investments. To explore this possibility, I develop a theory that unifies models of investment choice, informal risk‐sharing, and formal financial contracts. I then test the predictions of this theory using a series of experiments with clients of a large microfinance institution in India. The experiments confirm the theoretical predictions that joint liability creates two potential inefficiencies. First, borrowers free‐ride on their partners, making risky investments without compensating partners for this risk. Second, the addition of peer‐monitoring overcompensates, leading to sharp reductions in risk‐taking and profitability. Equity‐like financing, in which partners share both the benefits and risks of more profitable projects, overcomes both of these inefficiencies and merits further testing in the field.