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891.
We study a principal‐agent relationship between a politician and a researcher that captures stylized facts regarding the involvement of politics into scientific research. The politician has some ideal policy that he would like to implement, but needs to contract with a researcher to choose a policy that is supported by scientific advice. We study the implemented contracts under symmetric and under asymmetric information about the researcher's ability and concern for reputation, and discuss with which types of researchers the politician will contract. We identify several conflicts between the interests of voters and those of the politician. (JEL D72, D82, D83) 相似文献
892.
Patrick Murigu Kamau Njage Clementine Henri Pimlapas Leekitcharoenphon Michel‐Yves Mistou Rene S. Hendriksen Tine Hald 《Risk analysis》2019,39(6):1397-1413
Next‐generation sequencing (NGS) data present an untapped potential to improve microbial risk assessment (MRA) through increased specificity and redefinition of the hazard. Most of the MRA models do not account for differences in survivability and virulence among strains. The potential of machine learning algorithms for predicting the risk/health burden at the population level while inputting large and complex NGS data was explored with Listeria monocytogenes as a case study. Listeria data consisted of a percentage similarity matrix from genome assemblies of 38 and 207 strains of clinical and food origin, respectively. Basic Local Alignment (BLAST) was used to align the assemblies against a database of 136 virulence and stress resistance genes. The outcome variable was frequency of illness, which is the percentage of reported cases associated with each strain. These frequency data were discretized into seven ordinal outcome categories and used for supervised machine learning and model selection from five ensemble algorithms. There was no significant difference in accuracy between the models, and support vector machine with linear kernel was chosen for further inference (accuracy of 89% [95% CI: 68%, 97%]). The virulence genes FAM002725, FAM002728, FAM002729, InlF, InlJ, Inlk, IisY, IisD, IisX, IisH, IisB, lmo2026, and FAM003296 were important predictors of higher frequency of illness. InlF was uniquely truncated in the sequence type 121 strains. Most important risk predictor genes occurred at highest prevalence among strains from ready‐to‐eat, dairy, and composite foods. We foresee that the findings and approaches described offer the potential for rethinking the current approaches in MRA. 相似文献
893.
Despite their fear of repercussions on career advancement and gender identity, Korean fathers taking parental leave have continually increased. Why do Korean fathers take parental leave in spite of the risk of being stigmatized as less masculine and less ideal workers? Are they willing to be ‘ideological renegades' to be new involved fathers? In‐depth interviews with fathers who took parental leave provide interesting answers. Overall, taking parental leave does not make fathers become ideological renegades since it is mainly utilized in a manner that accommodates the work devotion schema, deviating from the formal policy objectives. This deviant utilization is encouraged and even valued by organizations. This may be part of a psychological contract between organizations and employees, ensuring that employees are dedicated to their career even during parental leave. Furthermore, beyond the legal eligibility of uptake, informal but powerful ‘organizational eligibility' such as high performance or their contribution to the organization, makes not only the likelihood but also the aftermath of taking up different across fathers. As a result, a hierarchy among fathers with class connotations emerges. This hierarchy among fathers, combined with the traditional gender hierarchy, may reinforce the masculine fabric of ideal workers as the norm. 相似文献
894.
Discussion on statistical analysis of carcinogenicity studies with an early terminated treated group
High rates of mortality on long term carcinogenicity studies can often result in challenges when it comes to the statistical analysis of tumor incidence. The current regulatory advice often results in treated groups being terminated earlier than the control group. However, this advice rarely considers the impact of this action on the statistical analyses. The nature of these analyses means that groups terminated at different times may not be directly comparable due to age differences of the animals. Here we discuss the issues related to this and investigate several approaches of how to incorporate these groups within the statistical analyses. Although no single method appears to resolve these issues consistently, inclusion of the early terminated group is still informative. Depending on the timing of the early termination, either pooling of the groups into a single terminal kill (TK) interval or reassignment of intervals based purely on time of death (ie, no separate TK interval) appear preferable. However, to draw meaningful conclusions the time of onset of a given tumor must also be considered alongside incident rates and any statistical findings. 相似文献
895.
896.
Mie Plotnikof Pia Bramming Layla Branicki Lrke Hjgaard Christiansen Kelly Henley Nina Kivinen Joo Paulo Resende de Lima Monika Kostera Emmanouela Mandalaki Saoirse O'Shea Banu
zkazan‐Pan Alison Pullen Jim Stewart Sierk Ybema Noortje van Amsterdam 《Gender, Work and Organization》2020,27(5):804-826
The spread of COVID‐19 acutely challenges and affects not just economic markets, demographic statistics and healthcare systems, but indeed also the politics of organizing and becoming in a new everyday life of academia emerging in our homes. Through a collage of stories, snapshots, vignettes, photos and other reflections of everyday life, this collective contribution is catching a glimpse of corona‐life and its micro‐politics of multiple, often contradicting claims on practices as many of us live, work and care at home. It embodies concerns, dreams, anger, hope, numbness, passion and much more emerging amongst academics from across the world in response to the crisis. As such, this piece manifests a shared need to — together, apart — enact and explore constitutive relations of resistance, care and solidarity in these dis/organizing times of contested spaces, identities and agencies as we are living–working–caring at home during lockdowns. 相似文献
897.
Elizabeth T. Hallers‐Haalboom Marleen G. Groeneveld Sheila R. van Berkel Joyce J. Endendijk Lotte D. van der Pol Marian J. Bakermans‐Kranenburg Judi Mesman 《Social Development》2016,25(1):82-98
From a traditional viewpoint, fathers are seen as the main disciplinarian in the family. However, recent studies suggest that these traditional family role patterns may have changed. In this study, we observed discipline strategies of mothers and fathers toward their sons and daughters. Participants included 242 families with two children (1 and 3 years of age). Findings revealed that parental discipline varied by the age of the children, but that mothers disciplined their children more often than fathers. Fathers, conversely, showed more laxness in response to child non‐compliance. Gender of the children was only related to physical interference, with mothers using more physical interference with boys than fathers, irrespective of birth order. Taken together, these findings highlight the importance of parent gender for parent–child interactions in early childhood, but also suggest that child age should be taken into account as important explanatory factors. 相似文献
898.
While theory suggests that information programs may correct market failures and improve welfare, the empirical impacts of these policies remain undetermined. We show that mandatory disclosure programs in the electricity industry achieve stated policy goals. We find that the proportion of fossil fuels decreases, and the proportion of clean fuels increases in response to disclosure programs. However, the programs may produce unintended consequences. For example, programs may make “clean” firms cleaner, while leaving “dirty” firms relatively unchanged. If the marginal benefits of pollution abatement are larger at dirty firms than at clean firms, disclosure programs may induce inefficient abatement allocations. (JEL D83, Q58, D21) 相似文献
899.
Elana Newman Traci Willard Robert Sinclair Danny Kaloupek 《Accountability in research》2013,20(4):309-329
Researchers and institutional review boards are routinely called upon to evaluate the cost‐benefit status of proposed research protocols that involve human participants. Often these assessments are based on subjective judgments in the absence of empirical data. This reliance on subjective judgments is of particular concern for studies involving clinical samples where unfounded assumptions may adversely affect research progress or clinical outcomes. The Reactions to Research Participation Questionnaire (RRPQ) was designed to address this shortcoming and to help promote ethical decision making about research practice. The present study describes development of the RRPQ and presents a series of exploratory and confirmatory analyses investigating its structure. Based on these findings, a revised version of the instrument and suggestions for future research are presented. This approach provides a foundation for scientifically informed protection of human subjects. 相似文献
900.
Existing ethical discussion considers the differences in care for identified versus statistical lives. However, there has been little attention to the different degrees of care that are taken for different kinds of statistical lives. Here we argue that for a given number of statistical lives at stake, there will sometimes be different, and usually greater, care taken to protect predictable statistical lives, in which the number of lives that will be lost can be predicted fairly accurately, than for unpredictable statistical lives, where the lives are at stake because of a low‐probability event, such that most likely no one will be affected by the decision but with low probability some lives will be at stake. One reason for this difference is the statistical challenge of estimating low probabilities, and in particular the tendency of common approaches to underestimate these probabilities. Another is the existence of rational incentives to treat unpredictable risks as if the probabilities were lower than they are. Some of these factors apply outside the pure economic context, to institutions, individuals, and governments. We argue that there is no ethical reason to treat unpredictable statistical lives differently from predictable statistical lives. Moreover, lives that are unpredictable from the perspective of an individual agent may become predictable when aggregated to the level of a societal decision. Underprotection of unpredictable statistical lives is a form of market failure that may need to be corrected by altering regulation, introducing compulsory liability insurance, or other social policies. 相似文献