Quantifying Potential Human Health Impacts of Animal Antibiotic Use: Enrofloxacin and Macrolides in Chickens

Use of similar or identical antibiotics in both human and veterinary medicine has come under increasing scrutiny by regulators concerned that bacteria resistant to animal antibiotics will infect people and resist treatment with similar human antibiotics, leading to excess illnesses and deaths. Scientists, regulators, and interest groups in the United States and Europe have urged bans on nontherapeutic and some therapeutic uses of animal antibiotics to protect human health. Many regulators and public health experts have also expressed dissatisfaction with the perceived limitations of quantitative risk assessment and have proposed alternative qualitative and judgmental approaches ranging from "attributable fraction" estimates to risk management recommendations based on the precautionary principle or on expert judgments about the importance of classes of compounds in human medicine. This article presents a more traditional quantitative risk assessment of the likely human health impacts of continuing versus withdrawing use of fluoroquinolones and macrolides in production of broiler chickens in the United States. An analytic framework is developed and applied to available data. It indicates that withdrawing animal antibiotics can cause far more human illness-days than it would prevent: the estimated human BENEFIT:RISK health ratio for human health impacts of continued animal antibiotic use exceeds 1,000:1 in many cases. This conclusion is driven by a hypothesized causal sequence in which withdrawing animal antibiotic use increases illnesses rates in animals, microbial loads in servings from the affected animals, and hence human health risks. This potentially important aspect of human health risk assessment for animal antibiotics has not previously been quantified.     

Enabling a Powerful Marine and Offshore Decision-Support Solution Through Bayesian Network Technique

A powerful practical solution is by far the most desired output when making decisions under the realm of uncertainty on any safety-critical marine or offshore units and their systems. With data and information typically being obtained incrementally, adopting Bayesian network (BN) is shown to realistically deal with the random uncertainties while at the same time making risk assessments easier to build and to check. A well-matched methodology is proposed to formalize the reasoning in which the focal mechanism of inference processing relies on the sound Bayes's rule/theorem that permits the logic. Expanding one or more influencing nodal parameters with decision and utility node(s) also yields an influence diagram (ID). BN and ID feasibility is shown in a marine evacuation scenario and that of authorized vessels to floating, production, storage, and offloading collision, developed via a commercial computer tool. Sensitivity analysis and validation of the produced results are also presented.     

Analytical network process for software selection in product development: A case study

Application of software for manufacturing processes is one of the resolutions many enterprises have resorted to in the 21st century. This has been a result of increased complexity of products, globalization, rapid changes in technology and so on. The idea was that application of software especially for product development would increase the competitive advantage of industry nevertheless the irony has been that most of the investment in software has not achieved the expected results. We carry out a case study to introduce a methodology, the analytical network process as a multiattribute strategic decision making approach to help in the selection of appropriate software to suit the product development process of a particular product.     

The use of constructive-developmental theory to advance the understanding of leadership

Constructive-developmental theory is a stage theory of adult development that focuses on the growth and elaboration of a person's ways of understanding the self and the world. In this article we review how the constructive-developmental frameworks of Kegan [Kegan, R. (1982). The evolving self: Problem and process in human development. Cambridge, MA: Harvard University Press], Torbert [Torbert, W. R. (1987). Managing the corporate dream: Restructuring for long-term success. Homewood, IL: Dow Jones-Irwin.], and Kohlberg [Kohlberg, L. (1969). Stage and sequence: The cognitive developmental approach to socialization. In D. Goslin (Ed.), Handbook of socialization: Theory and research. New York: Rand McNally] have been applied in the theoretical and empirical literature on leadership and management. Although the literature has produced a number of propositions, the notion that a leader's order of development should impact his or her leadership effectiveness or managerial performance has generated the most research. We found mixed support for this proposition as well as a number of limitations in the research in general. To have a greater impact on the leadership field, constructive-developmental theory needs to generate more robust research, to link more clearly with on-going streams of leadership research, and to explore the contribution of aspects of the theory beyond individual order of development.     

An ISO 9001:2000-based framework for realizing quality in small businesses

The purpose of ISO 9001:2000 Quality Management System (QMS) is to provide businesses with a model to grow systematically while assuring the quality of their products. The validity of ISO 9001:2000 QMS stems, largely, from the fact that the best minds worldwide have contributed to its development and maintenance, and the fact that many companies have reported real business gains because of its implementation. Unfortunately, many small businesses fail to survive due to the absence or lack of adequate system for managing quality. An obvious recommendation would be to implement ISO 9001:2000 QMS. Nevertheless, small businesses often cite lack of resources and time as the main reasons for not implementing ISO 9001:2000 QMS.     

Formative Versus Reflective Indicators in Organizational Measure Development: A Comparison and Empirical Illustration

A comparison is undertaken between scale development and index construction procedures to trace the implications of adopting a reflective versus formative perspective when creating multi‐item measures for organizational research. Focusing on export coordination as an illustrative construct of interest, the results show that the choice of measurement perspective impacts on the content, parsimony and criterion validity of the derived coordination measures. Implications for practising researchers seeking to develop multi‐item measures of organizational constructs are considered.     

Proximity and inter‐organizational collaboration: A literature review

The proximity concept is used in many different ways in the literature. These dimensions of proximity are, however, defined and measured in many different (sometimes even contradictory) ways, show large amounts of overlap, and often are under‐ or over‐specified. The goal of this paper is to specify the different dimensions of proximity relevant in inter‐organizational collaboration more precisely and to provide definitions of these dimensions. The research presented contributes to reducing the ambiguity of the proximity concept as used in the literature. Based on the above, the following research question is addressed in this paper: ‘Which dimensions of proximity are relevant in inter‐organizational collaboration and how are they defined?’ A systematic literature review is presented in order to disentangle the dimensions of the proximity concept. Based on this literature review, three dimensions of proximity relevant in inter‐organizational collaboration are distinguished: geographical proximity, organizational proximity and technological proximity. Examples (case studies) from the literature are used to illustrate the current conceptual ambiguity as well as to clarify how the proposed dimensions of proximity reduce this conceptual ambiguity.     

On the computational hardness based on linear FPT-reductions

The notion of linear fpt-reductions has been recently introduced to derive strong computational lower bounds for well-known NP-hard problems. In this paper, we formally investigate the notion of W[t]-hardness under the linear fpt-reduction, and study the structural properties of the corresponding complexity classes. Additional complexity lower bounds on important computational problems are established. Some observations on structural properties of the standard parameterized hierarchy, the W -hierarchy, are also presented. In this paper, we always assume that complexity functions are “nice” with both domain and range being non-negative integers and the values of the functions and their inverses can be easily computed.