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71.
An Empirical Approach to Sufficient Similarity: Combining Exposure Data and Mixtures Toxicology Data
Scott Marshall Chris Gennings Linda K. Teuschler LeAnna G. Stork Rogelio Tornero‐Velez Kevin M. Crofton Glenn E. Rice 《Risk analysis》2013,33(9):1582-1595
When assessing risks posed by environmental chemical mixtures, whole mixture approaches are preferred to component approaches. When toxicological data on whole mixtures as they occur in the environment are not available, Environmental Protection Agency guidance states that toxicity data from a mixture considered “sufficiently similar” to the environmental mixture can serve as a surrogate. We propose a novel method to examine whether mixtures are sufficiently similar, when exposure data and mixture toxicity study data from at least one representative mixture are available. We define sufficient similarity using equivalence testing methodology comparing the distance between benchmark dose estimates for mixtures in both data‐rich and data‐poor cases. We construct a “similar mixtures risk indicator”(SMRI) (analogous to the hazard index) on sufficiently similar mixtures linking exposure data with mixtures toxicology data. The methods are illustrated using pyrethroid mixtures occurrence data collected in child care centers (CCC) and dose‐response data examining acute neurobehavioral effects of pyrethroid mixtures in rats. Our method shows that the mixtures from 90% of the CCCs were sufficiently similar to the dose‐response study mixture. Using exposure estimates for a hypothetical child, the 95th percentile of the (weighted) SMRI for these sufficiently similar mixtures was 0.20 (i.e., where SMRI <1, less concern; >1, more concern). 相似文献
72.
David Alastair Lindsay Coldwell Chris William Callaghan 《Journal for the theory of social behaviour》2014,44(3):347-367
Organizational citizenship behaviour has generally been associated with organizational effectiveness. However, recent research has shown that this may not always be the case and that certain types of organizational citizenship behaviour such as compulsory citizenship behaviour, may be inimical to the fulfillment of formal goals and organizational effectiveness. Using military historical and business organizational secondary data, the paper maintains that extreme variance in either organizational (task) or personal (social psychological) support organizational citizenship behaviour generates entropic citizenship behaviour which derails completely the effective accomplishment of formal organizational goals. A general model of organizational citizenship behaviour with entropic citizenship behavior as its novel conceptual boundary is developed in the paper, and four specific propositions with implications for future empirical research are delineated. 相似文献
73.
Siu-Kei Wong Lawrence Wai-Chung Lai Daniel Chi-Wing Ho Kwong-Wing Chau Cindy Lo-Kuen Lam Chris Hung-Fai Ng 《Habitat International》2009,33(4):463-471
The outbreak of a highly communicable disease, SARS, in Asia in 2003 has revealed the health risk of living in a high-density environment. To show the important connection between human health and environmental quality, this study surveys the prevalence of sick building syndrome (SBS) among apartment residents and their evaluation of indoor environmental quality (IEQ). Based on a sample of 748 households living in Hong Kong, two interesting findings are revealed: (1) nasal discomfort was the commonest home-related SBS symptom despite the absence of any central ventilation system in apartment buildings; (2) noise, rather than ventilation, was the major IEQ problem perceived by residents. Our statistical analysis further showed that residents with SBS symptoms were less satisfied with their IEQ than those without. That is, despite a positive evaluation of specific IEQ criteria with respect to the building residents lived in, if they reported feeling SBS related symptoms, the overall IEQ evaluation of their building could still be negative. This perception bias gives rise to a sample selection problem in measuring perceived IEQ, which has implications on housing management practices and the formulation of a healthy housing policy. 相似文献
74.
Chris John Shepherd 《East Asian Science, Technology and Society: An International Journal》2009,3(2-3):315-342
The anthropology of development seeks to understand the complex encounter between international and national development regimes and local patterns of livelihood and being. As science and development move objects, at once material and discursive, through the networks of the social to reach “impoverished” others, local groups reach out to development actors to evaluate and appropriate their resources and accept or redirect those efforts. In a political interplay of disciplinary measures and localizing translations, development projects are re-invented, or aspects thereof refused, just as development actors strain to keep projects on track. With input from science and technology studies, this article explores the participatory, authoritative, and distributive dimensions to agricultural development in East Timor. Across four cases studies—a dairy, a greenhouse, a seed development program, and a permanent farming initiative—the politics of projects are compared and discussed within the broader context of colonial and postcolonial development. The article is based on a total of 1 year of fieldwork conducted in 2003, 2008, and 2009. 相似文献
75.
Armed combat in childhood is a form of child abuse. It may lead to serious consequences, including post‐traumatic stress disorder. The inherent emotional abuse and acts or omissions by caregivers may cause behavioural, cognitive, emotional or mental disorder in the child. Nineteen former child soldiers were interviewed in a rehabilitation centre using a standard questionnaire. Reasons for recruitment included: volunteered (18), hatred of enemy (revenge) (5), virtue of being a freedom fighter (martyrdom) (9), as a means of supporting their family (economic) (3). One child was abducted, 7 joined for fear of the ‘enemy’ abducting them, and in 5 a family member was killed by ‘enemy’ or own group. The children were involved in manual labour (15), guard duty (15), front‐line fighting (7), bomb manufacture (5), setting sea/land mines (5) and radio and communication (2). Fifteen were trained in firearms and 14 in self‐destruction. Twelve children attempted to or did run away and 11 refused to obey orders or argued. This led to various punishments, including kitchen duty, beatings, imprisonment, blackmail or death threats. A majority of the children felt sad and emotionally upset when they remembered their mother and family. Children's involvement in war, whatever the ‘justifications’ may be, should always be considered as forced, as they cannot truly comprehend their action in war. The responsibility must be taken by the adult caregivers. The following definition of the abuse of children in armed conflict is proposed: ‘The involvement of dependent, developmentally immature children and adolescents in armed conflict they do not truly comprehend, to which they are unable to give informed consent, and which adversely affects the child's right to unhindered growth and identity as a child’. Firm international agreement on guidelines for the lower age limit of recruitment of children into armed forces is required. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
76.
Infants follow the gaze of an individual with whom they are directly interacting by the end of the first year. By 18 months infants are capable of learning novel words in observational (or third‐party) contexts (Floor & Akhtar, 2006). To examine third‐party gaze following in 12‐ and 18‐month‐olds, the parent and experimenter engaged in a conversation while the infant was present. For 8 trials approximately every 30 sec the experimenter would turn her head to the right or left to fixate on a toy placed on either side of the room with the parent following suit. In the first experiment, the parent was seated next to the infant and the experimenter opposite, whereas in the second experiment the positions of the adults were switched. In Experiment 1, 18‐month‐olds but not 12‐month‐olds followed gaze. In Experiment 2, 12‐month‐olds acquired a tendency to follow gaze during the experimental session. These results suggest that an incipient ability to follow third‐party gaze is present by 12 months and that infants acquire a more reliable and general ability to follow the gaze of noninteractive others between 12 and 18 months. 相似文献
77.
Walmes Marques Zeviani Paulo Justiniano Ribeiro Jr Wagner Hugo Bonat Silvia Emiko Shimakura Joel Augusto Muniz 《Journal of applied statistics》2014,41(12):2616-2626
Event counts are response variables with non-negative integer values representing the number of times that an event occurs within a fixed domain such as a time interval, a geographical area or a cell of a contingency table. Analysis of counts by Gaussian regression models ignores the discreteness, asymmetry and heteroscedasticity and is inefficient, providing unrealistic standard errors or possibly negative predictions of the expected number of events. The Poisson regression is the standard model for count data with underlying assumptions on the generating process which may be implausible in many applications. Statisticians have long recognized the limitation of imposing equidispersion under the Poisson regression model. A typical situation is when the conditional variance exceeds the conditional mean, in which case models allowing for overdispersion are routinely used. Less reported is the case of underdispersion with fewer modeling alternatives and assessments available in the literature. One of such alternatives, the Gamma-count model, is adopted here in the analysis of an agronomic experiment designed to investigate the effect of levels of defoliation on different phenological states upon the number of cotton bolls. Data set and code for analysis are available as online supplements. Results show improvements over the Poisson model and the semi-parametric quasi-Poisson model in capturing the observed variability in the data. Estimating rather than assuming the underlying variance process leads to important insights into the process. 相似文献
78.
Susan Davis Deana Groves Alison C. Roth Emily McElroy Chris Brady 《Serials Review》2013,39(4):354-359
AbstractReports on the Ohio Valley Group of Technical Services Librarians (OVGTSL) Annual Conference, the April 2004 New England Technical Services Librarians (NETSL) Conference, the 2004 Acquisitions Institute at Timberline Lodge, and the 2004 Conference of the North American Serials Interest Group (NASIG).Reports are from four conferences held in various parts of the United States and cover a wide range of topics. The Ohio Valley Group of Technical Services Librarians program emphasized the relationship between technical and public services. Education, both formal and continuing, was the theme for the New England Technical Services Librarians. Timberline Lodge hosted another Acquisitions Institute featuring sessions on new discoveries. The report on the 2004 North American Serials Group Annual Conference allows Conference Student Grant Award winner Chris Brady to include some personal reflections along with summaries of the sessions he attended. 相似文献
79.
Amélie Desvars-Larrive Mario Baldi Theresa Walter Richard Zink Chris Walzer 《Urban Ecosystems》2018,21(5):951-964
Nowadays, the majority of human beings live in urban ecosystems, with this proportion expected to continue increasing in the future. With the growing importance of urban rat-associated issues (e.g. damages to urban infrastructures, costs of rat-control programs, rat-associated health risks), it is becoming indispensable to fill the identified gaps in knowledge on the urban brown rat regarding, among others, its density, home range, genetic structure, and infectious status. In this context, live-trapping is a crucial prerequisite to any scientific investigation. This paper assesses the main constraints and challenges regarding the urban field and describes the major steps to be considered when planning research on urban rats. The primary challenges are i) the characterization of the urban experimental unit; ii) the choice of a trapping design: the use of live-trapping in capture-mark-recapture design, in association with modern statistics, is highly recommended to answer ecological questions (although these methods, mostly developed in natural ecosystems, need to be implemented for the urban field); iii) the potential ethical considerations with regard to animal welfare and field-worker safety; iv) the building of mutually-beneficial collaborations with city stakeholders, pest control professionals, and citizens. Emphasis must be put on communication to the public and education of field-workers. One major need of modern urban rat research is a peer-validated field methodology allowing reproducibility, repeatability, and inference from urban field studies and enabling researchers to answer long-standing key questions about urban rat ecology. 相似文献
80.