泰乐松注射液的毒理学试验研究

为提供泰乐松注射液的安全性毒理学评价资料,本试验采用改进Karber法测定小鼠LD_(50);以剂量递增法测定小鼠蓄积性和耐受性;分别以剂量340、130、30mg／kg为3个试验组．设阴性和阳性对照组进行小鼠骨髓微核试验;分别以剂量500、250、120mg／kg为3个剂量组．设阴性和阳性对照组进行小鼠精于畸形试验。结果表明：其LD_(50)为669．80mg／kg,蓄积系数大于5．3,无明显蓄积毒性和耐受性（P＞0．05）,小鼠骨髓微核试验和精子畸形试验结果均为阴性。     

Going to Pieces: Paul Monette and the Fragments of the Tribe

Author of the highly acclaimed Borrowed Time: An AIDS Memoir (1988) and winner of the 1992 National Book Award for his autobiography Becoming a Man: Half a Life Story, Paul Monette died of complications from AIDS in Los Angeles on February 12, 1995. His most recent work, Last Watch of the Night: Essays Too Personal and Otherwise (1994), is his third volume in a trilogy of autobiographical writing on growing up gay, coming-out, and living with AIDS. A graduate of Phillips Academy and Yale University, Monette received a number of awards for his writing and his work as an outspoken voice in the battle against AIDS, including the National Book Award, three Lambda Literary awards, the PEN Center West Freedom to Write Award, and three honorary doctorate degrees, from Wesleyan University, the City University of New York, and the State University of New York at Oswego. A memorial service was held for Monette on Sunday, February 19, 1995, at the Directors Guild of America on Sunset Boulevard in Los Angeles. Paul Monette was 49.     

Sensitivity of the Optimum to Perturbations of the Profit or Weight of an Item in the Binary Knapsack Problem

In the binary single constraint Knapsack Problem, denoted KP, we are given a knapsack of fixed capacity c and a set of n items. Each item j, j = 1,...,n, has an associated size or weight w_j and a profit p_j. The goal is to determine whether or not item j, j = 1,...,n, should be included in the knapsack. The objective is to maximize the total profit without exceeding the capacity c of the knapsack. In this paper, we study the sensitivity of the optimum of the KP to perturbations of either the profit or the weight of an item. We give approximate and exact interval limits for both cases (profit and weight) and propose several polynomial time algorithms able to reach these interval limits. The performance of the proposed algorithms are evaluated on a large number of problem instances.     

Buchbesprechungen

Ohne Zusammenfassung     

Dual Career Couples als eine Variante von Work-Life-Integration

Dual Career Couples as a form of work-life-integrationThe author discusses the situation of dual career couples, when both are university graduates following an own career. Basing on a respective publication she delineates the current, mostly American research and reports on several German research projects, which endeavour to analyse the relation between gender and inequality in dual career couples.     

Von der Supervision zur Mediation und zurück

From supervision to mediation and vice versaMediation in organizations becomes more and more important because of increasing conflicts. The question is, which competencies of the counsellor are necessary, and above all, whether mediation is a particular method. The author explains the method of mediation and illustrates his concept of “patchwork-mediation”. This procedure allows to build a bridge between supervision and mediation.     

Ebert. Wolfgang (2001): Systemtheorien in der Supervision — Bestandsaufnahme und Perspektiven

Ohne Zusammenfassung