PI3K pathway and Bcl-2 family. Clinicopathological features in prostate cancer

The phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathways and Bcl-2 family play a central role in prostate cancer (PC). The aim was to determine influence in the biochemical progression in PC. To evaluate the association between clinic pathological and immunohistochemical variables, Spearman’s test was performed. Log-rank test and Kaplan–Meier curves were used for survival comparisons. To explore the correlation of the studied immunohistochemical parameters and the established prognostic variables with biochemical progression, univariate and multivariate Cox proportional Hazard regression analyses were performed. Spearman analysis showed correlation between stroma expression and tumor expression of PI3K with biochemical progression (p?=?.009, p?=?.004), respectively, and tumor immunohistochemical score with biochemical progression (p?=?.051). In the multivariate Cox regression model, only PI3K was retained as independent predictors of biochemical progression. In stroma expression, PI3K is (HR 0.172, 95% CI 0.065–0.452, p?=?.000); tumor expression, PI3K is (HR 0.087, 95% CI 0.026–0.293, p?=?.000), and tumor immunohistochemical score (HR 0.382, 95% CI 0.209–0.697 p?=?.002). Our results suggest a role for prostatic expression of PI3K was prognostic markers for PC. PI3K/AKT/mTOR and Bcl-2 family are becoming an important therapeutic target and predictive biomarkers of onset and progression of PC.     

Core Indicators to Assess Quality of Life in Population with Brain Injury

Assessing quality of life of people with brain injury has a relevant role for developing strategies focused on personal outcomes that allow us to guide good practices and rehabilitation. So far, assessment of quality of life for this population has been restricted to an evaluation of personal outcomes from a health-related quality of life perspective. This approach it is mostly centered on physical health, however, quality of life needs to be addressed from a holistic and multidimensional perspective. The goal of this study is to identify core indicators of quality of life in brain injury based on a comprehensive theoretical model focused on the most relevant aspects of this population functioning. A Delphi study was carried out to obtain the specific core indicators of quality of life for this population. The methodology used to reach a consensus about the best indicators and items to measure quality of life involved four rounds and 14 experts on rehabilitation of people with brain injury. The Delphi study provided evidence of content validity for the field-test version of a new scale that will be applied to a wide sample in order to empirically check its suitability for this population.     

Impact of Individual and Organizational Variables on Quality of Life

The general goal of this study consists of analyzing the influence of different types of human services in the quality of life of their nested users. Several multilevel models were proposed to test for significant differences not only in the overall quality of life score, but also in each of the eight core domains. Participants included 11,624 users of social and human services and the assessment quality of life instrument was the GENCAT Scale. Variables that were studied in the different models were gender, age, and diagnostic group (elderly, intellectual disability, physical disability, mental health problems, and chemical dependency) at the individual user level (level 1: individual), while type of services—in terms of the main population addressed by their supports (i.e. the aforementioned groups)—was studied at service level (level 2: organizational). In order to explain differences, individual characteristics were introduced first, types of services were introduced next, and finally joint individual and service variables were introduced in a single model. The main results of this study were that personal and organizational variables exhibited a different level of influence on users’ quality of life; and also that the type of services significantly influenced the quality of life of its users. The results of this study lead to practical implications for services providing support to these diagnostic groups, especially for those interested in managing, assessing, and improving quality of life related personal outcomes at the user level as well as quality enhancement at the organizational level.     

Goodness-of-Fit of the Distribution of Time-to-First-Occurrence in Recurrent Event Models

Imperfect repair models are a class of stochastic models that deal with recurrent phenomena. This article focuses on the Block, Borges, and Savits (1985) age-dependent minimal repair model (the BBS model) in which a system that fails at time t undergoes one of two types of repair: with probability p(t), a perfect repair is performed, or with probability 1-p(t), a minimal repair is performed. The goodness-of-fit problem of interest concerns the initial distribution of the failure ages. In particular, interest is on testing the null hypothesis that the hazard rate function of the time-to-first-event-occurrence, λ(·), is equal to a prespecified hazard rate function λ₀(·). This paper extends the class of hazard-based smooth goodness-of-fit tests introduced in Peña (1998a) to the case where data accrual is from a BBS model. The goodness-of-fit tests are score tests derived by reformulating Neyman's idea of smooth tests in terms of hazard functions. Omnibus as well as directional tests are developed and simulation results are presented to illustrate the sensitivities of the proposed tests for certain types of alternatives.     

Forensics ergonomics in Spain. Research priorities by the Delphi technique

Among the many fields of application of Ergonomics, this research deals with the services offered to Justice from the expertise recognized by the Law on prevention of occupational risks within the framework of the Law of Civil Procedure: Ergonomics forensic also called Legal Ergonomics. In Spain there are experiences since 1995 and an important development and this paper is to investigate the actions required for a more widespread use in trials. Consensus methods such as the Delphi survey technique are being employed to help enhance effective decision-making in the future development of Ergonomics Forensics. The Delphi survey is a group facilitation technique, which is an iterative multistage process, designed to transform opinion into group consensus. It is a flexible approach, that is used commonly within the health and social sciences, however, there is little use and practice of ergonomics as a technique to facilitate the participation of all experts involved: judges, lawyers and expert ergonomists.     

Involvement and emancipation of the worker. Action research in a university hospital

The present action research article is linked to an ergonomics project in a university hospital. The author's proposal is to focus action on the effective worker involvement required for the creation of spaces/mechanisms within organizations where people can enhance cooperation and deliberation on matters relating to work. For this purpose, a committee was introduced to assist in finding problems and solutions directly in work situations, so that workers could experience relative autonomy allowing them to develop procedures and choose tools appropriate to their own real needs. Based on this organizational implementation and on subsequent interviews, the practical results are analyzed and related to employee involvement. One can conclude that workers in all areas of the organization can be active elements for improving working conditions and productivity in companies.     

The workers role in knowledge management and sustainability policies

Based on the concepts of sustainability and knowledge management, this article seeks to identify points of contact between the two themes through an exploratory study of existing literature. The first objective is to find, in international literature, the largest number of papers jointly related to the theme of knowledge management and sustainability. In these documents, the authors looked at the kind of relationship existing between the two themes and what the benefits introduced in organizations are. Based on an ergonomic point of view, the second objective of this article is to analyze the role of the worker (whether at the strategic or operational level) and his importance in this context. The results demonstrate that there is very little literature that addresses the two themes together. The few papers found, however, can be said to show the many advantages of introducing sustainability policies supported by adequate knowledge management. Very little has been studied with regards to the role of workers, which could be interpreted as meaning that little importance is given to the proactive role they may play. On the other hand, there is a high potential for future research in these areas, based on the high level of consideration of workers in knowledge management and sustainability literature, as well as in literature in the areas of ergonomics and sociology.     

Evolution and decomposition of income inequality in Italy, 1991–2004

The aggregate measures of inequality do not display any significant trend in the concentration of equivalent income among the Italian households in the early 2000s. Yet some sizeable shifts in the income distribution seem to suggest that the relative positions of groups of households have changed on the income scale. Through a decomposition analysis of Gini index by income source we find that in the more recent years the income from self-employment is the main disequalizing factor. The decomposition by social groups provides the evidence that it is the group of self-employed and managers who have gained more ground on the income scale. This work has been debated by the three Authors under the coordination of Claudio Quintano. Rosalia Castellano has written Sect. 1, while Andrea Regoli has written Sects. 2 to 6.     

Overconfidence and risk seeking in credit markets: an experimental game

Behavioral biases may influence bank decisions when granting credit to their customers. This paper explores this possibility in an experimental setting, contributing to the literature in two ways. First, we designed a business simulation game that replicates the basic decision-making processes of a bank granting credit to clients under conditions of risk and uncertainty. Second, we implemented a series of short tests to measure participants’ overconfidence and risk profile according to prospect theory and then conduct an experimental implementation of the simulation game. We find that higher levels of overprecision and risk seeking for gains (mostly attributable to distortion of probabilities) foster lower prices and higher volumes of credit, and reduce quality. The most consistent result is that distortion of probabilities affects the ability to discriminate between the quality of borrowers according to objective information, fostering strategies of lower loan prices to lower quality clients. The external validity of the results is also discussed.