Exploring the Clustering Effect of the Frailty Survival Model by Means of the Brier Score

In this article, the Brier score is used to investigate the importance of clustering for the frailty survival model. For this purpose, two versions of the Brier score are constructed, i.e., a “conditional Brier score” and a “marginal Brier score.” Both versions of the Brier score show how the clustering effects and the covariate effects affect the predictive ability of the frailty model separately. Using a Bayesian and a likelihood approach, point estimates and 95% credible/confidence intervals are computed. The estimation properties of both procedures are evaluated in an extensive simulation study for both versions of the Brier score. Further, a validation strategy is developed to calculate an internally validated point estimate and credible/confidence interval. The ensemble of the developments is applied to a dental dataset.     

A randomized phase I Bayesian dose escalation design for the combination of anti‐cancer drugs

Nowadays, treatment regimens for cancer often involve a combination of drugs. The determination of the doses of each of the combined drugs in phase I dose escalation studies poses methodological challenges. The most common phase I design, the classic ‘3+3' design, has been criticized for poorly estimating the maximum tolerated dose (MTD) and for treating too many subjects at doses below the MTD. In addition, the classic ‘3+3' is not able to address the challenges posed by combinations of drugs. Here, we assume that a control drug (commonly used and well‐studied) is administered at a fixed dose in combination with a new agent (the experimental drug) of which the appropriate dose has to be determined. We propose a randomized design in which subjects are assigned to the control or to the combination of the control and experimental. The MTD is determined using a model‐based Bayesian technique based on the difference of probability of dose limiting toxicities (DLT) between the control and the combination arm. We show, through a simulation study, that this approach provides better and more accurate estimates of the MTD. We argue that this approach may differentiate between an extreme high probability of DLT observed from the control and a high probability of DLT of the combination. We also report on a fictive (simulation) analysis based on published data of a phase I trial of ifosfamide combined with sunitinib.Copyright © 2014 John Wiley & Sons, Ltd.     

A Systematic Review of African-Centered Therapeutic Interventions with Black American Adults

Clinical Social Work Journal - While substantial theoretical literature and growing evidence support the benefits of employing African-centered approaches with Black youth, research examining the...     

Blinking While Speaking and Talking,Hearing, and Listening: Communication or Individual Underlying Process?

Journal of Nonverbal Behavior - Why do eye-blinks activate during conversation? We manipulated informational content and communicative intent exchanged within dyads. By comparison to a silent...     

WebStress: a web interface to explore a multidatabase bibliographic corpus on occupational stress

A bibliographic study on a multidisciplinary subject, such as occupational stress, requires a multidatabase query facility. Given this, we searched eight databases belonging to different fields (medicine, psychology, etc.) and from different countries. Thus, more than 26000 references on occupational stress were gathered. A bibliographic corpus of this sort is unusable because of the heterogeneous format of the records and the number of duplicate entries. Considering the limitations of commercial programs, we have developed a system, called WebStress, for reformatting the data and removing duplicates. The huge number of references and the research needs of updating and searching have necessitated the addition of several other functions to WebStress. Therefore WebStress comprises a web interface that makes it possible to search the corpus with advanced features (using clustering, a specialized thesaurus on stress and Boolean queries). In addition to the usual bibliographic queries on a specific database such as Medline, WebStress provides bibliometric analysis of the corpus, which might contribute to a detailed analysis on occupational stress in order to highlight the networks of researchers and to find the main topics studied in this area. WebStress is not yet available to researchers in general. It is being further developed, and also permission needs to be obtained from the eight commercial bibliographic databases that it consults.     

Alignment between Quality Enforcement Devices and Governance Structures in the Agro-food Vertical Chains

Using a Transaction Cost Economics framework, this paper studies how supply chain governance are aligned with the type of quality enforcement mechanisms used in transactions with consumers. Specifically we compare governance of supply chains when private brand assures quality to chains where official certification assures products’ quality for customers. To test our proposition, we conducted a set of 42 case studies in 3 agro-food sectors (processed meat, cheese, fruits and vegetable) from 7 European countries. We found that supply chain governance is closer to hierarchy-like modes of organization in cases where reputational capital is the main quality assurance device, whereas market-like governance is more prevalent in cases with public certification.     

On the distribution of some ordered variables

Abstract

Motivated by a recent article published by Adam and Tawn, we characterize the distribution of two random variables X, Y ordered linearly like X < Y. We suppose that the random variables follow a bivariate extreme value distribution.     

A Bayesian ordinal logistic regression model to correct for interobserver measurement error in a geographical oral health study

Summary.  We present an approach for correcting for interobserver measurement error in an ordinal logistic regression model taking into account also the variability of the estimated correction terms. The different scoring behaviour of the 16 examiners complicated the identification of a geographical trend in a recent study on caries experience in Flemish children (Belgium) who were 7 years old. Since the measurement error is on the response the factor 'examiner' could be included in the regression model to correct for its confounding effect. However, controlling for examiner largely removed the geographical east–west trend. Instead, we suggest a (Bayesian) ordinal logistic model which corrects for the scoring error (compared with a gold standard) using a calibration data set. The marginal posterior distribution of the regression parameters of interest is obtained by integrating out the correction terms pertaining to the calibration data set. This is done by processing two Markov chains sequentially, whereby one Markov chain samples the correction terms. The sampled correction term is imputed in the Markov chain pertaining to the regression parameters. The model was fitted to the oral health data of the Signal–Tandmobiel^® study. A WinBUGS program was written to perform the analysis.     

Too Big to Learn: The Effects of Major Acquisition Failures on Subsequent Acquisition Divestment

We examine whether firms learn from their major acquisition failures. Drawing from a threat‐rigidity theoretical framework, we suggest that firms do not learn from their major acquisition failures. Furthermore, we hypothesize that host‐country experience reinforces the negative effects of major acquisition failures. Our research hypotheses are tested using an event history analysis of 741 acquisitions undertaken by French listed and non‐listed firms in the USA between January 1988 and December 2008. We use failure divestment (divestment resulting from acquisition failure) as a proxy for acquisition performance. Consistent with our theoretical framework, we find that major acquisition failures have a negative impact on future acquisition performance. Furthermore, we find that such negative effects are reinforced by firms’ host‐country experience.     

Investigation of mixed model repeated measures analyses and non‐linear random coefficient models in the context of long‐term efficacy data

The longitudinal data from 2 published clinical trials in adult subjects with upper limb spasticity (a randomized placebo‐controlled study [NCT01313299] and its long‐term open‐label extension [NCT01313312]) were combined. Their study designs involved repeat intramuscular injections of abobotulinumtoxinA (Dysport®), and efficacy endpoints were collected accordingly. With the objective of characterizing the pattern of response across cycles, Mixed Model Repeated Measures analyses and Non‐Linear Random Coefficient (NLRC) analyses were performed and their results compared. The Mixed Model Repeated Measures analyses, commonly used in the context of repeated measures with missing dependent data, did not involve any parametric shape for the curve of changes over time. Based on clinical expectations, the NLRC included a negative exponential function of the number of treatment cycles, with its asymptote and rate included as random coefficients in the model. Our analysis focused on 2 specific efficacy parameters reflecting complementary aspects of efficacy in the study population. A simulation study based on a similar study design was also performed to further assess the performance of each method under different patterns of response over time. This highlighted a gain of precision with the NLRC model, and most importantly the need for its assumptions to be verified to avoid potentially biased estimates. These analyses describe a typical situation and the conditions under which non‐linear mixed modeling can provide additional insights on the behavior of efficacy parameters over time. Indeed, the resulting estimates from the negative exponential NLRC can help determine the expected maximal effect and the treatment duration required to reach it.