Depressive Symptoms and Their Association With Adverse Environmental Factors and Substance Use in Runaway and Homeless Youths

We used diathesis‐stress and stress‐sensitization models to determine whether family maltreatment, street‐related traumatic events, stressful life events, and substance use were associated with depressive symptoms in runaway and homeless youths (RHY) in Los Angeles. Greater severity of depressive symptoms was significantly related to family maltreatment, being exposed to more traumatic stressors during homelessness, and current substance use compared to no substance use. Family maltreatment was also found to moderate the relationship between traumatic stressors and depressive symptoms. Importantly, cumulative exposure to the investigated risk factors at varying levels was associated with more severe depressive symptoms. Using a trauma‐informed approach to screen for RHY at risk of depression may pave the way for secondary prevention of major depression in RHY.     

‘That right level of intoxication’: A Grounded Theory study on young adults’ drinking in nightlife settings

The present study examined the meaning and functions of drinking across different nightlife settings (e.g., bars, dance clubs) in a sample of Italian young adults. A Grounded Theory recursive and iterative process of data collection, through 10 focus group interviews, and data analysis revealed the complex and dynamic nature of young people's experience of drinking in nightlife settings. Results indicated that three major categories of social nightlife settings associated with different meanings and uses of alcohol: a more moderate social drinking in bars, a pursuit of a desired level of intoxication in dancing settings, like nightclubs, with festivities and celebratory settings most associated with alcohol abuse and heavy drunkenness as a mean to maximize the celebration and the uniqueness of the event. The core category emerging was related to the collective social process of youngsters optimizing alcohol intake throughout the night to find and maintain a desired level of intoxication (‘just the right buzz’) in dancing settings, to reach a controlled disinhibition to get what they consider positive outcomes minimizing negative ones. Results can be informative for other cultural regions too where differences in the drinking experience across nightlife settings have not been fully addressed yet.     

Cultural adaptations in psychosocial interventions for post-traumatic stress disorder among refugees: A systematic review

ABSTRACT

The aim of this study was to systematically review randomized controlled trials on non-pharmaceutical interventions for post-traumatic stress disorder (PTSD) among adult refugees with a focus on identifying common cultural adaptations and reviewing possible effects of such adaptations on outcomes. The conducted systematic search yielded 11 studies. The strongest support was for eye movement desensitization and reprocessing (EMDR). Commonly used cultural adaptations in the reviewed studies included modifications in personnel and setting context, changes in content, and translation or adaptation of evaluation tools.     

PATENT BREADTH IN AN INTERNATIONAL SETTING

We examine the Nash equilibria of a game where two national governments set patent breadth strategically. Broader patents make R&D more attractive, but the effect on static efficiency is nonmonotonic. In a North–South model, where only the North can innovate, harmonization of patent breadth lowers welfare relative to the Nash equilibrium. When both countries can innovate, harmonization toward narrower patent breadth may raise world welfare. (JEL F02, F13, O3, O31, O32)     

Using Bayesian analysis in repeated preclinical in vivo studies for a more effective use of animals

Whilst innovative Bayesian approaches are increasingly used in clinical studies, in the preclinical area Bayesian methods appear to be rarely used in the reporting of pharmacology data. This is particularly surprising in the context of regularly repeated in vivo studies where there is a considerable amount of data from historical control groups, which has potential value. This paper describes our experience with introducing Bayesian analysis for such studies using a Bayesian meta‐analytic predictive approach. This leads naturally either to an informative prior for a control group as part of a full Bayesian analysis of the next study or using a predictive distribution to replace a control group entirely. We use quality control charts to illustrate study‐to‐study variation to the scientists and describe informative priors in terms of their approximate effective numbers of animals. We describe two case studies of animal models: the lipopolysaccharide‐induced cytokine release model used in inflammation and the novel object recognition model used to screen cognitive enhancers, both of which show the advantage of a Bayesian approach over the standard frequentist analysis. We conclude that using Bayesian methods in stable repeated in vivo studies can result in a more effective use of animals, either by reducing the total number of animals used or by increasing the precision of key treatment differences. This will lead to clearer results and supports the “3Rs initiative” to Refine, Reduce and Replace animals in research. Copyright © 2016 John Wiley & Sons, Ltd.     

Classification of three-level strength-3 arrays

Generalized aberration (GA) is one of the most frequently used criteria to quantify the suitability of an orthogonal array (OA) to be used as an experimental design. The two main motivations for GA are that it quantifies bias in a main-effects only model and that it is a good surrogate for estimation efficiencies of models with all the main effects and some two-factor interaction components. We demonstrate that these motivations are not appropriate for three-level OAs of strength 3 and we propose a direct classification with other criteria instead. To illustrate, we classified complete series of three-level strength-3 OAs with 27, 54 and 81 runs using the GA criterion, the rank of the matrix with two-factor interaction contrasts, the estimation efficiency of two-factor interactions, the projection estimation capacity, and a new model robustness criterion. For all of the series, we provide a list of admissible designs according to these criteria.