Does Voluntary Association Participation Boost Social Resources?*

Objectives. Conflicting arguments exist in the literature about whether associational involvement can enhance people's social resources (operationalized as the extent to which people have nearby social networks they can rely on). We aim to test these arguments. Methods. We use two‐wave panel data. These are needed, as a causal relationship is presumed: participation as antecedent and social resources as outcome. To test this relationship, we compared two groups: respondents who became members of an association (between the two waves) and respondents who remained uninvolved. Results. We found no general membership effect. However, starting volunteer work showed a small, positive effect on the growth of social resources. Furthermore, membership effects were found among groups with fewer possibilities of acquiring social resources in other contexts (the elderly, people without a partner, and ethnic minorities). Conclusions. In line with the more skeptical ideas about voluntary associations, the effects of voluntary association participation seem small. However, people differ in the extent to which they profit from this participation.     

Multilevel governance from below: how Dutch cities respond to intra-EU mobility

ABSTRACT

‘Intra-EU mobility’ from new member states provides a governance challenge to European countries like the Netherlands. Freedom of movement within the EU enables mobility but also has important social consequences at the urban level in particular. This article discusses to what extent local, national and European governments have interacted in the governance of ‘intra-EU movement’ and how this has affected their policies regarding migrants from Central and Eastern Europe in particular. Focusing on the Dutch case, including the cities of The Hague and Rotterdam, this article shows a development from a decoupled relationship, to localist governance and only recently evidence of emerging ‘multilevel governance’. Speaking to the broader literature on multilevel governance, this article firstly shows that in spite of its broad theoretical application, multilevel governance should be seen as one of the varied types of governance in a multilevel setting. And secondly, it shows how and why local governments can play a key role in the bottom-up development of governance in a multilevel setting.     

Substance use and decision‐making in adolescent best friendship dyads: The role of popularity

In adolescent best friendship dyads, we examined: (a) similarity in substance use and decision‐making; (b) associations between participants' decision‐making and their own and best friend's substance use, (c) the influence of relative popularity within the dyad on these associations. Participants (n = 172; 12–18 years) named their best friend, completed popularity ratings, and a substance use questionnaire. Computer tasks were administered to assess risk‐taking and immediate reward preferences. Reciprocated same‐sex best friendship dyads (n = 49) were distinguished on their popularity, and we controlled for age differences between dyads in the analyses. Best friends were similar in substance use and risk‐taking preferences. More popular friends' risk‐taking preferences were positively associated with alcohol use of less popular friends. These findings underscore best friendship similarity in risky behaviors, and the influence of popular friends.     

PubPredict: Prediction of progression and survival in oncology leveraging publications and early efficacy data

In oncology/hematology early phase clinical trials, efficacies were often observed in terms of response rate, depth, timing, and duration. However, the true clinical benefits that eventually support registrational purpose are progression-free survival (PFS) and/or overall survival (OS), the follow-up of which are typically not long enough in early phase trials. This gap imposes challenges in strategies for late phase drug development. In this article, we tackle the question by leveraging published study to establish a quantitative link between early efficacy outcomes and late phase efficacy endpoints. We used solid tumor cancer as disease model. We modeled the disease course of a RECISTv1.1 assessed solid tumor with a continuous Markov chain (CMC) model. We parameterize the transition intensity matrix of a CMC model based on published aggregate-level summary statistics, and then simulate subject-level time-to-event data. The simulated data is shown to have good approximation to published studies. PFS and/or OS could be predicted with the transition intensity matrix modified given clinical knowledge to reflect various assumptions on response rate, depth, timing, and duration. The authors have built a R shiny application named PubPredict, the tool implements the algorithm described above and allows customized features including multiple response levels, treatment crossover and varying follow-up duration. This toolset has been applied to advise phase 3 trial design when only early efficacy data are available from phase 1 or 2 studies.     

Leveraging identities: the strategic manipulation of social hierarchies for political gain

Much scholarship on boundary-making focuses on dyadic relationships between “us” and “them.” Yet the presence of multiple categories within societies allows for complex interactions among more than two potentially relevant groups. To capture this phenomenon and its dynamics better, we develop the concept of leveraging: the strategic manipulation of social distance among three or more constructed groups for political gain. The use of one group as a lever against another may involve stigmatizing or elevating categories of people along boundaries of race, ethnicity, national origin, religion, gender, class, sexual orientation, or other salient social markers. We theorize these processes and identify the motivations of the initiators of leveraging as well as the range of possible responses to it. We use a pair of empirical case studies drawn from contemporary Europe and additional examples from other settings to demonstrate the relevance of the concept. Conceptualizing leveraging both improves our scholarly understanding of group-making processes and offers political actors tools for interpreting and responding to a common set of strategic practices.