统计四大工程建设的法制保障研究

 推进基本单位名录库、企业一套表制度、数据采集处理软件系统和联网直报系统四大工程建设,这是当前我国统计工作的核心任务。然而,目前的法律制度还存在诸多缺陷和空白。因此,应当修订或出台相关规定,为统计四大工程建设提供坚实的法制保障。     

房地产预警指标体系及综合预警方法研究

 本文在对常用的房地产预警指标体系选择方法及筛选流程进行分析的基础上,提出了一种主、客观相结合的房地产预警指标选择方法,即先采用综合分析方法对指标进行初次选择,然后用聚类分析和相关分析相结合的方法进行再次选择。最后建立了武汉市房地产预警指标系统,并进行了房地产综合预警。     

Assessing additivity in nonparametric models —A kernel‐based method

In this article, we address the testing problem for additivity in nonparametric regression models. We develop a kernel‐based consistent test of a hypothesis of additivity in nonparametric regression, and establish its asymptotic distribution under a sequence of local alternatives. Compared to other existing kernel‐based tests, the proposed test is shown to effectively ameliorate the influence from estimation bias of the additive component of the nonparametric regression, and hence increase its efficiency. Most importantly, it avoids the tuning difficulties by using estimation‐based optimal criteria, while there is no direct tuning strategy for other existing kernel‐based testing methods. We discuss the usage of the new test and give numerical examples to demonstrate the practical performance of the test. The Canadian Journal of Statistics 39: 632–655; 2011. © 2011 Statistical Society of Canada     

Empirical likelihood for quantile regression models with longitudinal data

We develop two empirical likelihood-based inference procedures for longitudinal data under the framework of quantile regression. The proposed methods avoid estimating the unknown error density function and the intra-subject correlation involved in the asymptotic covariance matrix of the quantile estimators. By appropriately smoothing the quantile score function, the empirical likelihood approach is shown to have a higher-order accuracy through the Bartlett correction. The proposed methods exhibit finite-sample advantages over the normal approximation-based and bootstrap methods in a simulation study and the analysis of a longitudinal ophthalmology data set.     

统计数据项目、发布渠道与用户质量感知

 通过实施统计用户满意度调查,测量统计用户对于政府统计部门所生产各类统计数据项目的综合质量感知,及其在主要发布渠道的具体质量感知状况。基于调查数据的分析结果表明：各类统计数据项目的综合用户质量感知水平存在较为明显的差异,用户质量感知与其使用频率之间保持了一定的正相关关系;而各类统计项目在不同发布渠道的具体质量表现也不尽相同。据此可以有效确立统计数据质量管理工作的重点环节。     

面板数据模型的截面相关检验研究

 相关系数的绝对值形式可以很好的避免Pesaran（2004）的CD统计量中异向相关性相互抵消的情况,相应得到一个新的检验面板数据模型扰动项截面相关的统计量。蒙特卡洛模拟显示,无论是在因子模型下还是在空间移动平均模型下,新提出的统计量水平扭曲(size distortion)检验和功效(power)检验表现较好。通过模拟还发现当存在序列相关的扰动项时,先将扰动项进行去序列相关处理可以有效地避免序列相关导致的水平扭曲,并且不会降低统计量的功效。     

Exponential tilt models for two-group comparison with censored data

We study application of the Exponential Tilt Model (ETM) to compare survival distributions in two groups. The ETM assumes a parametric form for the density ratio of the two distributions. It accommodates a broad array of parametric models such as the log-normal and gamma models and can be sufficiently flexible to allow for crossing hazard and crossing survival functions. We develop a nonparametric likelihood approach to estimate ETM parameters in the presence of censoring and establish related asymptotic results. We compare the ETM to the Proportional Hazards Model (PHM) in simulation studies. When the proportional hazards assumption is not satisfied but the ETM assumption is, the ETM has better power for testing the hypothesis of no difference between the two groups. And, importantly, when the ETM relation is not satisfied but the PHM assumption is, the ETM can still have power reasonably close to that of the PHM. Application of the ETM is illustrated by a gastrointestinal tumor study.     

Borrowing Information across Populations in Estimating Positive and Negative Predictive Values

A marker's capacity to predict risk of a disease depends on disease prevalence in the target population and its classification accuracy, i.e. its ability to discriminate diseased subjects from non-diseased subjects. The latter is often considered an intrinsic property of the marker; it is independent of disease prevalence and hence more likely to be similar across populations than risk prediction measures. In this paper, we are interested in evaluating the population-specific performance of a risk prediction marker in terms of positive predictive value (PPV) and negative predictive value (NPV) at given thresholds, when samples are available from the target population as well as from another population. A default strategy is to estimate PPV and NPV using samples from the target population only. However, when the marker's classification accuracy as characterized by a specific point on the receiver operating characteristics (ROC) curve is similar across populations, borrowing information across populations allows increased efficiency in estimating PPV and NPV. We develop estimators that optimally combine information across populations. We apply this methodology to a cross-sectional study where we evaluate PCA3 as a risk prediction marker for prostate cancer among subjects with or without previous negative biopsy.     

Why a Bayesian approach to safety analysis in pharmacovigilance is important

Large databases of routinely collected data are a valuable source of information for detecting potential associations between drugs and adverse events (AE). A pharmacovigilance system starts with a scan of these databases for potential signals of drug-AE associations that will subsequently be examined by experts to aid in regulatory decision-making. The signal generation process faces some key challenges: (1) an enormous volume of drug-AE combinations need to be tested (i.e. the problem of multiple testing); (2) the results are not in a format that allows the incorporation of accumulated experience and knowledge for future signal generation; and (3) the signal generation process ignores information captured from other processes in the pharmacovigilance system and does not allow feedback. Bayesian methods have been developed for signal generation in pharmacovigilance, although the full potential of these methods has not been realised. For instance, Bayesian hierarchical models will allow the incorporation of established medical and epidemiological knowledge into the priors for each drug-AE combination. Moreover, the outputs from this analysis can be incorporated into decision-making tools to help in signal validation and posterior actions to be taken by the regulators and companies. We discuss in this paper the apparent advantage of the Bayesian methods used in safety signal generation and the similarities and differences between the two widely used Bayesian methods. We will also propose the use of Bayesian hierarchical models to address the three key challenges and discuss the reasons why Bayesian methodology still have not been fully utilised in pharmacovigilance activities.