Clustering of Microarray data via Clique Partitioning

Microarrays are repositories of gene expression data that hold tremendous potential for new understanding, leading to advances in functional genomics and molecular biology. Cluster analysis (CA) is an early step in the exploration of such data that is useful for purposes of data reduction, exposing hidden patterns, and the generation of hypotheses regarding the relationship between genes and phenotypes. In this paper we present a new model for the clique partitioning problem and illustrate how it can be used to perform cluster analysis in this setting.     

Cross‐Milieu Terrorist Collaboration: Using Game Theory to Assess the Risk of a Novel Threat

This article uses a game‐theoretic approach to analyze the risk of cross‐milieu terrorist collaboration—the possibility that, despite marked ideological differences, extremist groups from very different milieus might align to a degree where operational collaboration against Western societies becomes possible. Based upon theoretical insights drawn from a variety of literatures, a bargaining model is constructed that reflects the various benefits and costs for terrorists’ collaboration across ideological milieus. Analyzed in both sequential and simultaneous decision‐making contexts and through numerical simulations, the model confirms several theoretical arguments. The most important of these is that although likely to be quite rare, successful collaboration across terrorist milieus is indeed feasible in certain circumstances. The model also highlights several structural elements that might play a larger role than previously recognized in the collaboration decision, including that the prospect of nonmaterial gains (amplification of terror and reputational boost) plays at least as important a role in the decision to collaborate as potential increased capabilities does. Numerical simulation further suggests that prospects for successful collaboration over most scenarios (including operational) increase when a large, effective Islamist terrorist organization initiates collaboration with a smaller right‐wing group, as compared with the other scenarios considered. Although the small number of historical cases precludes robust statistical validation, the simulation results are supported by existing empirical evidence of collaboration between Islamists and right‐ or left‐wing extremists. The game‐theoretic approach, therefore, provides guidance regarding the circumstances under which such an unholy alliance of violent actors is likely to succeed.     

Restaurant Revenue Management at Chevys: Determining the Best Table Mix

Revenue management has been used in a variety of industries and generally takes the form of managing demand by manipulating length of customer usage and price. Supply mix is rarely considered, although it can have considerable impact on revenue. In this research, we focused on developing an optimal supply mix, specifically on determining the supply mix that would maximize revenue. We used data from a Chevys restaurant, part of a large chain of Mexican restaurants, in conjunction with a simulation model to evaluate and enumerate all possible supply (table) mixes. Compared to the restaurant's existing table mix, the optimal mix is capable of handling a 30% increase in customer volume without increasing waiting times beyond their original levels. While our study was in a restaurant context, the results of this research are applicable to other service businesses.     

Country-specific institutional effects on ownership: concentration and performance of continental European firms

This paper examines the effect of country-specific institutional constructs on the relationship between ownership concentration and performance for firms in the eight Continental European countries of Austria, Belgium, Germany, Spain, France, Italy, the Netherlands and Portugal. Using data from publicly-traded firms owned by other companies (i.e., blocks), measures of the quality of investor and creditor protection and the effectiveness of legal institutions are applied. Employing a hierarchical moderated multiple regression analysis, differential validity is established for the relationship between ownership concentration and performance as measured by return on shareholders’ funds. This differential effect comes from creditor protection regimes and is consistent with a relational corporate governance model based on debt finance and concentrated ownership.     

Effects of repeated multi-source feedback on the influence behavior and effectiveness of managers: A field experiment

Despite the widespread use of multi-source behavioral feedback as a method of leadership development, little research has been conducted to identify facilitating conditions that can make the feedback more effective. This article reports results from a longitudinal field experiment on the effects of providing feedback about influence behavior to middle managers in the corporate office of a supermarket chain. Managers who only attended a single feedback workshop were compared to managers who attended a second feedback workshop several months after the initial one. A significant increase in the use of “core” influence tactics with subordinates and peers was found only for the managers who received repeated feedback, and they were also rated higher in overall effectiveness by their bosses. Practical implications for leadership development and suggestions for future research are discussed.     

Binary Response Models for Panel Data: Identification and Information

This paper considers a panel data model for predicting a binary outcome. The conditional probability of a positive response is obtained by evaluating a given distribution function (F) at a linear combination of the predictor variables. One of the predictor variables is unobserved. It is a random effect that varies across individuals but is constant over time. The semiparametric aspect is that the conditional distribution of the random effect, given the predictor variables, is unrestricted. This paper has two results. If the support of the observed predictor variables is bounded, then identification is possible only in the logistic case. Even if the support is unbounded, so that (from Manski (1987)) identification holds quite generally, the information bound is zero unless F is logistic. Hence consistent estimation at the standard pn rate is possible only in the logistic case.     

Decision Theory Applied to an Instrumental Variables Model

This paper applies some general concepts in decision theory to a simple instrumental variables model. There are two endogenous variables linked by a single structural equation; k of the exogenous variables are excluded from this structural equation and provide the instrumental variables (IV). The reduced‐form distribution of the endogenous variables conditional on the exogenous variables corresponds to independent draws from a bivariate normal distribution with linear regression functions and a known covariance matrix. A canonical form of the model has parameter vector (ρ, φ, ω), where φis the parameter of interest and is normalized to be a point on the unit circle. The reduced‐form coefficients on the instrumental variables are split into a scalar parameter ρand a parameter vector ω, which is normalized to be a point on the (k−1)‐dimensional unit sphere; ρmeasures the strength of the association between the endogenous variables and the instrumental variables, and ωis a measure of direction. A prior distribution is introduced for the IV model. The parameters φ, ρ, and ωare treated as independent random variables. The distribution for φis uniform on the unit circle; the distribution for ωis uniform on the unit sphere with dimension k‐1. These choices arise from the solution of a minimax problem. The prior for ρis left general. It turns out that given any positive value for ρ, the Bayes estimator of φdoes not depend on ρ; it equals the maximum‐likelihood estimator. This Bayes estimator has constant risk; because it minimizes average risk with respect to a proper prior, it is minimax. The same general concepts are applied to obtain confidence intervals. The prior distribution is used in two ways. The first way is to integrate out the nuisance parameter ωin the IV model. This gives an integrated likelihood function with two scalar parameters, φand ρ. Inverting a likelihood ratio test, based on the integrated likelihood function, provides a confidence interval for φ. This lacks finite sample optimality, but invariance arguments show that the risk function depends only on ρand not on φor ω. The second approach to confidence sets aims for finite sample optimality by setting up a loss function that trades off coverage against the length of the interval. The automatic uniform priors are used for φand ω, but a prior is also needed for the scalar ρ, and no guidance is offered on this choice. The Bayes rule is a highest posterior density set. Invariance arguments show that the risk function depends only on ρand not on φor ω. The optimality result combines average risk and maximum risk. The confidence set minimizes the average—with respect to the prior distribution for ρ—of the maximum risk, where the maximization is with respect to φand ω.     

Learning How and Learning What: Effects of Tacit and Codified Knowledge on Performance Improvement Following Technology Adoption

This paper examines effects of tacit and codified knowledge on performance improvement as organizations gain experience with a new technology. We draw from knowledge management and learning curve research to predict improvement rate heterogeneity across organizations. We first note that the same technology can present opportunities for improvement along more than one dimension, such as efficiency and breadth of use. We compare improvement for two dimensions: one in which the acquisition of codified knowledge leads to improvement and another in which improvement requires tacit knowledge. We hypothesize that improvement rates across organizations will be more heterogeneous for dimensions of performance that rely on tacit knowledge than for those that rely on codified knowledge (H1), and that group membership stability predicts improvement rates for dimensions relying on tacit knowledge (H2). We further hypothesize that when performance relies on codified knowledge, later adopters should improve more quickly than earlier adopters (H3). All three hypotheses are supported in a study of 15 hospitals learning to use a new surgical technology. Implications for theory and practice are discussed.     

Measurement error, skewness, and risk analysis: coping with the long tail of the distribution.

Probabilistic risk analyses often construct multistage chance trees to estimate the joint probability of compound events. If random measurement error is associated with some or all of the estimates, we show that resulting estimates of joint probability may be highly skewed. Joint probability estimates based on the analysis of multistage chance trees are more likely than not to be below the true probability of adverse events, but will sometimes substantially overestimate them. In contexts such as insurance markets for environmental risks, skewed distributions of risk estimates amplify the "winner's curse" so that the estimated risk premium for low-probability events is likely to be lower than the normative value. Skewness may result even in unbiased estimators of expected value from simple lotteries, if measurement error is associated with both the probability and pay-off terms. Further, skewness may occur even if the error associated with these two estimates is symmetrically distributed. Under certain circumstances, skewed estimates of expected value may result in risk-neutral decisionmakers exhibiting a tendency to choose a certainty equivalent over a lottery of equal expected value, or vice versa. We show that when distributions of estimates of expected value are, positively skewed, under certain circumstances it will be optimal to choose lotteries with nominal values lower than the value of apparently superior certainty equivalents. Extending the previous work of Goodman (1960), we provide an exact formula for the skewness of products.