Effects of DISCOVER on the Career Maturity of Middle School Students

This study evaluated the effects of DISCOVER (American College Testing [ACT], 1991), a computer-assisted career guidance system, on the career maturity of 38 students (22 girls and 16 boys) enrolled in a rural middle school. Students randomly assigned to the treatment group worked with DISCOVER for approximately 1 hour a day over a 2-week period, whereas students in the control group did not have access to the DISCOVER program. Results indicated significant gains in career maturity among students in the treatment group (p <.05).     

Mental health and behavioral problems of youth in the child welfare system: residential treatment centers compared to therapeutic foster care in the Odyssey Project population

This is the first multisite, prospective study of behavioral and mental health disorders of youth in residential treatment centers (RTC) and therapeutic foster care (TFC), and the first study to compare the two. This study addressed two questions in a sample of 22 agencies in 13 states: (1) how prevalent were emotional and behavioral disorders in the youth admitted to RTCs and TFC?, and (2) were the youth in RTCs significantly more likely to be disturbed than youth served in TFCs? Data were drawn from the Time 1 phase of the longitudinal national "Odyssey Project" developed by the Child Welfare League of America (1995). Measures included an extensive child and family characteristics form (CFC) and the Child Behavior Checklist (CBCL). The results revealed extremely high levels of behavioral and mental health disorders in the sample as a whole, well above the norms for a non-child welfare population. The prevalence of disorder in the RTC population was substantially greater than in the TFC population.     

Material Hardship,Poverty, and Disability Among Working‐Age Adults*

Objectives. We used data from the 1996 panel of the Survey of Income and Program Participation to examine the extent to which working‐age people with disabilities experience several types of material hardships. Methods. We constructed a series of logistic regression models to assess the importance of disability to material hardship experiences after controlling for income and other sociodemographic characteristics. Results. The findings indicate that disability is an important determinant of material hardship even after controlling for these factors. We also found that a large majority of the low‐income respondents reporting a material hardship also reported being work‐limited for some period of time. Conclusions. Our findings provide support for policies that account for disability‐related expenditures and needs when determining eligibility for means‐tested assistance programs, and highlight an important limitation of the official poverty measure—it overstates the relative economic well‐being of people with disabilities.     

What is the value of qualitative longitudinal research with children and young people for international development?

This paper draws on data from Young Lives, a longitudinal study of childhood poverty, to explore how international development research might be strengthened by including qualitative longitudinal research (QLR). We review three problems in development studies: (a) the relatively low status of qualitative research within the hierarchy of development knowledge, (b) the predominance of cross-sectional research, and, (c) marginality of research with children and young people. We offer examples from Young Lives research on early marriage in Ethiopia, household poverty dynamics in India and Ethiopia, and aspirations and migration in Peru, to highlight the potential of QLR to address these drawbacks. We suggest that QLR illuminates the dynamic complexities of the processes and practices of everyday life, how they are experienced by children and young people, the responses they make, and the shifting trajectories of their lives.     

Detecting bliss synergy in in vivo combination studies with a tumor kinetic model

Linear models are generally reliable methods for analyzing tumor growth in vivo, with drug effectiveness being represented by the steepness of the regression slope. With immunotherapy, however, not all tumor growth follows a linear pattern, even after log transformation. Tumor kinetics models are mechanistic models that describe tumor proliferation and tumor killing macroscopically, through a set of differential equations. In drug combination studies, although an additional drug‐drug interaction term can be added to such models, however, the drug interactions suggested by tumor kinetics models cannot be translated directly into synergistic effects. We have developed a novel statistical approach that simultaneously models tumor growth in control, monotherapy, and combination therapy groups. This approach makes it possible to test for synergistic effects directly and to compare such effects among different studies.     

A Phase I/II adaptive design for heterogeneous groups with application to a stereotactic body radiation therapy trial

Dose‐finding studies that aim to evaluate the safety of single agents are becoming less common, and advances in clinical research have complicated the paradigm of dose finding in oncology. A class of more complex problems, such as targeted agents, combination therapies and stratification of patients by clinical or genetic characteristics, has created the need to adapt early‐phase trial design to the specific type of drug being investigated and the corresponding endpoints. In this article, we describe the implementation of an adaptive design based on a continual reassessment method for heterogeneous groups, modified to coincide with the objectives of a Phase I/II trial of stereotactic body radiation therapy in patients with painful osseous metastatic disease. Operating characteristics of the Institutional Review Board approved design are demonstrated under various possible true scenarios via simulation studies. Copyright © 2015 John Wiley & Sons, Ltd.