Home visits,holy visits: Diasporic pilgrimage to the ‘Holy Land’ amongst Palestinian–Jordanian Christians from Amman

This paper contributes to ‘visiting friends and relatives’ (VFR) discussions within migration and diaspora literatures by proposing a closer theorization of religious mobilities through the conceptual framework of ‘diasporic pilgrimage’. It advances VFR thinking by considering religion as a productive analytical category to interrogate relationships between people and place which sustain and constitute diasporic connection and attachment. This will be explored through the experiences and encounters of Palestinian–Jordanian Christians undertaking visits to places of religious and relational significance across Israel and/or Palestine from Jordan. Through an exploration of ethnographic data collected amongst diasporic Palestinian Christians living in Jordan, diasporic pilgrimage will be theorized as a localized process critically engaging with everyday facets of familiarity and regularity. This will revolve around three main elements of diasporic pilgrimage: translocal connections, temporalities and power geometries which constitute visits from Jordan and the so-called ‘Holy Land’ a diasporic form of religious mobility.     

A Bayesian method for safety signal detection in ongoing blinded randomised controlled trials

Sponsors have a responsibility to minimise risk to participants in clinical studies through safety monitoring. The FDA Final Rule for IND Safety Reporting requires routine aggregate safety evaluation, including in ongoing blinded studies. We are interested in estimating the probability that the true adverse event rate in the experimental arm exceeds that in the control arm. We developed a Bayesian approach that specifies an informative meta-analytic predictive prior on the event probability in the control arm and an uninformative prior on that in the experimental arm. We combined these priors with a mixture likelihood that considers each patient in the ongoing blinded study may belong to the experimental or control arm. This allowed us to estimate the quantity of interest without unblinding. We evaluated our method by simulation, pairing scenarios that differed only in whether a safety signal was present or missing, and quantifying the ability of our model to discriminate using signal detection theory. Our approach shows benefit. It detects safety signals more reliably with greater sample sizes and for common rather than rare events. Performance does not deteriorate markedly when historical studies exhibit heterogeneous hazards or non-constant hazards. Our method will allow us to monitor safety signals in ongoing blinded studies with the goal of earlier identification and risk mitigation. Our method could be adapted to use informative priors on both arms or predictive covariates where pertinent data exist. We stress that ongoing safety monitoring should involve a multi-disciplinary team where statistical methods are paired with medical judgement.     

Embedding Expertise for Policy Responses to COVID-19: Comparing Decision-Making Structures in Two Federal Democracies

Public Organization Review - The COVID-19 crisis focused attention on how experts from different scientific fields provided advice to governments through expert committees and task forces. We...     

Animal Advocacy and the “Good Cop-Bad Cop” Radical Flanking of Laboratory Research

This research explores the concurrent effects of radical and reformist approaches to animal advocacy on how animal welfare is institutionalized in laboratory research. The long-term outcomes of militant animal rights activism are not adequately explained by the two current radical flank effect models: a positive effect where militancy helps moderates, and a negative effect where militancy compromises the movement as a whole. Interviews and participant observation were used to identify a third model—good cop-bad cop radical flanking—that more accurately captures how a longstanding radical fringe of activism affects the institutionalization of animal advocates' demands. Contrary to existing models that describe immediate radical flank effects, a good cop-bad cop model helps explain the long-term effects of militancy and reformism on institutional practices, where activists' seemingly opposing efforts are, in fact, mutually reinforcing.     

A preliminary review of the parenting assessment and skill development service: A 10-day residential service for families at risk of child maltreatment

Tweddle's Parenting Assessment and Skill Development Service (PASDS) is a 10-day residential programme for families at risk of child maltreatment. The service aims to conduct a comprehensive parenting capacity assessment to inform case management and improve parenting practices. The aims of the study were to (1) describe the psychosocial functioning of parents taking part in PASDS, (2) describe the key parenting assessment outcomes, and (3) explore parents' experiences of participation in PASDS including (a) perceived barriers and enablers of participation and (b) perceived outcomes for their family. Participants were 18 parents who participated in Tweddle's PASDS in Melbourne, Australia. A mixed methods study comprising a case file review and qualitative interviews was conducted. Parents accessing PASDS had experienced adverse childhood events, and many were experiencing mental health difficulties. Interviews with parents revealed perceived benefits of PASDS in improving parenting knowledge and skills, family relationships, and parenting confidence. At the time of discharge, 33% of families were assessed as unable to provide independent care for their child. The current findings have important implications for the further evaluation of evidenced-based services which can improve the accuracy of parenting capacity assessments, aiding in child protection decision-making related to child placement and safety.     

AIDE: Adaptive intrapatient dose escalation designs to accelerate Phase I clinical trials

Designing Phase I clinical trials is challenging when accrual is slow or sample size is limited. The corresponding key question is: how to efficiently and reliably identify the maximum tolerated dose (MTD) using a sample size as small as possible? We propose model-assisted and model-based designs with adaptive intrapatient dose escalation (AIDE) to address this challenge. AIDE is adaptive in that the decision of conducting intrapatient dose escalation depends on both the patient's individual safety data, as well as other enrolled patient's safety data. When both data indicate reasonable safety, a patient may perform intrapatient dose escalation, generating toxicity data at more than one dose. This strategy not only provides patients the opportunity to receive higher potentially more effective doses, but also enables efficient statistical learning of the dose-toxicity profile of the treatment, which dramatically reduces the required sample size. Simulation studies show that the proposed designs are safe, robust, and efficient to identify the MTD with a sample size that is substantially smaller than conventional interpatient dose escalation designs. Practical considerations are provided and R code for implementing AIDE is available upon request.     

There Goes the Neighborhood: How Racial Threat Shapes the Formation of Integrated and Segregated Neighborhoods

Neighborhoods in the United States are highly segregated by race. Black–white segregation is particularly acute. Although racial segregation has been declining in recent years, it remains extremely high—especially in the largest metropolitan areas. The historical pattern has been that as African Americans move into a neighborhood, whites move out and thus the neighborhood (gradually or rapidly) transitions from predominantly white to predominantly black. A seemingly contradictory pattern has recently been observed: integrated neighborhoods are becoming more common. Why do some neighborhoods transition from white to black and others become integrated? We use racial competition theory to answer this question. We examine the characteristics of stable, integrated neighborhoods and contrast them with segregated predominantly white, predominantly black, and rapidly transitioning neighborhoods in six large metropolitan areas. We find that the location of black neighborhoods is a key factor in whether an integrated neighborhood remains integrated. Specifically, we find integrated neighborhoods are spatially distant from majority black neighborhoods while transitioning neighborhoods are adjacent to them. Our findings support the “sense of threat” hypothesis of racial competition theory.     

ORGANIZATIONAL CHOICE AND SOME CORRELATES OF INDIVIDUALS' EXPECTANCIES1

This study uses expectancy theory to predict the sorority choices of 121 undergraduate students. Results show that the complete, multiplicative expectancy model is only a slightly better predictor of choice behavior than other versions of the model. Several personal and situational correlates of individuals' expectancies of entering sororities also are examined. Results show significant relationships between expectancy and subjects' self-esteem, perception of value similarity with sorority members, and number of perceived friendships with sorority members.