P-value adjustment for multiple binary endpoints

The p-value-based adjustment of individual endpoints and the global test for an overall inference are the two general approaches for the analysis of multiple endpoints. Statistical procedures developed for testing multivariate outcomes often assume that the multivariate endpoints are either independent or normally distributed. This paper presents a general approach for the analysis of multivariate binary data under the framework of generalized linear models. The generalized estimating equations (GEE) approach is applied to estimate the correlation matrix of the test statistics using the identity and exchangeable working correlation matrices with the model-based as well as robust estimators. The objectives of the approaches are the adjustment of p-values of individual endpoints to identify the affected endpoints as well as the global test of an overall effect. A Monte Carlo simulation was conducted to evaluate the overall family wise error (FWE) rates of the single-step down p-value adjustment approach from two adjustment methods to three global test statistics. The p-value adjustment approach seems to control the FWE better than the global approach Applications of the proposed methods are illustrated by analyzing a carcinogenicity experiment designed to study the dose response trend for 10 tumor sites, and a developmental toxicity experiment with three malformation types: external, visceral, and skeletal.     

Estimating a frequency distribution when the sampling is biased

A simple random sample on a random variable A allows its density to be consistently estimated, by a histogram or preferably a kernel density estimate. When the sampling is biased towards certain x-values these methods instead estimate a weighted version of the density function. This article proposes a method for estimating both the density and the sampling bias simultaneously. The technique requires two independent samples and utilises ideas from mark-recapture experiments. An estimator of the size of the sampled population also follows simply from this density estimate.     

Surveillance of the interaction parameter of the ising model

Surveillance to detect changes of spatial patterns is of interest in many areas such as environmental control and regional analysis. Here the interaction parameter of the Ising model, is considered. A minimal sufficient statistic and its asymptotic distribution are used. It is demonstrated that the convergence to normal, distribution is rapid. The main result is that when the lattice is large, all approximations are better in several respects. It is shown that, for large lattice sizes, earlier results on surveillance of a normally distributed random variable can be used in cases of most interest. The expected delay of alarm at a fixed level of false alarm probability is examined for some examples.     

Some Observations,a Suggestion,and Some Comments on the Conway-Roberts Article

This article provides new tools for the evaluation of dynamic stochastic general equilibrium (DSGE) models and applies them to a large-scale new Keynesian model. We approximate the DSGE model by a vector autoregression, and then systematically relax the implied cross-equation restrictions and document how the model fit changes. We also compare the DSGE model's impulse responses to structural shocks with those obtained after relaxing its restrictions. We find that the degree of misspecification in this large-scale DSGE model is no longer so large as to prevent its use in day-to-day policy analysis, yet is not small enough to be ignored.     

Predicting Insurance Losses Under Cross-Classification: A Comparison of Alternative Approaches

Various mathematical and statistical models for estimation of automobile insurance pricing are reviewed. The methods are compared on their predictive ability based on two sets of automobile insurance data for two different states collected over two different periods. The issue of model complexity versus data availability is resolved through a comparison of the accuracy of prediction. The models reviewed range from the use of simple cell means to various multiplicative-additive schemes to the empirical-Bayes approach. The empirical-Bayes approach, with prediction based on both model-based and individual cell estimates, seems to yield the best forecast.     

A Framework for Time Varying Parameter Regression Modeling

A framework for time varying parameter regression models is developed and employed in modeling and forecasting price expectations, using the Livingston data. Alternative model formulations, which include various choices for both the stochastic processes generating the varying parameters and the sets of explanatory variables, are examined and compared by using this framework. These models, some of which have appeared elsewhere and some of which are new, are estimated and used to assess the expectations formation process.     

The Relative Size of Windfall Income and the Permanent Income Hypothesis

A reconciliation is offered for the diverse test results on Friedman's permanent income hypothesis. A large data sample of those receiving windfall income in the Bureau of Labor Statistics' 1972–1973 Consumer Expenditure Survey is divided according to the size of the windfall relative to estimated permanent income. A pattern of a declining marginal propensity to consume windfall income as the relative size of the windfall increases is apparent. These results support the permanent income hypothesis for relatively large windfalls.     

Primal and Dual Capacity Utilization: An Application to Productivity Measurement in the U.S. Automobile Industry

Capacity utilization measures have traditionally been constructed as indexes of actual, as compared to “potential,” output. This potential or capacity output (Y*) can be represented within an economic model of the firm as the tangency between the short- and long-run average cost curves. Economic theoretical measures of capacity utilization (CU) can then be characterized as Y/Y* where Y is the realized level of output. These quantity or primal CU measures allow for economic interpretation; they provide explicit inference as to how changes in exogenous variables affect CU. Additional information for analyzing deviations from capacity production can be obtained by assessing the “dual” cost of the gap.

In this article the definitions and representations of primal-output and dual-cost CU measures are formalized within a dynamic model of a monopolistic firm. As an illustration of this approach to characterizing CU measures, a model is estimated for the U.S. automobile industry, 1959–1980, and primal and dual CU indexes are constructed. Application of these indexes to adjustment-of-productivity measures for “disequilibrium” is then carried out, using the dual-cost measure.     

The True Cost-of-Living Index With Changing Preferences

This article investigates the theoretical and empirical properties of a true cost-of-living index under conditions of changing preferences. A family of true indexes is defined based on the notion of the current utility function. A particular index, based on the previous period's utility level, is then defined. Given this definition, a true cost-of-living index is computed based on a quadratic expenditure system estimated with quarterly data from 1960–1981. For empirical purposes, changes in preferences are represented by the linear habit formation hypothesis. This index is then compared with Paasche and Laspeyres indexes. The true cost-of-living index grows somewhat faster than either the Paasche or Laspeyres index. It also displays considerably more variability.