Differences in meconium stained amniotic fluid in an Australian population: A retrospective study

Background

Meconium stained amniotic fluid commonly occurs postdates (?>40 weeks gestation) indicating fetal maturity. Previous literature indicates that different ethnicities mature at different rates.

Statistical considerations in clinical trial design with event-free survival as the primary efficacy endpoint

In late-phase confirmatory clinical trials in the oncology field, time-to-event (TTE) endpoints are commonly used as primary endpoints for establishing the efficacy of investigational therapies. Among these TTE endpoints, overall survival (OS) is always considered as the gold standard. However, OS data can take years to mature, and its use for measurement of efficacy can be confounded by the use of post-treatment rescue therapies or supportive care. Therefore, to accelerate the development process and better characterize the treatment effect of new investigational therapies, other TTE endpoints such as progression-free survival and event-free survival (EFS) are applied as primary efficacy endpoints in some confirmatory trials, either as a surrogate for OS or as a direct measure of clinical benefits. For evaluating novel treatments for acute myeloid leukemia, EFS has been gradually recognized as a direct measure of clinical benefits. However, the application of an EFS endpoint is still controversial mainly due to the debate surrounding definition of treatment failure (TF) events. In this article, we investigate the EFS endpoint with the most conservative definition for the timing of TF, which is Day 1 since randomization. Specifically, the corresponding non-proportional hazard pattern of the EFS endpoint is investigated with both analytical and numerical approaches.     

A Diamond-Stiglitz approach to the demand for self-protection

The existing research concerning the relationship between risk aversion and prudence and the demand for self-protection assumes that the loss variable follows a Bernoulli distribution, and that changes in the level of self-protection are mean preserving. The analysis here replaces these two very strong conditions with ones which are more general. When doing this, the method of analysis is also significantly modified. This modification includes representing a change in the level of self-protection using the procedure developed by Diamond and Stiglitz (Journal of Economic Theory 8:337-360, 1974) for representing a change in risk. This alternate representation allows the existing findings to be generalized considerably, and also simplifies the analysis.     

Differential Recovery Migration across the Rural–Urban Gradient: Minimal and Short-Term Population Gains for Rural Disaster-Affected Gulf Coast Counties

Places affected or threatened by extreme environmental disturbances confront a number of significant issues, including whether their populations will stay the same or change through migration. Research on Hurricanes Katrina and Rita shows some displaced residents returned to their disaster-affected communities once the built environment was restored, new migrants settled in affected places as part of the rebuilding effort, and the regional migration system grew more urbanized and spatially concentrated during post-disaster years. Research also shows that not all disaster-affected places recovered their populations. Our study examines whether differential recovery is systematically patterned along the rural–urban gradient. Using U.S. Census Bureau estimates and IRS county-to-county migration data, we investigate whether the 2005 hurricane season differentially exacerbated or altered previous migration trends across a rural–urban gradient that incorporates proximity to metropolitan areas and disaster-related housing loss. We find a rural–urban differential in Gulf Coast recovery migration: The disaster boosted migration among non-metropolitan counties, yet these increases were smaller and short-lived compared to the patterns found for metropolitan counties, most especially high loss metropolitan counties. Our findings encourage theories of environmental migration to incorporate spatial differentiation and scenarios of environmental changes to account for differential impacts on settlement patterns across the rural–urban continuum.     

Effects of a Mindfulness Task on Women’s Sexual Response

Mindfulness-based interventions are effective at improving symptoms of sexual dysfunction in women. The mechanisms by which mindfulness improves sexual function are less clear. The main objective of our study was to investigate the impact of a mindfulness task on sexual response in women. Forty-one women (mean age = 27.2, SD = 5.6) participated in two laboratory sessions that each included two erotic films and one attention task that were presented in counterbalanced order. Both attention tasks consisted of a six-minute audio recording of either a modified body scan, focusing on genital arousal sensations (mindfulness condition), or a visualization exercise. Subjective and genital sexual arousal were measured continuously during stimulus presentation. The mindfulness task led to greater subjective and lower genital arousal. The agreement of subjective and genital sexual arousal (i.e., concordance) was greater in the mindfulness condition. Trait mindfulness was related to lower sexual arousal but also greater sexual concordance in women. Mindfulness-based interventions that encourage women to focus on physical arousal sensations in the here and now may be associated with women’s improved sexual function by enhancing feelings of sexual arousal during sexual activity and by increasing concordance between subjective and genital sexual arousal.     

Implementing School Based Youth Courts in a Rural Context: The Impact on Students’ Perceptions of School Climate,Individual Functioning,and Interpersonal Relationships

The Youth Court in Schools Project was implemented in two low-income, violent, racially/ethnically diverse rural counties. This study examined if the presence of Youth Court impacted students’ perceptions of school danger, individual functioning, and interpersonal relationships. Data were gathered from 3454 youth; following multiple imputation, data were analyzed using paired samples t tests. Results indicated that perceptions of school danger increased significantly and self-esteem decreased significantly in the control schools pretest to posttest. Violent behavior, anxiety, friend rejection, and bullying victimization decreased significantly in the Youth Court intervention schools pretest to posttest, but did not change significantly in the control schools. Findings provide preliminary evidence that Youth Court is an effective way of improving school climate, individual functioning, and interpersonal relationships.     

Modeling Synergy and Learning under Multiple Advanced Manufacturing Technologies

The advent of the wide variety of new, highly integrated, advanced manufacturing technologies available for acquisition by a firm's managers has brought to light an accompanying set of unexpected issues. These issues include expectations for the benefits and costs of these technologies, determining the appropriate order of implementation and finding a way to justify acquisition when many of the benefits are a function of the technology's learning and synergistic effects on other operations and technologies. We present here a model that captures the interaction effects of these highly integrated technologies and discuss the data requirements for application of the construct. We then illustrate the model's workings with a number of multitechnology examples and show the danger of ignoring the synergistic and learning effects of these technologies when considering their acquisition.     

DIVERSIFICATION GAINS FROM INCLUDING REAL ESTATE IN MIXED-ASSET PORTFOLIOS*

Diversification gains in mean-variance efficiency derived from including real estate in financial asset portfolios are examined. Optimal financial and mixed-asset portfolios were generated by selecting from an investment universe including several distinct financial and real estate media. Deficiencies of previous studies were overcome by employing data with improved representativeness and comparability. The efficient mixed-asset portfolios dominated the efficient financial asset portfolios implying that purely financial asset diversification is inefficient. The optimal mixed-asset portfolio prescribed that approximately two-thirds of the investment wealth be allocated to real estate and one-third to the financial media.     

“Everything That We Can Do”: A Content Analysis of the Protective Strategies Used by GLBTQ Parents

Despite increased access to parenting rights through legal marriage and adoption, U.S. gay, lesbian, bisexual, transgender, and queer (GLBTQ) parents continue to experience varying levels of support for their families. This study explored protective strategies, or actions taken to meet one's safety needs when vulnerable, that GLBTQ parents pursue. This study included 454 GLBTQ parents from a national survey. Participants' open-ended responses about protective strategies were extracted from the survey and analyzed using content analysis. Responses were coded into 10 categories capturing strategies GLBTQ parents used to protect their families. While strategies utilizing legal supports were common, the most cited strategies were symbolic strategies, including creating a family name and developing written statements of parent wishes. Exploratory analyses revealed no difference in mean number of strategies used between parents who reported having legal status as a parent through adoption or listing on the birth certificate and those without legal parenting status. These results suggest that GLBTQ parents, regardless of their legal parenting status, take intentional measures to achieve a sense of safety and increase social support. The findings reiterate the importance of both legal and social support of GLBTQ parents.