A new algorithm for clustering based on kernel density estimation

In this paper, we present an algorithm for clustering based on univariate kernel density estimation, named ClusterKDE. It consists of an iterative procedure that in each step a new cluster is obtained by minimizing a smooth kernel function. Although in our applications we have used the univariate Gaussian kernel, any smooth kernel function can be used. The proposed algorithm has the advantage of not requiring a priori the number of cluster. Furthermore, the ClusterKDE algorithm is very simple, easy to implement, well-defined and stops in a finite number of steps, namely, it always converges independently of the initial point. We also illustrate our findings by numerical experiments which are obtained when our algorithm is implemented in the software Matlab and applied to practical applications. The results indicate that the ClusterKDE algorithm is competitive and fast when compared with the well-known Clusterdata and K-means algorithms, used by Matlab to clustering data.     

On An Intriguing Distributional Identity

For a continuous random variable X with support equal to (a, b), with c.d.f. F, and g: Ω₁ → Ω₂ a continuous, strictly increasing function, such that Ω₁∩Ω₂?(a, b), but otherwise arbitrary, we establish that the random variables F(X) ? F(g(X)) and F(g^{? 1}(X)) ? F(X) have the same distribution. Further developments, accompanied by illustrations and observations, address as well the equidistribution identity U ? ψ(U) = ^dψ^{? 1}(U) ? U for U ～ U(0, 1), where ψ is a continuous, strictly increasing and onto function, but otherwise arbitrary. Finally, we expand on applications with connections to variance reduction techniques, the discrepancy between distributions, and a risk identity in predictive density estimation.     

Controlling type 1 error rate for sequential,bioequivalence studies with crossover designs

Sample size reestimation in a crossover, bioequivalence study can be a useful adaptive design tool, particularly when the intrasubject variability of the drug formulation under investigation is not well understood. When sample size reestimation is done based on an interim estimate of the intrasubject variability and bioequivalence is tested using the pooled estimate of intrasubject variability, type 1 error inflation will occur. Type 1 error inflation is caused by the pooled estimate being a biased estimator of the intrasubject variability. The type 1 error inflation and bias of the pooled estimator of variability are well characterized in the setting of a two‐arm, parallel study. The purpose of this work is to extend this characterization to the setting of a crossover, bioequivalence study with sample size reestimation and to propose an estimator of the intrasubject variability that will prevent type 1 error inflation.     

Semiparametric temporal process regression of survival-out-of-hospital

Lifetime Data Analysis - The recurrent/terminal event data structure has undergone considerable methodological development in the last 10–15 years. An example of the data structure that has...     

Generating synthetic data to produce public-use microdata for small geographic areas based on complex sample survey data with application to the National Health Interview Survey

Small area statistics obtained from sample survey data provide a critical source of information used to study health, economic, and sociological trends. However, most large-scale sample surveys are not designed for the purpose of producing small area statistics. Moreover, data disseminators are prevented from releasing public-use microdata for small geographic areas for disclosure reasons; thus, limiting the utility of the data they collect. This research evaluates a synthetic data method, intended for data disseminators, for releasing public-use microdata for small geographic areas based on complex sample survey data. The method replaces all observed survey values with synthetic (or imputed) values generated from a hierarchical Bayesian model that explicitly accounts for complex sample design features, including stratification, clustering, and sampling weights. The method is applied to restricted microdata from the National Health Interview Survey and synthetic data are generated for both sampled and non-sampled small areas. The analytic validity of the resulting small area inferences is assessed by direct comparison with the actual data, a simulation study, and a cross-validation study.     

Mixture structure analysis using the Akaike Information Criterion and the bootstrap

Given i.i.d. observations x1,x2,x3,...,xn drawn from a mixture of normal terms, one is often interested in determining the number of terms in the mixture and their defining parameters. Although the problem of determining the number of terms is intractable under the most general assumptions, there is hope of elucidating the mixture structure given appropriate caveats on the underlying mixture. This paper examines a new approach to this problem based on the use of Akaike Information Criterion (AIC) based pruning of data driven mixture models which are obtained from resampled data sets. Results of the application of this procedure to artificially generated data sets and a real world data set are provided.     

Iterated full partitions

Algebraic calculations that depend upon a full partition can be automated through the use of an operator P for the derivation of such a partition. Calculations that require the repeated use of P are automated by simply iterating the operator. The resulting output is general and contains sufficient structure to identify the result of a calculation for a variety of settings.     

Robust models in probability sampling

In the estimation of a population mean or total from a random sample, certain methods based on linear models are known to be automatically design consistent, regardless of how well the underlying model describes the population. A sufficient condition is identified for this type of robustness to model failure; the condition, which we call 'internal bias calibration', relates to the combination of a model and the method used to fit it. Included among the internally bias-calibrated models, in addition to the aforementioned linear models, are certain canonical link generalized linear models and nonparametric regressions constructed from them by a particular style of local likelihood fitting. Other models can often be made robust by using a suboptimal fitting method. Thus the class of model-based, but design consistent, analyses is enlarged to include more realistic models for certain types of survey variable such as binary indicators and counts. Particular applications discussed are the estimation of the size of a population subdomain, as arises in tax auditing for example, and the estimation of a bootstrap tail probability.     

t-Latinized Designs

A variety trial sometimes requires a resolvable block design in which the replicates are set out next to each other. The long blocks running through the replicates are then of interest. A t -latinized design is one in which groups of these t long blocks are binary. In this paper examples of such designs are given. It is shown that the algorithm described by John & Whitaker (1993) can be used to construct designs with high average efficiency factors. Upper bounds on these efficiency factors are also derived.     

Acute Middle Ear Infection in Small Children: A Bayesian Analysis Using Multiple Time Scales

The study is based on a sample of 965 children living in Oulu region (Finland), who were monitored for acute middle ear infections from birth to the age of two years. We introduce a nonparametrically defined intensity model for ear infections, which involves both fixed and time dependent covariates, such as calendar time, current age, length of breast-feeding time until present, or current type of day care. Unmeasured heterogeneity, which manifests itself in frequent infections in some children and rare in others and which cannot be explained in terms of the known covariates, is modelled by using individual frailty parameters. A Bayesian approach is proposed to solve the inferential problem. The numerical work is carried out by Monte Carlo integration (Metropolis-Hastings algorithm).