Mitochondrial abnormalities and oxidative imbalance in neurodegenerative disease

An increasing body of evidence now suggests the involvement of mitochondrial abnormalities in the etiology of neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer disease. In this Perspective, we describe a recent study that shows that treatment of human patients with the antioxidant coenzyme Q(10'), which functions in concert with certain mitochondrial enzymes, reduced the worsening of symptoms associated with PD. These findings are consistent with the hypothesis that mitochondrial dysfunction plays a role in the pathogenesis of PD and that treatments that target mitochondrial biochemistry might ameliorate the functional decline observed in patients suffering from PD.     

How parental drug use and drug treatment compliance relate to family reunification

This study uses Cox regression to assess the relationships among parental drug use, drug treatment compliance, and reunification from substitute care. The study finds that drug treatment compliance is associated with faster reunification, even when accounting for ongoing drug use and three parenting measures. The findings are consistent with a conceptual framework suggesting that certain client actions, such as drug treatment compliance, may serve as markers that substantially affect client outcomes.     

“The Sociologist as Voyeur”: Social Theory and Sexuality Research, 1910–1978

Sociology has a long history of social theory and ethnographic research in the area of sexuality. Although it has been largely overlooked, this body of work prefigures later advances by social constructionists and queer theorists. This article reviews some of the early theoretical and empirical contributions to the sociology of sexuality, organized into five broad themes: the denaturalization of sexuality and its origins; the historicization of sexuality; the analytic shift from deviants to deviance/margins to center; the destabilization of sexual categories and identities and emphasis on the fluid and diverse meanings of sexual acts; and the theorization of sexuality and gender as performance. This article suggests that sexual stigma may contribute to the marginalization of sexuality studies in sociology.     

Differences in African American and White college students' drinking behaviors: consequences, harm reduction strategies, and health information sources

The authors explored the differences between African American and White college students' drinking behaviors and their attitudes toward consequences, harm-reduction strategies, and health information sources. They collected data from a randomly selected sample of 1,110 students in a large public university to examine the effects of a high-risk drinking prevention intervention. In the current analysis, they compared African American and White students on indicators of high-risk drinking, drinking consequences, harm-reduction strategies, the sources that students typically used for health information, and the believability of those sources. The African American students scored lower on drinking measures than the White students did, reported fewer negative consequences, and more regularly employed drinking-reduction strategies, with one exception--choosing a designated driver. Both African and White respondents reported that their parents were their most frequent and usual sources of health-related information and said that parents and health professionals were the most credible sources.     

Technology and managing people:

conclusion The Information Age has revolutionized the workplace. While it is possible to purchase or copy machines and technology, their very interchangeability means they fail to cre-ate a sustained competitive advantage for an organization (Barney, 1991). The research directions this paper offers are intended to develop firm knowledge that allows creation of inimitable human resources. Importantly, in the rush to embrace new information technologies, organizations must remember the fundamental principle that workers will invest in firm goals in the presence of shared values and a commitment by the firm to make their well-being a priority. We urge continued attention to fulfillment of the psy-chological contract, and to the "people issues" that frequently seem less critical than issues of hardware or technology.     

'Bataille's boys': postmodernity, Fascists and football fans

In his analysis of football hooliganism, Anthony King claims to reveal the historical, conceptual scheme young, male supporters draw upon. This 'masculine vision', he states, is similar to that held by the Freikorps. Both groups are said to adhere to modernist notions of masculinity, sexuality and nationhood, reinforced by rituals which maintain boundaries between these 'proper' males and deviant 'others'. Occasionally, football hooligans breach these boundaries in acts of postmodern transgression. King also claims that fans link sex and violence in their imaginations. In this response I examine King's critique of his fellow theorists; challenge his 'Freikorps-Fans' analogy; demonstrate the problem he has in establishing the sex-violence link and question the relevance of his concept of postmodernity.     

Local volunteers respond to the Rena oil spill in Maketū, New Zealand

Following the MV Rena grounding and oil spill in the Bay of Plenty, New Zealand in October 2011, the Māori community of Maketū were quick to respond to the arrival of oil on their beaches. They asserted their rangatiratanga by establishing their marae as a base and successfully coordinated a clean-up by more than 450 volunteers, feeding these volunteers every day. We interviewed 11 clean-up leaders and volunteers in Maketū to gather information about how the oil spill affected people in the community and how they ensured the success of their clean-up efforts. Many volunteers returned to help with the clean-up day after day over several weeks. Concepts of kaitiakitanga and manaakitanga underpinned the work of the Maketū clean-up organisers. Participants attributed the success of the Maketū clean-up to the speed with which they responded, the support they received from their community and local businesses, and their local knowledge.     

MEANINGFUL REGRESSION AND ASSOCIATION MODELS FOR CLUSTERED ORDINAL DATA

Many proposed methods for analyzing clustered ordinal data focus on the regression model and consider the association structure within a cluster as a nuisance. However, the association structure is often of equal interest—for example, temporal association in longitudinal studies and association between responses to similar questions in a survey. We discuss the use, appropriateness, and interpretability of various latent variable and Markov models for the association structure and propose a new structure that exploits the ordinality of the response. The models are illustrated with a study concerning opinions regarding government spending and an analysis of stability and change in teenage marijuana use over time, where we reveal different behavioral patterns for boys and girls through a comprehensive investigation of individual response profiles.