Human Health Risk Assessment of Penicillin/Aminopenicillin Resistance in Enterococci Due to Penicillin Use in Food Animals

Penicillin and ampicillin drugs are approved for use in food animals in the United States to treat, control, and prevent diseases, and penicillin is approved for use to improve growth rates in pigs and poultry. This article considers the possibility that such uses might increase the incidence of ampicillin-resistant Enterococcus faecium (AREF) of animal origin in human infections, leading to increased hospitalization and mortality due to reduced response to ampicillin or penicillin. We assess the risks from continued use of penicillin-based drugs in food animals in the United States, using several assumptions to overcome current scientific uncertainties and data gaps. Multiplying the total at-risk population of intensive care unit (ICU) patients by a series of estimated factors suggests that not more than 0.04 excess mortalities per year (under conservative assumptions) to 0.14 excess mortalities per year (under very conservative assumptions) might be prevented in the whole U.S. population if current use of penicillin drugs in food animals were discontinued and if this successfully reduced the prevalence of AREF infections among ICU patients. These calculations suggest that current penicillin usage in food animals in the United States presents very low (possibly zero) human health risks.     

Temporal Disaggregation: Methods,Information Loss,and Diagnostics

This research provides a generalized framework to disaggregate lower-frequency time series and evaluate the disaggregation performance. The proposed framework combines two models in separate stages: a linear regression model to exploit related independent variables in the first stage and a state–space model to disaggregate the residual from the regression in the second stage. For the purpose of providing a set of practical criteria for assessing the disaggregation performance, we measure the information loss that occurs during temporal aggregation while examining what effects take place when aggregating data. To validate the proposed framework, we implement Monte Carlo simulations and provide two empirical studies. Supplementary materials for this article are available online.     

Virtual Interpersonal Touch and Digital Chameleons

We studied the characteristics of hand touch with a mechanical device that approximated a handshake, and we then examined the effect of handshake mimicry on assessment of a partner. Two participants interacted with a force-feedback joystick that recorded each of their hand movements individually. The two participants then greeted one another by feeling the recording of the other person’s movements via the force-feedback device. For each dyad, one of the participants actually received his or her own virtual handshake back under the guise that it was the other person’s virtual handshake. Results demonstrated three significant findings. First, for any given participant, a metric that took into account position, angle, speed, and acceleration of the hand movements correlated highly within individuals across two handshakes. Second, across participants, these metrics demonstrated specific differences by gender. Finally, there was an interaction between gender and mimicry, such that male participants liked people who mimicked their handshakes more than female participants did. We discuss the implications of these findings and relate them to theories of social interaction.

走向一种绿色意识形态

与价值观不同，意识形态既是规范性的又是描述性的，或者说，既是价值评估性的也是知识追求性的。事实与价值之间的关系，被传统地以“二分法”的方式加以构建，实际上二者是一种互补关系，但这也并不意味着对矛盾关系的否认。一种建立在摆脱教条主义的唯物主义基础上的绿色理论，更有利于开展一种行之有效的实践，而这或许是绿色运动可以从马克思主义那里继承的最为重要的遗产。如果生态主义要想成为一种有影响的意识形态，就必须发展一种“绿色实践观”，创建“理论-实践”的统一体，并借助包含着价值考量在内的“中介”来跨越二者之间的鸿沟。     

Predicting What Will Happen When You Intervene

This paper offers some rules of thumb that practicing social workers can use for case studies that aim to construct, albeit not fully and never entirely reliably, models designed to help predict what will happen if they intervene in specific ways to help this particular client, here and now. We call these ’ex ante case-specific causal models’. ’Ex ante’ because they are for before-the-fact prediction of what the likely effects of proposed actions are. ’Case-specific’ because we are not concerned with studies that provide evidence for some general conclusion but rather with using what general and local knowledge one can get to predict what will happen to a specific client in the real settings in which they live. ’Causal’ because this kind of case study aims to trace out as best possible the web of causal processes that will be responsible for what happens. In this sense our case studies resemble post facto realist evaluations.     

Influence in covariance structure analysis: with an application to confirmatory factor analysis

Influence functions are derived for the parameters in covariance structure analysis, where the parameters are estimated by minimizing a discrepancy function between the assumed covariance matrix and the sample covariance matrix. The case of confirmatory factor analysis is studied precisely with a numerical example. Comparing with a general procedure called one-step estimation, the proposed procedure has two advantages:1) computing cost is cheaper, 2) the property that arbitrary influence can be decomposed into a fi-nite number of components discussed by Tanaka and Castano-Tostado(1990) can be used for efficient computing and the characterization of a covariance structure model from the sensitivity perspective. A numerical comparison is made among the confirmatory factor analysis and some procedures of ex-ploratory factor analysis by using the decomposition mentioned above.     

Peacebuilding through the Electoral Participation of Displaced Populations

The participation of displaced populations in elections organizedas part of a peacebuilding process is increasingly recognizedas fundamental to the goal of peacebuilding itself. Guaranteesfor their electoral participation are important, first and foremost,as a matter of rights. They also are critical for the legitimacyof the election and its results, and thus for national and regionalstability. However, translating these provisions into practicecan be a complex task, which requires addressing a range oflegal, administrative, practical, and political issues. Thisarticle explores the relationship between peacebuilding andthe electoral participation of displaced populations, arguingthat it is not possible to build peace when exclusion is dejure or de facto built into the process.     

The Determinants of Retail Productivity: A Critical Review of the Evidence

This paper discusses the literature on the established determinants of productivity in the retail sector. It also draws attention to some neglected strands of research which provide useful insights into strategies that could allow productivity enhancements in this area of the economy. To date, very few attempts have been made to integrate different specialisms in order to explain what drives productivity in retail. Here this paper rectifies this omission by putting together studies from economics, geography, knowledge management and employment studies. It is the authors’ view that quantitative studies of retail productivity should focus on total factor productivity in retailing as the result of competition/composition effects, planning regulations, information and communications technology, the multinational operation element and workforce skills. Further, the fact that retail firms possess advantages that are transferable between locations suggests that investment in strategies enhancing the transfer of explicit and tacit knowledge between and within businesses are crucial to achieve productivity gains.